CA1186992A - Stable radiographic imaging agents - Google Patents

Stable radiographic imaging agents

Info

Publication number
CA1186992A
CA1186992A CA000430066A CA430066A CA1186992A CA 1186992 A CA1186992 A CA 1186992A CA 000430066 A CA000430066 A CA 000430066A CA 430066 A CA430066 A CA 430066A CA 1186992 A CA1186992 A CA 1186992A
Authority
CA
Canada
Prior art keywords
acid
composition
stabilizer
reductant
deoxyascorbic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000430066A
Other languages
English (en)
French (fr)
Inventor
Mahdi B. Fawzi
James J. Benedict
Joseph E. Bugaj
Charles R. Degenhardt
Barry F. Vanduzee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of CA1186992A publication Critical patent/CA1186992A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicinal Preparation (AREA)
  • Measurement Of Radiation (AREA)
CA000430066A 1982-06-10 1983-06-09 Stable radiographic imaging agents Expired CA1186992A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US387,138 1982-06-10
US06/387,138 US4440738A (en) 1982-06-10 1982-06-10 Stable radiographic imaging agents

Publications (1)

Publication Number Publication Date
CA1186992A true CA1186992A (en) 1985-05-14

Family

ID=23528633

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000430066A Expired CA1186992A (en) 1982-06-10 1983-06-09 Stable radiographic imaging agents

Country Status (7)

Country Link
US (1) US4440738A (enExample)
EP (1) EP0096930B1 (enExample)
JP (1) JPS595126A (enExample)
AT (1) ATE26537T1 (enExample)
AU (1) AU555898B2 (enExample)
CA (1) CA1186992A (enExample)
DE (1) DE3370935D1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504462A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
DE3237573A1 (de) * 1982-10-09 1984-04-12 Hoechst Ag, 6230 Frankfurt Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung
US4707353A (en) * 1982-12-08 1987-11-17 Mallinckrodt, Inc. Radiographic imaging agents
US4510125A (en) * 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
EP0111414A3 (en) * 1982-12-08 1985-05-02 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents
US5393512A (en) * 1985-01-14 1995-02-28 Vanderheyden; Jean-Luc Stable therapeutic radionuclide compositions and methods for preparation thereof
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
US4778672A (en) * 1985-11-27 1988-10-18 University Of Cincinnati Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution
US4935222A (en) * 1986-06-13 1990-06-19 University Of Cincinnati Procedure for isolating and purifying radioactive ligated rhenium pharmaceuticals and use thereof and kit
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
DE3780820D1 (enExample) * 1987-10-30 1992-09-03 Sorin Biomedica S.P.A., Saluggia, Vercelli, It
DE3810819A1 (de) * 1988-03-30 1989-10-12 Hoechst Ag Tc-99m-(omega)-alkylphosphinico-1-hydroxyalkan-1, 1-diphosphonate enthaltende praeparate zur knochenszintigraphie sowie verfahren zur herstellung dieser praeparate
US4880615A (en) * 1988-11-25 1989-11-14 Merck & Co., Inc. Stabilized radiopharmaceutical compositions
US5116944A (en) * 1989-12-29 1992-05-26 Neorx Corporation Conjugates having improved characteristics for in vivo administration
WO1993004702A1 (en) * 1991-08-29 1993-03-18 Mallinckrodt Medical, Inc. Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
HRP930131A2 (en) * 1993-02-05 1997-02-28 Bozidar Suskovic Amino-ascorbic acid derivatives, process for the preparation and use thereof
US5559251A (en) * 1993-02-05 1996-09-24 Pliva, Farmaceutska Derivatives of amino-ascorbic acid, the processes for their preparation and use
US6187286B1 (en) * 1996-12-27 2001-02-13 The General Hospital Corporation Tumor imaging agents, methods and kits
US6548042B2 (en) * 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
JP5139678B2 (ja) * 2003-07-24 2013-02-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法
US8440787B2 (en) 2007-10-23 2013-05-14 Nektar Therapeutics Hydroxyapatite-targeting multiarm polymers and conjugates made therefrom
EP2572736A1 (en) * 2011-09-23 2013-03-27 Spago Imaging AB Nanostructures comprising manganese

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832689A (en) * 1952-01-24 1958-04-29 Research Corp Preservation of organic materials by irradiation
US3735295A (en) * 1972-03-28 1973-05-22 Westinghouse Electric Corp Electric control devices with mechanical interlock
US3735001A (en) * 1972-05-24 1973-05-22 Atomic Energy Commission Technetium bone scanning medium
CA1027135A (en) * 1973-06-11 1978-02-28 Research Corporation Bone-seeking technetium-99m complex
ZA761944B (en) * 1975-04-30 1977-03-30 Procter & Gamble Stable radiographic scanning agents
US4364920A (en) * 1975-04-30 1982-12-21 Medi-Physics, Inc. Stable diagnostic reagents
DE2543349C2 (de) * 1975-09-29 1984-05-10 Henkel KGaA, 4000 Düsseldorf Preaparate zur herstellung von99m technetium-radiagnostica
US4054645A (en) * 1976-08-24 1977-10-18 Minnesota Mining And Manufacturing Company Radiodiagnostic complexes employing fluorine-containing tin reducing agents
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4229427A (en) * 1978-06-28 1980-10-21 The Procter & Gamble Company Radioactive scanning agents with hydroquinone stabilizer
US4247534A (en) * 1978-07-31 1981-01-27 The Procter & Gamble Company Radiographic scanning agent
US4427647A (en) * 1980-08-12 1984-01-24 Amersham International Limited Method and reagent for making a radiopharmaceutical composition based on pertechnetate
JPS5750928A (en) * 1980-09-13 1982-03-25 Nippon Mejifuijitsukusu Kk Diagnostic agent for scanning bone
DE3047107A1 (de) * 1980-12-13 1982-07-29 Hoechst Ag, 6000 Frankfurt Verfahren zur hertellung von 1-amino-alkan-1,1-diphosphonsaeuren

Also Published As

Publication number Publication date
AU555898B2 (en) 1986-10-16
JPS595126A (ja) 1984-01-12
JPH0536415B2 (enExample) 1993-05-31
DE3370935D1 (en) 1987-05-21
EP0096930B1 (en) 1987-04-15
AU1567283A (en) 1983-12-15
US4440738A (en) 1984-04-03
EP0096930A2 (en) 1983-12-28
ATE26537T1 (de) 1987-05-15
EP0096930A3 (en) 1984-03-07

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Publication Publication Date Title
CA1186992A (en) Stable radiographic imaging agents
EP0006658B1 (en) Radioactive scanning agents with hydroquinone as stabilizer and method for preparing them
US4233284A (en) Stabilized radiographic scanning agents
US4247534A (en) Radiographic scanning agent
EP0006659B1 (en) Compositions useful in the preparation of stabilized radiographic scanning agents, a method of preparing them and the use of stannous gentisilate as stabilizer in these compositions
US4497744A (en) Gentisic acid salts as radiographic scanning agent stabilizers
US4504462A (en) Process for making a lyophilized product for use in skeletal imaging
US4234562A (en) Radiographic scanning
US4504463A (en) Process for making a lyophilized product for use in skeletal imaging
EP0096931B1 (en) Radiographic imaging agents
EP0096934B1 (en) Radiographic imaging agents
US4432963A (en) Radiographic scanning agent
Bevan Radiographic scanning agent
Fawzi Stabilized radiographic scanning agents
Fawzi Radioactive scanning agents with stabilizer

Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry