CA1180000A - Method for manufacturing a stable powder containing a very hygroscopic active product - Google Patents
Method for manufacturing a stable powder containing a very hygroscopic active productInfo
- Publication number
- CA1180000A CA1180000A CA000396164A CA396164A CA1180000A CA 1180000 A CA1180000 A CA 1180000A CA 000396164 A CA000396164 A CA 000396164A CA 396164 A CA396164 A CA 396164A CA 1180000 A CA1180000 A CA 1180000A
- Authority
- CA
- Canada
- Prior art keywords
- powder
- weight
- dry yeast
- organic
- organic powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/127—Structure or manufacture of heads, e.g. inductive
- G11B5/187—Structure or manufacture of the surface of the head in physical contact with, or immediately adjacent to the recording medium; Pole pieces; Gap features
- G11B5/255—Structure or manufacture of the surface of the head in physical contact with, or immediately adjacent to the recording medium; Pole pieces; Gap features comprising means for protection against wear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
- G11B5/00—Recording by magnetisation or demagnetisation of a record carrier; Reproducing by magnetic means; Record carriers therefor
- G11B5/127—Structure or manufacture of heads, e.g. inductive
- G11B5/1274—Structure or manufacture of heads, e.g. inductive with "composite" cores, i.e. cores composed in some parts of magnetic particles and in some other parts of magnetic metal layers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Dairy Products (AREA)
- Feed For Specific Animals (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
In a method for manufacturing a stable powder from a substance which contains in its molecule a rather precise number of water molecules making the powder deliquescent and unsuitable for distribution in hard capsules or in bags, the step of crushing the substance is performed in the presence of a finely pulverulent dry organic powder in order to produce finely pulverulent homogeneous products which are stable and able to he easily put in hard capsules or in bags.
In a method for manufacturing a stable powder from a substance which contains in its molecule a rather precise number of water molecules making the powder deliquescent and unsuitable for distribution in hard capsules or in bags, the step of crushing the substance is performed in the presence of a finely pulverulent dry organic powder in order to produce finely pulverulent homogeneous products which are stable and able to he easily put in hard capsules or in bags.
Description
3~
As known, some pharmaceutical products incorporate substances which contain in their molecule a rather precise number of water molecules, whieh makes them very difficult to be kept for a long time due to the fact it i5 not possible to include them in hard capsules or in bags.
Thus, their life in jars is very much reduced, particularly in very humid countries, such as temperate countries or countries in the equatorial areas.
Thus, in the past there has been used mechanical means, such as vacuum wrapping means, but the cost is then very high, and this increase in the price of the wrapping means restrains the sale of the medicament itself which is, generally, o~ an extremely low cost.
This is particularly the case when the medicament contains hydrated calcium chloxide C12Ca, 6H2O or hyd:rated magn~sium sulfate SO4~1g, 7H2O. Actually, these substances are very hygroscopic in the open air and, if they are placed without any partieular proteetion in hard eapsules, the substance is modified and the capsule becomes soft, thus requiring destruction of the medicament which is no longer ingestible.
It has thus been proposed to introduce a dryinq or desiccative powder in the active product which contains water moleeules, and for this purpose there has been used talcum powder or the like, but these substances have two principal drawbacks, namely introduction of a mineral material which is not without action on the gastric or intestinal pH of the human system and also absorption of the active substanee by the dryina or dessieeative powder which makes it less available for the human system.
Accordingly, it is a general object of the present invention to provide a novel and useful method for manufacturing a stable powder containing a product with ~L~3~
very great hygroscopic activity, in which the above described disadvantages have been overcome. According to the present invention there is provided a method for manufacturing a stable powder from a substance which contains in its mole-cule a rather precise number of water molecules making thepowder deliquescent and unsuitable for distribution in hard capsules or in ba~s, comprising the step of crushing the substance, characterized in that the crushin~ step is performed in the presence of a finely pulverulent dry organic powder, such as for example yeast, in order to give finely pulverulent homogeneous products which are stable and able to be easily put in hard capsules or in bags.
According to a preferred embodiment of the invention there is used 12 parts by wei~ht of crystallized hygroscopic product which is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
According to a further preferred embodiment of the invention, 3 parts by weight o~ hy~roscopic product in crystallized form is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
Other objects and further features o the present invention will be apparent from the following detailed description.
As it has been stated above, the invention relates to a method in which a substance containing in its molecule a rat~er precise number of water molecules is reduced in a fine powder in the presence of an anhydrous dry and finely pulverized powder which can for example be a dry yeast, non-viable germs, a flour, a milk powder, a meat powder, a fish powder or any other alimentary, dietetic, medicamentous or cosmetic organic powder.
Dry yeast is an alimentary organic material which - ,i is rich in vitamins and biological products useful to the human system.
Experiments have shown that the ra-tio between the hygroscopic product and the organic powder may be between 15:1 and 2:1.
Non 1imitative examples of the manufacturing method 1. 120 kg of crystalli7ed SO4PIg, 7H2O is finely crushed in the presence of 10 kg of dry yeast of a very fine particle size (i.e~, in a ratio of 12:1 by weight).
The mixture which is thus obtained can perfectly be distributed in hard capsules and may be kept for years in blister packs or in pill boxes.
As known, some pharmaceutical products incorporate substances which contain in their molecule a rather precise number of water molecules, whieh makes them very difficult to be kept for a long time due to the fact it i5 not possible to include them in hard capsules or in bags.
Thus, their life in jars is very much reduced, particularly in very humid countries, such as temperate countries or countries in the equatorial areas.
Thus, in the past there has been used mechanical means, such as vacuum wrapping means, but the cost is then very high, and this increase in the price of the wrapping means restrains the sale of the medicament itself which is, generally, o~ an extremely low cost.
This is particularly the case when the medicament contains hydrated calcium chloxide C12Ca, 6H2O or hyd:rated magn~sium sulfate SO4~1g, 7H2O. Actually, these substances are very hygroscopic in the open air and, if they are placed without any partieular proteetion in hard eapsules, the substance is modified and the capsule becomes soft, thus requiring destruction of the medicament which is no longer ingestible.
It has thus been proposed to introduce a dryinq or desiccative powder in the active product which contains water moleeules, and for this purpose there has been used talcum powder or the like, but these substances have two principal drawbacks, namely introduction of a mineral material which is not without action on the gastric or intestinal pH of the human system and also absorption of the active substanee by the dryina or dessieeative powder which makes it less available for the human system.
Accordingly, it is a general object of the present invention to provide a novel and useful method for manufacturing a stable powder containing a product with ~L~3~
very great hygroscopic activity, in which the above described disadvantages have been overcome. According to the present invention there is provided a method for manufacturing a stable powder from a substance which contains in its mole-cule a rather precise number of water molecules making thepowder deliquescent and unsuitable for distribution in hard capsules or in ba~s, comprising the step of crushing the substance, characterized in that the crushin~ step is performed in the presence of a finely pulverulent dry organic powder, such as for example yeast, in order to give finely pulverulent homogeneous products which are stable and able to be easily put in hard capsules or in bags.
According to a preferred embodiment of the invention there is used 12 parts by wei~ht of crystallized hygroscopic product which is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
According to a further preferred embodiment of the invention, 3 parts by weight o~ hy~roscopic product in crystallized form is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
Other objects and further features o the present invention will be apparent from the following detailed description.
As it has been stated above, the invention relates to a method in which a substance containing in its molecule a rat~er precise number of water molecules is reduced in a fine powder in the presence of an anhydrous dry and finely pulverized powder which can for example be a dry yeast, non-viable germs, a flour, a milk powder, a meat powder, a fish powder or any other alimentary, dietetic, medicamentous or cosmetic organic powder.
Dry yeast is an alimentary organic material which - ,i is rich in vitamins and biological products useful to the human system.
Experiments have shown that the ra-tio between the hygroscopic product and the organic powder may be between 15:1 and 2:1.
Non 1imitative examples of the manufacturing method 1. 120 kg of crystalli7ed SO4PIg, 7H2O is finely crushed in the presence of 10 kg of dry yeast of a very fine particle size (i.e~, in a ratio of 12:1 by weight).
The mixture which is thus obtained can perfectly be distributed in hard capsules and may be kept for years in blister packs or in pill boxes.
2. 120 kg of crystallized C12 Ca, 6H2O is finely crushed in the presence o 40 kq of drv yeast of a very fine particle size (i.e., in a ratio of 3:1 by weight). The mixture which is thus obtained can perfectly be distributed in hard capsules and may be kept for years in blister packs or in pill boxes.
The crushing step is performed by any suitable means normally used in the art.
The crushing step is performed by any suitable means normally used in the art.
Claims (12)
- THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
l. A method for manufacturing a stable powder from a substance which contains in its molecule a rather precise number of water molecules making the powder deliquescent and unsuitable for distribution in hard capsules or in bags, comprising the step of crushing the substance, characterized in that the crushing step is performed in the presence of a finely pulverulent dry organic powder in order to give finely pulverulent homogeneous products which are stable and able to be easily put in hard capsules or in bags. - 2. Method according to claim l, characterized in that the substance containing in its molecule a rather precise number of water molecules and the organic powder are within a ratio of 15:1 and a ratio of 2:1 by weight.
- 3. Method according to claim 1, characterized in that there is used 12 parts by weight of crystallized hydroscopic product which is finely crushed in the presence of l part by weight of dry yeast of a very fine particle size.
- 4. Method according to claim 2, characterized in that there is used 12 parts by weight of crystallized hydroscopic product which is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
- 5. Method according to claim 1, characterized in that 3 parts by weight of the hydroscopic product in crystallized form is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
- 6. Method according to claim 2, characterized in that 3 parts by weight of the hydroscopic product in crystallized form is finely crushed in the presence of 1 part by weight of dry yeast of a very fine particle size.
- 7. Method according to claim 1, characterized in that the organic powder is selected from the group consisting of dry yeast, non-viable germs, flour, milk powder, meat powder, fish powder and any other alimentary, dietetic, medicamentous and cosmetic organic powder.
- 8. Method according to claim 2, characterized in that the organic powder is selected from the group consisting of dry yeast, non-viable germs, flour, milk powder, meat powder, fish powder and any other alimentary, dietetic, medicamentous and cosmetic organic powder.
- 9. Method according to claim 3, characterized in that the organic powder is selected from the group consisting of dry yeast, non-viable germs, flour, milk powder, meat powder, fish powder and any other alimentary, dietetic, medicamentous and cosmetic organic powder.
- 10. Method according to claim 4, characterized in that the organic powder is selected from the group consisting of dry yeast, non-viable terms, flour, milk powder, meat powder, fish powder and any other alimentary, dietetic, medicamentous and cosmetic organic powder.
- 11. Method according to claim 5, characterized in that the organic powder is selected from the group consisting of dry yeast, non-viable germs, flour, milk powder, meat powder, fish powder and any other alimentary, dietetic, medieamentous and cosmetic organic powder.
- 12. Method according to claim 6, characterized in that the organic powder is selected from the group consisting of dry yeast, non-viable terms, flour, milk powder, meat powder, fish powder, and any other alimentary, dietetic, medicamentous and cosmetic organic powder.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8102844 | 1981-02-13 | ||
| FR8102844A FR2500005B1 (en) | 1981-02-13 | 1981-02-13 | PROCESS FOR PRODUCING A STABLE POWDER CONTAINING A HIGHLY HYGROSCOPIC ACTIVE PRODUCT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1180000A true CA1180000A (en) | 1984-12-27 |
Family
ID=9255166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000396164A Expired CA1180000A (en) | 1981-02-13 | 1982-02-12 | Method for manufacturing a stable powder containing a very hygroscopic active product |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0058584B1 (en) |
| KR (1) | KR860000273B1 (en) |
| AT (1) | ATE14378T1 (en) |
| CA (1) | CA1180000A (en) |
| DE (2) | DE58584T1 (en) |
| ES (1) | ES8606897A1 (en) |
| FR (1) | FR2500005B1 (en) |
| GR (1) | GR75863B (en) |
| IL (1) | IL64966A (en) |
| MA (1) | MA19385A1 (en) |
| MC (1) | MC1443A1 (en) |
| OA (1) | OA07017A (en) |
| PT (1) | PT74409B (en) |
| ZA (1) | ZA82867B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8917470D0 (en) * | 1989-07-31 | 1989-09-13 | Quadrant Bioresources Ltd | Composition and method |
| FR2715299B1 (en) * | 1994-01-21 | 1996-06-14 | Georges Serge Grimberg | Medicine with a pediatric presentation facilitating its absorption by a child. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2175083A (en) * | 1937-03-01 | 1939-10-03 | Armour & Co | Compositions of matter containing antihygroscopic agents |
| US3613579A (en) * | 1954-12-01 | 1971-10-19 | Us Army | Antipersonnel fragmentation weapon |
| US2879161A (en) * | 1956-05-14 | 1959-03-24 | American Cyanamid Co | Stable dry powder compositions containing choline chloride and methods of preparing same |
| US3297529A (en) * | 1964-11-25 | 1967-01-10 | Sutton Lab Inc | Magnesium sulfate stabilized choline salicylate |
| DE2512247A1 (en) * | 1975-03-20 | 1976-10-14 | Thomae Gmbh Dr K | Tablets contg. drying agents - for protection against moisture |
-
1981
- 1981-02-13 FR FR8102844A patent/FR2500005B1/en not_active Expired
-
1982
- 1982-01-21 EP EP82400110A patent/EP0058584B1/en not_active Expired
- 1982-01-21 DE DE198282400110T patent/DE58584T1/en active Pending
- 1982-01-21 DE DE8282400110T patent/DE3264804D1/en not_active Expired
- 1982-01-21 AT AT82400110T patent/ATE14378T1/en active
- 1982-02-05 ES ES509370A patent/ES8606897A1/en not_active Expired
- 1982-02-05 OA OA57612A patent/OA07017A/en unknown
- 1982-02-09 MA MA19590A patent/MA19385A1/en unknown
- 1982-02-09 PT PT74409A patent/PT74409B/en not_active IP Right Cessation
- 1982-02-09 IL IL64966A patent/IL64966A/en unknown
- 1982-02-10 GR GR67275A patent/GR75863B/el unknown
- 1982-02-11 MC MC821574A patent/MC1443A1/en unknown
- 1982-02-11 ZA ZA82867A patent/ZA82867B/en unknown
- 1982-02-12 CA CA000396164A patent/CA1180000A/en not_active Expired
- 1982-02-13 KR KR8200632A patent/KR860000273B1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0058584B1 (en) | 1985-07-24 |
| FR2500005A1 (en) | 1982-08-20 |
| PT74409B (en) | 1983-07-07 |
| EP0058584A1 (en) | 1982-08-25 |
| IL64966A (en) | 1985-07-31 |
| DE3264804D1 (en) | 1985-08-29 |
| PT74409A (en) | 1982-03-01 |
| IL64966A0 (en) | 1982-04-30 |
| ZA82867B (en) | 1982-12-29 |
| GR75863B (en) | 1984-08-02 |
| ES509370A0 (en) | 1986-05-16 |
| ATE14378T1 (en) | 1985-08-15 |
| DE58584T1 (en) | 1983-03-17 |
| OA07017A (en) | 1983-08-31 |
| ES8606897A1 (en) | 1986-05-16 |
| MA19385A1 (en) | 1982-10-01 |
| FR2500005B1 (en) | 1985-06-14 |
| MC1443A1 (en) | 1982-12-06 |
| KR830008671A (en) | 1983-12-14 |
| KR860000273B1 (en) | 1986-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEC | Expiry (correction) | ||
| MKEX | Expiry |