CA1174995A - Process for preparing polyether antibiotic - Google Patents
Process for preparing polyether antibioticInfo
- Publication number
- CA1174995A CA1174995A CA000369064A CA369064A CA1174995A CA 1174995 A CA1174995 A CA 1174995A CA 000369064 A CA000369064 A CA 000369064A CA 369064 A CA369064 A CA 369064A CA 1174995 A CA1174995 A CA 1174995A
- Authority
- CA
- Canada
- Prior art keywords
- narasin
- medium
- nrrl
- culture
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title description 10
- 239000002460 polyether antibiotic agent Substances 0.000 title description 2
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- VHKXXVVRRDYCIK-UHFFFAOYSA-N Narasin Natural products CC1CC(C)C(C(CC)C(O)=O)OC1C(C)C(O)C(C)C(=O)C(CC)C1C(C)CC(C)C2(C=CC(O)C3(OC(C)(CC3)C3OC(C)C(O)(CC)CC3)O2)O1 VHKXXVVRRDYCIK-UHFFFAOYSA-N 0.000 claims abstract description 27
- 229960001851 narasin Drugs 0.000 claims abstract description 27
- 241000218483 Streptomyces lydicus Species 0.000 claims abstract description 16
- 238000010564 aerobic fermentation Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 16
- 239000001963 growth medium Substances 0.000 claims description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
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- 239000013587 production medium Substances 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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- 210000002421 cell wall Anatomy 0.000 description 4
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- 238000002360 preparation method Methods 0.000 description 2
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- 239000011780 sodium chloride Substances 0.000 description 2
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- 239000011573 trace mineral Substances 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- RULSWEULPANCDV-PIXUTMIVSA-N turanose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](C(=O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O RULSWEULPANCDV-PIXUTMIVSA-N 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US115,656 | 1980-01-28 | ||
| US06/115,656 US4309504A (en) | 1980-01-28 | 1980-01-28 | Process for preparing narasin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1174995A true CA1174995A (en) | 1984-09-25 |
Family
ID=22362679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000369064A Expired CA1174995A (en) | 1980-01-28 | 1981-01-22 | Process for preparing polyether antibiotic |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4309504A (enExample) |
| EP (1) | EP0034009B1 (enExample) |
| JP (1) | JPS56121486A (enExample) |
| KR (1) | KR840000749B1 (enExample) |
| AR (1) | AR228445A1 (enExample) |
| BE (1) | BE887199A (enExample) |
| CA (1) | CA1174995A (enExample) |
| CH (1) | CH650797A5 (enExample) |
| DE (1) | DE3160499D1 (enExample) |
| FR (1) | FR2476128A1 (enExample) |
| GB (1) | GB2068372B (enExample) |
| HU (1) | HU179912B (enExample) |
| IE (1) | IE51169B1 (enExample) |
| IL (1) | IL61960A (enExample) |
| IT (1) | IT1141957B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342829A (en) * | 1981-05-06 | 1982-08-03 | Eli Lilly And Company | Process for preparing narasin |
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US4920050A (en) * | 1989-02-27 | 1990-04-24 | Pfizer Inc. | Acidic polycyclic ether antibiotic |
| TWI656872B (zh) | 2014-11-13 | 2019-04-21 | 美商益農美國公司 | 甲基鹽黴素於豬飼料中之抗病毒效果 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038384A (en) * | 1974-06-10 | 1977-07-26 | Eli Lilly And Company | Antibiotic a-28086 and process for production thereof |
| US4141907A (en) * | 1977-10-20 | 1979-02-27 | Eli Lilly And Company | Deoxynarasin antibiotics |
-
1980
- 1980-01-28 US US06/115,656 patent/US4309504A/en not_active Expired - Lifetime
-
1981
- 1981-01-22 EP EP81300300A patent/EP0034009B1/en not_active Expired
- 1981-01-22 CA CA000369064A patent/CA1174995A/en not_active Expired
- 1981-01-22 AR AR284036A patent/AR228445A1/es active
- 1981-01-22 DE DE8181300300T patent/DE3160499D1/de not_active Expired
- 1981-01-22 GB GB8101939A patent/GB2068372B/en not_active Expired
- 1981-01-22 IL IL61960A patent/IL61960A/xx unknown
- 1981-01-23 BE BE1/10109A patent/BE887199A/fr not_active IP Right Cessation
- 1981-01-23 FR FR8101284A patent/FR2476128A1/fr active Granted
- 1981-01-26 IT IT19333/81A patent/IT1141957B/it active
- 1981-01-26 CH CH478/81A patent/CH650797A5/fr not_active IP Right Cessation
- 1981-01-27 IE IE143/81A patent/IE51169B1/en unknown
- 1981-01-27 KR KR8100239A patent/KR840000749B1/ko not_active Expired
- 1981-01-27 JP JP1146581A patent/JPS56121486A/ja active Pending
- 1981-01-27 HU HU8181171A patent/HU179912B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE810143L (en) | 1981-07-28 |
| IL61960A (en) | 1984-07-31 |
| GB2068372A (en) | 1981-08-12 |
| FR2476128B1 (enExample) | 1984-05-11 |
| AR228445A1 (es) | 1983-03-15 |
| US4309504A (en) | 1982-01-05 |
| KR840000749B1 (en) | 1984-05-31 |
| EP0034009A3 (en) | 1981-11-11 |
| EP0034009B1 (en) | 1983-06-29 |
| IE51169B1 (en) | 1986-10-29 |
| GB2068372B (en) | 1984-06-27 |
| HU179912B (en) | 1982-12-28 |
| EP0034009A2 (en) | 1981-08-19 |
| IT8119333A0 (it) | 1981-01-26 |
| FR2476128A1 (fr) | 1981-08-21 |
| KR830005357A (ko) | 1983-08-13 |
| DE3160499D1 (en) | 1983-08-04 |
| IL61960A0 (en) | 1981-02-27 |
| JPS56121486A (en) | 1981-09-24 |
| CH650797A5 (fr) | 1985-08-15 |
| BE887199A (fr) | 1981-07-23 |
| IT1141957B (it) | 1986-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |