CA1167047A - Benzodioxanne l,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments - Google Patents
Benzodioxanne l,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicamentsInfo
- Publication number
- CA1167047A CA1167047A CA000374619A CA374619A CA1167047A CA 1167047 A CA1167047 A CA 1167047A CA 000374619 A CA000374619 A CA 000374619A CA 374619 A CA374619 A CA 374619A CA 1167047 A CA1167047 A CA 1167047A
- Authority
- CA
- Canada
- Prior art keywords
- propanol
- benzodioxan
- methoxy
- tert
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 25
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 9
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims abstract description 4
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 4
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 4
- 150000002367 halogens Chemical class 0.000 claims abstract description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 4
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 23
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 9
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 claims description 7
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- 239000000126 substance Substances 0.000 claims description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8007719A FR2479825A1 (fr) | 1980-04-04 | 1980-04-04 | Benzodioxanne 1,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments |
| FR8007719 | 1980-04-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1167047A true CA1167047A (fr) | 1984-05-08 |
Family
ID=9240576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000374619A Expired CA1167047A (fr) | 1980-04-04 | 1981-04-03 | Benzodioxanne l,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments |
Country Status (11)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2479825A1 (fr) * | 1980-04-04 | 1981-10-09 | Fabre Sa Pierre | Benzodioxanne 1,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments |
| CA1220059A (en) * | 1983-10-03 | 1987-04-07 | Edmund Isakov | Two-prong rotary bit, especially for use with roof drills, and insert therefor |
| DE69325698T2 (de) * | 1992-12-21 | 2000-01-27 | Duphar International Research B.V., Weesp | Enzymatisches Verfahren zur stereoselektiven Herstellung einem Enantiomer aus einem hetero bicyclischen Alkohols |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| AR049646A1 (es) * | 2004-06-16 | 2006-08-23 | Janssen Pharmaceutica Nv | Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados |
| CN101090896B (zh) * | 2004-08-24 | 2011-10-26 | 詹森药业有限公司 | 用作抗惊厥药的苯并稠合杂芳基氨基磺酰胺衍生物 |
| BRPI0610864A2 (pt) * | 2005-05-20 | 2010-08-03 | Janssen Pharmaceutica Nv | processo para preparação de derivados de sulfamida |
| US8497298B2 (en) * | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8492431B2 (en) * | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
| US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US20070155827A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
| US8691867B2 (en) * | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
| US8937096B2 (en) * | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| WO2007137167A2 (en) * | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Co-therapy for the treatment of epilepsy |
| US20090247618A1 (en) * | 2008-03-26 | 2009-10-01 | Ballentine Scott A | Process for preparation of benzo-fused heteroaryl derivatives |
| US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
| WO2010008776A2 (en) * | 2008-06-23 | 2010-01-21 | Janssen Pharmaceutica Nv | Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE635203A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1962-07-20 | |||
| GB1100960A (en) * | 1963-06-20 | 1968-01-31 | Ward Blenkinsop & Co Ltd | 1,4-benzodioxane derivatives |
| GB1058822A (en) * | 1963-07-30 | 1967-02-15 | Ici Ltd | 3-amino-2-hydroxypropoxy heterocyclic derivatives |
| GB1509527A (en) * | 1974-06-05 | 1978-05-04 | Ici Ltd | 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them |
| FR2358142A1 (fr) * | 1976-07-12 | 1978-02-10 | Parcor | Nouveaux derives du benzodioxanne |
| JPS5377081A (en) * | 1976-12-20 | 1978-07-08 | Yoshitomi Pharmaceut Ind Ltd | 1,4-benzodioxepin derivative, its acid addition salt, and its preparation |
| US4187313A (en) * | 1978-01-30 | 1980-02-05 | Ciba-Geigy Corporation | 2-Aminoethyl-1,4-benzodioxans |
| US4261907A (en) * | 1978-01-30 | 1981-04-14 | Ciba-Geigy Corporation | Stereospecific process |
| FR2479825A1 (fr) * | 1980-04-04 | 1981-10-09 | Fabre Sa Pierre | Benzodioxanne 1,4 methoxy-2 propanolamines, leur preparation et leur application en tant que medicaments |
-
1980
- 1980-04-04 FR FR8007719A patent/FR2479825A1/fr active Granted
-
1981
- 1981-03-28 ES ES500822A patent/ES8201572A1/es not_active Expired
- 1981-04-02 EP EP81400529A patent/EP0037778B1/fr not_active Expired
- 1981-04-02 US US06/250,407 patent/US4456614A/en not_active Expired - Fee Related
- 1981-04-02 DE DE8181400529T patent/DE3161750D1/de not_active Expired
- 1981-04-02 AT AT81400529T patent/ATE5722T1/de not_active IP Right Cessation
- 1981-04-03 ZA ZA00812263A patent/ZA812263B/xx unknown
- 1981-04-03 CA CA000374619A patent/CA1167047A/fr not_active Expired
- 1981-04-03 DK DK153581A patent/DK152288C/da not_active IP Right Cessation
- 1981-04-03 JP JP5103681A patent/JPS56156275A/ja active Granted
- 1981-04-06 AU AU69099/81A patent/AU543364B2/en not_active Ceased
-
1983
- 1983-01-03 US US06/455,125 patent/US4539413A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0037778A1 (fr) | 1981-10-14 |
| JPS56156275A (en) | 1981-12-02 |
| ES500822A0 (es) | 1982-01-01 |
| FR2479825B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-07-08 |
| DE3161750D1 (en) | 1984-02-02 |
| DK152288B (da) | 1988-02-15 |
| FR2479825A1 (fr) | 1981-10-09 |
| JPS649994B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-02-21 |
| ES8201572A1 (es) | 1982-01-01 |
| US4456614A (en) | 1984-06-26 |
| DK152288C (da) | 1988-07-11 |
| EP0037778B1 (fr) | 1983-12-28 |
| AU6909981A (en) | 1981-10-08 |
| ATE5722T1 (de) | 1984-01-15 |
| AU543364B2 (en) | 1985-04-18 |
| DK153581A (da) | 1981-10-05 |
| US4539413A (en) | 1985-09-03 |
| ZA812263B (en) | 1982-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |