CA1163562A - Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants - Google Patents

Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

Info

Publication number
CA1163562A
CA1163562A CA000363110A CA363110A CA1163562A CA 1163562 A CA1163562 A CA 1163562A CA 000363110 A CA000363110 A CA 000363110A CA 363110 A CA363110 A CA 363110A CA 1163562 A CA1163562 A CA 1163562A
Authority
CA
Canada
Prior art keywords
lipid
fat
pharmaceutical composition
saline
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000363110A
Other languages
English (en)
French (fr)
Inventor
John S. Wolff, Iii
George R. Hemsworth
Keith E. Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of CA1163562A publication Critical patent/CA1163562A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA000363110A 1979-10-26 1980-10-23 Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants Expired CA1163562A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US088,638 1979-10-26
US06/088,638 US4310550A (en) 1979-10-26 1979-10-26 Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

Publications (1)

Publication Number Publication Date
CA1163562A true CA1163562A (en) 1984-03-13

Family

ID=22212534

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000363110A Expired CA1163562A (en) 1979-10-26 1980-10-23 Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants

Country Status (7)

Country Link
US (1) US4310550A (https=)
JP (1) JPS5671024A (https=)
AU (1) AU522338B2 (https=)
CA (1) CA1163562A (https=)
DE (1) DE2945788A1 (https=)
NZ (1) NZ195354A (https=)
PT (1) PT71236A (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0058021A3 (en) * 1981-02-06 1982-10-27 Beecham Group Plc Pharmaceutical compositions
IL74289A (en) * 1985-02-10 1989-02-28 Israel State Vaccine system comprising a live-non-virulent vaccine and an adjuvant
NL9000207A (https=) * 1990-01-29 1991-08-16 Duphar Int Res
US6369201B1 (en) 1998-02-19 2002-04-09 Metamorphix International, Inc. Myostatin multimers
AU2002218927B2 (en) 2001-01-04 2007-08-30 The University Of British Columbia Enterohemorrhagic Escherichia coli vaccine
BRPI0415816A (pt) 2003-10-31 2006-12-26 Univ British Columbia composição, bactéria ou um preparado da mesma, método para detectar a presença de um patógeno de a/e em uma amostra, método para provocar uma resposta imunológica contra um patógeno de a/e ou um componente do mesmo em um animal, método para reduzir a colonização de um patógeno de a/e em um animal, método para reduzir a disseminação de um patógeno de a/e em um animal, método para o tratamento ou a prevenção da infecção por um patógeno de a/e, método para atenuar a virulência de um patógeno de a/e, método para a seleção de um composto que atenue a virulência de um patógeno e a/e, método para a produção de um polipeptìdio de patógeno de a/e, polipeptìdio recombinante, molécula de ácido nucléico isolada, vetor, célula hospedeira, uso da composição e kit
AU2005230708B2 (en) 2004-04-05 2009-01-15 Zoetis Services Llc Microfluidized oil-in-water emulsions and vaccine compositions
US20080102067A1 (en) * 2006-10-25 2008-05-01 Cook Mark E Immunogenic composition
WO2017011918A1 (en) 2015-07-22 2017-01-26 University Of Saskatchewan Mycoplasma bovis vaccines and uses thereof
CA3176303A1 (en) 2020-04-20 2021-10-28 Antonio FACCIUOLO Compositions and methods for preventing, controlling and diagnosing mycobacterial infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA725596A (en) * 1960-08-26 1966-01-11 J. Wretlind Arvid Method of preparing intravenously injectable fat emulsions free from side reactions or complications
US3872171A (en) * 1971-05-24 1975-03-18 Pfizer Polyamines as antiviral agents in animals
US4034040A (en) * 1971-05-24 1977-07-05 Pfizer Inc. Xylene-diamines as antiviral agents
US4173641A (en) * 1978-05-15 1979-11-06 Pfizer Inc. Di-O-n-alkyl glycerol derivatives as immune stimulants

Also Published As

Publication number Publication date
DE2945788A1 (de) 1981-05-07
JPS6225646B2 (https=) 1987-06-04
US4310550A (en) 1982-01-12
NZ195354A (en) 1982-12-21
AU6366480A (en) 1981-04-30
JPS5671024A (en) 1981-06-13
AU522338B2 (en) 1982-05-27
PT71236A (en) 1980-06-01
DE2945788C2 (https=) 1988-01-28

Similar Documents

Publication Publication Date Title
US4806350A (en) Vaccine formulation
EP0785802B1 (en) Saponin preparations and use thereof in iscoms
EP1539231B1 (en) Iscom preparation and use thereof
EP0549074B1 (en) Adjuvants
US5376369A (en) Vaccine adjuvant
AU755445B2 (en) Adjuvant composition and methods for its use
CA1163562A (en) Lipid amines formulated with fat or lipid emulsions as vaccine adjuvants
US20160114034A1 (en) Compositions comprising iscom particles and live micro-organisms
EP0315153B1 (en) Vaccine adjuvant
US4395394A (en) Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants
JP2002532559A (ja) 不活化ｗ／ｏ乳濁液アジュバント化ワクチンの産生法
US4428932A (en) Pharmaceutical compositions
US5773011A (en) Method of preparing a synergistic immunological adjuvant formulation
US6083513A (en) Method for increasing the yield of antibodies in the techniques of immunology
RU2214278C1 (ru) Адьювант для биопрепаратов
AU686891B2 (en) Saponin preparations and use thereof in iscoms
NZ333608A (en) Use of saponin preparations in eliciting or inducing immune responses
MXPA01006375A (en) Method to produce inactivated w/o emulsion adjuvated vaccines
HK1138516A1 (en) Parenteral vaccine formulations and uses thereof

Legal Events

Date Code Title Description
MKEX Expiry