CA1134267A - Composition adapted to purifying blood and its uses - Google Patents
Composition adapted to purifying blood and its usesInfo
- Publication number
- CA1134267A CA1134267A CA319,485A CA319485A CA1134267A CA 1134267 A CA1134267 A CA 1134267A CA 319485 A CA319485 A CA 319485A CA 1134267 A CA1134267 A CA 1134267A
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- group
- member selected
- organic
- anhydrides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 210000004369 blood Anatomy 0.000 title claims abstract description 6
- 239000008280 blood Substances 0.000 title claims abstract description 6
- 150000008064 anhydrides Chemical class 0.000 claims abstract description 11
- 229920000642 polymer Polymers 0.000 claims abstract description 9
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims abstract description 4
- 238000000746 purification Methods 0.000 claims abstract description 3
- 150000007524 organic acids Chemical class 0.000 claims abstract 5
- 150000008065 acid anhydrides Chemical class 0.000 claims abstract 2
- 239000000835 fiber Substances 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229920002284 Cellulose triacetate Polymers 0.000 claims description 3
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- 235000005985 organic acids Nutrition 0.000 claims 4
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 150000002731 mercury compounds Chemical class 0.000 abstract description 3
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical class SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 abstract description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002657 fibrous material Substances 0.000 abstract 1
- 229940100892 mercury compound Drugs 0.000 abstract 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 12
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 9
- 238000010521 absorption reaction Methods 0.000 description 8
- WQAQPCDUOCURKW-UHFFFAOYSA-N butanethiol Chemical compound CCCCS WQAQPCDUOCURKW-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 5
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 5
- 229960003180 glutathione Drugs 0.000 description 4
- 239000000644 isotonic solution Substances 0.000 description 4
- 108010024636 Glutathione Proteins 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 235000013878 L-cysteine Nutrition 0.000 description 2
- 239000004201 L-cysteine Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- -1 aromatic amino-acids Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000009877 rendering Methods 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 238000009987 spinning Methods 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- ACTKAGSPIFDCMF-UHFFFAOYSA-N 1,3-oxazol-2-amine Chemical compound NC1=NC=CO1 ACTKAGSPIFDCMF-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 239000005745 Captan Substances 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 108010053070 Glutathione Disulfide Proteins 0.000 description 1
- 208000000857 Hepatic Insufficiency Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001253 acrylic acids Chemical class 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 229940117949 captan Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- WBLIXGSTEMXDSM-UHFFFAOYSA-N chloromethane Chemical compound Cl[CH2] WBLIXGSTEMXDSM-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Materials For Medical Uses (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT19623A/78 | 1978-01-26 | ||
| IT19623/78A IT1093275B (it) | 1978-01-26 | 1978-01-26 | Composizione adatta alla purificazione del sangue e suoi impieghi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1134267A true CA1134267A (en) | 1982-10-26 |
Family
ID=11159775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA319,485A Expired CA1134267A (en) | 1978-01-26 | 1979-01-11 | Composition adapted to purifying blood and its uses |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4252645A (enExample) |
| JP (1) | JPS54104697A (enExample) |
| BE (1) | BE873709A (enExample) |
| CA (1) | CA1134267A (enExample) |
| CH (1) | CH641048A5 (enExample) |
| DE (1) | DE2903060A1 (enExample) |
| FR (1) | FR2415462A1 (enExample) |
| GB (1) | GB2013226B (enExample) |
| IT (1) | IT1093275B (enExample) |
| LU (1) | LU80824A1 (enExample) |
| NL (1) | NL7900657A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7611831B2 (en) * | 1998-01-06 | 2009-11-03 | Cerus Corporation | Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix |
| ES2224415T3 (es) | 1998-01-06 | 2005-03-01 | Cerus Corporation | Metodos para inhibir desactivadores patogenos en materiales biologicos. |
| AU2005302256B2 (en) * | 2004-10-29 | 2011-01-20 | Cerus Corporation | Improved quenching methods for red blood cell inactivation process |
| CA2720824C (en) | 2008-04-09 | 2021-09-14 | Cerus Corporation | Improved quenching methods for red blood cell pathogen inactivation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1885475A (en) * | 1927-02-12 | 1932-11-01 | Ig Farbenindustrie Ag | Artificial products from cellulose derivatives and process of preparing the same |
| US2955017A (en) * | 1958-04-04 | 1960-10-04 | Du Pont | Process of flowing filamentis in laminar flow surrounded by an outer area of turbulent flow |
| NL126934C (enExample) * | 1960-10-21 | |||
| FR2124098A1 (en) * | 1971-02-04 | 1972-09-22 | Thomson Csf | Microcapsules contg detoxicant - for detoxifying blood |
| US3885069A (en) * | 1972-08-11 | 1975-05-20 | Us Agriculture | Preparation of crosslinked polyethylenimine and impregnation of cellulosic material with in situ crosslink-polymerized ethylenimine |
| US3957698A (en) * | 1974-11-05 | 1976-05-18 | The Dow Chemical Company | Thermally reversible, amphoteric ion exchange resins consisting of crosslinked microbeads embedded in crosslinked matrix of opposite exchange group type |
| IT1038741B (it) * | 1975-06-06 | 1979-11-30 | Snam Progetti | Processo per l inglobamento di agenti sequestranti in strutture filamentose agenti seqesttanti inglobati cose ottenuti e loro applicazioni |
-
1978
- 1978-01-26 IT IT19623/78A patent/IT1093275B/it active
-
1979
- 1979-01-04 US US06/000,816 patent/US4252645A/en not_active Expired - Lifetime
- 1979-01-05 CH CH9979A patent/CH641048A5/it not_active IP Right Cessation
- 1979-01-11 CA CA319,485A patent/CA1134267A/en not_active Expired
- 1979-01-11 GB GB7901140A patent/GB2013226B/en not_active Expired
- 1979-01-12 JP JP138479A patent/JPS54104697A/ja active Pending
- 1979-01-23 FR FR7901694A patent/FR2415462A1/fr active Granted
- 1979-01-24 LU LU80824A patent/LU80824A1/xx unknown
- 1979-01-25 BE BE0/193075A patent/BE873709A/xx not_active IP Right Cessation
- 1979-01-26 NL NL7900657A patent/NL7900657A/xx not_active Application Discontinuation
- 1979-01-26 DE DE19792903060 patent/DE2903060A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| GB2013226A (en) | 1979-08-08 |
| FR2415462B1 (enExample) | 1982-11-26 |
| US4252645A (en) | 1981-02-24 |
| LU80824A1 (fr) | 1979-06-05 |
| DE2903060A1 (de) | 1979-08-02 |
| GB2013226B (en) | 1982-06-23 |
| FR2415462A1 (fr) | 1979-08-24 |
| BE873709A (fr) | 1979-07-25 |
| IT1093275B (it) | 1985-07-19 |
| NL7900657A (nl) | 1979-07-30 |
| CH641048A5 (it) | 1984-02-15 |
| JPS54104697A (en) | 1979-08-17 |
| IT7819623A0 (it) | 1978-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |