CA1122488A - Vaginal contraceptive - Google Patents
Vaginal contraceptiveInfo
- Publication number
- CA1122488A CA1122488A CA343,609A CA343609A CA1122488A CA 1122488 A CA1122488 A CA 1122488A CA 343609 A CA343609 A CA 343609A CA 1122488 A CA1122488 A CA 1122488A
- Authority
- CA
- Canada
- Prior art keywords
- devices
- surfactant
- front face
- cervical
- membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003433 contraceptive agent Substances 0.000 title claims abstract description 29
- 230000002254 contraceptive effect Effects 0.000 title claims abstract description 26
- 239000004094 surface-active agent Substances 0.000 claims abstract description 118
- 230000001150 spermicidal effect Effects 0.000 claims abstract description 31
- 210000001215 vagina Anatomy 0.000 claims abstract description 14
- 239000012528 membrane Substances 0.000 claims description 74
- 239000000178 monomer Substances 0.000 claims description 38
- 230000032258 transport Effects 0.000 claims description 32
- 239000000463 material Substances 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 16
- 239000000693 micelle Substances 0.000 claims description 15
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000000934 spermatocidal agent Substances 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- -1 aliphatic alcohols Chemical class 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 102000003939 Membrane transport proteins Human genes 0.000 claims description 4
- 108090000301 Membrane transport proteins Proteins 0.000 claims description 4
- 230000009061 membrane transport Effects 0.000 claims description 4
- 238000005304 joining Methods 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 239000012858 resilient material Substances 0.000 claims description 3
- QAXPOSPGRHYIHE-UHFFFAOYSA-N 2-[2-[2-[2-(2-decoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCOCCOCCOCCOCCOCCO QAXPOSPGRHYIHE-UHFFFAOYSA-N 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 abstract description 8
- 238000010276 construction Methods 0.000 abstract description 5
- 230000014759 maintenance of location Effects 0.000 abstract description 2
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000003821 menstrual periods Effects 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 description 69
- 238000013270 controlled release Methods 0.000 description 23
- 229920001296 polysiloxane Polymers 0.000 description 16
- 239000000243 solution Substances 0.000 description 16
- 239000003814 drug Substances 0.000 description 14
- 239000012530 fluid Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000008901 benefit Effects 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 7
- 239000010839 body fluid Substances 0.000 description 7
- 210000003679 cervix uteri Anatomy 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 229920001971 elastomer Polymers 0.000 description 6
- 230000003204 osmotic effect Effects 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 239000001913 cellulose Substances 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 238000013268 sustained release Methods 0.000 description 5
- 239000012730 sustained-release form Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 229940124558 contraceptive agent Drugs 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 229920000126 latex Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000005060 rubber Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000008293 association colloid Substances 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 2
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004914 menses Anatomy 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229920000260 silastic Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- PYKLUAIDKVVEOS-RAXLEYEMSA-N (e)-n-(cyanomethoxy)benzenecarboximidoyl cyanide Chemical compound N#CCO\N=C(\C#N)C1=CC=CC=C1 PYKLUAIDKVVEOS-RAXLEYEMSA-N 0.000 description 1
- VLDFXDUAENINOO-UHFFFAOYSA-N 4-methyl-2-[4-(4-methyl-5-phenyl-1,3-oxazol-2-yl)phenyl]-5-phenyl-1,3-oxazole Chemical compound CC=1N=C(C=2C=CC(=CC=2)C=2OC(=C(C)N=2)C=2C=CC=CC=2)OC=1C1=CC=CC=C1 VLDFXDUAENINOO-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 description 1
- 241000905957 Channa melasoma Species 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- 208000003629 Rupture Diseases 0.000 description 1
- 208000036366 Sensation of pressure Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100036378 T-cell immunomodulatory protein Human genes 0.000 description 1
- 101710194900 T-cell immunomodulatory protein Proteins 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- ZXQYGBMAQZUVMI-QQDHXZELSA-N [cyano-(3-phenoxyphenyl)methyl] (1r,3r)-3-[(z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@@H](\C=C(/Cl)C(F)(F)F)[C@H]1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-QQDHXZELSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- 238000003490 calendering Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000012611 container material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- CEJLBZWIKQJOAT-UHFFFAOYSA-N dichloroisocyanuric acid Chemical compound ClN1C(=O)NC(=O)N(Cl)C1=O CEJLBZWIKQJOAT-UHFFFAOYSA-N 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 230000009123 feedback regulation Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 239000002650 laminated plastic Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3,452 | 1979-01-15 | ||
| US06/003,452 US4200090A (en) | 1979-01-15 | 1979-01-15 | Vaginal contraceptive and method of using |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1122488A true CA1122488A (en) | 1982-04-27 |
Family
ID=21705944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA343,609A Expired CA1122488A (en) | 1979-01-15 | 1980-01-14 | Vaginal contraceptive |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4200090A (enExample) |
| EP (1) | EP0014484B1 (enExample) |
| JP (1) | JPS55120867A (enExample) |
| AU (1) | AU530831B2 (enExample) |
| CA (1) | CA1122488A (enExample) |
| DE (1) | DE3065223D1 (enExample) |
| GR (1) | GR68715B (enExample) |
| PH (1) | PH16502A (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4326510A (en) * | 1979-11-20 | 1982-04-27 | World Health Organization | Barrier contraceptive torus |
| US4304226A (en) * | 1980-03-03 | 1981-12-08 | The Procter & Gamble Company | Vaginal contraceptive |
| US4447373A (en) * | 1982-02-16 | 1984-05-08 | The Procter & Gamble Company | Process for making filled articles from polymeric material |
| US4589880A (en) * | 1983-07-14 | 1986-05-20 | Southern Research Institute | Disposable spermicide-releasing diaphragm |
| FI82885C (fi) * | 1983-07-19 | 1991-05-10 | Population Council Inc | Som preventivmedel anvaendbar membranring. |
| US4630602A (en) * | 1984-03-29 | 1986-12-23 | Strickman Melvyn B | Disposable contraceptive cervical barrier |
| AU601170B2 (en) * | 1985-06-19 | 1990-09-06 | Fortune Capital Management B.V. | Pessary |
| US5386836A (en) * | 1986-10-14 | 1995-02-07 | Zedlani Pty Limited | Urinary incontinence device |
| US4895170A (en) * | 1987-07-20 | 1990-01-23 | Page Hanes, Inc. | Method of contraception using disposable cervical cap |
| US4785804A (en) * | 1987-07-20 | 1988-11-22 | Page Hanes, Inc. | Disposable cervical cap |
| US4931298A (en) * | 1988-05-12 | 1990-06-05 | Horizons International Foods, Inc. | Process for preparing potato granule coated french fried potatoes |
| US4922928A (en) * | 1988-08-17 | 1990-05-08 | Michael Burnhill | Vaginal device |
| US5295984A (en) * | 1989-12-07 | 1994-03-22 | Ultrafem, Inc. | Vaginal discharge collection device and intravaginal drug delivery system |
| US6264638B1 (en) | 1989-12-07 | 2001-07-24 | Ultrafem, Inc. | Intravaginal drug delivery system and discharge collection device |
| WO1994000166A1 (en) * | 1992-06-30 | 1994-01-06 | Government Of The United States As Represented By Secretary Department Of Health And Human Services | Method for producing viral protective barrier materials |
| US5851188A (en) * | 1994-10-12 | 1998-12-22 | Bullard; Kelli M. | Device for holding medical instrumentation sensors at and upon the cervix os of a human female, particularly for holding the ultrasonic transducers of an ultrasonic transit time, real-time, cervical effacement and dilatation monitor |
| KR20000022465A (ko) | 1996-07-03 | 2000-04-25 | 세바스티안 레슬리 제이. | 탄성중합체 물질을 제작하기 위한 방법 및장치. |
| US5857959A (en) * | 1997-02-03 | 1999-01-12 | Veos France Eurl | Conception kit |
| WO1999024085A2 (en) * | 1997-11-07 | 1999-05-20 | The Johns Hopkins University | Device for simultaneously delingering beneficial agents and method |
| US8454493B2 (en) * | 2007-03-28 | 2013-06-04 | Conceivex, Inc. | Conception device and related methods |
| US20080242919A1 (en) * | 2007-03-28 | 2008-10-02 | Melrock Ltd. | Conception cap and related methods |
| US8282612B1 (en) | 2008-03-07 | 2012-10-09 | Denise H. Miller | Methods and devices for intrauterine absorption |
| JP6037442B2 (ja) * | 2009-05-18 | 2016-12-07 | ザ ストーク アイビー2シー, インク.The Stork Ib2C, Inc. | 人工受精 |
| USD682810S1 (en) * | 2011-01-24 | 2013-05-21 | Hon Hai Precision Industry Co., Ltd. | Diaphragm |
| CA2774254C (en) * | 2012-04-11 | 2014-07-15 | Neil L. Maurette | Cervical shield sexual aid device and method for use during intercourse |
| US9078786B1 (en) | 2012-10-19 | 2015-07-14 | Denise H. Miller | Methods and devices for collecting body fluids |
| CN112494195A (zh) * | 2014-04-01 | 2021-03-16 | 保利医学公司 | 避孕装置及相关装置 |
| US10226387B2 (en) | 2014-09-19 | 2019-03-12 | Gwynne Marie Hite | Cervical pad |
| US10874432B2 (en) | 2018-05-01 | 2020-12-29 | Conceivex, Inc. | Conception device and related methods |
| US20240374508A1 (en) * | 2023-05-11 | 2024-11-14 | Elle, MD Biotechnologies Inc. | Devices and methods of use thereof for non-hormonal contraception |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB243186A (en) * | 1924-12-29 | 1925-11-26 | Tom Stanley Harrison | Improvements in pessaries |
| US2020107A (en) * | 1934-08-06 | 1935-11-05 | George A Cruickshank | Combination pessary and vaginal suppository |
| US2097033A (en) * | 1934-09-08 | 1937-10-26 | Mcvittie John | Tampon |
| US2141040A (en) * | 1937-03-23 | 1938-12-20 | Holt Helen | Pessary |
| FR859835A (fr) * | 1939-09-01 | 1940-12-30 | Dispositif pour applications médicinales | |
| US2423356A (en) * | 1945-07-06 | 1947-07-01 | Diaphragm & Chemical Company | Pessary |
| US2697057A (en) * | 1948-12-23 | 1954-12-14 | Ortho Pharma Corp | Method of making a diaphragm |
| DE845832C (de) * | 1950-02-02 | 1952-08-07 | Franz Aichinger Dr Med | Pessar |
| US2580133A (en) * | 1950-08-07 | 1951-12-25 | Herbert A Sheen | Diaphragm type pessary |
| US3015598A (en) * | 1958-11-03 | 1962-01-02 | Jones John Leslie | Manufacturing absorbent diaphragms |
| US3279996A (en) * | 1962-08-28 | 1966-10-18 | Jr David M Long | Polysiloxane carrier for controlled release of drugs and other agents |
| US3216422A (en) * | 1962-11-23 | 1965-11-09 | Johnson & Johnson | Vaginal tampon |
| US3993073A (en) * | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| DE7014153U (de) * | 1970-04-17 | 1970-08-27 | Hild Heinrich | Okklussivpessar. |
| US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
| US3786807A (en) * | 1972-02-29 | 1974-01-22 | D Dubin | Disposable diaphragm and insertion-removal unit therefor |
| US4016251A (en) * | 1972-08-17 | 1977-04-05 | Alza Corporation | Vaginal drug dispensing device |
| US3971367A (en) * | 1972-12-27 | 1976-07-27 | Alza Corporation | Intrauterine device having means for changing from uterine-retentive shape to nonuterine-retentive shape |
| DE2445971A1 (de) * | 1974-09-24 | 1976-04-08 | Schering Ag | Arzneimittelwirkstofftraeger ii |
| ZA761193B (en) * | 1975-03-19 | 1977-02-23 | Procter & Gamble | Controlled release articles |
| US3983874A (en) * | 1975-06-26 | 1976-10-05 | Davis Alwyn K | Catamenial diaphragm with replaceable tampon |
| US3995633A (en) * | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal Medicament dispensing device |
| US3991760A (en) * | 1975-12-02 | 1976-11-16 | The Procter & Gamble Company | Vaginal medicament dispensing means |
| US3995634A (en) * | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal cavity dispensing means and method |
| US4031202A (en) * | 1975-12-08 | 1977-06-21 | The Procter & Gamble Company | Controlled release contraceptive article |
-
1979
- 1979-01-15 US US06/003,452 patent/US4200090A/en not_active Expired - Lifetime
-
1980
- 1980-01-08 DE DE8080200013T patent/DE3065223D1/de not_active Expired
- 1980-01-08 EP EP80200013A patent/EP0014484B1/en not_active Expired
- 1980-01-10 GR GR60930A patent/GR68715B/el unknown
- 1980-01-11 PH PH23499A patent/PH16502A/en unknown
- 1980-01-14 CA CA343,609A patent/CA1122488A/en not_active Expired
- 1980-01-14 AU AU54583/80A patent/AU530831B2/en not_active Ceased
- 1980-01-16 JP JP346180A patent/JPS55120867A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU5458380A (en) | 1980-07-24 |
| EP0014484B1 (en) | 1983-10-12 |
| PH16502A (en) | 1983-11-04 |
| JPS55120867A (en) | 1980-09-17 |
| DE3065223D1 (en) | 1983-11-17 |
| US4200090A (en) | 1980-04-29 |
| AU530831B2 (en) | 1983-07-28 |
| EP0014484A1 (en) | 1980-08-20 |
| GR68715B (enExample) | 1982-02-03 |
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