CA1118446A - Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents - Google Patents

Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents

Info

Publication number
CA1118446A
CA1118446A CA000317175A CA317175A CA1118446A CA 1118446 A CA1118446 A CA 1118446A CA 000317175 A CA000317175 A CA 000317175A CA 317175 A CA317175 A CA 317175A CA 1118446 A CA1118446 A CA 1118446A
Authority
CA
Canada
Prior art keywords
biphenyl
propionamide
ethyl
diethyl
bromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000317175A
Other languages
English (en)
French (fr)
Inventor
Vittorio Pestellini
Mario Ghelardoni
Claudio Bianchini
Piero Del Soldato
Giovanna Volterra
Alberto Meli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Menarini SAS
Original Assignee
Menarini SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini SAS filed Critical Menarini SAS
Application granted granted Critical
Publication of CA1118446A publication Critical patent/CA1118446A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA000317175A 1977-11-30 1978-11-30 Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents Expired CA1118446A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT9643A/77 1977-11-30
IT964377A IT1090782B (it) 1977-11-30 1977-11-30 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi

Publications (1)

Publication Number Publication Date
CA1118446A true CA1118446A (en) 1982-02-16

Family

ID=11132874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000317175A Expired CA1118446A (en) 1977-11-30 1978-11-30 Racemic forms and optically active forms of 2-(4-biphenylyl)-n-(diethylamino alkyl) propionamide and salts thereof as well as processes for their production and use as spasmoltyic agents

Country Status (9)

Country Link
JP (1) JPS5490157A (xx)
BE (1) BE872403A (xx)
CA (1) CA1118446A (xx)
CH (1) CH637370A5 (xx)
DE (1) DE2851416A1 (xx)
ES (1) ES475533A1 (xx)
FR (1) FR2410641A1 (xx)
IT (1) IT1090782B (xx)
NL (1) NL7811698A (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012025A1 (it) * 2001-09-28 2003-03-28 Dompe Spa Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
DK2049482T3 (en) * 2006-08-08 2016-02-01 Techfields Biochem Co Ltd Positively charged, water-soluble prodrugs of aryl and heteroaryl acetic acids with very fast skin penetration rate
CN101506161B (zh) * 2006-08-15 2013-11-13 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的芳基和杂芳基丙酸类前药
AU2013206218B2 (en) * 2006-08-15 2016-06-30 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of aryl- and heteroarylpropionic acids with very fast skin penetration rate
KR20190091378A (ko) 2007-06-04 2019-08-05 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
KR20210123406A (ko) 2008-12-04 2021-10-13 충시 위 고투과력을 가진 조성물 및 이의 적용
JP5940036B2 (ja) * 2013-10-08 2016-06-29 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ
JP6290947B2 (ja) * 2016-02-05 2018-03-07 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584547A (xx) * 1968-06-05 1969-12-26
FR1593024A (xx) * 1968-09-18 1970-05-25
FR2119846A1 (en) * 1970-12-28 1972-08-11 Choay Sa N,n-diethylaminoethylamide of para isobutyl phenylacetic - acid - antiinflammatory and analgesic
US4145435A (en) * 1976-11-12 1979-03-20 The Upjohn Company 2-aminocycloaliphatic amide compounds

Also Published As

Publication number Publication date
JPS631286B2 (xx) 1988-01-12
IT1090782B (it) 1985-06-26
BE872403A (fr) 1979-03-16
JPS5490157A (en) 1979-07-17
DE2851416A1 (de) 1979-05-31
FR2410641B1 (xx) 1983-04-15
ES475533A1 (es) 1980-01-16
DE2851416C2 (xx) 1989-02-23
FR2410641A1 (fr) 1979-06-29
NL7811698A (nl) 1979-06-01
CH637370A5 (en) 1983-07-29

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Legal Events

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