CA1118155A - Implant device of bio-compatible carbon substrate coated with collagen - Google Patents
Implant device of bio-compatible carbon substrate coated with collagenInfo
- Publication number
- CA1118155A CA1118155A CA000320243A CA320243A CA1118155A CA 1118155 A CA1118155 A CA 1118155A CA 000320243 A CA000320243 A CA 000320243A CA 320243 A CA320243 A CA 320243A CA 1118155 A CA1118155 A CA 1118155A
- Authority
- CA
- Canada
- Prior art keywords
- implant device
- substrate
- carbon
- collagen
- filaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/062—Apparatus for the production of blood vessels made from natural tissue or with layers of living cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/443—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
AN IMPLANT DEVICE
Abstract An implant device comprising a biocompatible carbon substrate (1) which is substantially non-porous and nonbiodegradable having at least its exterior coated with collagen (3). Such an implant device may be used as a tissue grafting substrate, a tissue or blood vessel replacement or a covering or sealing means for implantable prosthetic devices.
Abstract An implant device comprising a biocompatible carbon substrate (1) which is substantially non-porous and nonbiodegradable having at least its exterior coated with collagen (3). Such an implant device may be used as a tissue grafting substrate, a tissue or blood vessel replacement or a covering or sealing means for implantable prosthetic devices.
Description
~1~8~
DESCRIPTION
AN IMPLANT DEVICE
Field of the Invention This invention is directed to an implant device of a biocompatible carbon substrate coated with collagen.
Such a device may be utilized as a tissue grafting substrate or as a tissue or blood vessel replacement.
Further, the implant device may be used as a covering for implantable prosthetic devices or for a sealing of tissue about implanted devices.
Brief Description of the Prior Art There are a number of situations in which it is necessary to provide fluid communication with a body organ or vascular system. For example, patients suffering from a kidney failure require the dialysis of their blood by means external from the body. Blood containing toxic substances, such as urea, ureic acid, creatine, phosphorous and calcium must be removed from the blood system, treated and then returned to the patient. Patients requiring such blood dialysis need treatment at least two or three times per week.
Patients suffering from hypoalimentation require a device for providing access to the body's vascular system on at least a daily basis.
Further, there are many situations in which it is necessary to perform an enterostomy on a patient.
This operation involves external zing an internal . .
:
:~
;
vessel organ. The most common vessels or organs which require externalizing are the ileum, colon, ureter, urethra, and the bladder and pelvis or the kidney.Enterostomies may be accomplished by severing the vessel to be externalized or ; creating a tube from the wall of the organ which is to be externalized and then suturing the wall of the vessel to tube through an opening which has been form-ed on the surface of the body. Generally, the wall of the vessel and the dermis of the skin surrounding the opening would grow together to permanently secure the vessel to the surface of the body. An implant device may be used in enter-ostomies in order to prevent the excrements which are discharged from the exter-nalized vessel or organ from contacting the surface of the skin.
- Lastly, there are many instances when portions of a body require re-construction including the formation of artificial blood vessels and tissue.
Summary of the Invention This invention is directed to an implant device characterized in a biocompatible carbon substrate the substrate having at least its exterior coat-ed with collagen. In a preferred embodiment, the carbon substrate is comprised of a number of carbon filaments which are arranged in an overlapping orientationin order to form a fibrous mat-like structure. The carbon filaments are bound together and held by means of a binder of collagen. The carbon is preferably either a pyrolytic carbon disposed on a graphite substrate or vitreous carbon.
In a further preferred embodiment the collagen binder substantially occludes anyinterstices between the overlapping carbon filaments.
The term "nonbiodegradable device" is used to mean that the structure of the device will not biologically degrade or diminish. "Biocompatible" means compatible with the body.
Brief Description of Drawings The details of my invention will now be described with reference to
DESCRIPTION
AN IMPLANT DEVICE
Field of the Invention This invention is directed to an implant device of a biocompatible carbon substrate coated with collagen.
Such a device may be utilized as a tissue grafting substrate or as a tissue or blood vessel replacement.
Further, the implant device may be used as a covering for implantable prosthetic devices or for a sealing of tissue about implanted devices.
Brief Description of the Prior Art There are a number of situations in which it is necessary to provide fluid communication with a body organ or vascular system. For example, patients suffering from a kidney failure require the dialysis of their blood by means external from the body. Blood containing toxic substances, such as urea, ureic acid, creatine, phosphorous and calcium must be removed from the blood system, treated and then returned to the patient. Patients requiring such blood dialysis need treatment at least two or three times per week.
Patients suffering from hypoalimentation require a device for providing access to the body's vascular system on at least a daily basis.
Further, there are many situations in which it is necessary to perform an enterostomy on a patient.
This operation involves external zing an internal . .
:
:~
;
vessel organ. The most common vessels or organs which require externalizing are the ileum, colon, ureter, urethra, and the bladder and pelvis or the kidney.Enterostomies may be accomplished by severing the vessel to be externalized or ; creating a tube from the wall of the organ which is to be externalized and then suturing the wall of the vessel to tube through an opening which has been form-ed on the surface of the body. Generally, the wall of the vessel and the dermis of the skin surrounding the opening would grow together to permanently secure the vessel to the surface of the body. An implant device may be used in enter-ostomies in order to prevent the excrements which are discharged from the exter-nalized vessel or organ from contacting the surface of the skin.
- Lastly, there are many instances when portions of a body require re-construction including the formation of artificial blood vessels and tissue.
Summary of the Invention This invention is directed to an implant device characterized in a biocompatible carbon substrate the substrate having at least its exterior coat-ed with collagen. In a preferred embodiment, the carbon substrate is comprised of a number of carbon filaments which are arranged in an overlapping orientationin order to form a fibrous mat-like structure. The carbon filaments are bound together and held by means of a binder of collagen. The carbon is preferably either a pyrolytic carbon disposed on a graphite substrate or vitreous carbon.
In a further preferred embodiment the collagen binder substantially occludes anyinterstices between the overlapping carbon filaments.
The term "nonbiodegradable device" is used to mean that the structure of the device will not biologically degrade or diminish. "Biocompatible" means compatible with the body.
Brief Description of Drawings The details of my invention will now be described with reference to
-2-- 1118~55 accompanying drawings in which Figure 1 is a perspective view of one embodiment ; of the invention, and Figure 2 is a perspective view of another embodiment of ~ the invention.
i :`
,, .
~r '~
~4 -2a-.5~
Detailed Descri~tion of the Invention Collagen is a natural substance. It is a princlpal component of skin, tendon, cartilage and bone. Its molecular structure has been aralyzed and documente~. The collagen structure is characterized by a high proportion of proline and by hydroxyproline residues, and by frequent repetition of the se~uence glycine, proline, hydroxyproline.
HO
< ~ CH-C~ H-~
Proline residue ~.ydroxyproline 15The structure of collagen comblnes the helical nature of alpha-type proteins with the inter-chain hydrogen bonding of the beta-type proteins. The three chains are held strongly together by hydrogen bonding between glycine residues and betwen -OH groups of hydroxyproline. See generally, Morrison and Boyd, Organic Chemistry,Chapter 36, Amino Acids and Proteins (3d ed 1973).
Referring now to Figure 1, a plurality of carbon filaments 1, are shown orientated in an overlapp ng manner in order to form a fibrous ~at-like structure.
The carbon substrate is either a pyrolytic carbon disposed on a graphite substrate or vitreous carbon.
The carbon filaments are shown to be bound together by collagen 3.
30Figure 2 illustrates another embodiment of the invention wherein a carbon substrate 1 is coated with collagen 3. The implant device of figure 2 has an annular portion 7 about a cavity 5.
It is envisioned that implant devices of the type illustrated in figures 1 and 2 may be used as tissue grafting substrates wherein the tlssue may bond !:,` to the collasen bonded carbon substrate. In other -` embodiments, the implant device may be used as an artificial blood vessel or as a tissue replacement.
Further, the lmplant device of this invention may be used as a covering for an implan~ible prosthetlc device providing both tissue attachment and ceiling of tissue to the implant devices.
While the preferred embodiments in the appli-cation of this invention have been shown and described, it will be apparent to those skilled in the art that ~ modifications thereto may be made without from the inventive concepts herein described. The invention is, therefore, to be limited only by the scope of the claims apended hereto.
i :`
,, .
~r '~
~4 -2a-.5~
Detailed Descri~tion of the Invention Collagen is a natural substance. It is a princlpal component of skin, tendon, cartilage and bone. Its molecular structure has been aralyzed and documente~. The collagen structure is characterized by a high proportion of proline and by hydroxyproline residues, and by frequent repetition of the se~uence glycine, proline, hydroxyproline.
HO
< ~ CH-C~ H-~
Proline residue ~.ydroxyproline 15The structure of collagen comblnes the helical nature of alpha-type proteins with the inter-chain hydrogen bonding of the beta-type proteins. The three chains are held strongly together by hydrogen bonding between glycine residues and betwen -OH groups of hydroxyproline. See generally, Morrison and Boyd, Organic Chemistry,Chapter 36, Amino Acids and Proteins (3d ed 1973).
Referring now to Figure 1, a plurality of carbon filaments 1, are shown orientated in an overlapp ng manner in order to form a fibrous ~at-like structure.
The carbon substrate is either a pyrolytic carbon disposed on a graphite substrate or vitreous carbon.
The carbon filaments are shown to be bound together by collagen 3.
30Figure 2 illustrates another embodiment of the invention wherein a carbon substrate 1 is coated with collagen 3. The implant device of figure 2 has an annular portion 7 about a cavity 5.
It is envisioned that implant devices of the type illustrated in figures 1 and 2 may be used as tissue grafting substrates wherein the tlssue may bond !:,` to the collasen bonded carbon substrate. In other -` embodiments, the implant device may be used as an artificial blood vessel or as a tissue replacement.
Further, the lmplant device of this invention may be used as a covering for an implan~ible prosthetlc device providing both tissue attachment and ceiling of tissue to the implant devices.
While the preferred embodiments in the appli-cation of this invention have been shown and described, it will be apparent to those skilled in the art that ~ modifications thereto may be made without from the inventive concepts herein described. The invention is, therefore, to be limited only by the scope of the claims apended hereto.
Claims (7)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. An implant device characterized in a biocompatible carbon substrate, the substrate having at least its exterior coated with collagen.
2. The implant device claimed in claim 1 wherein the biocompatible substrate is characterized in a plurality of carbon filaments and the collagen coating binds the carbon filaments.
3. The implant device claimed in claim 2 characterized in that the car-bon filaments are arranged in a substantially overlapping orientation for form-ing a fibrous mat-like structure and the collagen binder substantially occludes any interstices between said overlapping carbon filaments.
4. The implant device as claimed in either claim 2 or claim 3 character-ized in that the substrate is substantially nonporous and nonbiodegradable.
5. The implant device claimed in claim 1, 2 or 3 characterized in that the substrate is formed of a material selected from the group comprising a pyro-lytic carbon disposed on a graphite substrate and vitreous carbon.
6. The implant device claimed in claim 2 characterized in that the sub-strate is substantially nonporous and nonbiodegradable and further is formed of a material selected from the group comprising a pyrolytic carbon disposed on a graphite substrate and vitreous carbon.
7. The implant device claimed in claim 3 characterized in that the substrate is substantially nonporous and nonbiodegradable and further is formed of a material selected from the group comprising a pyrolytic carbon disposed on a graphite substrate and vitreous carbon.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87224178A | 1978-01-25 | 1978-01-25 | |
| US872,241 | 1978-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1118155A true CA1118155A (en) | 1982-02-16 |
Family
ID=25359139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000320243A Expired CA1118155A (en) | 1978-01-25 | 1979-01-25 | Implant device of bio-compatible carbon substrate coated with collagen |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS54119798A (en) |
| BR (1) | BR7900377A (en) |
| CA (1) | CA1118155A (en) |
| DE (1) | DE2853614A1 (en) |
| FR (1) | FR2415456A1 (en) |
| GB (1) | GB2014475B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57134154A (en) * | 1981-02-12 | 1982-08-19 | Otani Sugirou | Carbonacious artificial filler and prosthetic material and production thereof |
| FR2510394A1 (en) * | 1981-07-30 | 1983-02-04 | Ceraver | Ligament or tendon prosthesis stimulating tissue regrowth - comprises fibrous material, e.g. carbon fibres, coated with collagen |
| FR2511249A1 (en) * | 1981-08-14 | 1983-02-18 | Bentley Lab | Implant for fluid passage - fitted with anchorage and netting made of pyrolysis carbon on graphite substrate |
| JPH0669741B2 (en) * | 1985-01-16 | 1994-09-07 | 東レ株式会社 | Sheet |
| US4699141A (en) * | 1986-01-16 | 1987-10-13 | Rhode Island Hospital | Neovascularization |
| US6309635B1 (en) | 1986-11-20 | 2001-10-30 | Children's Medical Center Corp. | Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo |
| US5759830A (en) * | 1986-11-20 | 1998-06-02 | Massachusetts Institute Of Technology | Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo |
| CA1340581C (en) * | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| JP2799596B2 (en) * | 1989-08-10 | 1998-09-17 | 株式会社ジェイ・エム・エス | Bioimplant device and method for producing the same |
| US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| US5716404A (en) | 1994-12-16 | 1998-02-10 | Massachusetts Institute Of Technology | Breast tissue engineering |
| US6123727A (en) | 1995-05-01 | 2000-09-26 | Massachusetts Institute Of Technology | Tissue engineered tendons and ligaments |
| US5855610A (en) | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185332B (en) * | 1961-03-01 | 1965-01-14 | Ethicon Inc | Surgical prosthesis |
| DE1494939B2 (en) * | 1963-06-11 | 1972-03-02 | Buddecke, Eckhart, Prof Dr , 4400 Munster | Implantation material for prostheses for the replacement of arteries and other pathways and hollow organs containing body juices and processes for the production thereof |
| DE1491218C3 (en) * | 1963-06-15 | 1973-01-04 | Spofa Sdruzheni Podniku Pro Zdravotnickou Vyrobu, Prag | Blood vessel prosthesis and method for making the same |
| GB1165698A (en) * | 1965-11-05 | 1969-10-01 | Guinness De Laszlo M A P Henry | Improvements in or relating to Prostheses |
| US3479670A (en) * | 1966-10-19 | 1969-11-25 | Ethicon Inc | Tubular prosthetic implant having helical thermoplastic wrapping therearound |
| DE1902700A1 (en) * | 1969-01-17 | 1970-08-20 | Carlton Sports Company Ltd | Artificial bones and joints for the human - body |
| DE2017330A1 (en) * | 1970-04-10 | 1971-12-09 | BIO-CAL Instrument GmbH, 8032 Gräfelfing | Blood vessel connector - for artificial kidneys or lungs |
| CS148134B1 (en) * | 1970-11-20 | 1973-02-22 | ||
| SE393290B (en) * | 1971-05-20 | 1977-05-09 | Vitek Inc | MATERIAL COMPOSITION FOR USE FOR IMPLANTATION IN VIVO, WHICH COMPOSITION CONTAINS A FIBROS, POROS STRUCTURE AND PROCEDURES FOR THE PRODUCTION OF SUCH A COMPOSITION |
-
1978
- 1978-12-12 DE DE19782853614 patent/DE2853614A1/en not_active Withdrawn
-
1979
- 1979-01-22 BR BR7900377A patent/BR7900377A/en unknown
- 1979-01-24 JP JP701079A patent/JPS54119798A/en active Pending
- 1979-01-24 GB GB7902460A patent/GB2014475B/en not_active Expired
- 1979-01-24 FR FR7901843A patent/FR2415456A1/en not_active Withdrawn
- 1979-01-25 CA CA000320243A patent/CA1118155A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2014475B (en) | 1982-04-21 |
| DE2853614A1 (en) | 1979-07-26 |
| JPS54119798A (en) | 1979-09-17 |
| FR2415456A1 (en) | 1979-08-24 |
| GB2014475A (en) | 1979-08-30 |
| BR7900377A (en) | 1979-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |