CA1102240A - Method for the manufacture and the application of pharmaceutical products for the veterinary science - Google Patents
Method for the manufacture and the application of pharmaceutical products for the veterinary scienceInfo
- Publication number
- CA1102240A CA1102240A CA276,697A CA276697A CA1102240A CA 1102240 A CA1102240 A CA 1102240A CA 276697 A CA276697 A CA 276697A CA 1102240 A CA1102240 A CA 1102240A
- Authority
- CA
- Canada
- Prior art keywords
- admixture
- aroma
- dosage unit
- unit form
- pharmaceutical compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 8
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract description 6
- 229940127557 pharmaceutical product Drugs 0.000 title abstract description 4
- 239000000126 substance Substances 0.000 claims abstract description 45
- 241001465754 Metazoa Species 0.000 claims abstract description 35
- 150000001875 compounds Chemical class 0.000 claims description 42
- 239000000796 flavoring agent Substances 0.000 claims description 36
- 235000019634 flavors Nutrition 0.000 claims description 36
- 238000002360 preparation method Methods 0.000 claims description 35
- 235000013336 milk Nutrition 0.000 claims description 19
- 239000008267 milk Substances 0.000 claims description 19
- 210000004080 milk Anatomy 0.000 claims description 19
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 12
- 241000282887 Suidae Species 0.000 claims description 11
- 241000283690 Bos taurus Species 0.000 claims description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 241000283086 Equidae Species 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 235000020247 cow milk Nutrition 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- 210000004767 rumen Anatomy 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 5
- 229960000448 lactic acid Drugs 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- OALYTRUKMRCXNH-UHFFFAOYSA-N 5-pentyloxolan-2-one Chemical compound CCCCCC1CCC(=O)O1 OALYTRUKMRCXNH-UHFFFAOYSA-N 0.000 claims description 4
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims description 3
- 229940116333 ethyl lactate Drugs 0.000 claims description 2
- OALYTRUKMRCXNH-QMMMGPOBSA-N gamma-Nonalactone Natural products CCCCC[C@H]1CCC(=O)O1 OALYTRUKMRCXNH-QMMMGPOBSA-N 0.000 claims description 2
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 2
- SPRJWMSXOLZOIO-UHFFFAOYSA-N 2-hydroxypropanoyl octanoate Chemical compound CCCCCCCC(=O)OC(=O)C(C)O SPRJWMSXOLZOIO-UHFFFAOYSA-N 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 241000894007 species Species 0.000 abstract description 12
- 239000003814 drug Substances 0.000 description 15
- 229940079593 drug Drugs 0.000 description 14
- 239000000839 emulsion Substances 0.000 description 12
- 239000006187 pill Substances 0.000 description 9
- 239000008188 pellet Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 238000005899 aromatization reaction Methods 0.000 description 6
- 238000011194 good manufacturing practice Methods 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 101100476962 Drosophila melanogaster Sirup gene Proteins 0.000 description 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 4
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 4
- 244000309466 calf Species 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- 244000215068 Acacia senegal Species 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 3
- 241000282849 Ruminantia Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 244000000054 animal parasite Species 0.000 description 3
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 201000006549 dyspepsia Diseases 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000012054 meals Nutrition 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 240000001987 Pyrus communis Species 0.000 description 2
- 241000283984 Rodentia Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000006052 feed supplement Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- 241000282421 Canidae Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000194031 Enterococcus faecium Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000005605 isobutyric acids Chemical class 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Birds (AREA)
- Physiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH586276A CH630808A5 (en) | 1976-05-08 | 1976-05-08 | Process for aromatising pharmaceutical preparations for veterinary medicine |
| CH005862/76 | 1977-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1102240A true CA1102240A (en) | 1981-06-02 |
Family
ID=4300540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA276,697A Expired CA1102240A (en) | 1976-05-08 | 1977-04-21 | Method for the manufacture and the application of pharmaceutical products for the veterinary science |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT355859B (show.php) |
| AU (1) | AU2609277A (show.php) |
| CA (1) | CA1102240A (show.php) |
| CH (1) | CH630808A5 (show.php) |
| DE (1) | DE2716269A1 (show.php) |
| DK (1) | DK192277A (show.php) |
| FR (1) | FR2350105A1 (show.php) |
| GB (1) | GB1577765A (show.php) |
| IE (1) | IE45054B1 (show.php) |
| NL (1) | NL7704768A (show.php) |
| ZA (1) | ZA772514B (show.php) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10653633B2 (en) | 2013-12-04 | 2020-05-19 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical compositions of pimobendan |
| US12357696B2 (en) | 2013-07-19 | 2025-07-15 | Boehringer Ingelheim Vetmedica Gmbh | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| FR2934156B1 (fr) * | 2008-07-23 | 2010-09-24 | Virbac | Medicament appetissant a administration orale sous forme solide |
| DK2755498T3 (en) | 2011-09-15 | 2018-05-22 | Friulchem Spa | COMPOSITION FOR ORAL ADMINISTRATION FOR ANIMALS AND PROCEDURE FOR OBTAINING |
| ES2924478T3 (es) | 2012-03-15 | 2022-10-07 | Boehringer Ingelheim Vetmedica Gmbh | Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos |
| CA2883139C (fr) | 2012-08-31 | 2021-08-10 | Friulchem Spa | Compositions pour administration orale aux animaux, leurs procedes d'obtention et leurs utilisations |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
-
1976
- 1976-05-08 CH CH586276A patent/CH630808A5/de not_active IP Right Cessation
-
1977
- 1977-04-13 DE DE19772716269 patent/DE2716269A1/de not_active Withdrawn
- 1977-04-21 CA CA276,697A patent/CA1102240A/en not_active Expired
- 1977-04-27 ZA ZA00772514A patent/ZA772514B/xx unknown
- 1977-05-02 NL NL7704768A patent/NL7704768A/xx not_active Application Discontinuation
- 1977-05-03 GB GB18506/77A patent/GB1577765A/en not_active Expired
- 1977-05-03 DK DK192277A patent/DK192277A/da unknown
- 1977-05-04 AT AT316177A patent/AT355859B/de not_active IP Right Cessation
- 1977-05-06 IE IE933/77A patent/IE45054B1/en unknown
- 1977-05-06 FR FR7713960A patent/FR2350105A1/fr active Granted
- 1977-06-14 AU AU26092/77A patent/AU2609277A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12357696B2 (en) | 2013-07-19 | 2025-07-15 | Boehringer Ingelheim Vetmedica Gmbh | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
| US10653633B2 (en) | 2013-12-04 | 2020-05-19 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical compositions of pimobendan |
| US10874620B2 (en) | 2013-12-04 | 2020-12-29 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical compositions of pimobendan |
| US11298325B2 (en) | 2013-12-04 | 2022-04-12 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical compositions of pimobendan |
| US12257350B2 (en) | 2013-12-04 | 2025-03-25 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical compositions of pimobendan |
Also Published As
| Publication number | Publication date |
|---|---|
| IE45054L (en) | 1977-11-08 |
| ATA316177A (de) | 1979-08-15 |
| FR2350105A1 (fr) | 1977-12-02 |
| CH630808A5 (en) | 1982-07-15 |
| DE2716269A1 (de) | 1977-11-17 |
| AU2609277A (en) | 1978-12-21 |
| NL7704768A (nl) | 1977-11-10 |
| IE45054B1 (en) | 1982-06-16 |
| ZA772514B (en) | 1978-04-26 |
| DK192277A (da) | 1977-11-09 |
| AT355859B (de) | 1980-03-25 |
| FR2350105B3 (show.php) | 1980-03-07 |
| GB1577765A (en) | 1980-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |