CA1095406A - Enzyme-inhibitor-complexes in thrombosis test - Google Patents
Enzyme-inhibitor-complexes in thrombosis testInfo
- Publication number
- CA1095406A CA1095406A CA261,260A CA261260A CA1095406A CA 1095406 A CA1095406 A CA 1095406A CA 261260 A CA261260 A CA 261260A CA 1095406 A CA1095406 A CA 1095406A
- Authority
- CA
- Canada
- Prior art keywords
- bloodplasma
- coagulation
- complex
- blood
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 8
- 238000012360 testing method Methods 0.000 title abstract description 62
- 230000023555 blood coagulation Effects 0.000 claims abstract description 40
- 230000003480 fibrinolytic effect Effects 0.000 claims abstract description 38
- 239000003527 fibrinolytic agent Substances 0.000 claims abstract description 37
- 230000004520 agglutination Effects 0.000 claims abstract description 29
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 29
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- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
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- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 1
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- 206010033675 panniculitis Diseases 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8128—Antithrombin III
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/968—Plasmin, i.e. fibrinolysin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL75.11055 | 1975-09-19 | ||
| NL7511055A NL7511055A (nl) | 1975-09-19 | 1975-09-19 | Trombosetest. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1095406A true CA1095406A (en) | 1981-02-10 |
Family
ID=19824501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA261,260A Expired CA1095406A (en) | 1975-09-19 | 1976-09-15 | Enzyme-inhibitor-complexes in thrombosis test |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4216291A (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5241222A (cg-RX-API-DMAC10.html) |
| BE (1) | BE846155A (cg-RX-API-DMAC10.html) |
| CA (1) | CA1095406A (cg-RX-API-DMAC10.html) |
| DE (1) | DE2641840C2 (cg-RX-API-DMAC10.html) |
| FR (1) | FR2326705A1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB1525143A (cg-RX-API-DMAC10.html) |
| IT (1) | IT1125181B (cg-RX-API-DMAC10.html) |
| NL (1) | NL7511055A (cg-RX-API-DMAC10.html) |
| SE (1) | SE7610302L (cg-RX-API-DMAC10.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016575A1 (de) * | 1980-04-30 | 1981-11-05 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur immunologischen bestimmung von enzymen, mittel zur durchfuehrung des verfahrens und seine verwandung |
| JPS56163729A (en) * | 1980-05-20 | 1981-12-16 | Sumitomo Metal Ind Ltd | Dehumidifying method of air for combustion |
| US4753875A (en) * | 1981-11-02 | 1988-06-28 | Ryan James W | Method for assaying proteases with tagged proteinaceous inhibitors |
| JPS60172284A (ja) * | 1984-02-17 | 1985-09-05 | Ajinomoto Co Inc | 酵素を利用した有用物質の製造方法及び装置 |
| US4668621A (en) * | 1985-04-22 | 1987-05-26 | Wake Forest University | Detecting blood clotting factors with immobilized fibrinogen and labeled fibrinogen |
| US5372812A (en) * | 1988-04-04 | 1994-12-13 | The General Hospital Corporation | Composition and method for acceleration of clot lysis |
| US5071745A (en) * | 1988-12-14 | 1991-12-10 | Elcatech, Inc. | Fibrinolytic assay |
| JP2569383B2 (ja) * | 1989-01-19 | 1997-01-08 | 帝人株式会社 | 免疫学的測定方法、試薬及びキツト |
| CA2075937C (en) * | 1990-12-20 | 2002-01-29 | Gilbu Soe | Anti-human plasmin-.alpha.2- plasmin inhibitor complex antibodies, hybridomas, and immunological determination method |
| DE4115993A1 (de) * | 1991-05-16 | 1992-11-19 | Behringwerke Ag | Monoklonale antikoerper gegen den plasmin-atiplasmin komplex, verfahren zu ihrer herstellung sowie ihre verwendung |
| AT398004B (de) * | 1992-04-14 | 1994-08-25 | Berbi Gmbh | Verfahren zur bestimmung von plasmin-alpha2- antiplasmin-komplexen unter verwendung eines komplexspezifischen monoklonalen antikörpers |
| FR2706466B1 (fr) * | 1993-06-14 | 1995-08-25 | Aetsrn | Concentré d'immunoglobulines G à usage thérapeutique et procédé de production dudit concentré. |
| CN1111739C (zh) * | 1997-02-04 | 2003-06-18 | 许文俊 | 凝血、纤溶功能动态测定试剂 |
| CN101732700B (zh) * | 2009-12-18 | 2012-07-25 | 刘天银 | 一种保健酒及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1362776A (en) * | 1970-07-17 | 1974-08-07 | Wellcome Found | Immunological reagent |
-
1975
- 1975-09-19 NL NL7511055A patent/NL7511055A/xx not_active Application Discontinuation
-
1976
- 1976-09-13 BE BE1007619A patent/BE846155A/xx not_active IP Right Cessation
- 1976-09-15 CA CA261,260A patent/CA1095406A/en not_active Expired
- 1976-09-15 GB GB38230/76A patent/GB1525143A/en not_active Expired
- 1976-09-16 SE SE7610302A patent/SE7610302L/xx unknown
- 1976-09-17 IT IT51343/76A patent/IT1125181B/it active
- 1976-09-17 DE DE2641840A patent/DE2641840C2/de not_active Expired
- 1976-09-17 FR FR7628057A patent/FR2326705A1/fr active Granted
- 1976-09-18 JP JP51112390A patent/JPS5241222A/ja active Pending
-
1978
- 1978-10-10 US US05/949,631 patent/US4216291A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT1125181B (it) | 1986-05-14 |
| JPS5241222A (en) | 1977-03-30 |
| FR2326705A1 (fr) | 1977-04-29 |
| US4216291A (en) | 1980-08-05 |
| SE7610302L (sv) | 1977-03-20 |
| NL7511055A (nl) | 1977-03-22 |
| DE2641840C2 (de) | 1986-07-24 |
| FR2326705B1 (cg-RX-API-DMAC10.html) | 1982-11-19 |
| GB1525143A (en) | 1978-09-20 |
| BE846155A (nl) | 1977-03-14 |
| DE2641840A1 (de) | 1977-04-07 |
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