CA1092117A - Method for the production of 6,7-dimethoxy-4-amino-2- ¬4-(2-furoyl)-1-piperazinyl| quinazoline having an antihypertensive effect - Google Patents
Method for the production of 6,7-dimethoxy-4-amino-2- ¬4-(2-furoyl)-1-piperazinyl| quinazoline having an antihypertensive effectInfo
- Publication number
- CA1092117A CA1092117A CA293,065A CA293065A CA1092117A CA 1092117 A CA1092117 A CA 1092117A CA 293065 A CA293065 A CA 293065A CA 1092117 A CA1092117 A CA 1092117A
- Authority
- CA
- Canada
- Prior art keywords
- furoyl
- dimethoxy
- piperazinyl
- formula
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/16—Isothiocyanates
- C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
ABSTRACT OF THE DISCLOSURE
A novel process is provided for the preparation of 6,7-dimethoxy-4-amino-2[4-(2-furoyl)-1-piperazinyl]quinazoline. It includes as a final step, cyclizing methyl-N-(3,4-dimethoxy-6-cyanophenyl)-[4-(2-furoyl)-1-piperazinyl]
thioformamidate by heating, together with ammonia, in a polar solvent, in the presence of an alkali metal amide. The methyl-N-(3,4-dimethoxy-6-cyanophenyl)-[4-(2-furoyl)-1-piperazinyl]thioformamidate is preferably formed by reacting 3,4-dimethoxy-6-[4-(2-furoyl)-1-piperazinyl-thiocarbamido]benzonitrile with methyl chloride. By this process the quinazoline ring in prazosine is produced within the molecule, rather than in a reaction between two different molecules.
A novel process is provided for the preparation of 6,7-dimethoxy-4-amino-2[4-(2-furoyl)-1-piperazinyl]quinazoline. It includes as a final step, cyclizing methyl-N-(3,4-dimethoxy-6-cyanophenyl)-[4-(2-furoyl)-1-piperazinyl]
thioformamidate by heating, together with ammonia, in a polar solvent, in the presence of an alkali metal amide. The methyl-N-(3,4-dimethoxy-6-cyanophenyl)-[4-(2-furoyl)-1-piperazinyl]thioformamidate is preferably formed by reacting 3,4-dimethoxy-6-[4-(2-furoyl)-1-piperazinyl-thiocarbamido]benzonitrile with methyl chloride. By this process the quinazoline ring in prazosine is produced within the molecule, rather than in a reaction between two different molecules.
Description
09~l7 The present invention relates to a novel process for producing 6,7-dimethoxy-4-a~lno-2-~4-(2-furoyl)-1-piperazinyl] quinazoline, a con~iound having an antihypertensive effect.
This co~ound, which is known as prazosine, is known to have a strong antih~pertensive effect (Cohen, Journal of Clinieal Pharmacology, 0 (1970) ) ~ e formula of the comp~und is 3 ~ ~rN N - C
I
Several proeesses have been disclosed in U.S. Patent 3 511 836 for producing 6,7~dimethoxy-4~amino-2-~4-substituted)-1-piperazinyl] ~uinazo-lines. One of these processes for pr~ducing pra~osine is to cause 6,7-di-methoxy-4-amino-2-ehloro_quinazoline to react with (2-fry~yl)-1-piperazine aeeording to the reaction fornLla below:
)~ + H-N~ - OC ~ ~ pr~ osine :~ 20 2 :~ .
Duteh Patent 7206067 discloses another process for producing, among other things, prazosine, and aecording to this proeess 3,4-dimetho~y-6-aminobenzonitrile is caused to reaet with l-eyano-4-~2 furoyl)-piperazine according to ~he reaction fornNla below:
G 3 ~ H2 ~ O
3 ~ NC - N N - OC ~ ~ prazos ne
This co~ound, which is known as prazosine, is known to have a strong antih~pertensive effect (Cohen, Journal of Clinieal Pharmacology, 0 (1970) ) ~ e formula of the comp~und is 3 ~ ~rN N - C
I
Several proeesses have been disclosed in U.S. Patent 3 511 836 for producing 6,7~dimethoxy-4~amino-2-~4-substituted)-1-piperazinyl] ~uinazo-lines. One of these processes for pr~ducing pra~osine is to cause 6,7-di-methoxy-4-amino-2-ehloro_quinazoline to react with (2-fry~yl)-1-piperazine aeeording to the reaction fornLla below:
)~ + H-N~ - OC ~ ~ pr~ osine :~ 20 2 :~ .
Duteh Patent 7206067 discloses another process for producing, among other things, prazosine, and aecording to this proeess 3,4-dimetho~y-6-aminobenzonitrile is caused to reaet with l-eyano-4-~2 furoyl)-piperazine according to ~he reaction fornNla below:
G 3 ~ H2 ~ O
3 ~ NC - N N - OC ~ ~ prazos ne
-2-One prior art process for producing prazosine is illustrated by the reactin ~ormula below:
C 30 ~ ~ ~ ~ ~rdZoS~e NH NH NH NH
where Q = CN or C and A = CN, C ~ ~ C\ or C
in which case R = an alkyl with 1-6 carbon atoms; however, when Q is CN, A is c~NH or C~'NH
~ OR ~ SR
An object of a principal aspect of the present invention is to provide a new process for producing prazosine, differing from previously known processes Ln the resEeot that the formation of the quin201ine ring occurs within the ~lecule to form the final oo~po,und ana not, as in kncwn processes, in a reaction between two different m~lecules.
The proce~s accor,ding ~o a broad aspect of this Lnvention for ErO-ducing prazosine9 6,7-dimetho~y-4-amino-2- r4- (2-furoyl)-1-piFerazinyl~
zollne, ~ rises: re~ct ~ 3,4 ~ imet ~ -6-~4-~2-furoyl)-1-piperazinyl-thiocarbanido~benzonitrile, having the formLla . .
CH30~NH ~ N ~ OC
with methyl iodide~ to fonm methyl N-(3~4-dimethlxy-6-cyanophenyl)-~4-(2-furoyl)-l-pip~razinyl]-thioformamidate, having the ~ornNla ~0Y~Z~l~
~, CH3~N=~--.'\1 N - O
CH3 o CN
III, and cyclizing such compound (III) by heating it, together with ammonia, in a polar solvent in the presence of alkali metal amide.
By one variant of this process, the reaction of the compound hav-ing formula (II) with methyl iodide is performed in formamide, in N,N-dimethyl formamide, in bis-methoxyethyl ether (diglyme), or in a mixture of such solvents, at 50-100C.
By another variant, the cyclization is performed in formamide or in N,N-dimethyl formamide at 100-150C, using 1-3 equivalents of an alkali metal amide.
By yet another variant, the reaction of the compound having for-mula II with methyl iodide and the cyclization of the compound having formula III is performed continuously in one and the same solvent without separating the intermediate products.
The compound 3,4-dimethoxy-6-E4-(2-furoyl)-1-piperazinyl-thio-carbamido]benzonitrile (II) used as the initial substance is a new com-pound; Processes for the production of this compound having formula (II)20 are disclosed and claimed in copending Canadian application Serial No.
293,066 filed Dec. 14, 1977. However, in summary, such compound can be prepared starting from 3,4-di-methoxy-6-aminobenzonitrile and 1-(2-furoyl) piperazine, using the processes illustrated by the reaction formulas below:
~z~
Cll 30~ CS C 12 3 ~ NCS
CH30 CN C~13~) CN
IV V
.~ V I I V I
r~ ~
CH30~NH- I - N N - OC
II
HN~I--OC ~ ~ Cl-~-N~I OC
VI VII
~ ccording to the first alternative, 3,4~dimethQxy-6-amino-benzoni-trile tIV) is first allowed to react with thiophosgene to fonm 3,4-dimethQxy-6-isothiocyanatobenzonitrile ~l), an~ then further with 1-(2-furoyl) pipera-zine ~I) to form 3,4-dimethoxy-6-~4--(2-furoyl)-1-piperazinylthiocarbamido]
benzonitrile ~II). Alternatively, oQ~pound II can be produced by allowing 1-(2-furoyl~pip2razine ~VI) to react first with thiophosgene to form acid chloride VII, and thereafter with 3,4-d~methcxy-6-amunobenzonitrile (IV~.
As disclosed above the prccess according to one aspect of the in-vention can also be carried out so that the production o~ prazosine starting fm m 3,4-dimetho~y-6-~4-~2-furoyl)-1-piperazinylthiocarb~mido]benzanitrile (II), (even starting from 3,4-di~methcxy-6-isothiocyanato~enzonitrile ~V)), can be perfoLmed continuously in one and the same reaction vessel and in cne ' - ~ a, ~Zl~IL7 in one and~the sc~me solvent, e.g. Eormamide, without separatiny the inter-mediate products.
me followin~ examples will illustrate various a~pects of the invention.
- 4 b -1[39Z~7 r`xamp:Le 1 a) 3,4-dimethoxy-6-isothiocyanatoben7Onitri:Le (V) 27,0 ~ (0.15 mo:Le) o~ 3,4-~i~nethoxy-6-~tlinol-x~n%onitr:ile (IV) is dissolved in 150 ml of 1,2-dichloroethane~ anrl added cJradually at 0-5C to a rnixture which contains 23.0 g (0.2 mvle) of thiophosc3ene, 100 ml of 1,2-dichloroethane, 20.0 cJ (0.2 mole) of calcium carbonate, and 200 ml oE water. After this addition, the mixture is stirred for 1 hour at 0-5C, thereafter for 16 hours a-t 20C, and finally Eor 1 hour at 35C. The reaction mixture is ~ tered and the dichloroethane layer separa-ted, washed with dilute hydrochloric acid and wa-ter, and dried with MqSO~. The solvent is removed in vacuum, and the crystalline residue (m.p. 126-127C) is used as such for the nex-t s-tage. The yield is 31.0 g (94~ of the -theoretical) of 3,9-dimethoxy-6-isothiocyanatobenzonitrile.
C10I~8N22S calc. C = 54.53 Obs. C = 53.43 El = 3.66 l-l = 3.78 N = 12.72 N = 12.18 S = 14.56 S = 13.79 b) 3,4-dimethoxy-6-i4-(2-furoyl)-1-piperazinylt}liocarbamidol-benzonitrile (II) 11.2 g (0.051 mole) of 3,4-dimethoxy-6-isothiocyanatobenzonitrile (V) is dissolved in 65 Ml of ethyl acetate and added ~radually, while stirring , at 0C to a solution which contains 9.2 g (0.051 mole) of 1-(2-furoyl)-piperazine in 65 ml of ethyl ace-tate. The solution is allowed to stand overnight at -25C, whereby the product crys-tallizes. It is filtered and the crys-tals are washed wi-th cold ethyl acetate and dried. The yield is 16~3 g (80~ of the theoretical) of 3,4-dimethoxy-6-14-(2-furoyl)-l-piperazinylthiocarbamidolbenzonitrile. M.p. 178-180C.
19 20N4O4S Calc. C = 56.99 Obs. C = 57.41 H = 5.03 H = 5.39 N = 13.99 N = 14.14 S = 8.01 S = 7.68 . ~
092~
_ample 2
C 30 ~ ~ ~ ~ ~rdZoS~e NH NH NH NH
where Q = CN or C and A = CN, C ~ ~ C\ or C
in which case R = an alkyl with 1-6 carbon atoms; however, when Q is CN, A is c~NH or C~'NH
~ OR ~ SR
An object of a principal aspect of the present invention is to provide a new process for producing prazosine, differing from previously known processes Ln the resEeot that the formation of the quin201ine ring occurs within the ~lecule to form the final oo~po,und ana not, as in kncwn processes, in a reaction between two different m~lecules.
The proce~s accor,ding ~o a broad aspect of this Lnvention for ErO-ducing prazosine9 6,7-dimetho~y-4-amino-2- r4- (2-furoyl)-1-piFerazinyl~
zollne, ~ rises: re~ct ~ 3,4 ~ imet ~ -6-~4-~2-furoyl)-1-piperazinyl-thiocarbanido~benzonitrile, having the formLla . .
CH30~NH ~ N ~ OC
with methyl iodide~ to fonm methyl N-(3~4-dimethlxy-6-cyanophenyl)-~4-(2-furoyl)-l-pip~razinyl]-thioformamidate, having the ~ornNla ~0Y~Z~l~
~, CH3~N=~--.'\1 N - O
CH3 o CN
III, and cyclizing such compound (III) by heating it, together with ammonia, in a polar solvent in the presence of alkali metal amide.
By one variant of this process, the reaction of the compound hav-ing formula (II) with methyl iodide is performed in formamide, in N,N-dimethyl formamide, in bis-methoxyethyl ether (diglyme), or in a mixture of such solvents, at 50-100C.
By another variant, the cyclization is performed in formamide or in N,N-dimethyl formamide at 100-150C, using 1-3 equivalents of an alkali metal amide.
By yet another variant, the reaction of the compound having for-mula II with methyl iodide and the cyclization of the compound having formula III is performed continuously in one and the same solvent without separating the intermediate products.
The compound 3,4-dimethoxy-6-E4-(2-furoyl)-1-piperazinyl-thio-carbamido]benzonitrile (II) used as the initial substance is a new com-pound; Processes for the production of this compound having formula (II)20 are disclosed and claimed in copending Canadian application Serial No.
293,066 filed Dec. 14, 1977. However, in summary, such compound can be prepared starting from 3,4-di-methoxy-6-aminobenzonitrile and 1-(2-furoyl) piperazine, using the processes illustrated by the reaction formulas below:
~z~
Cll 30~ CS C 12 3 ~ NCS
CH30 CN C~13~) CN
IV V
.~ V I I V I
r~ ~
CH30~NH- I - N N - OC
II
HN~I--OC ~ ~ Cl-~-N~I OC
VI VII
~ ccording to the first alternative, 3,4~dimethQxy-6-amino-benzoni-trile tIV) is first allowed to react with thiophosgene to fonm 3,4-dimethQxy-6-isothiocyanatobenzonitrile ~l), an~ then further with 1-(2-furoyl) pipera-zine ~I) to form 3,4-dimethoxy-6-~4--(2-furoyl)-1-piperazinylthiocarbamido]
benzonitrile ~II). Alternatively, oQ~pound II can be produced by allowing 1-(2-furoyl~pip2razine ~VI) to react first with thiophosgene to form acid chloride VII, and thereafter with 3,4-d~methcxy-6-amunobenzonitrile (IV~.
As disclosed above the prccess according to one aspect of the in-vention can also be carried out so that the production o~ prazosine starting fm m 3,4-dimetho~y-6-~4-~2-furoyl)-1-piperazinylthiocarb~mido]benzanitrile (II), (even starting from 3,4-di~methcxy-6-isothiocyanato~enzonitrile ~V)), can be perfoLmed continuously in one and the same reaction vessel and in cne ' - ~ a, ~Zl~IL7 in one and~the sc~me solvent, e.g. Eormamide, without separatiny the inter-mediate products.
me followin~ examples will illustrate various a~pects of the invention.
- 4 b -1[39Z~7 r`xamp:Le 1 a) 3,4-dimethoxy-6-isothiocyanatoben7Onitri:Le (V) 27,0 ~ (0.15 mo:Le) o~ 3,4-~i~nethoxy-6-~tlinol-x~n%onitr:ile (IV) is dissolved in 150 ml of 1,2-dichloroethane~ anrl added cJradually at 0-5C to a rnixture which contains 23.0 g (0.2 mvle) of thiophosc3ene, 100 ml of 1,2-dichloroethane, 20.0 cJ (0.2 mole) of calcium carbonate, and 200 ml oE water. After this addition, the mixture is stirred for 1 hour at 0-5C, thereafter for 16 hours a-t 20C, and finally Eor 1 hour at 35C. The reaction mixture is ~ tered and the dichloroethane layer separa-ted, washed with dilute hydrochloric acid and wa-ter, and dried with MqSO~. The solvent is removed in vacuum, and the crystalline residue (m.p. 126-127C) is used as such for the nex-t s-tage. The yield is 31.0 g (94~ of the -theoretical) of 3,9-dimethoxy-6-isothiocyanatobenzonitrile.
C10I~8N22S calc. C = 54.53 Obs. C = 53.43 El = 3.66 l-l = 3.78 N = 12.72 N = 12.18 S = 14.56 S = 13.79 b) 3,4-dimethoxy-6-i4-(2-furoyl)-1-piperazinylt}liocarbamidol-benzonitrile (II) 11.2 g (0.051 mole) of 3,4-dimethoxy-6-isothiocyanatobenzonitrile (V) is dissolved in 65 Ml of ethyl acetate and added ~radually, while stirring , at 0C to a solution which contains 9.2 g (0.051 mole) of 1-(2-furoyl)-piperazine in 65 ml of ethyl ace-tate. The solution is allowed to stand overnight at -25C, whereby the product crys-tallizes. It is filtered and the crys-tals are washed wi-th cold ethyl acetate and dried. The yield is 16~3 g (80~ of the theoretical) of 3,4-dimethoxy-6-14-(2-furoyl)-l-piperazinylthiocarbamidolbenzonitrile. M.p. 178-180C.
19 20N4O4S Calc. C = 56.99 Obs. C = 57.41 H = 5.03 H = 5.39 N = 13.99 N = 14.14 S = 8.01 S = 7.68 . ~
092~
_ample 2
3~4-dimethoxy-6-l4-(2-Euroyl)-]-piperaz:inylth:iocar~amido~benzo-nitrile (IL) 5.0 C3 (0.02~ moJe) of 1-(2-Euroyl)piE)erLlzirle (VI) and 2.33 ~3 (0.028 mole) of triethylamine are dissolvecl in 60 ml of dichlorometlla1le. 'rhis solution is addecl, while stirrinc3 , at approx. 0C to a mixture which contains 3.~ g (0.0336 Mole) of thiophoscJene in 50 mJ of dichloromethane. After this addition, the mixture is stirr~d for Z hours at 0C and for 3 hours at room -temperature. The triethylamine hydroch]oride is filtered off, and the solution is completely evaporated in a vacuum. The residue, 9-(2-furoyl)piperazinyl-thiocarbonyl chloride (VII), is redissolved in 50 ml of dichloromet}lane and added, while aqitating, at 0C to a solution which contains 4.98 g (0.028 mole) of 3,4-dime-thoxy-6-aminobenzonitrile (IV) and 2.83 ~ (0.028 mole) of triethylamine in 60 ml of dichloromethane. The mixture is~agitatecl for 2 hours a-t 0C and thereaE-ter for 2 3 hours at room tempera-ture. The triethylamine hydrochloride is filtered off, and the solution is washed with water, dried with M~SO4, and completely evaporated in a vacuum. ~thyl acetate is added, the mix-ture is cooled -to -25C and filtered. I'he yield is 6.2 g (55% of the theore-tical) of 3,4-dimethoxy-6-[4-(2-furoyl)-1-piperazinylthiocarbamidoJbenzonitrile. M.p. 175-178C.
Exam~le 3 a) Methyl N-(3,4-dimethoxy-6-cyanophenyl)-14-(2-furoyl)-1-piperazinyl~thioformamidate hydrolodide (III-HI) 20;0 C3 (0.05 mole) of 3,4-dimethoxy-6-l4-(2-furoyl)~l-piperazinylthiocarbamido~benzonitrile is dissolved in 200 ml of bis-methoxyethyl ether (diglyme), and 14.2 ~3 (0.1 mole) of methyl iodide is added. The mixture is refluxed for 9 hours at 60C. The solution is cooled to room temperature and filtered. The crys-talline reac-tion product is washed with ether al-d dried. The yield is 24.6 c3 (90~ of the theoretical) of methyl N~(3,4-dimethoxy-6-cyanopllenyl)-l4-(2-furoyl)-l-piperazinyll-thioformami-:late hyclroioclide. M.p. 163C.
~09Z~i7 C20H23IN404S Calc. C - 44.29 Obs C = 44.25 H = '~.27 ~ ~ 4.26 I = 23.39 I = 22.93 N = 10,33 N = 9.61 S = 5.91 S = 5.58 b) Methyl N~(3l4~dimethoxy-6-cyanophenyl~r4~(2~furoyl)-l~piperazinyl]thio-formamidate (III) 62.0 g (0.114 mole) of methyl N-(3,4~dimethoxy~6~cyanophenyl)~[4-(2-furoyl)~l~piperazinyl]thioformamidate hydroiodide i9 dissolved at 0~5C
in 350 ml of methanol, and 186 ml of a 25 % ammonia solution is added, while stirring. The mixture is agitated for 2 hours at 0C, filtered, and washed with ether. The yield is 42,7 g (90 of the theoretical) of methyl N-(3,4~dimethoxy~6~cyanophenyl)~r4~(2-furoyl)~l~piperazinyl]~
thioformamidate. M.p. 105~107C. , 20 22N44S Calc. C = 57.95 Obs. C = 58.01 H = 5.36 H = 5.54 N = 13.52 N = 13.73 S = 7.73 S = 7.53 c) 6,7-dimethoxy-4~amino~2 [4~(2~furoyl)-l~piperazinyl]~quinazoline (I) 7.0 g (0.017 mole) of methyl N~(3,4~dimethoxy-6-dyanophenyl)~~4-(2-furoyl)-l~pipera~inyl]thioformamidate is dissolved in 100 ml of formamide, and 2.0 g (0.051 mole) of sodium amide is addedO The solution is saturated wlth NH3 gas at 0C. The temperature of the solution is rised slowly to 120 C, and it is heated for 24 more hours at this temperature, in th~ stream of NH3 gas. The cooled reaction mixture is poured into 100 ml of ice water and extracted 6~7 times with 50 ml of chloroform. The chloroform extract is washed 4 times with 50 ml of water, dried, and completely evaporated in a vacuum. The product is crystallized from an ethanol~
water mixture (50:15). The product is 6,7-dimethoxy-4-amino~2-[4~(2-2~L~iL7 furoyl)-l-piperazinyl.]-qu:Lnazollne, M.p. 262-264C. The IR and NMR
spectra of the product are identical ~7ith the spectra of the compound produced by processes prevlously described in literature.
- 7 a -Z~l~
19 21 5 4 Ca]c. C = 59.52 Obs. C = 59.28 Il = 5.52 ll = 5.88 N = 18.27 N = 17.99 Example 4 6,7-dimethoxy-4-amino-2-14-(2-furoyl)-1-piperazlnyllquinazoline (Ij 9.7 g (0.044 mole) of 3,4-dimethoxy-6-iso-thiocyanatobenzonitrile (V) is suspellded in :100 ml oE formamide, and to this suspension is added CJI. adually, while stirring, at room temperature 7.9 y (0.044 mole) of 1-(2-furoyl)piperazine (VI) dissolved in 65 ml of formamide. After this addition, the stirring is continued at room temperature until all of -the 3,4-dimethoxy-6-isothiocyanatobenzonitrile is dissolved (3-4 hours). There-after 12.5 g (0.088 mole) of methyl iodide is added to the mixture and the mixture is heated for 9 hours at 60C. Excess methyl iodide is removed by evaporating and the solution is satura~ted with Nl13 gas at 0C, and 6.9 g (0.176 mole) of sodium amide is added to the solu-tion. The ternperature is rised to 120-l90C, and the so]ution ls heated for 24 hours at this-te~lr~erature, in ~le stream of NE13 cJas. The cooled reaction mixture is poured into ice water (approx. 150 ml) and extracted using chloroform (8 x 50 ml). The chloroform extract is washed with water, treated wi-th activa-ted carbon, dried, and completely evaporated in a vacuum. The resiclue is crystallized from an ethanol-water mixture (50:15). The product is 6,7-dimethoxy-4-amino-2-14-(2-furoyl)-1-piperazinyl]quinazoline.
M.p. 263-265C.
Exam~le 3 a) Methyl N-(3,4-dimethoxy-6-cyanophenyl)-14-(2-furoyl)-1-piperazinyl~thioformamidate hydrolodide (III-HI) 20;0 C3 (0.05 mole) of 3,4-dimethoxy-6-l4-(2-furoyl)~l-piperazinylthiocarbamido~benzonitrile is dissolved in 200 ml of bis-methoxyethyl ether (diglyme), and 14.2 ~3 (0.1 mole) of methyl iodide is added. The mixture is refluxed for 9 hours at 60C. The solution is cooled to room temperature and filtered. The crys-talline reac-tion product is washed with ether al-d dried. The yield is 24.6 c3 (90~ of the theoretical) of methyl N~(3,4-dimethoxy-6-cyanopllenyl)-l4-(2-furoyl)-l-piperazinyll-thioformami-:late hyclroioclide. M.p. 163C.
~09Z~i7 C20H23IN404S Calc. C - 44.29 Obs C = 44.25 H = '~.27 ~ ~ 4.26 I = 23.39 I = 22.93 N = 10,33 N = 9.61 S = 5.91 S = 5.58 b) Methyl N~(3l4~dimethoxy-6-cyanophenyl~r4~(2~furoyl)-l~piperazinyl]thio-formamidate (III) 62.0 g (0.114 mole) of methyl N-(3,4~dimethoxy~6~cyanophenyl)~[4-(2-furoyl)~l~piperazinyl]thioformamidate hydroiodide i9 dissolved at 0~5C
in 350 ml of methanol, and 186 ml of a 25 % ammonia solution is added, while stirring. The mixture is agitated for 2 hours at 0C, filtered, and washed with ether. The yield is 42,7 g (90 of the theoretical) of methyl N-(3,4~dimethoxy~6~cyanophenyl)~r4~(2-furoyl)~l~piperazinyl]~
thioformamidate. M.p. 105~107C. , 20 22N44S Calc. C = 57.95 Obs. C = 58.01 H = 5.36 H = 5.54 N = 13.52 N = 13.73 S = 7.73 S = 7.53 c) 6,7-dimethoxy-4~amino~2 [4~(2~furoyl)-l~piperazinyl]~quinazoline (I) 7.0 g (0.017 mole) of methyl N~(3,4~dimethoxy-6-dyanophenyl)~~4-(2-furoyl)-l~pipera~inyl]thioformamidate is dissolved in 100 ml of formamide, and 2.0 g (0.051 mole) of sodium amide is addedO The solution is saturated wlth NH3 gas at 0C. The temperature of the solution is rised slowly to 120 C, and it is heated for 24 more hours at this temperature, in th~ stream of NH3 gas. The cooled reaction mixture is poured into 100 ml of ice water and extracted 6~7 times with 50 ml of chloroform. The chloroform extract is washed 4 times with 50 ml of water, dried, and completely evaporated in a vacuum. The product is crystallized from an ethanol~
water mixture (50:15). The product is 6,7-dimethoxy-4-amino~2-[4~(2-2~L~iL7 furoyl)-l-piperazinyl.]-qu:Lnazollne, M.p. 262-264C. The IR and NMR
spectra of the product are identical ~7ith the spectra of the compound produced by processes prevlously described in literature.
- 7 a -Z~l~
19 21 5 4 Ca]c. C = 59.52 Obs. C = 59.28 Il = 5.52 ll = 5.88 N = 18.27 N = 17.99 Example 4 6,7-dimethoxy-4-amino-2-14-(2-furoyl)-1-piperazlnyllquinazoline (Ij 9.7 g (0.044 mole) of 3,4-dimethoxy-6-iso-thiocyanatobenzonitrile (V) is suspellded in :100 ml oE formamide, and to this suspension is added CJI. adually, while stirring, at room temperature 7.9 y (0.044 mole) of 1-(2-furoyl)piperazine (VI) dissolved in 65 ml of formamide. After this addition, the stirring is continued at room temperature until all of -the 3,4-dimethoxy-6-isothiocyanatobenzonitrile is dissolved (3-4 hours). There-after 12.5 g (0.088 mole) of methyl iodide is added to the mixture and the mixture is heated for 9 hours at 60C. Excess methyl iodide is removed by evaporating and the solution is satura~ted with Nl13 gas at 0C, and 6.9 g (0.176 mole) of sodium amide is added to the solu-tion. The ternperature is rised to 120-l90C, and the so]ution ls heated for 24 hours at this-te~lr~erature, in ~le stream of NE13 cJas. The cooled reaction mixture is poured into ice water (approx. 150 ml) and extracted using chloroform (8 x 50 ml). The chloroform extract is washed with water, treated wi-th activa-ted carbon, dried, and completely evaporated in a vacuum. The resiclue is crystallized from an ethanol-water mixture (50:15). The product is 6,7-dimethoxy-4-amino-2-14-(2-furoyl)-1-piperazinyl]quinazoline.
M.p. 263-265C.
Claims (5)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. In a process for preparing 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)-1-piperazinyl]quinazoline having the formula:
I
the improvement which comprises cyclizing methyl N-(3,4-dimethoxy-6-cyano-phenyl)-[4-(2-furoyl)-1-piperazinyl]thioformamidate having the formula:
III
by heating, together with ammonia, in a polar solvent in the presence of an alkali metal amide.
I
the improvement which comprises cyclizing methyl N-(3,4-dimethoxy-6-cyano-phenyl)-[4-(2-furoyl)-1-piperazinyl]thioformamidate having the formula:
III
by heating, together with ammonia, in a polar solvent in the presence of an alkali metal amide.
2. The improvement of claim 1 wherein said compound having formu-la (III) is prepared by reacting 3,4-dimethoxy-6-[4-(2-furoyl)-1-piperazinyl-thiocarbamido]benzonitrile having the formula:
II
with methyl iodide.
II
with methyl iodide.
3. The improvement of claim 2 wherein said reaction of the com-pound having Formula (II) with methyl iodide is performed in formamide, in N,N-dimethyl formamide, in bis-methoxyethyl ether (diglyme), or in a mix-ture of said solvents, at 50°-100°C.
4. The improvement of Claims 1, 2 or 3, wherein said cyclization is performed in formamide or in N,N-dimethyl formamide at 100°-150°C, using 1-3 equivalents of an alkali amide.
5. The improvement of Claims 1, 2 or 3, wherein said reaction of the compound having Formula II with methyl iodide and said cyclization of the compound having Formula III is performed continuously in one and the same solvent without separating the intermediate products.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI763613 | 1976-12-15 | ||
| FI763613A FI58125C (en) | 1976-12-15 | 1976-12-15 | PROCEDURE FOR FRAMSTATING AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE WITH BLODTRYCKSSAENKANDE VEKAN |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1092117A true CA1092117A (en) | 1980-12-23 |
Family
ID=8510503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA293,065A Expired CA1092117A (en) | 1976-12-15 | 1977-12-14 | Method for the production of 6,7-dimethoxy-4-amino-2- ¬4-(2-furoyl)-1-piperazinyl| quinazoline having an antihypertensive effect |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5387377A (en) |
| AT (1) | AT358048B (en) |
| BE (1) | BE861821A (en) |
| CA (1) | CA1092117A (en) |
| CH (1) | CH630625A5 (en) |
| CS (1) | CS195347B2 (en) |
| DD (1) | DD133671A1 (en) |
| DE (1) | DE2755637A1 (en) |
| DK (1) | DK144972C (en) |
| FI (1) | FI58125C (en) |
| HU (1) | HU174047B (en) |
| NL (1) | NL7713702A (en) |
| NO (1) | NO147244C (en) |
| PL (1) | PL106031B1 (en) |
| SE (1) | SE435284B (en) |
| SU (1) | SU753360A3 (en) |
| ZA (1) | ZA777223B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI67699C (en) * | 1979-01-31 | 1985-05-10 | Orion Yhtymae Oy | PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN |
| CA2873979C (en) * | 2012-05-23 | 2019-11-12 | Nerviano Medical Sciences S.R.L. | Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3935213A (en) * | 1973-12-05 | 1976-01-27 | Pfizer Inc. | Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives |
-
1976
- 1976-12-15 FI FI763613A patent/FI58125C/en not_active IP Right Cessation
-
1977
- 1977-11-24 CH CH1438177A patent/CH630625A5/en not_active IP Right Cessation
- 1977-11-25 SE SE7713376A patent/SE435284B/en not_active IP Right Cessation
- 1977-12-05 AT AT867277A patent/AT358048B/en not_active IP Right Cessation
- 1977-12-05 ZA ZA00777223A patent/ZA777223B/en unknown
- 1977-12-11 NL NL7713702A patent/NL7713702A/en not_active Application Discontinuation
- 1977-12-12 NO NO774262A patent/NO147244C/en unknown
- 1977-12-13 HU HU77OA538A patent/HU174047B/en not_active IP Right Cessation
- 1977-12-13 PL PL1977202899A patent/PL106031B1/en unknown
- 1977-12-14 SU SU772555247A patent/SU753360A3/en active
- 1977-12-14 DK DK558277A patent/DK144972C/en not_active IP Right Cessation
- 1977-12-14 DE DE19772755637 patent/DE2755637A1/en active Granted
- 1977-12-14 CA CA293,065A patent/CA1092117A/en not_active Expired
- 1977-12-14 BE BE183424A patent/BE861821A/en not_active IP Right Cessation
- 1977-12-15 JP JP15157077A patent/JPS5387377A/en active Granted
- 1977-12-15 CS CS778432A patent/CS195347B2/en unknown
- 1977-12-15 DD DD7700202666A patent/DD133671A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE435284B (en) | 1984-09-17 |
| ZA777223B (en) | 1978-09-27 |
| CH630625A5 (en) | 1982-06-30 |
| DE2755637C2 (en) | 1987-09-24 |
| FI763613A (en) | 1978-06-16 |
| AT358048B (en) | 1980-08-11 |
| JPS6225147B2 (en) | 1987-06-01 |
| DE2755637A1 (en) | 1978-06-22 |
| DK144972C (en) | 1988-08-29 |
| DD133671A1 (en) | 1979-01-17 |
| DK144972B (en) | 1982-07-19 |
| ATA867277A (en) | 1980-01-15 |
| NO147244C (en) | 1984-10-09 |
| NL7713702A (en) | 1978-06-19 |
| HU174047B (en) | 1979-10-28 |
| BE861821A (en) | 1978-03-31 |
| PL106031B1 (en) | 1979-11-30 |
| JPS5387377A (en) | 1978-08-01 |
| PL202899A1 (en) | 1978-08-28 |
| DK558277A (en) | 1978-06-16 |
| SE7713376L (en) | 1978-06-16 |
| FI58125B (en) | 1980-08-29 |
| NO147244B (en) | 1982-11-22 |
| SU753360A3 (en) | 1980-07-30 |
| FI58125C (en) | 1985-01-02 |
| CS195347B2 (en) | 1980-01-31 |
| NO774262L (en) | 1978-06-16 |
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