CA1085729A - Process and composition for treatment of leukemia and other tumors - Google Patents

Process and composition for treatment of leukemia and other tumors

Info

Publication number
CA1085729A
CA1085729A CA273,253A CA273253A CA1085729A CA 1085729 A CA1085729 A CA 1085729A CA 273253 A CA273253 A CA 273253A CA 1085729 A CA1085729 A CA 1085729A
Authority
CA
Canada
Prior art keywords
deazaminopterin
pharmaceutical composition
leukemia
pharmaceutically acceptable
ascites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA273,253A
Other languages
English (en)
French (fr)
Inventor
Joseph I. De Graw
Francis M. Sirotnak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc filed Critical SRI International Inc
Application granted granted Critical
Publication of CA1085729A publication Critical patent/CA1085729A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CA273,253A 1976-03-05 1977-03-04 Process and composition for treatment of leukemia and other tumors Expired CA1085729A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66421376A 1976-03-05 1976-03-05
US664,213 1976-03-05

Publications (1)

Publication Number Publication Date
CA1085729A true CA1085729A (en) 1980-09-16

Family

ID=24665062

Family Applications (1)

Application Number Title Priority Date Filing Date
CA273,253A Expired CA1085729A (en) 1976-03-05 1977-03-04 Process and composition for treatment of leukemia and other tumors

Country Status (10)

Country Link
JP (1) JPS52120134A (nl)
AU (1) AU511856B2 (nl)
BE (1) BE852095A (nl)
CA (1) CA1085729A (nl)
DE (1) DE2709506C2 (nl)
FR (1) FR2342732A1 (nl)
GB (1) GB1534238A (nl)
IE (1) IE45338B1 (nl)
IL (1) IL51593A (nl)
ZA (1) ZA771315B (nl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393064A (en) * 1976-03-05 1983-07-12 Sri International Process and composition for treatment of leukemia and process for preparing the same
US4460591A (en) * 1982-08-26 1984-07-17 Sri International 8,10-Dideazaminopterins
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
US4833145A (en) * 1986-06-30 1989-05-23 The Trustees Of Princeton University 4(3H)-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
US6358953B1 (en) * 1998-10-22 2002-03-19 Phillip B. B. Moheno Pterin antineoplastic agents

Also Published As

Publication number Publication date
IE45338L (en) 1977-09-05
GB1534238A (en) 1978-11-29
JPS613325B2 (nl) 1986-01-31
IL51593A0 (en) 1977-05-31
IL51593A (en) 1980-01-31
IE45338B1 (en) 1982-08-11
ZA771315B (en) 1978-05-30
BE852095A (fr) 1977-07-01
FR2342732A1 (fr) 1977-09-30
JPS52120134A (en) 1977-10-08
AU2292677A (en) 1978-09-07
FR2342732B1 (nl) 1980-02-01
DE2709506C2 (de) 1987-03-26
DE2709506A1 (de) 1977-09-08
AU511856B2 (en) 1980-09-11

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Legal Events

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