CA1083958A - Method and apparatus for automated competitive immunoassay of fluid samples - Google Patents

Method and apparatus for automated competitive immunoassay of fluid samples

Info

Publication number
CA1083958A
CA1083958A CA273,303A CA273303A CA1083958A CA 1083958 A CA1083958 A CA 1083958A CA 273303 A CA273303 A CA 273303A CA 1083958 A CA1083958 A CA 1083958A
Authority
CA
Canada
Prior art keywords
antigen
sample
antibody
solution
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA273,303A
Other languages
English (en)
French (fr)
Inventor
Gary Brooker
Wesley L. Terasaki
Michael G. Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
Original Assignee
University of Virginia UVA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/666,302 external-priority patent/US4022577A/en
Application filed by University of Virginia UVA filed Critical University of Virginia UVA
Application granted granted Critical
Publication of CA1083958A publication Critical patent/CA1083958A/en
Expired legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
CA273,303A 1976-03-12 1977-03-07 Method and apparatus for automated competitive immunoassay of fluid samples Expired CA1083958A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US666,302 1976-03-12
US05/666,302 US4022577A (en) 1976-03-12 1976-03-12 Automated radioimmunoassay
US730,630 1976-10-07
US05/730,630 US4104026A (en) 1976-03-12 1976-10-07 Immunoassay separation technique

Publications (1)

Publication Number Publication Date
CA1083958A true CA1083958A (en) 1980-08-19

Family

ID=27099430

Family Applications (1)

Application Number Title Priority Date Filing Date
CA273,303A Expired CA1083958A (en) 1976-03-12 1977-03-07 Method and apparatus for automated competitive immunoassay of fluid samples

Country Status (13)

Country Link
US (1) US4104026A (en, 2012)
JP (2) JPS52161693U (en, 2012)
AU (1) AU514237B2 (en, 2012)
BE (1) BE852344A (en, 2012)
CA (1) CA1083958A (en, 2012)
CH (1) CH618516A5 (en, 2012)
DD (1) DD130807A5 (en, 2012)
FR (1) FR2344020A1 (en, 2012)
GB (1) GB1574642A (en, 2012)
IL (1) IL51636A (en, 2012)
IT (1) IT1116804B (en, 2012)
NL (1) NL7702530A (en, 2012)
SE (1) SE7702800L (en, 2012)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410634A (en) * 1979-10-26 1983-10-18 Dynasciences Corporation Method of passively adsorbing immuno-reactive haptens to solid phases
JPS57131062A (en) * 1981-02-05 1982-08-13 Amano Pharmaceut Co Ltd Quantitative determination of antigen using enzyme- labelled antigen and second antibody insolubilizing carrier
DE3122019C2 (de) * 1981-06-03 1983-11-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Vorrichtung zur Durchführung eines automatisierten kontinuierlichen Enzymimmunotestes
EP0073593A1 (en) * 1981-09-01 1983-03-09 E.I. Du Pont De Nemours And Company Size-exclusion heterogeneous immunoassay
JPS58154662A (ja) * 1982-03-10 1983-09-14 Hitachi Ltd 前処理機能を備えた自動分析装置
US4618485A (en) * 1982-03-12 1986-10-21 International Immunoassay Laboratories, Inc. Kinetic radioimmunoassay test method and device
US4551298A (en) * 1982-05-26 1985-11-05 Westinghouse Electric Corp. Radiation monitoring apparatus
US4539292A (en) * 1982-12-29 1985-09-03 Reid Michael J Immunoassay technique for specific immunoglobulin E
US4871683A (en) * 1985-04-18 1989-10-03 Beckman Instruments, Inc. Apparatus and method using a new reaction capsule
US5459080A (en) * 1988-01-29 1995-10-17 Abbott Laboratories Ion-capture assays using a specific binding member conjugated to carboxymethylamylose
US5459078A (en) * 1988-01-29 1995-10-17 Abbott Laboratories Methods and reagents for performing ion-capture digoxin assays
US5866322A (en) * 1988-01-29 1999-02-02 Abbott Laboratories Method for performing Rubella assay
US5089424A (en) * 1988-06-14 1992-02-18 Abbott Laboratories Method and apparatus for heterogeneous chemiluminescence assay
SE9101413L (sv) * 1991-05-10 1992-11-11 Excorim Ab System foer behandling av en vaetska i en behandlingsanordning samt anvaendningen av detta system foer behandling av en biologisk vaetska
US5564104A (en) * 1993-06-08 1996-10-08 Cortex Biochem, Inc. Methods of removing radioactively labled biological molecules from liquid radioactive waste
US6103127A (en) 1993-06-08 2000-08-15 Cortex Biochem, Inc. Methods for removing hazardous organic molecules from liquid waste
US6271044B1 (en) 1998-05-06 2001-08-07 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method and kit for detecting an analyte
WO2000013698A1 (en) 1998-09-04 2000-03-16 University Of Utah Research Foundation Drug screening and diagnosis based on paracrine tubular renin-angiotensin system
US6420275B1 (en) 1999-08-30 2002-07-16 Micron Technology, Inc. System and method for analyzing a semiconductor surface
DE60213940T2 (de) * 2001-11-01 2007-09-06 Micromass UK Ltd., Simonsway Proben-Einführungssystem
US7655187B2 (en) * 2005-03-11 2010-02-02 Waters Technologies Corporation Systems for isolating toxins and collecting eluates for testing for toxins and methods using the same
JP7672989B2 (ja) 2019-04-11 2025-05-08 グローバルウェーハズ カンパニー リミテッド 本体長さ後半の歪みが低減されたインゴットの製造方法
SG11202111451WA (en) 2019-04-18 2021-11-29 Globalwafers Co Ltd Methods for growing a single crystal silicon ingot using continuous czochralski method
US11111596B2 (en) 2019-09-13 2021-09-07 Globalwafers Co., Ltd. Single crystal silicon ingot having axial uniformity
US11111597B2 (en) 2019-09-13 2021-09-07 Globalwafers Co., Ltd. Methods for growing a nitrogen doped single crystal silicon ingot using continuous Czochralski method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2797149A (en) * 1953-01-08 1957-06-25 Technicon International Ltd Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents
US3690833A (en) * 1970-05-04 1972-09-12 Damon Corp Automated fluids analyzer having selectively interrupted flow
GB1420916A (en) * 1971-09-08 1976-01-14 Bagshawe K D Performance of chemical or biological reactions
US3843326A (en) * 1972-06-07 1974-10-22 Technicon Instr Method and apparatus for successive sample analysis without inter-sample contamination
US4009005A (en) * 1973-03-19 1977-02-22 Becton, Dickinson And Company Apparatus for radioimmunoassay with regeneration of immunadsorbent
US3896217A (en) * 1973-03-19 1975-07-22 Summa Corp Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent

Also Published As

Publication number Publication date
IL51636A0 (en) 1977-05-31
CH618516A5 (en, 2012) 1980-07-31
FR2344020A1 (fr) 1977-10-07
AU2304777A (en) 1978-09-14
SE7702800L (sv) 1977-09-13
JPS5310495A (en) 1978-01-30
FR2344020B1 (en, 2012) 1981-02-27
GB1574642A (en) 1980-09-10
JPS52161693U (en, 2012) 1977-12-07
AU514237B2 (en) 1981-01-29
IL51636A (en) 1981-03-31
NL7702530A (nl) 1977-09-14
US4104026A (en) 1978-08-01
IT1116804B (it) 1986-02-10
DD130807A5 (de) 1978-05-03
BE852344A (fr) 1977-09-12

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Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 19970819