CA1073698A - Dual channel photo-optical clot detection apparatus - Google Patents
Dual channel photo-optical clot detection apparatusInfo
- Publication number
- CA1073698A CA1073698A CA243,036A CA243036A CA1073698A CA 1073698 A CA1073698 A CA 1073698A CA 243036 A CA243036 A CA 243036A CA 1073698 A CA1073698 A CA 1073698A
- Authority
- CA
- Canada
- Prior art keywords
- cuvettes
- readout position
- plasma
- circular
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000001514 detection method Methods 0.000 title claims abstract description 19
- 230000009977 dual effect Effects 0.000 title description 6
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 64
- 238000012360 testing method Methods 0.000 claims abstract description 62
- 238000005070 sampling Methods 0.000 claims abstract description 30
- 230000005855 radiation Effects 0.000 claims abstract description 25
- 238000010438 heat treatment Methods 0.000 claims abstract description 14
- 229920003023 plastic Polymers 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 9
- 238000003856 thermoforming Methods 0.000 claims description 7
- 238000003491 array Methods 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 5
- 238000005259 measurement Methods 0.000 abstract description 9
- 238000011534 incubation Methods 0.000 description 19
- 239000000523 sample Substances 0.000 description 19
- 230000035602 clotting Effects 0.000 description 14
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 7
- 108010000499 Thromboplastin Proteins 0.000 description 7
- 102000002262 Thromboplastin Human genes 0.000 description 7
- 108010094028 Prothrombin Proteins 0.000 description 6
- 102100027378 Prothrombin Human genes 0.000 description 6
- 229940039716 prothrombin Drugs 0.000 description 6
- 206010053567 Coagulopathies Diseases 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 230000015271 coagulation Effects 0.000 description 4
- 238000005345 coagulation Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 230000002572 peristaltic effect Effects 0.000 description 4
- 230000004913 activation Effects 0.000 description 3
- 238000013100 final test Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000393496 Electra Species 0.000 description 1
- 102100035115 Testin Human genes 0.000 description 1
- 101710070533 Testin Proteins 0.000 description 1
- 241000193803 Therea Species 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920006218 cellulose propionate Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000012802 pre-warming Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000007666 vacuum forming Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA322,824A CA1080995A (en) | 1975-01-08 | 1979-03-06 | Circular sample tray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/539,520 US3969079A (en) | 1975-01-08 | 1975-01-08 | Dual channel photo-optical clot detection apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1073698A true CA1073698A (en) | 1980-03-18 |
Family
ID=24151573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA243,036A Expired CA1073698A (en) | 1975-01-08 | 1976-01-06 | Dual channel photo-optical clot detection apparatus |
Country Status (7)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4448534A (en) * | 1978-03-30 | 1984-05-15 | American Hospital Corporation | Antibiotic susceptibility testing |
| US4166094A (en) * | 1978-05-22 | 1979-08-28 | The Perkin-Elmer Corporation | Automatic fluid sampling transport system |
| JPS55136957A (en) * | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
| JPS55136958A (en) * | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
| US4285906A (en) * | 1979-05-11 | 1981-08-25 | Warner-Lambert Company | Rotatable detector |
| USD266588S (en) | 1979-10-15 | 1982-10-19 | Warner-Lambert Company | Cuvette tray design |
| DE3007722A1 (de) * | 1980-02-29 | 1981-09-17 | Herbert 4933 Blomberg Krone | Verfahren zur bestimmung der gerinnung von fluessigkeiten und coagulometer zu dessen durchfuehrung |
| US4298570A (en) * | 1980-04-18 | 1981-11-03 | Beckman Instruments, Inc. | Tray section for automated sample handling apparatus |
| US4335620A (en) * | 1980-07-16 | 1982-06-22 | The Upjohn Company | Temperature controlled sample carrier |
| IT1146764B (it) * | 1981-03-23 | 1986-11-19 | Salus Ricerca & Sviluppo Di Cr | Metodo per lo studio dell'emogoagulazione e dell'aggregazione delle piastrine nel sangue e dispositivo impiegato per attuare tale metodo |
| USD271993S (en) | 1981-05-22 | 1983-12-27 | Swartz Peter J | Cuvette array |
| USD273807S (en) | 1981-06-04 | 1984-05-08 | Abbott Laboratories | Sample cup or the like |
| USD273986S (en) | 1981-07-08 | 1984-05-22 | Warner Lambert Technologies, Inc. | Design for a blood clot detection instrument |
| US4443408A (en) * | 1981-07-09 | 1984-04-17 | International Technidyne, Inc. | Apparatus for analyzing the influence of additive reagents upon the coagulation of blood |
| US4477192A (en) * | 1982-06-25 | 1984-10-16 | Warner-Lambert Company | Magnetic stirring apparatus and method |
| US4640896A (en) * | 1982-11-04 | 1987-02-03 | Unisearch Limited | Whole blood clotting timer |
| US4855110A (en) * | 1987-05-06 | 1989-08-08 | Abbott Laboratories | Sample ring for clinical analyzer network |
| US5098661A (en) * | 1988-11-16 | 1992-03-24 | Medical Laboratory Automation, Inc. | Coded cuvette for use in testing apparatus |
| DE3904201C1 (en) * | 1989-02-13 | 1990-05-03 | Heinrich Amelung Gmbh, 4920 Lemgo, De | Apparatus for the photometric determination of the coagulation behaviour of blood, blood plasma or the like |
| US5039617A (en) * | 1989-04-20 | 1991-08-13 | Biotrack, Inc. | Capillary flow device and method for measuring activated partial thromboplastin time |
| DE3923833C2 (de) * | 1989-07-19 | 1998-07-02 | Boehringer Mannheim Gmbh | Analysegerät für heterogene immunologische Tests |
| CA2031912A1 (en) * | 1989-12-22 | 1991-06-23 | Robert Fred Pfost | Heated cover device |
| US5207987A (en) * | 1990-05-21 | 1993-05-04 | Pb Diagnostic Systems Inc. | Temperature controlled chamber for diagnostic analyzer |
| CN1320350C (zh) * | 2004-07-06 | 2007-06-06 | 武汉市华中电测技术开发有限公司 | 凝血功能系统检测装置 |
| JP5265558B2 (ja) * | 2006-11-03 | 2013-08-14 | テューダー アルヴィンテ | 試料評価方法および装置 |
| EP2770318B1 (en) | 2013-02-21 | 2018-03-21 | Roche Diagniostics GmbH | Method and apparatus for detecting clots in a liquid and laboratory automation system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3477822A (en) * | 1967-12-26 | 1969-11-11 | Xerox Corp | Chemical package |
| US3540858A (en) * | 1968-01-22 | 1970-11-17 | Beckman Instruments Inc | Sample holder with filter means |
| US3622279A (en) * | 1968-06-14 | 1971-11-23 | Hycel Inc | Automatic chemical testing apparatus |
| US3542515A (en) * | 1968-08-06 | 1970-11-24 | Perkin Elmer Corp | Determining reaction rates by simultaneous two-point measurements |
| US3607099A (en) * | 1969-03-11 | 1971-09-21 | Medical Laboratory Automation | Prothrombin time measuring apparatus |
| US3754866A (en) * | 1971-07-30 | 1973-08-28 | Sherwood Medical Ind Inc | Optical detecting system |
-
1975
- 1975-01-08 US US05/539,520 patent/US3969079A/en not_active Expired - Lifetime
- 1975-12-19 GB GB16220/77A patent/GB1535329A/en not_active Expired
- 1975-12-19 GB GB52056/75A patent/GB1535328A/en not_active Expired
-
1976
- 1976-01-05 DE DE2600217A patent/DE2600217C2/de not_active Expired
- 1976-01-06 CA CA243,036A patent/CA1073698A/en not_active Expired
- 1976-01-07 FR FR7600267A patent/FR2297423A1/fr active Granted
- 1976-01-08 JP JP51001817A patent/JPS5195895A/ja active Pending
-
1981
- 1981-07-27 JP JP1981111464U patent/JPS5910605Y2/ja not_active Expired
- 1981-12-10 HK HK612/81A patent/HK61281A/xx unknown
- 1981-12-10 HK HK611/81A patent/HK61181A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5195895A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-08-23 |
| GB1535328A (en) | 1978-12-13 |
| JPS5910605Y2 (ja) | 1984-04-03 |
| HK61281A (en) | 1981-12-18 |
| DE2600217A1 (de) | 1976-07-15 |
| US3969079A (en) | 1976-07-13 |
| FR2297423A1 (fr) | 1976-08-06 |
| JPS5739353U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-03-03 |
| DE2600217C2 (de) | 1982-12-02 |
| GB1535329A (en) | 1978-12-13 |
| FR2297423B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-12-24 |
| HK61181A (en) | 1981-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |