CA1072013A - Method of enhancing reproductive efficiency in non-human animals - Google Patents
Method of enhancing reproductive efficiency in non-human animalsInfo
- Publication number
- CA1072013A CA1072013A CA264,897A CA264897A CA1072013A CA 1072013 A CA1072013 A CA 1072013A CA 264897 A CA264897 A CA 264897A CA 1072013 A CA1072013 A CA 1072013A
- Authority
- CA
- Canada
- Prior art keywords
- dopa
- animal feed
- feed according
- derivative
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001850 reproductive effect Effects 0.000 title abstract description 9
- 238000000034 method Methods 0.000 title description 4
- 230000002708 enhancing effect Effects 0.000 title description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims abstract description 39
- 241001465754 Metazoa Species 0.000 claims abstract description 36
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000004480 active ingredient Substances 0.000 claims description 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 108010016626 Dipeptides Proteins 0.000 claims description 4
- 150000002081 enamines Chemical class 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 150000001408 amides Chemical class 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 238000006731 degradation reaction Methods 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 238000001727 in vivo Methods 0.000 claims description 3
- 125000005041 acyloxyalkyl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 125000003277 amino group Chemical group 0.000 claims description 2
- BNQDCRGUHNALGH-UHFFFAOYSA-N benserazide Chemical compound OCC(N)C(=O)NNCC1=CC=C(O)C(O)=C1O BNQDCRGUHNALGH-UHFFFAOYSA-N 0.000 claims description 2
- 239000000534 dopa decarboxylase inhibitor Substances 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- -1 pivaloyloxymethyl esters Chemical class 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims 3
- VIYKYVYAKVNDPS-HKGPVOKGSA-N (2s)-2-azanyl-3-[3,4-bis(oxidanyl)phenyl]propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 VIYKYVYAKVNDPS-HKGPVOKGSA-N 0.000 claims 1
- 241000555028 Sternidius alpha Species 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229910052500 inorganic mineral Chemical class 0.000 claims 1
- 239000011707 mineral Chemical class 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 abstract description 4
- 229940100197 antimetabolite Drugs 0.000 abstract description 4
- 239000002256 antimetabolite Substances 0.000 abstract description 4
- 230000035935 pregnancy Effects 0.000 abstract description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 241000700159 Rattus Species 0.000 description 20
- 230000000694 effects Effects 0.000 description 8
- ONIKNECPXCLUHT-UHFFFAOYSA-N 2-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1Cl ONIKNECPXCLUHT-UHFFFAOYSA-N 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 238000009395 breeding Methods 0.000 description 6
- 230000001488 breeding effect Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229960005190 phenylalanine Drugs 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 4
- 230000017448 oviposition Effects 0.000 description 4
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 230000027758 ovulation cycle Effects 0.000 description 3
- 238000007911 parenteral administration Methods 0.000 description 3
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003101 oviduct Anatomy 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 206010061079 Congenital uterine anomaly Diseases 0.000 description 1
- 241000777300 Congiopodidae Species 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 206010046764 Uterine atrophy Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- CEXFHIYDTRNBJD-RSAXXLAASA-N benzyl (2s)-2-amino-3-phenylpropanoate;hydrochloride Chemical compound Cl.C([C@H](N)C(=O)OCC=1C=CC=CC=1)C1=CC=CC=C1 CEXFHIYDTRNBJD-RSAXXLAASA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 description 1
- 208000037516 chromosome inversion disease Diseases 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000001158 estrous effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002710 gonadal effect Effects 0.000 description 1
- 239000000745 gonadal hormone Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- WFGNJLMSYIJWII-FJXQXJEOSA-N methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WFGNJLMSYIJWII-FJXQXJEOSA-N 0.000 description 1
- SWVMLNPDTIFDDY-FVGYRXGTSA-N methyl (2s)-2-amino-3-phenylpropanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CC1=CC=CC=C1 SWVMLNPDTIFDDY-FVGYRXGTSA-N 0.000 description 1
- 101150072047 nei1 gene Proteins 0.000 description 1
- 101150008002 nei2 gene Proteins 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000013594 poultry meat Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000583 progesterone congener Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960004509 serum gonadotrophin Drugs 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13227175A JPS5257330A (en) | 1975-11-04 | 1975-11-04 | Breeding accelerators for animals |
| JP3795776A JPS52122630A (en) | 1976-04-05 | 1976-04-05 | Breeding rate accelerator for animal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1072013A true CA1072013A (en) | 1980-02-19 |
Family
ID=26377134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA264,897A Expired CA1072013A (en) | 1975-11-04 | 1976-11-04 | Method of enhancing reproductive efficiency in non-human animals |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU509270B2 (enExample) |
| CA (1) | CA1072013A (enExample) |
| DE (1) | DE2649914A1 (enExample) |
| FR (1) | FR2330384A1 (enExample) |
| GB (1) | GB1518726A (enExample) |
| NZ (1) | NZ182523A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4241082A (en) * | 1977-09-02 | 1980-12-23 | Sankyo Company Limited | Agents for promoting reproductive ability of domestic animals |
| AU8076691A (en) * | 1990-06-13 | 1992-01-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The | Process for activating reproduction of seasonal breeding animals by administering l-dihydroxyphenylalanine (l-dopa) |
| US5665375A (en) * | 1995-05-31 | 1997-09-09 | Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College | Method of altering the contents of eggs |
| MD4166C1 (ro) * | 2011-09-16 | 2012-12-31 | Институт Физиологии И Санокреатологии Академии Наук Молдовы | Stimulator al spermatogenezei la cocoşi |
| MD4193C1 (ro) * | 2012-06-22 | 2013-08-31 | Институт Физиологии И Санокреатологии Академии Наук Молдовы | Stimulator al spermatogenezei la cocoşi |
-
1976
- 1976-10-27 GB GB44665/76A patent/GB1518726A/en not_active Expired
- 1976-10-29 DE DE19762649914 patent/DE2649914A1/de not_active Withdrawn
- 1976-11-04 AU AU19304/76A patent/AU509270B2/en not_active Expired
- 1976-11-04 CA CA264,897A patent/CA1072013A/en not_active Expired
- 1976-11-04 NZ NZ182523A patent/NZ182523A/xx unknown
- 1976-11-04 FR FR7633276A patent/FR2330384A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NZ182523A (en) | 1982-06-29 |
| GB1518726A (en) | 1978-07-26 |
| FR2330384B1 (enExample) | 1981-07-03 |
| DE2649914A1 (de) | 1977-05-12 |
| FR2330384A1 (fr) | 1977-06-03 |
| AU509270B2 (en) | 1980-05-01 |
| AU1930476A (en) | 1978-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |