CA1038378A - 13-cis prostaglandin derivatives and methods of making - Google Patents

13-cis prostaglandin derivatives and methods of making

Info

Publication number
CA1038378A
CA1038378A CA172,898A CA172898A CA1038378A CA 1038378 A CA1038378 A CA 1038378A CA 172898 A CA172898 A CA 172898A CA 1038378 A CA1038378 A CA 1038378A
Authority
CA
Canada
Prior art keywords
hydrogen
formulas
isomer
compound
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA172,898A
Other languages
English (en)
French (fr)
Other versions
CA172898S (en
Inventor
Arthur F. Kluge
Karl G. Untch
John H. Fried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Application granted granted Critical
Publication of CA1038378A publication Critical patent/CA1038378A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
CA172,898A 1972-07-18 1973-05-29 13-cis prostaglandin derivatives and methods of making Expired CA1038378A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US272880A US3867377A (en) 1972-07-18 1972-07-18 Method of making 13-cis prostaglandin derivatives

Publications (1)

Publication Number Publication Date
CA1038378A true CA1038378A (en) 1978-09-12

Family

ID=23041674

Family Applications (1)

Application Number Title Priority Date Filing Date
CA172,898A Expired CA1038378A (en) 1972-07-18 1973-05-29 13-cis prostaglandin derivatives and methods of making

Country Status (13)

Country Link
US (1) US3867377A (OSRAM)
JP (1) JPS4992027A (OSRAM)
AT (1) AT341688B (OSRAM)
AU (1) AU474934B2 (OSRAM)
BE (2) BE802385A (OSRAM)
CA (1) CA1038378A (OSRAM)
CH (1) CH592620A5 (OSRAM)
DE (2) DE2357571A1 (OSRAM)
ES (1) ES416998A1 (OSRAM)
FR (2) FR2192830B1 (OSRAM)
GB (1) GB1430995A (OSRAM)
IL (1) IL42425A (OSRAM)
NL (1) NL7310007A (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110368A (en) * 1972-07-24 1978-08-29 American Cyanamid Company Hydro substituted prostanoic acids and esters
US3998852A (en) * 1973-04-16 1976-12-21 Syntex (U.S.A.) Inc. Novel prostaglandin intermediates and process for the production thereof
US4055564A (en) * 1975-01-15 1977-10-25 Syntex (U.S.A.) Inc. Novel prostaglandin intermediates and process for the production thereof
US4026909A (en) * 1975-07-14 1977-05-31 The Upjohn Company Cis-13-PGF2.sub.α analogs
FR2353287A1 (fr) * 1975-08-29 1977-12-30 Roussel Uclaf Nouveaux derives du cyclopentanol, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
US3867377A (en) 1975-02-18
ATA632673A (de) 1977-06-15
ES416998A1 (es) 1976-06-16
AU5690473A (en) 1974-12-19
DE2334764A1 (de) 1974-02-14
CH592620A5 (OSRAM) 1977-10-31
FR2283118B1 (OSRAM) 1979-07-27
DE2357571A1 (de) 1974-10-03
AT341688B (de) 1978-02-27
NL7310007A (OSRAM) 1974-01-22
GB1430995A (en) 1976-04-07
BE802385A (fr) 1974-01-16
IL42425A (en) 1976-09-30
JPS4992027A (OSRAM) 1974-09-03
IL42425A0 (en) 1973-08-29
FR2192830B1 (OSRAM) 1977-07-01
AU474934B2 (en) 1976-08-05
BE802386A (fr) 1974-01-16
FR2283118A1 (fr) 1976-03-26
FR2192830A1 (OSRAM) 1974-02-15

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