CA1033354A - 4',5'-DIHYDRO-7.alpha.-ALKOXYCARBONYLSPIRO (ANDROST-4-ENE-17,2'(3'H)-FURAN)-3-ONES AND .DELTA.1,4 COMPOUNDS CORRESPONDING - Google Patents

4',5'-DIHYDRO-7.alpha.-ALKOXYCARBONYLSPIRO (ANDROST-4-ENE-17,2'(3'H)-FURAN)-3-ONES AND .DELTA.1,4 COMPOUNDS CORRESPONDING

Info

Publication number
CA1033354A
CA1033354A CA209,165A CA209165A CA1033354A CA 1033354 A CA1033354 A CA 1033354A CA 209165 A CA209165 A CA 209165A CA 1033354 A CA1033354 A CA 1033354A
Authority
CA
Canada
Prior art keywords
alkoxycarbonylspiro
androst
ene
furan
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA209,165A
Other languages
English (en)
French (fr)
Other versions
CA209165S (en
Inventor
Richard M. Weier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle and Co of Canada Ltd
Original Assignee
GD Searle and Co of Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle and Co of Canada Ltd filed Critical GD Searle and Co of Canada Ltd
Application granted granted Critical
Publication of CA1033354A publication Critical patent/CA1033354A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CA209,165A 1973-09-14 1974-09-13 4',5'-DIHYDRO-7.alpha.-ALKOXYCARBONYLSPIRO (ANDROST-4-ENE-17,2'(3'H)-FURAN)-3-ONES AND .DELTA.1,4 COMPOUNDS CORRESPONDING Expired CA1033354A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39723273A 1973-09-14 1973-09-14

Publications (1)

Publication Number Publication Date
CA1033354A true CA1033354A (en) 1978-06-20

Family

ID=23570365

Family Applications (1)

Application Number Title Priority Date Filing Date
CA209,165A Expired CA1033354A (en) 1973-09-14 1974-09-13 4',5'-DIHYDRO-7.alpha.-ALKOXYCARBONYLSPIRO (ANDROST-4-ENE-17,2'(3'H)-FURAN)-3-ONES AND .DELTA.1,4 COMPOUNDS CORRESPONDING

Country Status (6)

Country Link
JP (1) JPS5850239B2 (enExample)
CA (1) CA1033354A (enExample)
CH (1) CH602791A5 (enExample)
DE (1) DE2443746A1 (enExample)
FR (1) FR2243701B1 (enExample)
GB (1) GB1455220A (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997021720A2 (en) 1995-12-11 1997-06-19 G.D. Searle And Co. Processes for preparation of 7 alpha-carboxyl 9,11-epoxy steroids and intermediates useful therein and a general process for the epoxidation of olifinic double bonds
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
NZ336004A (en) 1996-12-11 2001-04-27 G Process for preparation of 3-keto-7-alpha-alkoxycarbonyl substituted delta-4,5-steroid by reacting 4,5-dihydro-5,7-lactone steroid substrate in the presence of a base
EP1148061B1 (en) * 1996-12-11 2007-10-17 G.D. Searle LLC. Epoxidation process
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
BRPI0515106A (pt) * 2004-09-09 2008-07-08 Pharmacia Corp processo para preparar esteróides 7(alfa)-alcoxicarbonil substituìdos

Also Published As

Publication number Publication date
FR2243701B1 (enExample) 1978-07-21
JPS5850239B2 (ja) 1983-11-09
GB1455220A (enExample) 1976-11-10
CH602791A5 (enExample) 1978-08-15
FR2243701A1 (enExample) 1975-04-11
JPS5053363A (enExample) 1975-05-12
DE2443746A1 (de) 1975-03-20

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