CA1030143A - METHOD OF PRODUCING I-N-(L-(-)-.alpha.-HYDROXY-.gamma.-AMINOBUTYRYL) XK-62-2 - Google Patents

METHOD OF PRODUCING I-N-(L-(-)-.alpha.-HYDROXY-.gamma.-AMINOBUTYRYL) XK-62-2

Info

Publication number
CA1030143A
CA1030143A CA218,494A CA218494A CA1030143A CA 1030143 A CA1030143 A CA 1030143A CA 218494 A CA218494 A CA 218494A CA 1030143 A CA1030143 A CA 1030143A
Authority
CA
Canada
Prior art keywords
aminobutyryl
gamma
alpha
hydroxy
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA218,494A
Other languages
English (en)
French (fr)
Inventor
Kunikatsu Shirahata
Takashi Nara
Shinji Tomioka
Yasuki Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of CA1030143A publication Critical patent/CA1030143A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA218,494A 1974-01-24 1975-01-23 METHOD OF PRODUCING I-N-(L-(-)-.alpha.-HYDROXY-.gamma.-AMINOBUTYRYL) XK-62-2 Expired CA1030143A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP973374A JPS5635195B2 (no) 1974-01-24 1974-01-24

Publications (1)

Publication Number Publication Date
CA1030143A true CA1030143A (en) 1978-04-25

Family

ID=11728500

Family Applications (1)

Application Number Title Priority Date Filing Date
CA218,494A Expired CA1030143A (en) 1974-01-24 1975-01-23 METHOD OF PRODUCING I-N-(L-(-)-.alpha.-HYDROXY-.gamma.-AMINOBUTYRYL) XK-62-2

Country Status (14)

Country Link
US (1) US4055715A (no)
JP (1) JPS5635195B2 (no)
AT (1) AT340045B (no)
CA (1) CA1030143A (no)
CH (1) CH613459A5 (no)
DE (1) DE2502935C3 (no)
DK (1) DK20175A (no)
FR (1) FR2259107A1 (no)
GB (1) GB1496741A (no)
NL (1) NL7500856A (no)
NO (1) NO140427C (no)
PH (1) PH14087A (no)
SE (1) SE7500716L (no)
ZA (1) ZA75496B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132846A (en) * 1974-03-07 1979-01-02 Abbott Laboratories 1-N-(α-Hydroxy-β-aminopropionyl) XK-62-2 and method of production thereof
JPS5119744A (en) * 1974-08-05 1976-02-17 Kyowa Hakko Kogyo Kk Koseibutsushitsu xkk6222 no shinkyudotainoseiho
US4218562A (en) * 1974-12-11 1980-08-19 Abbott Laboratories Antibiotic derivatives of XK-62-2
US4195171A (en) * 1975-07-15 1980-03-25 Abbott Laboratories Derivatives of an antibiotic XK-62-2 and process for the production thereof
US4339572A (en) * 1976-09-23 1982-07-13 Abbott Laboratories Fortimicin B derivatives and process for production thereof
US4424343A (en) 1977-04-28 1984-01-03 Bristol Myers Company Preparation of 1-N- ω-amino-α-hydroxyalkanoyl!kanamycin polysilylates and products
US4347354A (en) * 1977-04-28 1982-08-31 Bristol-Myers Company Preparation of 1-N-[ω-amino-α-hydroxyalkanoyl]aminoglycoside polysilylated antibiotics and products obtained therefrom
US4298690A (en) * 1977-05-19 1981-11-03 Kyowa Hakko Kogyo Co., Ltd. Antibiotics XK-62-3 and XK-62-4 and process for production thereof
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
US4223024A (en) * 1979-03-12 1980-09-16 Abbott Laboratories 4"-O-Alkylgentamicins and sagamicins
US4387219A (en) * 1979-11-13 1983-06-07 Sterling Drug Inc. 2-Hydroxy gentamicin compounds
AU2008326297B2 (en) * 2007-11-21 2012-11-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3781268A (en) * 1972-01-27 1973-12-25 Bristol Myers Co Antibiotic derivatives of kanamycin
US3780018A (en) * 1972-06-26 1973-12-18 Bristol Myers Co Derivatives of gentamicin c1
US3796699A (en) * 1972-11-06 1974-03-12 Bristol Myers Co Antibiotic derivatives of gentamicin c1a
JPS554118B2 (no) * 1973-08-29 1980-01-29

Also Published As

Publication number Publication date
ATA54875A (de) 1977-03-15
DE2502935B2 (de) 1977-10-06
GB1496741A (en) 1977-12-30
JPS50101336A (no) 1975-08-11
CH613459A5 (no) 1979-09-28
NL7500856A (nl) 1975-07-28
NO140427B (no) 1979-05-21
NO750174L (no) 1975-08-18
FR2259107A1 (no) 1975-08-22
SE7500716L (no) 1975-07-25
DK20175A (no) 1975-09-22
JPS5635195B2 (no) 1981-08-15
US4055715A (en) 1977-10-25
ZA75496B (en) 1976-01-28
AT340045B (de) 1977-11-25
PH14087A (en) 1981-02-10
DE2502935C3 (de) 1978-06-01
DE2502935A1 (de) 1975-07-31
AU7757975A (en) 1976-07-29
NO140427C (no) 1979-08-29

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