CA1026233A - Use of the 2-mercaptopropionylglycine and its alcaline salts for the treatment of respiratory diseases - Google Patents
Use of the 2-mercaptopropionylglycine and its alcaline salts for the treatment of respiratory diseasesInfo
- Publication number
- CA1026233A CA1026233A CA209,355A CA209355A CA1026233A CA 1026233 A CA1026233 A CA 1026233A CA 209355 A CA209355 A CA 209355A CA 1026233 A CA1026233 A CA 1026233A
- Authority
- CA
- Canada
- Prior art keywords
- les
- mercaptopropionylglycine
- caractérisées
- que
- par
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010058907 Tiopronin Proteins 0.000 title claims abstract description 20
- YTGJWQPHMWSCST-UHFFFAOYSA-N Tiopronin Chemical compound CC(S)C(=O)NCC(O)=O YTGJWQPHMWSCST-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 208000023504 respiratory system disease Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 11
- 239000011734 sodium Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 239000002270 dispersing agent Substances 0.000 claims 1
- 230000001079 digestive effect Effects 0.000 abstract description 2
- 159000000011 group IA salts Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000510 mucolytic effect Effects 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 239000004471 Glycine Substances 0.000 description 3
- -1 2-mercaptopropionylglycine o Chemical class 0.000 description 2
- LSIXBBPOJBJQHN-UHFFFAOYSA-N 2,3-Dimethylbicyclo[2.2.1]hept-2-ene Chemical compound C1CC2C(C)=C(C)C1C2 LSIXBBPOJBJQHN-UHFFFAOYSA-N 0.000 description 1
- 101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 101100014660 Rattus norvegicus Gimap8 gene Proteins 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 229940095054 ammoniac Drugs 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- WOMAZEJKVZLLFE-UHFFFAOYSA-N propionylglycine Chemical compound CCC(=O)NCC(O)=O WOMAZEJKVZLLFE-UHFFFAOYSA-N 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229960004402 tiopronin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00397865A US3857951A (en) | 1973-09-14 | 1973-09-14 | Use of 2-mercaptopropionylglycine and its alkali metal salts in treating respiratory diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1026233A true CA1026233A (en) | 1978-02-14 |
Family
ID=23572987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA209,355A Expired CA1026233A (en) | 1973-09-14 | 1974-09-13 | Use of the 2-mercaptopropionylglycine and its alcaline salts for the treatment of respiratory diseases |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3857951A (https=) |
| BE (1) | BE819823A (https=) |
| CA (1) | CA1026233A (https=) |
| DE (1) | DE2443492A1 (https=) |
| GB (1) | GB1482651A (https=) |
| ZA (1) | ZA745219B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053651A (en) * | 1976-05-10 | 1977-10-11 | E. R. Squibb & Sons, Inc. | Compounds and method for alleviating angiotensin related hypertension |
| US4199512A (en) * | 1976-05-10 | 1980-04-22 | E. R. Squibb & Sons, Inc. | Compounds for alleviating hypertension |
| US4140786A (en) * | 1976-05-10 | 1979-02-20 | E. R. Squibb & Sons, Inc. | Method for alleviating angiotensin related hypertension |
| US4113715A (en) * | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
| US4093739A (en) * | 1977-06-15 | 1978-06-06 | Mead Johnson & Company | Mercaptoacylamidobenzoyl glycine and mucolytic process |
| IT1098328B (it) * | 1978-06-16 | 1985-09-07 | Gargani Pietro | Sale sodico della mercapropropionilglicina,processo per la sua preparazione e suoi impieghi terapeutici |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR226M (fr) * | 1960-08-19 | 1961-02-27 | Rech S Et Propagande Scient | Médicament soufré, utilisable en particulier en oto-rhino-laryngologie et en pneumologie. |
| FR1491204A (fr) * | 1962-08-10 | 1967-08-11 | Santen Pharmaceutical Co Ltd | Procédés pour la préparation des alpha-et beta mercaptopropionylglycocolle et de leurs dérivés |
| GB1114313A (en) * | 1964-11-19 | 1968-05-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions |
-
1973
- 1973-09-14 US US00397865A patent/US3857951A/en not_active Expired - Lifetime
-
1974
- 1974-08-14 ZA ZA00745219A patent/ZA745219B/xx unknown
- 1974-09-11 DE DE2443492A patent/DE2443492A1/de active Granted
- 1974-09-12 BE BE148442A patent/BE819823A/xx not_active IP Right Cessation
- 1974-09-13 CA CA209,355A patent/CA1026233A/en not_active Expired
- 1974-09-16 GB GB40312/74A patent/GB1482651A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2443492A1 (de) | 1975-03-27 |
| ZA745219B (en) | 1975-09-24 |
| GB1482651A (en) | 1977-08-10 |
| DE2443492C2 (https=) | 1987-06-11 |
| US3857951A (en) | 1974-12-31 |
| BE819823A (fr) | 1975-03-12 |
| AU7139474A (en) | 1976-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2024419C (fr) | Nouveaux sels de metaux bivalents de l'acide n,n-di(carboxymethyl) amino-2cyano-3carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant | |
| BE1006227A3 (fr) | Inhibiteurs mixtes de la no synthase et de la cyclooxygenase, un procede pour leur preparation et des compositions therapeutiques les contenant. | |
| CA1026233A (en) | Use of the 2-mercaptopropionylglycine and its alcaline salts for the treatment of respiratory diseases | |
| FR2650503A1 (fr) | Composition pharmaceutique destinee a etre administree par voie orale et contenant de la n-acetyl-cysteine, et son application | |
| JP3883867B2 (ja) | モダフィニル及びそのｄ／ｌ鏡像異性体の新規な使用 | |
| FR2775901A1 (fr) | Sels de cetoacides et de derives amines, et leur utilisation pour la preparation de medicaments | |
| FR2503144A1 (fr) | Derives butyryles de la proline, de l'hydroxyproline et de l'hydroxylysine. mode de preparation. emploi chez l'homme dans des preparations cosmetiques ou therapeutiques et chez le vegetal comme agents de protection et de stimulation de developpement | |
| FR2505834A1 (fr) | Derives de la thiazolidine | |
| LU84428A1 (fr) | Nouveaux derives de l'acide 4-phenyl 4-oxo 2-butenoique,leurs sels,leur preparation,leur application comme medicaments et les compositions les renfermant | |
| FR2529546A1 (fr) | Nouveaux sels d'amino-(et imino-)acides a, o-sulfoniques n-substitues, vecteurs cationiques de haute penetration cellulaire | |
| LU84429A1 (fr) | A titre de medicaments,certains derives de l'acide 4-phenyl 4-oxo 2-butenoique et compositions les renfermant | |
| WO2018078010A1 (fr) | Derives d'acides quiniques polysubstitues et leur utilisation pour le traitement des maladies neurodégéneratives | |
| CH615673A5 (https=) | ||
| US2608508A (en) | N-amylsulfamyl benzoic acids | |
| RU94027770A (ru) | Препарат для профилактики и лечения гинекологических и послеродовых заболеваний самок сельскохозяйственных животных и способ его применения | |
| US2608506A (en) | Arylsulfamyl benzoic acids | |
| US20250177329A1 (en) | Gpr120 agonists for the treatment of inflammatory bowel disease | |
| CA1140111A (fr) | PROCEDE DE PREPARATION D'UN NOUVEAU DERIVE DU (20S) 3.alpha.- /(AMINO-ACETYL)AMINO/ 5.alpha.-PREGNAN-20-OL ET DE SES SELS | |
| CA1181341A (fr) | Compositions pharmaceutiques renfermant certains derives monosubstitues de l'acide 4-phenyl 4-oxo buten-2-oique | |
| EP0635267A1 (fr) | Compositions à base d'acides gras douées de propriétés anti-inflammatoires | |
| FR2488136A1 (fr) | Composition pharmaceutique a base de salicylate d'imidazole | |
| EP0027768A1 (fr) | Nouvelles résines échangeuses d'ions du type acide, leur préparation, leur application comme médicaments et les compositions les renfermant | |
| CA1227136A (fr) | Compositions pharmaceutiques contenant a titre de principe actif l'acide 4-(benzofuran-2-yl)4-oxo buten-2-oique et/ou de ses sels pharmaceutiquement acceptables | |
| FR2555899A1 (fr) | Composition pharmaceutique contenant au moins un derive d'acide glycyrrhetinique et au moins un derive de xanthine | |
| FR2624120A1 (fr) | Nouveaux sels organogermaniques utiles comme medicaments notamment comme activateurs des osteoblastes |