CA1017741A - Process for preparing 3-fluorocephalosporins - Google Patents

Process for preparing 3-fluorocephalosporins

Info

Publication number
CA1017741A
CA1017741A CA194,879A CA194879A CA1017741A CA 1017741 A CA1017741 A CA 1017741A CA 194879 A CA194879 A CA 194879A CA 1017741 A CA1017741 A CA 1017741A
Authority
CA
Canada
Prior art keywords
fluorocephalosporins
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA194,879A
Other languages
English (en)
Inventor
Gary A. Koppel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of CA1017741A publication Critical patent/CA1017741A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA194,879A 1974-02-06 1974-03-13 Process for preparing 3-fluorocephalosporins Expired CA1017741A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US439206A US3926978A (en) 1974-02-06 1974-02-06 Process for preparing 3-fluorocephalosporins

Publications (1)

Publication Number Publication Date
CA1017741A true CA1017741A (en) 1977-09-20

Family

ID=23743733

Family Applications (1)

Application Number Title Priority Date Filing Date
CA194,879A Expired CA1017741A (en) 1974-02-06 1974-03-13 Process for preparing 3-fluorocephalosporins

Country Status (32)

Country Link
US (1) US3926978A (xx)
JP (1) JPS612678B2 (xx)
AR (1) AR202209A1 (xx)
AT (1) AT329181B (xx)
BE (1) BE813169A (xx)
BG (1) BG25091A3 (xx)
BR (1) BR7404085A (xx)
CA (1) CA1017741A (xx)
CH (1) CH598263A5 (xx)
DD (1) DD117465A5 (xx)
DE (1) DE2417988A1 (xx)
DK (1) DK119874A (xx)
EG (1) EG11061A (xx)
ES (1) ES427235A1 (xx)
FI (1) FI99474A (xx)
FR (1) FR2259826B1 (xx)
GB (1) GB1462944A (xx)
GT (1) GT197432532A (xx)
HU (1) HU167748B (xx)
IE (1) IE38980B1 (xx)
IL (1) IL44361A (xx)
IN (1) IN139927B (xx)
MW (1) MW1074A1 (xx)
NL (1) NL7403126A (xx)
NO (1) NO741093L (xx)
OA (1) OA04641A (xx)
PH (1) PH12616A (xx)
PL (1) PL90989B1 (xx)
RO (1) RO63021A (xx)
SE (1) SE411453B (xx)
ZA (1) ZA741423B (xx)
ZM (1) ZM5674A1 (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208515A (en) * 1973-02-23 1980-06-17 Eli Lilly And Company 3-Halo cephalosporins
US4064343A (en) * 1974-04-01 1977-12-20 Eli Lilly And Company 3-Halo cephalosporins
US4252950A (en) * 1979-10-12 1981-02-24 Eli Lilly And Company 3-Halo cephalosporins
US4260745A (en) * 1979-10-12 1981-04-07 Eli Lilly And Company 3-Halo cephalosporins
US4281116A (en) * 1979-10-12 1981-07-28 Eli Lilly And Company 3-Halo cephalosporins
EP0280240B1 (en) * 1987-02-27 1994-09-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, process for their preparation and antibacterial agents
JPH0343723A (ja) * 1989-07-11 1991-02-25 Japan Servo Co Ltd 投影器
WO1993011132A1 (de) * 1991-12-06 1993-06-10 Ciba-Geigy Ag Verfahren zur herstellung des antibiotikums cefaclor
IT1255458B (it) * 1992-05-11 1995-11-02 Col Marco Da Procedimento per la preparazione di derivati beta-lattamici alogenati

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830808A (en) * 1968-06-14 1974-08-20 Glaxo Lab Ltd Cephalosporins having a thioetherified methyl group at the 3-position
GB1377651A (en) * 1971-01-12 1974-12-18 Glaxo Lab Ltd Esters

Also Published As

Publication number Publication date
ES427235A1 (es) 1976-07-16
ZA741423B (en) 1975-10-29
AR202209A1 (es) 1975-05-23
IE38980L (en) 1975-08-06
JPS50108287A (xx) 1975-08-26
SE411453B (sv) 1979-12-27
RO63021A (fr) 1978-05-15
MW1074A1 (en) 1975-07-09
FR2259826B1 (xx) 1977-06-24
ATA312174A (de) 1975-07-15
HU167748B (xx) 1975-12-25
IL44361A (en) 1977-07-31
PL90989B1 (xx) 1977-02-28
SE7403307L (xx) 1975-08-07
US3926978A (en) 1975-12-16
DK119874A (xx) 1975-09-29
CH598263A5 (xx) 1978-04-28
AT329181B (de) 1976-04-26
GT197432532A (es) 1975-09-25
DE2417988A1 (de) 1975-08-07
ZM5674A1 (en) 1977-04-21
BR7404085A (pt) 1976-01-27
FR2259826A1 (xx) 1975-08-29
JPS612678B2 (xx) 1986-01-27
IN139927B (xx) 1976-08-21
EG11061A (en) 1976-11-30
GB1462944A (en) 1977-01-26
DD117465A5 (xx) 1976-01-12
OA04641A (fr) 1980-07-31
PH12616A (en) 1979-07-05
IL44361A0 (en) 1974-06-30
FI99474A (xx) 1975-08-07
AU6640374A (en) 1975-09-11
BE813169A (fr) 1974-10-02
NL7403126A (nl) 1975-08-08
IE38980B1 (en) 1978-07-05
BG25091A3 (en) 1978-07-12
NO741093L (xx) 1975-09-01

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