CA1010444A - Process for preparing 6-(a-(guanylureidoalkanylamino) aracylamino) penicillanic acids - Google Patents

Process for preparing 6-(a-(guanylureidoalkanylamino) aracylamino) penicillanic acids

Info

Publication number
CA1010444A
CA1010444A CA167,956A CA167956A CA1010444A CA 1010444 A CA1010444 A CA 1010444A CA 167956 A CA167956 A CA 167956A CA 1010444 A CA1010444 A CA 1010444A
Authority
CA
Canada
Prior art keywords
guanylureidoalkanylamino
aracylamino
preparing
penicillanic acids
penicillanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA167,956A
Other languages
English (en)
Other versions
CA167956S (en
Inventor
Ernest S. Hamanaka
David S. Patton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of CA1010444A publication Critical patent/CA1010444A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/16—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/34—Isothioureas having sulfur atoms of isothiourea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/30—Isothioureas
    • C07C335/38—Isothioureas containing any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA167,956A 1972-05-16 1973-04-04 Process for preparing 6-(a-(guanylureidoalkanylamino) aracylamino) penicillanic acids Expired CA1010444A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00253856A US3838153A (en) 1972-05-16 1972-05-16 6-(alpha-(guanylureidoalkanoylamino)aracylamino)penicillanic acids

Publications (1)

Publication Number Publication Date
CA1010444A true CA1010444A (en) 1977-05-17

Family

ID=22961983

Family Applications (1)

Application Number Title Priority Date Filing Date
CA167,956A Expired CA1010444A (en) 1972-05-16 1973-04-04 Process for preparing 6-(a-(guanylureidoalkanylamino) aracylamino) penicillanic acids

Country Status (23)

Country Link
US (1) US3838153A (fi)
JP (1) JPS5533712B2 (fi)
AR (1) AR195914A1 (fi)
AT (1) AT325767B (fi)
AU (1) AU475922B2 (fi)
BE (1) BE798170A (fi)
CA (1) CA1010444A (fi)
CH (1) CH573434A5 (fi)
DE (1) DE2318986A1 (fi)
DK (1) DK137046B (fi)
ES (1) ES413937A1 (fi)
FI (1) FI56534C (fi)
FR (1) FR2184609B1 (fi)
GB (1) GB1404469A (fi)
IE (1) IE37491B1 (fi)
IL (1) IL41937A (fi)
NL (1) NL7305355A (fi)
PH (1) PH10024A (fi)
PL (1) PL89245B1 (fi)
SE (1) SE415976B (fi)
SU (1) SU504491A3 (fi)
YU (1) YU36965B (fi)
ZA (1) ZA732343B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1462421A (en) * 1973-12-14 1977-01-26 Pfizer 6-a-amidino-and -'midoylaminoalkanoylamino aracylamino-penicillanic acids and their preparation
US3994965A (en) * 1974-08-09 1976-11-30 Pfizer Inc. D-N-(guanylureidoacetyl)-α-aminophenyl acetic acid and D-N-(guanylureidoacetyl)-α-aminophenyl acetyl chloride
JPS5562537U (fi) * 1978-10-20 1980-04-28
DE3014353A1 (de) * 1980-04-15 1982-01-21 Bayer Ag, 5090 Leverkusen Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
JPS56161152A (en) * 1980-05-12 1981-12-11 Tachikawa Spring Co Manufacture of steel band with resin
US7973156B2 (en) * 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
IL134298A0 (en) 1997-08-21 2001-04-30 Quark Biotech Inc Hypoxia-regulating genes
US20030104973A1 (en) * 1997-08-21 2003-06-05 Quark Biotech, Inc. Hypoxia-regulated genes

Also Published As

Publication number Publication date
YU97773A (en) 1982-06-18
AR195914A1 (es) 1973-11-15
PH10024A (en) 1976-07-13
IE37491L (en) 1973-11-16
YU36965B (en) 1984-08-31
FI56534C (fi) 1980-02-11
SE415976B (sv) 1980-11-17
DK137046C (fi) 1978-06-12
BE798170A (fr) 1973-10-15
PL89245B1 (fi) 1976-11-30
IL41937A (en) 1976-10-31
CH573434A5 (fi) 1976-03-15
AU5428373A (en) 1974-10-10
ES413937A1 (es) 1976-06-01
FR2184609A1 (fi) 1973-12-28
IL41937A0 (en) 1973-06-29
NL7305355A (fi) 1973-11-20
US3838153A (en) 1974-09-24
GB1404469A (en) 1975-08-28
SU504491A3 (ru) 1976-02-25
ATA341573A (de) 1975-01-15
IE37491B1 (en) 1977-08-03
JPS4924991A (fi) 1974-03-05
FR2184609B1 (fi) 1976-10-22
AU475922B2 (en) 1976-09-09
DK137046B (da) 1978-01-09
FI56534B (fi) 1979-10-31
ZA732343B (en) 1974-01-30
AT325767B (de) 1975-11-10
DE2318986A1 (de) 1973-12-06
JPS5533712B2 (fi) 1980-09-02

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