CA1009652A - Imidazo-and pyrimido-(2,7-b)-quinazolin-2-ones - Google Patents

Imidazo-and pyrimido-(2,7-b)-quinazolin-2-ones

Info

Publication number
CA1009652A
CA1009652A CA162,747A CA162747A CA1009652A CA 1009652 A CA1009652 A CA 1009652A CA 162747 A CA162747 A CA 162747A CA 1009652 A CA1009652 A CA 1009652A
Authority
CA
Canada
Prior art keywords
pyrimido
quinazolin
imidazo
ones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA162,747A
Other languages
English (en)
Other versions
CA162747S (en
Inventor
Warren N. Beverung (Jr.)
Richard A. Partyka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Canada Inc
Original Assignee
Bristol Myers Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Canada Ltd filed Critical Bristol Myers Canada Ltd
Application granted granted Critical
Publication of CA1009652A publication Critical patent/CA1009652A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA162,747A 1972-02-04 1973-02-02 Imidazo-and pyrimido-(2,7-b)-quinazolin-2-ones Expired CA1009652A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22372372A 1972-02-04 1972-02-04
US29145072A 1972-09-22 1972-09-22

Publications (1)

Publication Number Publication Date
CA1009652A true CA1009652A (en) 1977-05-03

Family

ID=26918072

Family Applications (1)

Application Number Title Priority Date Filing Date
CA162,747A Expired CA1009652A (en) 1972-02-04 1973-02-02 Imidazo-and pyrimido-(2,7-b)-quinazolin-2-ones

Country Status (9)

Country Link
JP (1) JPS5623994B2 (de)
AU (1) AU475978B2 (de)
BE (1) BE794964A (de)
CA (1) CA1009652A (de)
DE (1) DE2305575A1 (de)
FR (1) FR2173988B1 (de)
GB (1) GB1418822A (de)
HK (1) HK15581A (de)
YU (2) YU210773A (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31617E (en) * 1972-02-04 1984-06-26 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
NL7807507A (nl) 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
CA1131631A (en) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Quinazoline derivatives and pharmaceutical preparations
ZW16481A1 (en) * 1980-08-15 1982-03-10 Hoffmann La Roche Novel imidazoquinazoline derivatives
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
AU665207B2 (en) * 1991-07-29 1995-12-21 Warner-Lambert Company Quinazoline derivatives as acetylcholinesterase inhibitors
WO1996005176A1 (fr) 1994-08-09 1996-02-22 Eisai Co., Ltd. Compose de pyridazine condense
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808947D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB0808968D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substitute quinazolines
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP3366698A1 (de) 2011-03-01 2018-08-29 Synergy Pharmaceuticals Inc. Guanylat-cyclase-c-agonisten
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP4424697A2 (de) 2013-06-05 2024-09-04 Bausch Health Ireland Limited Ultrareine agonisten der guanylatcyclase c, verfahren zur herstellung und verwendung davon
EP3492106B1 (de) 2013-08-09 2021-02-17 Ardelyx, Inc. Verbindungen und verfahren zur hemmung eines phosphattransports
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合
WO2022199627A1 (en) * 2021-03-23 2022-09-29 National Institute Of Biological Sciences, Beijing Polycyclic compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE760013A (fr) * 1969-12-18 1971-06-08 Smith Kline French Lab Imidazo et pyrimido -(2,1-b)quinazolines, leurs procedes de preparationet compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
AU5166873A (en) 1974-08-01
BE794964A (fr) 1973-08-02
DE2305575C2 (de) 1989-01-12
JPS4886894A (de) 1973-11-15
HK15581A (en) 1981-05-01
YU210773A (en) 1983-02-28
AU475978B2 (en) 1976-09-09
GB1418822A (en) 1975-12-24
JPS5623994B2 (de) 1981-06-03
DE2305575A1 (de) 1973-08-09
FR2173988B1 (de) 1976-10-22
YU151081A (en) 1983-12-31
FR2173988A1 (de) 1973-10-12

Similar Documents

Publication Publication Date Title
CA1009652A (en) Imidazo-and pyrimido-(2,7-b)-quinazolin-2-ones
CA1012534A (en) 2,6-diaminonebularine derivatives
CA1000274A (en) Diacyl-5,6,11,12-tetrahydro-dibenzo(b,f) (1,4) diazocines
CA993452A (en) 2,6-dihalo-4-cyanophenoxy-acetonitriles
GB1402046A (en) 11,12-epoxyerythromycins
CA1009666A (en) 2,5,5-trimethyl-hepta-2,6-dienal
CA1020953A (en) 2,2,3-endo-trimethyl-7-anti-amino-norbornanes
CA999595A (en) 3,5-dialkyl-4-hydroxybenzyl-oxiranes and -thiiranes
AU467306B2 (en) 15, 16-methylene-4-oestren-17 -ols
AU472337B2 (en) 11, 12-secoprostaglandins
AU474523B2 (en) Substituted 9,10-dihydroanthracenes
AU469505B2 (en) 1,4-ethano-2,3-dihydroquinoline derivatives
CA987669A (en) 10,11-anhydroerythromycins
CA986936A (en) 2,3,5-substituted-6-trifluoromethyl-1,3-diazin-4-ones
CA990280A (en) 5,6-trans-25-hydroxycholecalciferol
GB1404277A (en) 16,17-seco-d-homosteroids
AU5701673A (en) 3, 4-dialkanyloxyphenyl)-l-alanines
CA906006A (en) 2,4-dihalo-3,5-dinitrobenzotrifluorides
CA914198A (en) 1,4-disubstituted-cyclohex-3-enes
CA895310A (en) 1,2,4-triazine-5-ones
CA902042A (en) 21,21-dichlorosteroids
AU477691B2 (en) 2, 4, 5-trisubstituted-imidazoles
AU485879B2 (en) 3-diazine-substituted 1, 2, 4-benzothiadiazines
CA897172A (en) 3,4-dihydronaphthalenoneoxy-2-hydroxypropylamines
CA905931A (en) 3,4-diazapregnanes