BRPI9612617B8 - vetor recombinante, microorganismo hospedeiro geneticamente modificado, método para determinar a presença de compostos genotóxicos em uma amostra e método para determinar tanto a genotoxicidde quanto a mutagenicidade de uma amostra - Google Patents
vetor recombinante, microorganismo hospedeiro geneticamente modificado, método para determinar a presença de compostos genotóxicos em uma amostra e método para determinar tanto a genotoxicidde quanto a mutagenicidade de uma amostraInfo
- Publication number
- BRPI9612617B8 BRPI9612617B8 BRPI9612617A BR9612617A BRPI9612617B8 BR PI9612617 B8 BRPI9612617 B8 BR PI9612617B8 BR PI9612617 A BRPI9612617 A BR PI9612617A BR 9612617 A BR9612617 A BR 9612617A BR PI9612617 B8 BRPI9612617 B8 BR PI9612617B8
- Authority
- BR
- Brazil
- Prior art keywords
- determining
- sample
- genotoxicity
- mutagenicity
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"seqüência de ácido nucléico recombinante, microorganismo hospedeiro, método para determinar a presença de compostos genotóxicos múltiplos em uma amostra, método para determinar a presença de um composto genotóxico em uma amostra, método para determinar a cinética de genotoxicidade de uma amostra, método para determinar ambas a genotoxicidade e mutagenicidade de uma amostra e método para determinar a presença de um composto tóxico em uma amostra". uma seqüência de ácido nucléico recombinante compreendendo um promotor regulado por sos tendo uma razão de indução superior a 40, estando o citado promotor operacinalmente ligado a uma seqüência de ácido nucléico que codifica relator, codificando um relator resultando em um sinal que pode ser ensaiado como produção de luz. são divulagados um biosensor compreendendo tal seqüência de ácido nucléico e métodos para determinar a genotoxidade e a presença de compostos genotóxicos, usando tal biosensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9612617A BRPI9612617B8 (pt) | 1996-04-25 | 1996-04-25 | vetor recombinante, microorganismo hospedeiro geneticamente modificado, método para determinar a presença de compostos genotóxicos em uma amostra e método para determinar tanto a genotoxicidde quanto a mutagenicidade de uma amostra |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9612617A BRPI9612617B8 (pt) | 1996-04-25 | 1996-04-25 | vetor recombinante, microorganismo hospedeiro geneticamente modificado, método para determinar a presença de compostos genotóxicos em uma amostra e método para determinar tanto a genotoxicidde quanto a mutagenicidade de uma amostra |
| PCT/EP1996/001745 WO1997041251A1 (en) | 1996-04-25 | 1996-04-25 | Recombinant nucleic acid sequences and methods for determining both genotoxicity and mutagenicity of a sample and the kinetics of the genetoxicity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9612617A BR9612617A (pt) | 1999-12-28 |
| BR9612617B1 BR9612617B1 (pt) | 2014-08-26 |
| BRPI9612617B8 true BRPI9612617B8 (pt) | 2021-05-25 |
Family
ID=8166211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9612617A BRPI9612617B8 (pt) | 1996-04-25 | 1996-04-25 | vetor recombinante, microorganismo hospedeiro geneticamente modificado, método para determinar a presença de compostos genotóxicos em uma amostra e método para determinar tanto a genotoxicidde quanto a mutagenicidade de uma amostra |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6521751B1 (pt) |
| EP (1) | EP0907748B1 (pt) |
| JP (1) | JP4371432B2 (pt) |
| AU (1) | AU724155B2 (pt) |
| BR (1) | BRPI9612617B8 (pt) |
| CA (1) | CA2252699C (pt) |
| WO (1) | WO1997041251A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998038336A1 (en) * | 1997-02-28 | 1998-09-03 | E.I. Du Pont De Nemours And Company | A method for identifying the site of action of xenobiotic chemicals |
| EP0950717A1 (en) * | 1998-04-14 | 1999-10-20 | "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." | Diagnostic system and method for determining the presence of a genotoxic compound in a sample |
| WO2001024637A1 (en) * | 1999-10-04 | 2001-04-12 | Vion Pharmaceuticals, Inc. | Methods for treating solid tumors with irradiation and bacteria |
| ES2307395B2 (es) * | 2006-09-04 | 2009-07-09 | Universidad De Oviedo | Metodo rapido de deteccion y evaluacion de agentes genotoxicos. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0063522B1 (en) * | 1981-04-14 | 1989-07-19 | Institut Pasteur | An inducible dna replication-cell division coupling mechanism in escherichia coli |
| FR2533584B1 (fr) | 1982-09-28 | 1986-03-21 | Pasteur Institut | Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos |
| ES2117665T5 (es) | 1991-03-01 | 2002-11-16 | Vito | Genes fusionados y su utilizacion para determinar la presencia de metales o de compuestos xenobioticos. |
| IL107815A (en) * | 1992-12-04 | 2003-12-10 | Du Pont | Genetic constructs comprising a stress-responsive promoter linked to a lux reporter operon and methods of use in environmental testing |
| EP0649905B1 (en) | 1993-10-22 | 1998-09-23 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Methods of detection of mutagens using luminescence gene |
-
1996
- 1996-04-25 EP EP96913529.2A patent/EP0907748B1/en not_active Expired - Lifetime
- 1996-04-25 CA CA2252699A patent/CA2252699C/en not_active Expired - Lifetime
- 1996-04-25 BR BRPI9612617A patent/BRPI9612617B8/pt not_active IP Right Cessation
- 1996-04-25 AU AU56482/96A patent/AU724155B2/en not_active Expired
- 1996-04-25 WO PCT/EP1996/001745 patent/WO1997041251A1/en not_active Application Discontinuation
- 1996-04-25 JP JP53847797A patent/JP4371432B2/ja not_active Expired - Lifetime
- 1996-04-25 US US09/171,586 patent/US6521751B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2252699A1 (en) | 1997-11-06 |
| BR9612617A (pt) | 1999-12-28 |
| EP0907748B1 (en) | 2013-06-12 |
| JP2001507922A (ja) | 2001-06-19 |
| JP4371432B2 (ja) | 2009-11-25 |
| AU5648296A (en) | 1997-11-19 |
| CA2252699C (en) | 2010-06-22 |
| WO1997041251A1 (en) | 1997-11-06 |
| EP0907748A1 (en) | 1999-04-14 |
| BR9612617B1 (pt) | 2014-08-26 |
| AU724155B2 (en) | 2000-09-14 |
| US6521751B1 (en) | 2003-02-18 |
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Legal Events
| Date | Code | Title | Description |
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| FB36 | Technical and formal requirements: requirement - article 36 of industrial property law | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08E | Application fees: payment of additional fee required [chapter 8.5 patent gazette] | ||
| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1772 DE 20041221 POR TER SIDO INDEVIDO. |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/08/2014, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/04/1996 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Expiry acc. art. 78, item i of ipl- expiry of the term of protection |
Free format text: PATENTE EXTINTA EM 25/04/2016 |