BRPI9607583B8 - plasmídios procarióticos recombinantes. - Google Patents

plasmídios procarióticos recombinantes.

Info

Publication number
BRPI9607583B8
BRPI9607583B8 BRPI9607583A BR9607583A BRPI9607583B8 BR PI9607583 B8 BRPI9607583 B8 BR PI9607583B8 BR PI9607583 A BRPI9607583 A BR PI9607583A BR 9607583 A BR9607583 A BR 9607583A BR PI9607583 B8 BRPI9607583 B8 BR PI9607583B8
Authority
BR
Brazil
Prior art keywords
adenoviruses
recombinant prokaryotic
recombinant
plasmid
prokaryotic plasmids
Prior art date
Application number
BRPI9607583A
Other languages
English (en)
Other versions
BR9607583A (pt
BR9607583B1 (pt
Inventor
Cecile Orsini
Emmanuelle Vigne
Joel Crouzet
Laurent Naudin
Patrice Yeh
Original Assignee
Aventis Pharma Sa
Centelion
Gencell Sa
Gencell Sas
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9476085&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9607583(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa, Centelion, Gencell Sa, Gencell Sas, Rhone Poulenc Rorer Sa filed Critical Aventis Pharma Sa
Publication of BR9607583A publication Critical patent/BR9607583A/pt
Publication of BR9607583B1 publication Critical patent/BR9607583B1/pt
Publication of BRPI9607583B8 publication Critical patent/BRPI9607583B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

plasmídio procariótico, plasmídio pxl2638, célula procariótica, processo de produção de genomas de adenovírus recombinantes, processo de preparação de adenovírus recombinantes e composição farmacêutica. a presente invenção refere-se a um novo processo de preparação de adenovírus recombinantes e à utilização dos referidos adenovírus em terapia gênica. ela refere-se igualmente aos plasmídios utilizados para a construção destes adenovírus.
BRPI9607583A 1995-02-13 1996-02-09 plasmídios procarióticos recombinantes. BRPI9607583B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9501632A FR2730504B1 (fr) 1995-02-13 1995-02-13 Procede de preparation de genomes d'adenovirus recombinants
PCT/FR1996/000215 WO1996025506A1 (fr) 1995-02-13 1996-02-09 Procede de preparation de genome d'adenovirus recombinants

Publications (3)

Publication Number Publication Date
BR9607583A BR9607583A (pt) 1998-07-07
BR9607583B1 BR9607583B1 (pt) 2009-12-01
BRPI9607583B8 true BRPI9607583B8 (pt) 2016-11-08

Family

ID=9476085

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9607583A BRPI9607583B8 (pt) 1995-02-13 1996-02-09 plasmídios procarióticos recombinantes.

Country Status (19)

Country Link
US (1) US6261807B1 (pt)
EP (1) EP0809704B1 (pt)
JP (1) JP3842818B2 (pt)
KR (1) KR100575521B1 (pt)
AT (1) ATE405662T1 (pt)
AU (1) AU716777B2 (pt)
BR (1) BRPI9607583B8 (pt)
CA (1) CA2210956C (pt)
CZ (1) CZ294338B6 (pt)
DE (1) DE69637648D1 (pt)
FI (1) FI120046B (pt)
FR (1) FR2730504B1 (pt)
HU (1) HU222808B1 (pt)
IL (1) IL117115A (pt)
MX (1) MX9705937A (pt)
NO (1) NO327980B1 (pt)
SK (1) SK286965B6 (pt)
WO (1) WO1996025506A1 (pt)
ZA (1) ZA961153B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020136708A1 (en) * 1993-06-24 2002-09-26 Graham Frank L. System for production of helper dependent adenovirus vectors based on use of endonucleases
DE19620687A1 (de) * 1996-05-22 1997-11-27 Centeon Pharma Gmbh Neuer adenoviraler Vektor für den Transfer humaner Gene in vivo
EP0996735B1 (en) 1997-06-09 2003-12-10 Genvec, Inc. Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus
ATE303448T1 (de) * 1997-09-23 2005-09-15 Genvec Inc Duale selektionkassette und sie enthaltende plasmide
IL141403A0 (en) * 1998-08-28 2002-03-10 Univ Duke Deleted adenoviruses and methods of making and administering the same
JP2004501602A (ja) * 1999-02-18 2004-01-22 メルク　アンド　カンパニー　インコーポレイテッド エンドヌクレアーゼの使用に基づくヘルパー依存アデノウイルスベクターの生産のためのシステム
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
FR2799472B1 (fr) * 1999-10-07 2004-07-16 Aventis Pharma Sa Preparation d'adenovirus recombinants et de banques adenovirales
WO2001059071A2 (en) * 2000-02-09 2001-08-16 Genvec, Inc. Methods of preparing and using a viral vector library
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6573092B1 (en) 2000-10-10 2003-06-03 Genvec, Inc. Method of preparing a eukaryotic viral vector
AUPR518501A0 (en) 2001-05-22 2001-06-14 Unisearch Limited Yin yang-1
EP1453536A4 (en) 2001-12-12 2009-08-26 Mayne Pharma Int Pty Ltd COMPOSITION FOR PRESERVING VIRUSES
EP1697534B1 (en) 2003-12-01 2010-06-02 Life Technologies Corporation Nucleic acid molecules containing recombination sites and methods of using the same
US10000757B2 (en) 2005-05-27 2018-06-19 Ospedale San Raffaele S.R.L. Gene vector
UA100692C2 (ru) 2007-05-02 2013-01-25 Мериал Лимитед Днк-плазмиды, имеющие повышенную экспрессию и стабильность
US20110269119A1 (en) * 2009-10-30 2011-11-03 Synthetic Genomics, Inc. Encoding text into nucleic acid sequences
ES2661132T3 (es) * 2013-10-25 2018-03-27 Psioxus Therapeutics Limited Adenovirus oncolíticos armados con genes heterólogos
US10076562B2 (en) 2016-04-19 2018-09-18 The Board Of Regents Of The University Of Texas System Methods for treating plague
WO2018054822A1 (en) 2016-09-20 2018-03-29 Boehringer Ingelheim Vetmedica Gmbh New swine influenza vaccine
UY37405A (es) 2016-09-20 2018-03-23 Boehringer Ingelheim Vetmedica Gmbh Vectores de adenovirus canino
AU2017329669A1 (en) 2016-09-20 2019-03-21 Boehringer Ingelheim Vetmedica Gmbh New EHV insertion site ORF70
CN109790550B (zh) 2016-09-20 2024-02-09 勃林格殷格翰动物保健有限公司 新颖的启动子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2166118C (en) * 1993-06-24 2007-04-17 Frank L. Graham Adenovirus vectors for gene therapy
RU2219241C2 (ru) * 1993-07-13 2003-12-20 Рон-Пуленк Роре С.А. Дефектный рекомбинантный аденовирусный вектор (варианты)
WO1995003400A1 (en) * 1993-07-23 1995-02-02 Johns Hopkins University School Of Medicine Recombinationally targeted cloning in yeast artificial chromosomes
PT787200E (pt) * 1994-10-28 2005-08-31 Univ Pennsylvania Adenovirus melhorado e metodos para a sua utilizacao
FR2726285B1 (fr) * 1994-10-28 1996-11-29 Centre Nat Rech Scient Adenovirus depourvus de particules contaminantes viables, preparation et utilisation
FR2727689A1 (fr) * 1994-12-01 1996-06-07 Transgene Sa Nouveau procede de preparation d'un vecteur viral

Also Published As

Publication number Publication date
CA2210956C (fr) 2010-06-08
FI973309A0 (fi) 1997-08-12
EP0809704A1 (fr) 1997-12-03
FR2730504B1 (fr) 1997-03-28
US6261807B1 (en) 2001-07-17
IL117115A0 (en) 1996-06-18
JP3842818B2 (ja) 2006-11-08
WO1996025506A1 (fr) 1996-08-22
FR2730504A1 (fr) 1996-08-14
KR19980702139A (ko) 1998-07-15
CZ294338B6 (cs) 2004-12-15
EP0809704B1 (fr) 2008-08-20
AU4723596A (en) 1996-09-04
FI973309A (fi) 1997-08-12
NO973663L (no) 1997-08-08
NO327980B1 (no) 2009-11-02
KR100575521B1 (ko) 2006-10-24
NO973663D0 (no) 1997-08-08
CA2210956A1 (fr) 1996-08-22
HUP9800260A1 (hu) 1998-05-28
IL117115A (en) 2005-06-19
BR9607583A (pt) 1998-07-07
ZA961153B (en) 1996-08-23
AU716777B2 (en) 2000-03-09
BR9607583B1 (pt) 2009-12-01
DE69637648D1 (de) 2008-10-02
CZ255497A3 (en) 1997-11-12
ATE405662T1 (de) 2008-09-15
SK286965B6 (sk) 2009-08-06
MX9705937A (es) 1997-10-31
HUP9800260A3 (en) 2000-12-28
JPH11500007A (ja) 1999-01-06
HU222808B1 (hu) 2003-10-28
SK110097A3 (en) 1998-06-03
FI120046B (fi) 2009-06-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: AVENTIS PHARMA S.A. (FR)

Free format text: ALTERADO DE: RHONE-POULENC RORER S.A.

B25A Requested transfer of rights approved

Owner name: GENCELL S.A. (FR)

Free format text: TRANSFERIDO DE: AVENTIS PHARMA S.A.

B25F Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement

Owner name: GENCELL S.A. (FR)

Free format text: A FIM DE ATENDER O SOLICITADO NA PETICAO NO 030274/RJ DE 31/05/2004, QUEIRA APRESENTAR DOCUMENTO DE ALTERACAO DE NOME.

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: GENCELL S.A. (FR)

Free format text: REFERENTE A RPI 1858 COD. (25.6) DE 15/08/2006, POR TER SIDO INDEVIDO.

B25D Requested change of name of applicant approved

Owner name: GENCELL SAS (FR)

Free format text: ALTERADO DE: GENCELL S.A.

B25D Requested change of name of applicant approved

Owner name: CENTELION (FR)

Free format text: ALTERADO DE: GENCELL SAS

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/12/2009, OBSERVADAS AS CONDICOES LEGAIS.

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI-52400.68486/2013 ORIGEM: JUIZO DA 25A VARA FEDERAL DE SAO PAULO PROCESSO NO 0017574-93.2013.4.03.6100 ACAO DE NULIDADE DE PATENTE AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: BAYER SAS, CENTELION E CENTELION S.A., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MERCK SERONO S.A. E SAMJIN PHARMACEUTICAL CO. LTD.

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI-52400.068486/2013 SECAO JUDICIARIA DE SAO PAULO - 25A VARA FEDERAL CIVEL DE SAO PAULO PROCESSO NO0017574-93.2013.403.6100 AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: BAYER SAS, CENTELION, CENTELION S.A, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, MERCK SERONO S.A E SAMJIN PHARMACEUTICAL CO. LTDA DECISAO: JULGO PROCEDENTE O PEDIDO FORMULADO PARA DECLARAR A NULIDADE PARCIAL DAS PATENTES PI 9607583-0, PI 9610511-9, PI 9707889-1 E PI 9604907-3 E DETERMINO A RETIFICACAO DOS RESPECTIVOS PRAZOS DE VIGENCIA DE MODO A OBSERVAR A O DISPOSTO NO PARAGRAFO UNICO DO ARTIGO 229 DA LEI NO 9.279-96, EM INTERPRETACAO CONJUNTA COM O CAPUT DO ARTIGO 40 DO MESMO DIPLOMA.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REFERENTE A RPI 2030 DE 01/12/2009, QUANTO AO PRAZO DE VALIDADE POR DETERMINACAO DA 25A VARA CIVEL FEDERAL DE SAO PAULO, PROC. 0017574-93.2013.403.6100 - ACAO ORDINARIA - INPI 52400.068486/2013-05.

B19A Notification of judicial decision: notification of judicial decision

Free format text: INPI NO 52400.009771/2015-48 PROCESSO JUDICIAL: 0017574-93.2013.4.03.6100 NUP: 00848.000050/2015-10 (REF. 0017574-93.2013.4.03.6100) PARECER DE FORCA EXECUTORIA N. 00012/2020/EEFIN NAP/EEFINSP/PGF/AGU INTERESSADOS: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI E OUTROS DECISAO: O JUIZO DA 25A VARA CIVEL FEDERAL DE SAO PAULO JULGOU O PEDIDO PARCIALMENTE PROCEDENTE, PARA DECLARAR A NULIDADE PARCIAL DAS PATENTES PI 9607583-0, PI 9610511-9, E PI 9707889-1, ADEQUANDO AS PATENTES AOS ARTIGOS 229, P. U., E 40, CAPUT, DA LEI N. 9.279-96. ESTA DECISAO FOI POSTERIORMENTE CONFIRMADA PELO TRF DA 3A REGIAO, COM TRANSITO EM JULGADO EM 23 DE JULHO DE 2019.