BRPI1103081A2 - ORAL CARE PRODUCT COMPOSITIONS FOR THE DISPOSAL AND PREVENTION OF HALITOSIS (HALITOSIS) WITH ANTIBAFO, ANTISPTIC AND TEETH WHITE EFFECT - Google Patents

Abstract

COMPOSITIONS OF ORAL CARE PRODUCTS FOR ELIMINATION AND PREVENTION OF BAD BREATH (HALITOSIS), WITH ANTIBAPE, ANTISEPTIC AND TOOTH WHITENER EFFECT Compositions of products intended for hygiene, oral treatment and well-being of a person using peroxide (or similar) ) and xylitol that immediately deal with problems of bad breath and hygiene in the oral cavity. Continued use of the mouthwash and / or dentifrices can accomplish the unprecedented feat of a person waking up without any kind of breath, coating, tonsillitis or bad breath (when its origin is only oral). The continued use of the suggested compositions whitens the teeth, in addition to treating and preventing problems such as: gingivitis, plaque formation, cavities and tonsillitis. It can be presented in the forms of: mouthwash, mouthwash, toothpaste, including toothpastes and creams, gels, spray, orabase ointment, mints, lozenges and chewing gum. The present invention further describes several examples of compositions in their various forms of presentation.

Description

Report of the Invention Patent

5th

COMPOSITIONS OF ORAL CARE PRODUCTS FOR THE DISPOSAL AND PREVENTION OF HALITOSIS (HALITOSIS) WITH ANTIBAFO, ANTISPTIC AND TOOTH WHITENING EFFECT.

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Classifications: A61K8 / 35, A61Q 11/00, A61K8 / 34

BACKGROUND OF THE INVENTION

The effectiveness of proprietary mouthwash to prevent

diseases, validating them as essential allies to complement daily oral hygiene. With efficient management and adequate time for flossing and brushing, as well as choosing the right mouthwash, are key processes to ensure full health of both the mouth and the body.

Buccal, mouthwash, mouthwash or mouthwash are liquids used to perform oral cavity hygiene. Antiseptic refers to anything used to degrade or inhibit the proliferation of microorganisms present on the surface of the skin and mucous membranes. Daily use can prevent 25 different problems such as tooth decay, plaque formation, bad breath and gingivitis, among others.

Mouthwash products that are currently available for oral hygiene mainly utilize the following antimicrobial actives: chlorhexidine digluconate, triclosan, pyridine cetyl chloride, metal ion salts (Cu, Zn, Ag), oxygenating agents and others.

Some inventions include the use of 1.5% peroxide as Colgate's Peroxyl® product as a mouthwash and the patent Pl 0502145-6 A which mentions the use of peroxide in mouthwash characterized by the fact that the formulation may not contain alcohol. According to the US Food and Drug Administration (FDA), an internationally recognized US advisory board, concludes that 1.5% active hydrogen peroxide is safe and effective for topical use, such as mouthwash. Some countries in Europe have adopted xylitol as a substitute for conventional sugar (sucrose), as it besides sweetening has several other benefits on body and oral health. The expansion of its use has migrated to chewing gum, candy and oral care products.

However, no product has ever been able to join peroxide with

xylitol. It would be highly desirable the synergy of both, which is the subject of the present invention, as well as their compatibility with various types of raw materials, also resulting in different embodiments and versions of the invention.

BACKGROUND OF THE INVENTION

In general, the health of the body is directly linked to oral health, maintained mainly by good hygiene, reduced sugar intake or the use of non-cariogenic sweeteners.

Bad breath, also called halitosis, is a problem that

has been tormenting humanity for millennia. There are reports of treatments for bad breath dating back over 3,000,000 years. Even in the Bible, in the book Genesis, there are mention of breath-freshening treatments.

There are over 40 different causes for bad breath, but in over 20% of cases they originate in the mouth itself. They are caused by the action of the natural bacterial flora of our oropharynx on the food we eat. We have over 600 types of bacteria in our mouth, many of which are capable of producing odorous gases due to the metabolism of organic materials, especially proteins. These bacteria are proteolytic anaerobic and produce 25 at the end of their metabolism: Volatile Sulfur Compounds which upon reaching a given concentration provide a rotten odor to the breath.

Predictably, the lower the oral hygiene, the more food debris remains in the oral cavity and the more intense the bad breath. Inflammation such as gingivitis and periodontitis also favors halitosis.

Saliva is a natural mouthwash. In addition to possessing substances

antibacterial, it helps to rinse the oropharynx, reducing the residue of bacteria and food. The more dry the mouth, the worse the breath.

Tongue coating, or tongue-coating, is caused by an off-white plaque of bacteria and fleshy cells that adhere to the tongue, which is a common cause of bad breath. The coating usually comes from a lack of hydration in the oral cavity, usually from a lack of saliva, or from poor tongue brushing. Brushing your tongue and drinking plenty of water to keep your mouth always hydrated are simple ways to reduce the incidence of searing and, consequently, bad breath.

Still in the mouth, another point that can give rise to bad breath are the tonsils. Patients with recurrent tonsillitis often have small crypts in their tonsils that favor the deposition of food and cellular debris from old infections, forming the casse or caseum. From time to time, extremely smelly little "pebbles" come loose from these crypts leading the patient to imagine that his breath is as bad as this odor. In fact, the tonsil is not always the cause of bad breath, and not necessarily the breath of those who have bone is as bad as the smell of it.

Caries is the result of an infectious process triggered by bacteria present in dental plaque. Streptococcus bacteria found in the buccal flora are highly cariogenic since under acidic conditions they produce a large amount of lactic acid and synthesize extracellular polysaccharides, which increase the adhesion of plaque to the surface of teeth (Kandelman, 1997). ). The earlier these colonies appear on the teeth, and the greater their amount in the oral flora, the greater the risk of tooth decay.

A wide variety of antibacterial agents in the form of mouthwash, toothpaste, spray have appeared on the market to eliminate or reduce the amount of bacteria found harmful to the oral flora that besides halitosis are responsible for other problems known as caries. , dental plaque, gingivitis and periodontal disease. Despite efforts to develop oral care products and treatments, no product has so far achieved a straightforward and simple approach to a treatment that precisely eliminates halitosis when its origin is only oral. Thus it would be advantageous to have a product that is effective for

combat halitosis, caries, plaque, tonsil cases and oral cavity diseases, and prevent tonsil surgery due to the formation of tonsil cases. The object of the present patent simply illustrates that to eliminate the problem one must eliminate the cause and not deal with the consequences. And the present invention is not just about the mouthwash, but the range of products used for oral hygiene treatment: mouthwash, mouthwash, dentifrice, including toothpaste and creams, toothpaste, spray, orabase ointment and may even be applied to children's products. for oral hygiene.

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OBJECTIVES OF THE INVENTION

Objectives of this invention are:

- Combat halitosis and prevent the formation of tonsillary cases;

- Completely increase the oral hygiene status of an individual and, consequently, act in the elimination and prevention of cavities, plaques and diseases in the oral cavity;

- Elimination of plaque accumulation in the teeth and prevention of gingivitis;

- Elimination of volatile sulfur compounds (rotten egg odor from

bad breath), when these originate in the mouth of the individual;

- Elimination of an individual's halitosis when its origin is only

oral.

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SUMMARY OF THE INVENTION

The invention provides a topical pharmaceutical and / or cosmetic product composition containing nascent oxygen generating active compound

(hydrogen peroxide) in synergy with xylitol and can be presented in a range of products for oral hygiene and treatment, where we highlight: mouthwash, mouthwash, dentifrice, toothpastes and creams, dental gels, spray, orabase ointment, lozenges, gum chewing gum comprising at least: hydrogen peroxide or xylitol at the concentrations described in this invention.

DETAILED DESCRIPTION OF THE INVENTION

The invention proposes an efficient treatment for the elimination of halitosis and morning antibacterial when the origin of the problem is only oral, besides completely increasing the hygiene of the individual and, consequently, acting in the elimination and prevention of cavities, plaques and diseases in the cavity. oral. Where below we describe concepts and explanations important for the detailed accompaniment of this creation.

The mouth is stripped all the time. Dead cells accumulate on the tongue, mixing with food scraps, blood from gum disease and bacteria. All of this forms the coating, which is a grayish-white layer formed on the dingual dorsum and composed of sticky salivary proteins (mucins), skinned epithelial cells that will serve as a food substrate for a group of fungi, viruses and bacteria, and food-borne protein remains. . Bacteria such as Helicobacter PiIory1 Porphiromonas gingivalas, Forsythus Bacteroids, Dentinal Treponemas, and others are gram negative, anaerobic, and proteolytic, metabolize these proteins and stripped epithelial cells, reproduce, and start producing bad odor volatile sulfur compounds (CSVs). When CSVs reach a certain concentration, they are volatile and exhale a rotten egg characteristic sulfur smell upon exhalation. The permanence of the coating would serve as a means of fungal and bacterial culture, spreading its microbes to the oral, nasal, pharyngolaryngeal and stomach cavities, causing and / or exacerbating other regional and systemic loco diseases. Iingual coating is present in 90% of cases of oral halitosis and is generally associated with decreased salivary flow and poor oral hygiene.

Another important point is saliva, which is one of the most versatile, important and complex fluids in the human and animal body. It meets a broad spectrum of the organism's defensive and physiological needs. Its properties are essential for the lubrication of the oral pharyngolaryngological cavities (chewing, swallowing, kiss-sex, speech and beginning of digestion) and consequently the protection of the oropharynx, larynx and gastrointestinal epithelium. In addition to moistening all soft and hard tissues of the oral cavity, saliva has prominent functions in controlling the amount of water in the body. Saliva reduces mouth dryness, prevents tooth decay and other oral lesions and diseases. Normal saliva has a water content of 99.4 to 99.6% and in dry substances between mineral salts, proteins, carbohydrates, enzymes, glycoproteins and antibodies (serum albumin and gamma globulin) from 0.4 to 0.6%. . Saliva contains an enzyme called isozyme (the same found in tears), which has bactericidal and healing power. When injured animals lick their wounds and, thanks to this lysozyme, the healing process is accelerated.

At night, saliva production practically ceases, leaving bacteria more free to act because lysozyme is insufficient to act. They break down the coating, giving rise to volatile substances, especially sulfides - sulfur derivatives that have a horrible smell, breath.

The breath is also a consequence of prolonged fasting. After hours without food, blood sugar levels drop and this phenomenon releases other smelly gases that are carried by the bloodstream to the lungs. And then just open our mouth to exhale the stench.

As mentioned earlier, the invention is based on focused treatment of the root cause of most oral problems and bad breath which are anaerobic bacteria and fungi, ie bacteria that survive in the absence of oxygen and feed on proteins and food debris contained within. inside our mouth, tongue and between our teeth. For this reason good oral hygiene with brushing and flossing after meals is critical.

In accordance with the present invention, an anti-haze, anti-halitosis, anti-caries, anti-gingivitis composition is provided by the synergy of the action of an oxygen-releasing compound such as hydrogen peroxide but not limited to it and xylitol. We will describe below more information about each compound and, later, the discussion of industrial formulations. RISING OXYGEN GENERATING COMPOUNDS - PEROXIDE

In our invention peroxide (OOH) is an oxygen generator, when it comes into contact with bacteria, proteins, and food debris in the oral cavity, dyes and the catalase enzyme that our own body produces, it decomposes and generates oxygen. nascent [O], a highly reactive and oxidizing compound that in addition to immediately killing various anaerobic bacteria and fungi, cleans and sterilizes the entire oral cavity, tongue and teeth. This generated oxygen is highly functional as a "poison" to anaerobic bacteria and microorganisms and, in low concentration, is safe and beneficial to our oral cavity as long as used in the recommendations of our invention.

The decomposition reaction is accelerated by various chemical factors or agents such as light, elevated temperature, basic pH and MnO2.

2 H2O2 2 H2O + O2

In dilute solutions behaves like an acid.

H2O2 + H2O H3O + + H 00 "

Another interesting feature is the ability to whiten teeth with its continuous use. In just 4 weeks you can see significant teeth whitening results. Although not the main reason for this invention, it is a benefit that will be well accepted by users of the product.

One of the potential reactions of peroxide, which makes its use indispensable, is that, in addition to the above reasons, when coming into contact with some metal ions such as Fe, for example, the so-called Fenton reaction occurs:

Fe + 2 + H 2 O 2 Fe + 3 + OH '+ .OH

Fe + 3 + H 2 O 2 Fe + 2 +. OOH + H +

The reaction results in the reaction of reactive hydroxyl radicals (· 0Η), also known as nascent hydroxyls. The reactivity of this system was observed in 1894 by its inventor H.J.H. Fenton Today, Fenton's Reagent is used to treat a variety of industrial wastes that contain a range of toxic organic combinations (phenols, formaldehyde, and complex wastes, organochlorines, plastic additives, and rubber chemicals). As we can see this reaction is so powerful and oxidizing that it is used to break down and chemically destroy very difficult to break down molecules like organochlorines, phenols and others. In our mouth this reaction is generated in the presence of peroxide, because we have peroxides and also metals in small concentrations like iron in our saliva. The nascent hydroxyl (· ΟΗ) generated in this reaction is highly destructive to all anaerobic microorganisms present in our mouth, and has an exceptional effect on teeth whitening. Many products use peroxide in the form of carbamide peroxide for teeth whitening, but what is behind bleaching is not the peroxide itself but the nascent hydroxyl produced by the fenton reaction.

After this clarification of the fenton reaction, it is important to remember that it is vitally important that the maximum concentration of peroxide in the formulation is not high. The danger is not in peroxide, because our body produces the enzyme catalase and a single molecule could break down about 40,000,000 hydrogen peroxide molecules per second. The danger lies in the formation of nascent hydroxyl (· ΟΗ) which formed in high concentrations may cause in some users irritation and pain in the gums, teeth and / or temporarily white gums. Luckily, the effect is temporary and reversible, as the person discontinues use and drink plenty of water, causing no major problems.

In our invention we propose a hydrogen peroxide concentration ranging from 0.01 to 1.5% active weight by weight of peroxide, and preferably 0.2 to 0.5% active substance concentrations at 100% as ideal for the hygiene and destruction of microorganisms without causing irritation to the oral cavity of users with greater sensitivity. Preferably, we use hydrogen peroxide, but include all peroxide ion release (OOH) or active oxygen release compounds. Where we highlight: Sodium Percarbonate, Sodium Perborate, Carbamide Peroxide or Urea Peroxide, the PVP-H2O2 complexes (hereinafter "PVP-H2O2"). Both linear and crosslinked PVP-H2O2 complexes are known in the art and disclosed in US 3,376,110 and US 3,480,557 and US 5,122,370. PVP-H2O2 is stable in an anhydrous environment and when in contact with the oral cavity, dissociates into individual species (PVP and H2O2 polymer). The PVP-H2O2 complex is generally composed of about 80% polyvinylpyrrolidone and 20% by weight H2O2.

XYLITOL

As an active agent of this invention, xylitol plays a fundamental role in the synergy of action with peroxide. It has unique and enviable properties in buccal application where we will describe in more detail below.

Xylitol, a polyalcohol whose molecular formula is C5H12O5 (1,2,3,4,5-pentahydroxypentane), is a non-toxic substance, classified by the Food and Drug Administration (FDA) as a GRAS (Generally Regarded as Safe) additive, In addition to being a sweetener perfectly capable of replacing sucrose, it is tolerated by diabetics and has several clinical applications. Open-ended, the xylitol molecule has five hydroxyl (OH) groups, each attached to a carbon atom, which is why this compound is known as acyclic polyhydroxyalcohol or pentitol.

Caries is the result of an infectious process triggered by bacteria present in dental plaque. Streptococcus bacteria found in the buccal flora are highly cariogenic since under acidic conditions they produce a large amount of lactic acid and synthesize extracellular polysaccharides, which increase the adhesion of plaque to the surface of teeth (Kandelman, 1997). ). The earlier these colonies appear on the teeth, and the greater their amount in the oral flora, the greater the risk of tooth decay. Anticariogenicity, one of the most relevant properties of xylitol, is

mainly determined by its non-fermentability by bacteria of the genus Streptococcus, whose proliferation in the buccal flora becomes limited. Reducing the concentration of Streptococcus mutans decreases the amount of insoluble polysaccharides and increases that of soluble polysaccharides, resulting in a less adherent plaque that is easily removed by usual tooth brushing (Kõnig, 2000; Wales, Nguyen, 2000). .

In summary, xylitol contributes to oral health in six ways: o reducing the incidence of caries; o stabilizing calcium and phosphate ions in saliva and consequently remineralizing the teeth;

o stabilizing the cavities already formed;

reducing the growth of Streptococcus mutans and Lactobacillus in saliva;

o Stimulating saliva formation (without increasing acid production in dental plaque); (6) controlling plaque pH and saliva buffering capacity after sucrose consumption.

In our invention we have contemplated the use concentration of xylitol ranging from 0.001 to 25% active weight by weight of peroxide, and preferably 0.20 to 5.0% active substance concentrations as ideal for achieving its already existing properties. mentioned.

In summary the present invention contemplates and requires the right of the invention for compositions using hydrogen peroxide or the like which release peroxide ion (OOH ') in solution with the consequent formation of oxygen at a maximum concentration of 1.5% active substance. , together with xylitol at a maximum concentration of 25%. Regarding the compositions we cover any type of oral care and hygiene products where we highlight: mouthwash, mouthwash, dentifrice, including toothpaste and creams, gels, spray, orabase ointment, powders and may even be applied in children's oral hygiene products.

The following examples further illustrate the present invention in the various examples of compositions, but it is understood that the invention is not limited thereto. COMPOSITION EXAMPLE QS OF ORAL HYGIENE PRODUCTS -> Rinsing

A number of compositions were prepared using the ingredients

and concentrations listed in table 1 below, but not limited by them. Table 1

Composition (% w / w] A B C D E F G Raw Material I '------- Alcohol 15.00 - 5.00 _ 8.00 _ 10.00 Triclosan 0.30 0.10 0 .5 _ _ Chlorhexidine digluconate - - _ 0.10 _ 0.05 Methylparaben 0.05 - 0.10 _ 0.10 Eucalyptol 0.15 0.20 0.10 _ 0.05 0.10 Menthol 0.04 - 0,01 0,05 0,10 0,20 AROMA 0,40 1,00 2,00 2,00 1,00 3,00 HYDROGEN PEROXIDE 130 VOL 0,60 0,60 0,50 0,50 1 40 0.75 3.75 Poloxamer 407 2.00 - 3.00 3.00 2.00 2.00 Poloxamer 338 - 2.00 - - _ 2.00 Glycerin - - 10.00 15.00 - _ Sorbitol 15.00 15.00 - _ _ _ 10.00 Sodium Lauryl Sulfate 1.00 - - - 0.50 1.00 Cetyl Pyridine Chloride - 0.10 0.05 0.05 _ _ Sodium Saearin 0.05 0.10 0.10 0.05 0.10 0.08 0.05 Sodium Fluoride 0.05 - - 0.05 _ XYLITOL 1.00 1.00 2.00 3.00 4.00 4.00 5.00 Methyl Salate - - - _ _ _ 0.20 0.20 Sodium Citrate - - - _ 0.10 Sodium Phosphate - - - _ 0.10 _ Cftrieo Acid 0.02 0.02 0.02 0.02 _ 0.02 _ Water 64.36 79.90 77.09 76.20 82.85 88.92 69.00 TOTAL 100 100 100 100 100 100 100

The important thing in this type of product is to use the peroxide and xyitol doublet (spirit of our invention) together with a balanced mouthwash formulation with good mouthwash power and pleasant taste. We recommend that the final packaging of the product be preferably opaque to increase the stability of the peroxide in light.

The description of the invention and examples provided herein are merely exemplary in nature and thus variations that do not differ from the essence of the invention are intended to be within the scope of the invention. Such variations should not be considered as departing from the spirit and scope of the invention. -> Toothpaste

A number of compositions have been prepared using the ingredients and concentrations listed in table 2 below, but are not limited by them.

Table 2

Composition (% w / w) A B C D E F G Raw Material Alcohol 1.60 1.60 1.70 1.70 1.85 2.00 2.00 Carboxy Methyl Cellulose 1.20 1.20 1, 30 1.30 1.40 1.50 1.50 Methylparaben 0.10 0.10 0.15 - 0.20 0.10 - Imidazolidinyl Urea - - 0.15 0.30 - 0.20 0.30 Eucalyptol - 0.05 - - 0.10 - - Menthol - - 0.10 - - 0.10 0.10 FLAVOR 0.90 1.00 0.80 0.90 1.00 1.00 1.00 HYDROGEN PEROXIDE 130 VOL 0.60 0.60 0.50 0.50 1.40 0.75 1.00 Sodium Monofluor Phosphate 1.00 - 1.00 - 1.00 - - Glycerin - 7.00 18.00 - - 20 .00 - Sorbitol 17.00 10.00 - 19.00 - - 20.00 Sodium Lauryl Sulfate 30% 4.00 4.00 3.80 3.80 3.00 3.80 3.50 Neutral Sodium Silicate 0.50 0.50 0.50 - - 0.60 0.60 Sodium Saearin 0.20 0.20 0.17 0.17 0.15 0.13 0.10 Syllable 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Xylitol 1.00 1.00 2.00 2.00 3.00 4.00 5.00 Calcium Carbonate 40.00 40.00 38.00 38.00 37 .00 35.00 35.00 Sodium Citrate - 0.10 - - 0.20 - - Sodium Phosphate - 0.10 - - 0.20 - - Sodium Bicarbonate - - 0.50 - - - 0.70 Water 31.70 32.35 3 1.13 32.13 49.30 30.63 29.01 TOTAL 100 100 100 100 100 100 100

The important thing in this type of product is to use the peroxide and xylitol doublet (spirit of our invention) together with a good toothpaste base, as described in the examples above.

We can say that the application of peroxides is practically unheard of in home toothpaste (used only in professional toothpaste) and that its result with xylitol would be really surprising, including the use of toothpaste with the mouthwash. The description of the invention and examples provided herein are merely

exemplary in nature and thus variations which do not differ from the essence of the invention are intended to be within the scope of the invention. Such variations should not be considered as departing from the spirit and scope of the invention. -> Dental Gel

A number of compositions have been prepared using the ingredients and concentrations listed in table 3 below, but are not limited by them.

Table 3

Composition (% w / w) | A B C D EFG Raw Material Alcohol - 0.40 0.65 0.50 1.30 1.50 Carboxy Methyl Cellulose - 0.30 0.50 0.40 0.60 1.00 1.20 Methylparaben 0, 10 - 0.10 _ 0.10 0.15 Imidazolidinyl Urea - - _ 0.30 0.10 0.15 Sodium Benzoate - 0.10 0.10 0.10 _ Eucalyptol - - _ _ 0.05 0 , 10 Menthol - - - „„ 0.10 0.05 FLAVOR 1.00 1.00 0.90 1.00 0.75 0.80 0.80 0.60 HYDROGEN PEROXIDE 130 VOL 0.60 0.60 0.50 0.50 1.40 0.75 1.00 Sodium Monofluor Phosphate - 0.75 0.75 1.00 _ _ Glycerin 10.00 - 20.00 - 38.00 50.00 _ Sorbitol 70% 50.00 60.00 33.00 68.00 _ 40.00 PEG-1500 - -. 4.00 3.00 PEG-400 - 4.00 3.00 _ _ m Sodium Lauryl Sulphate 30% 3.50 4.00 3.50 4.20 2.50 2.50 2.50 Sodium Saccharin 0, 15 0.20 0.20 0.20 0.30 0.15 0.15 Abrasive Silica - 14.00 8.50 - 25.00 10.00 15.00 Thickener Silica 18.00 7.00 17.00 15 .00 _ 10.00 5.00 XYLITOL 1.00 1.00 2.00 2.00 3.00 4.00 5.00 Sodium Bicarbonate - - _ _ 15.00 _ _ Water 15.65 6.65 9.30 3.10 10.15 19.15 27.40 TOTAL 100 100 100 100 100 100 100

The important thing in this type of product is to use the peroxide and xylitol doublet (spirit of our invention) together with a good dental gel base, as described in the examples above.

The application would be identical to toothpaste. The differentiation is

It's just a marketing question of consumer taste and habit.

The description of the invention and examples provided herein are merely exemplary in nature and thus variations that do not differ from the essence of the invention are intended to be within the scope of the invention. Such variations should not be considered as departing from the spirit and scope of the invention. Children's Dental Gel

A number of compositions were prepared using the ingredients

and concentrations listed in but not limited to table 4 below.

Table 4

Raw Material I Carboxy Methyl Cellulose 0.80 0.80 0.50 0.40 1.20 0.80 0.80 Methylparaben 0.15 0.20 - _ _ 0.10 0.15 Imidazolidinyl Urea - - _ „ _ 0.15 Sodium Benzoate 0.40 0.10 - 0.10 _ _ Eucalyptol - - - _ 0.05 0.10 Menthol - 0.10 - _ 0.10 0.05 AROMA 1.00 0, 90 0.90 1.00 0.75 0.80 0.80 HYDROGEN PEROXIDE 130 VOL 0.60 0.60 0.50 0.50 0.50 0.50 0.50 Sodium Phosphate Monofluor - 0.20 - 0.30 _ _ - Glycerin 25.00 - 63.00 _ 70.00 60.00 20.00 Sorbitol 70% 52.00 60.00 - 68.00 _ _ 40.00 Sodium Lauryl Sarcosinate 30% 1 1.70 2.00 2.00 2.00 2.00 2.00 Saccharin Sodium 0.15 0.20 0.20 0.20 0.10 0.15 0.10 Sucralose 0.01 0, 01 - _ 0.01 _ 0.01 Abrasive Silica - - - _ _ _ _ Thickening Silica 10.00 10.00 12.00 15.00 _ 10.00 5.00 XYLITOL 2.00 2.00 2.00 2.00 3.00 4.00 5.00 Sodium erythrosyme 0.05 - - 0.05 0.05 Water 6.19 22.89 18.90 10.50 22.44 21.50 25.34 TOTAL 100 100 100 100 100 100 100

Like all children's products, the choice of raw materials must be more careful. They must be of low irritability and toxicity.

We should not use pediatric gel abrasive silica, the milder surfactant sodium lauryl sarcosinate replaces sodium lauryl sulfate.

Erythrosine is a dye that facilitates plaque diagnosis for the pediatric dentist, and sucralose is an FDA-approved low-calorie sweetener that does not cause tooth decay from the sugar itself and leaves no bitter residue.

We recommend a lower peroxide content, around 0.20% active substance for children's products, as it is a more sensitive mucosa.

The description of the invention and examples provided herein are merely exemplary in nature and thus variations that do not differ from the essence of the invention are intended to be within the scope of the invention. Such variations should not be considered as departing from the spirit and scope of the invention. -> Mouth Spray

A number of compositions have been prepared using the ingredients and concentrations listed in table 5 below, but are not limited by them.

Table S

Composition (% w / w) A B C D E F G Raw material Alcohol - - 1,00 - 2,00 - - Triclosan - 0,30 0,05 - - - 0,10 Chlorhexidine digluconate - - - 0 0.10 - 0.10 Methylparaben - 0.10 0.10 - - 0.20 - Imidazolidinyl Urea 0.30 0.10 0.30 Eucalyptol - - 0.10 - 0.05 0.10 0.05 Menthol 0 .05 - 0.01 0.05 - - 0.05 FLAVOR 0.50 0.50 1.00 0.80 0.50 0.50 0.40 HYDROGEN PEROXY 130 VOL 0.20 0.20 0.20 0.10 0.10 0.30 0.30 0.40 Poloxamer 407 or Pluronie F127 0.80 0.80 1.00 1.00 0.50 0.50 0.60 Glyerin 2.00 - - 5.00 - 1, 00 - Sorbitol - - 2.00 - 4.00 - - Cetyl Pyridine Chloride - 0.05 - 0.01 - - 0.01 Sodium Saearin 0.02 0.02 0.03 0.04 0.06 0, 08 0.05 Sodium Fluoride - - - - - - - XYLITOL 1.00 1.00 2.00 3.00 4.00 4.00 5.00 Water 95.13 96.93 92.61 89.90 88 .59 93.32 92.94 TOTAL 100 100 100 100 100 100 100

This type of product is not common in the Brazilian market. Its use is highly recommended for consumers who are traveling or away from home where they cannot perform the usual cleaning procedure or for people who have severe halitosis problems to use when necessary.

This type of mouth spray, spelled out in these formulations, has a special refreshing and cleansing power to the wearer, resulting in even a healthier and more refreshing kiss between lovers.

The description of the invention and examples provided herein are merely exemplary in nature and thus variations that do not differ from the essence of the invention are intended to be within the scope of the invention. Such variations should not be considered as departing from the spirit and scope of the invention. Chewing Gum, Chewing Gum

In the Brazilian market there are already certain types of chewing gum and lozenges that use xylitol to replace sucrose and other sweeteners. Used in dietary products because xylitol has an extremely beneficial effect as we have already mentioned.

However, we suggest in our invention the use of PVP-H2O2 together with hitherto unheard xylitol for the treatment of halitosis and oral well-being.

PVP-H2O2, which is stable in the solid vehicle of chewing gum upon contact with the oral cavity, gradually releases peroxide and in synergy with xylitol provides the aforementioned effects.

Its use is highly recommended for consumers who are traveling or away from home where they cannot perform the usual cleaning procedure or for people who have severe halitosis problems to use when needed. In addition, chewing gum itself stimulates natural salivation further increasing the strength of this type of product.

Both candies, chewing gums and chewing gums would have a new connotation in our market, whether before they were used only for fun, distraction or to taste good in the mouth. With the essence of this invention, they would also have a beneficial effect on the treatment of tooth decay, plaque, bad breath and even a refreshing and healthy breath, resulting in even a healthier and more refreshing kiss between lovers.

The description of the invention and examples provided herein are merely exemplary in nature and thus variations that do not differ from the essence of the invention are intended to be within the scope of the invention. Such variations should not be considered as departing from the spirit and scope of the invention.

Claims (17)

1. Compositions suitable for oral use, characterized in that they contain hydrogen peroxide and xylitol and have the properties and appeals of mouthwash, anti-decay, antibafo, antiplate, besides whitening teeth, being efficient in the treatment of prevention of problems such as: gingivitis, plaque formation, tooth decay, tonsillar caries and formation of the coating. Composition according to Claim 1, characterized in that it is presented in the form of: mouthwash, mouthwash, toothpaste, toothpaste and creams, gels, spray, orabase ointment, candies, chewing gum and powder. Product composition according to Claim 1, characterized in that the product is intended for oral hygiene, teeth whitening, treatment of bad breath and well-being of a person. Composition according to Claim 1, characterized in that the hydrogen peroxide compound is present in the composition in the concentration range 0.001 to 5% by weight. Composition according to Claim 1, characterized in that the xylitol compound is present in the composition in the concentration range 0.001 to 25% by weight. Composition according to Claim 1, characterized in that they use as bactericidal agents: chlorhexidine digluconate, triclosan, cetyl pyridine chloride, metal ion salts (Cu, Zn, Ag), alone or in combination, at usual concentrations. effectiveness and safety, but not limited to them. Composition according to Claim 1, characterized in that they use as emulsifying agents: polyaxamer 407, poloxamer 338, polysorbate 20, polyethylene glycol, alone or in combination, in an amount sufficient for but not limited to formulation stability. Compositions according to Claim 1, characterized in that the composition may further comprise raw materials or combinations within the component group of: anti-adhesion agents, antioxidant agents, anti-caries agents, bactericidal agents, bleaching agents, control agents. , periodontal actives, abrasives, breath freshening agents, odor control agents, tooth desensitizers, salivary stimulants, viscosity modifiers, rheology modifiers, diluents, vehicles, surfactants, pH modifying agents, pH, humectants, sweetening agents, sweeteners, mouthfeel agents, sweetening agents, flavoring agents, colorants, preservatives, vitamins, compatible enzymes, chlorophyll compounds. Composition according to Claim 1, characterized in that the hydrogen peroxide compound is sodium percarbonate. Composition according to Claim 9, characterized in that sodium percarbonate is present in the composition in the concentration range 0.001 to 25% by weight. Composition according to Claim 1, characterized in that the hydrogen peroxide compound is sodium perborate. Composition according to Claim 11, characterized in that sodium perborate is present in the composition with a concentration in the range 0.01 to 25% by weight. Composition according to Claim 1, characterized in that the hydrogen peroxide compound is PVP-H2O2 (polyvinylpyrrolidone and H2O2 polymer). Composition according to Claim 13, characterized in that PVP-H2O2 is present in the composition with a concentration in the range 0.01 to 50% by weight. Composition according to Claim 1, characterized in that the hydrogen peroxide compound is carbamide peroxide (or urea peroxide or urea hydrogen peroxide). Composition according to Claim 15, characterized in that carbamide peroxide is present in the composition in the concentration range 0.01 to 50% by weight. A method for eliminating oral halitosis in a person, comprising: The person must use for oral hygiene at least the composition of mouthwash and mouthwash according to claim 1, as well as, flossing in the morning, after meals and before bedtime. Repeat over a period of a plurality of days.