BRPI1101952B1 - Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida - Google Patents

Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida Download PDF

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Publication number
BRPI1101952B1
BRPI1101952B1 BRPI1101952-2A BRPI1101952A BRPI1101952B1 BR PI1101952 B1 BRPI1101952 B1 BR PI1101952B1 BR PI1101952 A BRPI1101952 A BR PI1101952A BR PI1101952 B1 BRPI1101952 B1 BR PI1101952B1
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BR
Brazil
Prior art keywords
reaction
process according
compound
hours
carboxamide
Prior art date
Application number
BRPI1101952-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Luiz Carlos Dias
Adriano Siqueira Vieira
Eliezer Jesus De Lacerda Barreiro
Original Assignee
Universidade Estadual De Campinas - Unicamp
Universidade Federal Do Rio De Janeiro - Ufrj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Estadual De Campinas - Unicamp, Universidade Federal Do Rio De Janeiro - Ufrj filed Critical Universidade Estadual De Campinas - Unicamp
Priority to BRPI1101952-2A priority Critical patent/BRPI1101952B1/pt
Priority to PCT/BR2011/000450 priority patent/WO2012145808A1/pt
Publication of BRPI1101952A2 publication Critical patent/BRPI1101952A2/pt
Publication of BRPI1101952B1 publication Critical patent/BRPI1101952B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI1101952-2A 2011-04-25 2011-04-25 Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida BRPI1101952B1 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI1101952-2A BRPI1101952B1 (pt) 2011-04-25 2011-04-25 Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida
PCT/BR2011/000450 WO2012145808A1 (pt) 2011-04-25 2011-11-25 Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI1101952-2A BRPI1101952B1 (pt) 2011-04-25 2011-04-25 Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida

Publications (2)

Publication Number Publication Date
BRPI1101952A2 BRPI1101952A2 (enExample) 2015-09-15
BRPI1101952B1 true BRPI1101952B1 (pt) 2022-02-01

Family

ID=47071505

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1101952-2A BRPI1101952B1 (pt) 2011-04-25 2011-04-25 Processo de obtenção de atorvastatina cálcica utilizando novos intermediários e atorvastatina assim obtida

Country Status (2)

Country Link
BR (1) BRPI1101952B1 (enExample)
WO (1) WO2012145808A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105111123A (zh) * 2013-11-25 2015-12-02 李兴惠 阿托伐他汀钙及组合物
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN106588689A (zh) * 2016-12-15 2017-04-26 河南豫辰药业股份有限公司 一种从结晶母液废液中回收阿托伐他汀中间体m4的方法
CN114195670B (zh) * 2021-12-31 2024-03-15 河南豫辰药业股份有限公司 一种阿托伐他汀母核m4的精制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US6476235B2 (en) * 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1756053A1 (en) * 2004-05-31 2007-02-28 Ranbaxy Laboratories Limited Process for the preparation of atorvastatin
DE102008030469B4 (de) * 2007-07-12 2018-11-15 Schaeffler Technologies AG & Co. KG Drehmomentwandler mit einem Innenring aus mehreren Abschnitten

Also Published As

Publication number Publication date
BRPI1101952A2 (enExample) 2015-09-15
WO2012145808A1 (pt) 2012-11-01

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 207/34 , C07D 317/10

Ipc: C07D 207/34 (2006.01), C07D 317/10 (2006.01), A61K

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/04/2011, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.