BRPI1011317A2 - microeletrodo e microeletrodos múltiplos compreendendo meios para liberação de drogas em um tecido - Google Patents

microeletrodo e microeletrodos múltiplos compreendendo meios para liberação de drogas em um tecido

Info

Publication number
BRPI1011317A2
BRPI1011317A2 BRPI1011317A BRPI1011317A BRPI1011317A2 BR PI1011317 A2 BRPI1011317 A2 BR PI1011317A2 BR PI1011317 A BRPI1011317 A BR PI1011317A BR PI1011317 A BRPI1011317 A BR PI1011317A BR PI1011317 A2 BRPI1011317 A2 BR PI1011317A2
Authority
BR
Brazil
Prior art keywords
microelectrode
tissue
delivering drugs
multiple microelectrodes
microelectrodes
Prior art date
Application number
BRPI1011317A
Other languages
English (en)
Inventor
Fredrik Ek
Jenny Eriksson Linsmeier
Jens Schouenborg
Nils Danielsen
Per Petersson
Original Assignee
Neuronano Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuronano Ab filed Critical Neuronano Ab
Publication of BRPI1011317A2 publication Critical patent/BRPI1011317A2/pt
Publication of BRPI1011317B1 publication Critical patent/BRPI1011317B1/pt
Publication of BRPI1011317B8 publication Critical patent/BRPI1011317B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0531—Brain cortex electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0536—Preventing neurodegenerative response or inflammatory reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37205—Microstimulators, e.g. implantable through a cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4094—Diagnosing or monitoring seizure diseases, e.g. epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Electrotherapy Devices (AREA)
  • Materials For Medical Uses (AREA)
BRPI1011317A 2009-06-09 2010-06-03 Microeletrodo médico para inserção em tecido mole, feixe de microeletrodo médico e arranjo dos mesmos BRPI1011317B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0900789 2009-06-09
SE0900789-9 2009-06-09
PCT/SE2010/000152 WO2010144016A1 (en) 2009-06-09 2010-06-03 Microelectrode and multiple microelectrodes comprising means for releasing drugs into the tissue

Publications (3)

Publication Number Publication Date
BRPI1011317A2 true BRPI1011317A2 (pt) 2016-03-15
BRPI1011317B1 BRPI1011317B1 (pt) 2021-08-03
BRPI1011317B8 BRPI1011317B8 (pt) 2021-12-21

Family

ID=43309080

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1011317A BRPI1011317B8 (pt) 2009-06-09 2010-06-03 Microeletrodo médico para inserção em tecido mole, feixe de microeletrodo médico e arranjo dos mesmos

Country Status (12)

Country Link
US (5) US8954142B2 (pt)
EP (1) EP2440283B1 (pt)
JP (2) JP5850501B2 (pt)
KR (1) KR101683028B1 (pt)
CN (2) CN102458564B (pt)
AU (1) AU2010259309B2 (pt)
BR (1) BRPI1011317B8 (pt)
CA (1) CA2764960C (pt)
DK (1) DK2440283T3 (pt)
EA (1) EA023177B1 (pt)
HK (1) HK1214190A1 (pt)
WO (1) WO2010144016A1 (pt)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102458564B (zh) * 2009-06-09 2017-08-04 神经毫微股份公司 用于控制药物释放到组织中的包含微电极和多重微电极的装置
US8588936B2 (en) * 2010-07-28 2013-11-19 University Of Utah Research Foundation Spinal cord stimulation system and methods of using same
EP2646107A2 (en) * 2010-12-01 2013-10-09 Spinal Modulation Inc. Agent delivery systems for selective neuromodulation
ITRM20110206A1 (it) * 2011-04-21 2012-10-22 Ab Medica Spa Sistema di acquisizione e monitoraggio di segnali bioelettrici provenienti dal cervello e di stimolazione intracranica.
US8489205B2 (en) * 2011-05-03 2013-07-16 Biotronik Se & Co. Kg System for temporary fixation of an implantable medical device
EP2739345A4 (en) * 2011-08-04 2015-04-15 Univ Ramot ELECTRODE COATED WITH IL-1 RECEPTOR ANTAGONISTS AND USES THEREOF
US9297781B2 (en) * 2011-10-14 2016-03-29 Samsung Electronics Co, Ltd. Electrode system and method for calculating character values of solution using the same
KR101304319B1 (ko) * 2011-11-11 2013-09-11 한국과학기술연구원 마이크로 프로브 및 그 제조 방법
US9241651B2 (en) * 2011-11-17 2016-01-26 Carnegie Mellon University Fabrication, methods, apparatuses, and systems for ultra-compliant probes for neural and other tissues
WO2013112144A1 (en) * 2012-01-25 2013-08-01 Advanced Bionics Ag Intraneural implant
CN104411360B (zh) * 2012-06-21 2017-06-27 神经毫微股份公司 医疗微电极、其制造方法、及其使用
CN102764119A (zh) * 2012-07-20 2012-11-07 中国科学院深圳先进技术研究院 电极阵列
WO2014016765A2 (en) * 2012-07-24 2014-01-30 Lavy Lev Multilayer coaxial probe for impedance spatial contrast measurement
US20150250421A1 (en) * 2012-09-26 2015-09-10 Advanced Diamond Technologies, Inc. Conductive nanocrystalline diamond micro-electrode sensors and arrays for in-vivo chemical sensing of neurotransmitters and neuroactive substances and method of fabrication thereof
US10074925B1 (en) * 2013-02-14 2018-09-11 Lockheed Martin Corporation System, connector and method for providing environmentally degradable electronic components
US10493265B2 (en) * 2013-03-15 2019-12-03 Medtronic, Inc. Medical leads and techniques for manufacturing the same
US10406349B2 (en) 2013-03-15 2019-09-10 Medtronic, Inc. Medical leads and techniques for manufacturing the same
CN106029161B (zh) * 2013-12-20 2019-09-03 神经毫微股份公司 包括电极和光源的医疗设备
WO2016032384A1 (en) * 2014-08-27 2016-03-03 Neuronano Ab Method of implantation of a medical device into neural tissue
PL226157B1 (pl) * 2014-10-21 2017-06-30 Inst Tech Materiałów Elektronicznych Mikrosonda do elektroporacji selektywnej i sposob wytwarzania takiej mikrosondy
CA2981474A1 (en) * 2015-03-31 2016-10-06 Oncosec Medical Incorporated Systems and methods for improved tissue-sensing based electroporation
CA2987936A1 (en) 2015-06-05 2016-12-08 Neuronano Ab Method and system for improving stimulation of excitable tissue
US11198003B2 (en) 2015-07-10 2021-12-14 Neuronano Ab Method and system for improving stimulation of excitable tissue
AU2016297642A1 (en) * 2015-07-22 2018-02-15 Incept, Llc Coated punctal plug
KR101731231B1 (ko) * 2015-07-31 2017-04-28 재단법인 오송첨단의료산업진흥재단 복합신경 자극용 이식형 리드 및 그 제조방법
CA2994692A1 (en) * 2015-08-06 2017-02-09 The Regents Of The University Of California Methods of fabricating an electrode array for transcutaneous electrical stimulation of the spinal cord
AU2016364680B2 (en) * 2015-11-30 2018-12-06 Neuronano Ab Haemorrhage avoiding microelectrode
WO2017146627A1 (en) * 2016-02-26 2017-08-31 Neuronano Ab Method of implantation of cell aggregates and tissue fragments
WO2017146626A1 (en) * 2016-02-26 2017-08-31 Neuronano Ab Method of providing an implantation site in soft tissue
DE102016110137A1 (de) * 2016-06-01 2017-12-07 Medizinische Hochschule Hannover Formadaptives medizinisches Implantat sowie Verwendung einer elektrischen Signalquelle
US20170360501A1 (en) * 2016-06-21 2017-12-21 Daniel Igor Branovan Disposable bipolar coaxial radio frequency ablation needle, system and method
US20200000516A1 (en) * 2016-06-21 2020-01-02 Daniel Igor Branovan Sterile disposable bipolar ablation needle, associated system, and method of use
CN109913401A (zh) * 2016-09-14 2019-06-21 四川蓝光英诺生物科技股份有限公司 人工组织前体及制备其的方法
US10588526B2 (en) * 2016-09-16 2020-03-17 International Business Machines Corporation Flexible neural probes
JP7095897B2 (ja) * 2016-12-05 2022-07-05 ニューロナノ アーベー 接続用マイクロ繊維を含むマイクロ電極アレイ
EP3332703A1 (en) * 2016-12-08 2018-06-13 IMEC vzw A surgical insertion device
US20180296145A1 (en) * 2017-04-14 2018-10-18 The Regents Of The University Of California System and method for detection of neurotransmitters and proteins in the cardiac system
US20200129266A1 (en) * 2017-05-29 2020-04-30 Neuronano Ab Method of microelectrode identification
DK3425064T3 (da) * 2017-07-03 2020-11-09 Numen Sensorics ApS Fremgangsmåde og elektronisk indretning til bestemmelse af koncentrationen af en analyt
CN111093492B (zh) * 2017-09-05 2023-01-03 首尔大学校产学协力团 生物电极及其形成方法
US11969589B2 (en) 2017-11-09 2024-04-30 Neuronano Ab Positional stabilization of tissue-implanted medical devices
KR102075594B1 (ko) 2017-11-13 2020-02-11 재단법인대구경북과학기술원 약물 전달 장치 및 이의 제조방법
JP7104938B2 (ja) * 2018-05-10 2022-07-22 株式会社テクノプロ プローブ刺入デバイスの作成方法、プローブ刺入デバイスの挿入方法、及び電気信号取得方法
US11000689B2 (en) 2018-07-15 2021-05-11 Eagle Point Medical LLC Leadless multi-electrode cardiac pacemakers and methods of implantation thereof
US10406370B1 (en) 2018-07-15 2019-09-10 Eagle Point Medical LLC Single conduit multi-electrode cardiac pacemaker and methods of using thereof
US10729902B1 (en) 2018-07-15 2020-08-04 Eagle Point Medical LLC Intraseptal multi-electrode cardiac pacemaker and methods of use thereof
US10695558B2 (en) 2018-07-15 2020-06-30 Eagle Point Medical LLC Single conduit multi-electrode cardiac pacemaker and methods of using thereof
AU2020204864A1 (en) * 2019-01-04 2021-07-22 Neuronano Ab Probe for implantation into nervous tissue comprising a microelectrode or a set of microelectrodes
EP3682941B1 (en) * 2019-01-18 2021-11-10 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Biomedical device comprising a mechanically adaptive member
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
JP7442914B2 (ja) * 2019-04-30 2024-03-05 エルジー・ケム・リミテッド カスパーゼ阻害剤のプロドラッグ
US20200383699A1 (en) * 2019-05-17 2020-12-10 Spineology Inc. Dilating neuro-monitoring probe
CN110201296A (zh) * 2019-05-20 2019-09-06 北京化工大学 一种用于可控药物释放的导电高分子微针贴片及其制备方法
GB2590083A (en) * 2019-12-04 2021-06-23 Ananda Shakti Tech Ltd Plasma generator
WO2022005386A1 (en) * 2020-07-03 2022-01-06 Neuronano Ab Microelectrode for insertion into soft tissue
CN111973181B (zh) * 2020-08-24 2023-12-08 中国科学院上海微系统与信息技术研究所 一种集成采集刺激功能的皮层脑电极及其制作方法
CN112244839B (zh) * 2020-09-29 2022-03-25 中国科学院上海微系统与信息技术研究所 用于长期植入的柔性电极探针及其制备方法、设备
WO2022132595A1 (en) * 2020-12-14 2022-06-23 University Of Washington Implantable patient-controlled analgesic device
TWI792518B (zh) * 2020-12-15 2023-02-11 財團法人工業技術研究院 神經調節探針
US11794002B2 (en) 2020-12-15 2023-10-24 Industrial Technology Research Institute Neuromodulation probe
US20240049994A1 (en) * 2021-02-05 2024-02-15 The Regents Of The University Of California One-touch fingertip sweat sensor and personalized data processing for reliable prediction of blood biomarker concentrations
CN113261969B (zh) * 2021-05-18 2022-02-08 清华大学 脑电极针体、脑电极单元及阵列化脑电极
CN113198105A (zh) * 2021-06-03 2021-08-03 烟台大学 一种表面毛化的随机仿生微织构脑深部刺激套管电极
WO2023132778A1 (en) * 2022-01-05 2023-07-13 Neuronano Ab Microelectrode for insertion into soft tissue
WO2024015444A1 (en) * 2022-07-12 2024-01-18 Case Western Reserve University Transient electrodes and associated systems and methods for neural modulation and recording
CN115799872B (zh) * 2022-11-09 2023-06-09 上海脑虎科技有限公司 一种柔性电极结构、制备方法及成型模具
CN116473551B (zh) * 2023-06-19 2023-08-29 中南大学 基于空心微针阵列的血液离子浓度传感芯片及检测装置

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3724467A (en) 1971-04-23 1973-04-03 Avery Labor Inc Electrode implant for the neuro-stimulation of the spinal cord
US3822708A (en) 1972-12-07 1974-07-09 Clinical Technology Corp Electrical spinal cord stimulating device and method for management of pain
US3995560A (en) 1975-08-12 1976-12-07 Charles Mackintosh Rail obstruction sensing means for a rail transportation system
US4379462A (en) 1980-10-29 1983-04-12 Neuromed, Inc. Multi-electrode catheter assembly for spinal cord stimulation
US4573481A (en) 1984-06-25 1986-03-04 Huntington Institute Of Applied Research Implantable electrode array
US5202120A (en) 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US4852573A (en) 1987-12-04 1989-08-01 Kennedy Philip R Implantable neural electrode
US4920979A (en) 1988-10-12 1990-05-01 Huntington Medical Research Institute Bidirectional helical electrode for nerve stimulation
US5031621A (en) 1989-12-06 1991-07-16 Grandjean Pierre A Nerve electrode with biological substrate
US6524274B1 (en) 1990-12-28 2003-02-25 Scimed Life Systems, Inc. Triggered release hydrogel drug delivery system
US5215008A (en) 1991-10-24 1993-06-01 Kartovaara Ilkka K Calendering machine for testing paper
CA2148823C (en) 1992-11-17 1999-03-09 Welfide Corporation Sustained release microsphere preparation containing antipsychotic drug and production process thereof
US5417719A (en) 1993-08-25 1995-05-23 Medtronic, Inc. Method of using a spinal cord stimulation lead
US5380299A (en) * 1993-08-30 1995-01-10 Med Institute, Inc. Thrombolytic treated intravascular medical device
US5501703A (en) 1994-01-24 1996-03-26 Medtronic, Inc. Multichannel apparatus for epidural spinal cord stimulator
US5741319A (en) 1995-01-27 1998-04-21 Medtronic, Inc. Biocompatible medical lead
US5782919A (en) 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
DE19529371C3 (de) 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
US5820589A (en) 1996-04-30 1998-10-13 Medtronic, Inc. Implantable non-invasive rate-adjustable pump
US6027721A (en) 1996-05-20 2000-02-22 Cytotherapeutics, Inc. Device and method for encapsulated gene therapy
US5944710A (en) * 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
AU728281B2 (en) * 1996-09-23 2001-01-04 Genzyme Corporation Polymerizable biodegradable polymers including carbonate or dioxanone linkages
US5957958A (en) 1997-01-15 1999-09-28 Advanced Bionics Corporation Implantable electrode arrays
JP2000514094A (ja) 1997-04-17 2000-10-24 レオネ，パオラ 脳への遺伝子治療のための送達システム
US5879697A (en) 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US6091978A (en) * 1998-04-07 2000-07-18 Cardiac Pacemakers, Inc. Removable cap for tissue-insertable connections
US6421566B1 (en) 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US6091979A (en) 1998-07-07 2000-07-18 Children's Medical Center Corporation Subdural electrode arrays for monitoring cortical electrical activity
US6245108B1 (en) 1999-02-25 2001-06-12 Spineco Spinal fusion implant
US6253110B1 (en) 1999-04-27 2001-06-26 Medtronic Inc Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode
US6471688B1 (en) 2000-02-15 2002-10-29 Microsolutions, Inc. Osmotic pump drug delivery systems and methods
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
US6632217B2 (en) 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
US7099718B1 (en) 2001-05-29 2006-08-29 Advanced Bionics Corporation Neural stimulation lead fixation
CN1204396C (zh) 2001-06-20 2005-06-01 松下电器产业株式会社 细胞外记录电极
US7146221B2 (en) 2001-11-16 2006-12-05 The Regents Of The University Of California Flexible electrode array for artifical vision
US6993392B2 (en) 2002-03-14 2006-01-31 Duke University Miniaturized high-density multichannel electrode array for long-term neuronal recordings
GB2389791B (en) 2002-04-30 2006-12-13 Steven Gill Implantable drug delivery pump
US20050058701A1 (en) 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
US7689260B2 (en) * 2003-11-06 2010-03-30 The Regents Of The University Of Colorado Shape-memory polymer coated electrodes
US20050136023A1 (en) 2003-12-18 2005-06-23 Kimberly-Clark Worldwide, Inc. Electrically conductive adhesive hydrogels with a thermally activated chemical initiator
US7709439B2 (en) 2004-02-20 2010-05-04 Boston Scientific Scimed, Inc. Biomaterials for enhanced healing
US7471689B1 (en) 2005-04-22 2008-12-30 Sun Microsystems, Inc. Method and apparatus for managing and accounting for bandwidth utilization within a computing system
WO2006131912A2 (en) * 2005-06-06 2006-12-14 Nano Biosensors Ltd. Microelectrode, applications thereof and method of manufacturing
US20070198063A1 (en) 2005-10-03 2007-08-23 Hunter William L Electrical devices and anti-scarring drug combinations
EP1931250B1 (en) * 2005-10-06 2012-07-11 Neuronano AB Electrode bundle
US20070197892A1 (en) 2006-02-23 2007-08-23 Medtrode Inc. Non-planar multi-channel electrode array
WO2007134315A1 (en) * 2006-05-15 2007-11-22 Cardiac Pacemakers, Inc. Porous surface electrode for coronary venous applications
WO2008038197A1 (en) * 2006-09-25 2008-04-03 Koninklijke Philips Electronics, N.V. Branching therapy elements and method of their insertion into living tissue
DE102006048819A1 (de) * 2006-10-10 2008-04-17 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Vorrichtung mit einem Grundkörper
JP5074521B2 (ja) * 2007-01-23 2012-11-14 ニューロナノ エービー 電極アレー
US8306632B2 (en) * 2007-01-23 2012-11-06 Neuronano Ab Dissociating multi-channel electrode
WO2008150974A1 (en) * 2007-06-01 2008-12-11 Med-El Elektromedizinische Geraete Gmbh Biodegradable flexible coating for implantable medical devices
WO2009052425A1 (en) * 2007-10-17 2009-04-23 Neuronexus Technologies Implantable device including a resorbable carrier
CA2708758C (en) * 2007-12-10 2015-02-10 Neuronano Ab Medical electrode, electrode bundle and electrode bundle array
CN102458564B (zh) * 2009-06-09 2017-08-04 神经毫微股份公司 用于控制药物释放到组织中的包含微电极和多重微电极的装置

Also Published As

Publication number Publication date
EP2440283A1 (en) 2012-04-18
HK1214190A1 (zh) 2016-07-22
WO2010144016A1 (en) 2010-12-16
US9878147B2 (en) 2018-01-30
JP2014221423A (ja) 2014-11-27
EP2440283A4 (en) 2012-12-12
AU2010259309B2 (en) 2014-10-09
CN105194796B (zh) 2017-11-24
US20120123318A1 (en) 2012-05-17
KR20120032521A (ko) 2012-04-05
US8954142B2 (en) 2015-02-10
CA2764960C (en) 2017-07-18
JP5850501B2 (ja) 2016-02-03
CN105194796A (zh) 2015-12-30
US10188854B2 (en) 2019-01-29
CA2764960A1 (en) 2010-12-16
CN102458564B (zh) 2017-08-04
BRPI1011317B8 (pt) 2021-12-21
EA201190300A1 (ru) 2012-08-30
BRPI1011317B1 (pt) 2021-08-03
CN102458564A (zh) 2012-05-16
EA023177B1 (ru) 2016-05-31
DK2440283T3 (en) 2018-11-26
KR101683028B1 (ko) 2016-12-06
US20170087352A1 (en) 2017-03-30
US20140323948A1 (en) 2014-10-30
US20170274201A1 (en) 2017-09-28
US20150151109A1 (en) 2015-06-04
JP2012529338A (ja) 2012-11-22
JP5876905B2 (ja) 2016-03-02
US9533140B2 (en) 2017-01-03
US10363411B2 (en) 2019-07-30
AU2010259309A1 (en) 2011-12-15
EP2440283B1 (en) 2018-08-01

Similar Documents

Publication Publication Date Title
BRPI1011317A2 (pt) microeletrodo e microeletrodos múltiplos compreendendo meios para liberação de drogas em um tecido
EP2521483A4 (en) SYSTEMS, DEVICES AND METHODS FOR DELIVERING BIOLOGICAL DRUGS OR FACTORS TO A SUBJECT
BRPI1013986A2 (pt) dispositivo de orifício de acesso para fornecer acesso subcutâneo em um paciente
ZA201400616B (en) Methods and devices for drug delivery to ocular tissue using microneedle
DK2396072T3 (da) Stimulerende elektrode-leveringssystem
EP2435978A4 (en) RATING SYSTEM AND METHOD FOR MEDICATION RENEWAL
BRPI1009049A2 (pt) "sistema estruturado para facilitar a terapia comportamental cognitiva para um paciente apresentando insônia"
IL239390A0 (en) Analogues of pyridonemorphine and biological activity at opioid receptors
EP2699182A4 (en) EXPANDABLE CATHETER SYSTEM FOR PERIOSTIAL INJECTION AND ABLATION OF NERVOUS AND MUSCULAR FIBERS
EP2750754A4 (en) MICRONADELFELDER FOR BIOSENSING AND DRUG RELIEF
BRPI1010279A2 (pt) dispositivo de distribuição de fármaco
EP2303685A4 (en) CURVED WING TIP
BR112012010199A2 (pt) agulha para inserção em paciente
BRPI1012730A2 (pt) dispositivo de distribuição de fármaco
BRPI1010237A2 (pt) dispositivo de distribuição de fármaco
BRPI1012578A2 (pt) conjunto para um dispositivo para distribuição de fármaco e dispositivo para distribuição de fármaco
BR112012009021A2 (pt) dispositivo de cuidados para tecidos
IL219002A0 (en) Device and method for drug delivery to a targeted skin layer
BRPI0821248A2 (pt) Inibidores de cinesina como fármacos terapêuticos para câncer
PL2647337T3 (pl) Urządzenie wywołujące bodźce skóry
BRPI1008365A2 (pt) sistemas e métodos para organizar e escovar um conjunto de administração iv
BR112012000799A2 (pt) dispositivo de distribuição de fármaco
EP2402305A4 (en) LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
BR112013015979A2 (pt) tampão de fratura modular e método para a construção do mesmo
BR112012000420A2 (pt) método de dispensação de droga

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/06/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2639 DE 03/08/2021 QUANTO AO ENDERECO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 14A ANUIDADE.