BRPI0916390A2 - moduladores de gama-secretase à base de piridinila - Google Patents
moduladores de gama-secretase à base de piridinilaInfo
- Publication number
- BRPI0916390A2 BRPI0916390A2 BRPI0916390A BRPI0916390A BRPI0916390A2 BR PI0916390 A2 BRPI0916390 A2 BR PI0916390A2 BR PI0916390 A BRPI0916390 A BR PI0916390A BR PI0916390 A BRPI0916390 A BR PI0916390A BR PI0916390 A2 BRPI0916390 A2 BR PI0916390A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyridinyl
- gamma secretase
- secretase modulators
- based gamma
- modulators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8258608P | 2008-07-22 | 2008-07-22 | |
| US12/478,820 US7968725B2 (en) | 2008-07-22 | 2009-06-05 | Pyridinyl modulators of γ-secretase |
| PCT/US2009/051211 WO2010011626A2 (en) | 2008-07-22 | 2009-07-21 | Pyridinyl modulators of ϒ-secretase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0916390A2 true BRPI0916390A2 (pt) | 2018-02-06 |
Family
ID=41569200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0916390A BRPI0916390A2 (pt) | 2008-07-22 | 2009-07-21 | moduladores de gama-secretase à base de piridinila |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7968725B2 (pt) |
| EP (1) | EP2321278A2 (pt) |
| JP (1) | JP5498493B2 (pt) |
| CN (1) | CN102159544A (pt) |
| AR (1) | AR072585A1 (pt) |
| AU (1) | AU2009274154B2 (pt) |
| BR (1) | BRPI0916390A2 (pt) |
| CA (1) | CA2731190A1 (pt) |
| TW (1) | TW201018466A (pt) |
| UY (1) | UY32002A (pt) |
| WO (1) | WO2010011626A2 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903335A (zh) * | 2007-10-19 | 2010-12-01 | 詹森药业有限公司 | 连接有胺的γ-分泌酶调节剂 |
| MX2010004309A (es) * | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| EP2215043B1 (en) | 2007-10-19 | 2013-03-06 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
| EP2430662A4 (en) * | 2009-04-24 | 2014-10-01 | Alphamicron Inc | SUNBATHING DEVICES FOR VARIABLE LIGHT WEAKENING AND ARRANGEMENTS THEREFOR |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1284729A4 (en) | 2000-04-13 | 2007-12-19 | Mayo Foundation | REDUCTION AGENTS OF A (BETA) 42 |
| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| GB0416508D0 (en) | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| DK1847524T3 (da) * | 2006-04-21 | 2010-01-11 | Cellzome Ltd | Terphenylderivater til behandling af Alzheimers sygdom |
-
2009
- 2009-06-05 US US12/478,820 patent/US7968725B2/en not_active Expired - Fee Related
- 2009-07-21 CA CA2731190A patent/CA2731190A1/en not_active Abandoned
- 2009-07-21 EP EP09790657A patent/EP2321278A2/en not_active Withdrawn
- 2009-07-21 WO PCT/US2009/051211 patent/WO2010011626A2/en active Application Filing
- 2009-07-21 AU AU2009274154A patent/AU2009274154B2/en not_active Ceased
- 2009-07-21 JP JP2011520128A patent/JP5498493B2/ja not_active Expired - Fee Related
- 2009-07-21 BR BRPI0916390A patent/BRPI0916390A2/pt not_active IP Right Cessation
- 2009-07-21 CN CN2009801382848A patent/CN102159544A/zh active Pending
- 2009-07-21 TW TW098124504A patent/TW201018466A/zh unknown
- 2009-07-21 AR ARP090102775A patent/AR072585A1/es unknown
- 2009-07-22 UY UY0001032002A patent/UY32002A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201018466A (en) | 2010-05-16 |
| UY32002A (es) | 2010-01-29 |
| JP2011529059A (ja) | 2011-12-01 |
| US7968725B2 (en) | 2011-06-28 |
| AR072585A1 (es) | 2010-09-08 |
| AU2009274154B2 (en) | 2013-10-10 |
| CA2731190A1 (en) | 2010-01-28 |
| US20100022583A1 (en) | 2010-01-28 |
| WO2010011626A2 (en) | 2010-01-28 |
| AU2009274154A1 (en) | 2010-01-28 |
| JP5498493B2 (ja) | 2014-05-21 |
| WO2010011626A3 (en) | 2010-04-01 |
| CN102159544A (zh) | 2011-08-17 |
| EP2321278A2 (en) | 2011-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2471 DE 15-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |