BRPI0812729A2 - materiais e métodos para tratamento e diagnósticos de distúrbios associados com estresse oxidativo - Google Patents
materiais e métodos para tratamento e diagnósticos de distúrbios associados com estresse oxidativoInfo
- Publication number
- BRPI0812729A2 BRPI0812729A2 BRPI0812729-8A BRPI0812729A BRPI0812729A2 BR PI0812729 A2 BRPI0812729 A2 BR PI0812729A2 BR PI0812729 A BRPI0812729 A BR PI0812729A BR PI0812729 A2 BRPI0812729 A2 BR PI0812729A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- lipoic acid
- compositions
- oxidative stress
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 230000036542 oxidative stress Effects 0.000 title abstract 4
- 239000000463 material Substances 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 208000035475 disorder Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 7
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 abstract 6
- 235000019136 lipoic acid Nutrition 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229960002663 thioctic acid Drugs 0.000 abstract 3
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 2
- 241000792859 Enema Species 0.000 abstract 2
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 239000007920 enema Substances 0.000 abstract 2
- 229940095399 enema Drugs 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 abstract 1
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 abstract 1
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 abstract 1
- 208000014997 Crohn colitis Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000013200 Stress disease Diseases 0.000 abstract 1
- 229960004436 budesonide Drugs 0.000 abstract 1
- 230000001010 compromised effect Effects 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93450507P | 2007-06-13 | 2007-06-13 | |
US60/934,505 | 2007-06-13 | ||
US6374508P | 2008-02-06 | 2008-02-06 | |
US61/063,745 | 2008-02-06 | ||
PCT/US2008/007401 WO2008156671A2 (en) | 2007-06-13 | 2008-06-13 | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0812729A2 true BRPI0812729A2 (pt) | 2019-02-12 |
Family
ID=40156844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0812729-8A BRPI0812729A2 (pt) | 2007-06-13 | 2008-06-13 | materiais e métodos para tratamento e diagnósticos de distúrbios associados com estresse oxidativo |
Country Status (14)
Country | Link |
---|---|
US (2) | US8476233B2 (pt) |
EP (2) | EP2162125B1 (pt) |
JP (1) | JP2010529197A (pt) |
KR (1) | KR20100038098A (pt) |
CN (1) | CN101707877B (pt) |
AT (1) | ATE529105T1 (pt) |
AU (1) | AU2008266996A1 (pt) |
BR (1) | BRPI0812729A2 (pt) |
CA (1) | CA2691132C (pt) |
IL (1) | IL202685A0 (pt) |
MX (1) | MX2009013683A (pt) |
NZ (1) | NZ581710A (pt) |
WO (1) | WO2008156671A2 (pt) |
ZA (1) | ZA200908828B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100112088A1 (en) * | 2003-08-29 | 2010-05-06 | Jay Pravda | Materials and methods for treatment of disorders associated with oxidative stress |
US8916546B2 (en) | 2003-08-29 | 2014-12-23 | Therapeutic Research Llc | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress |
ES2882880T3 (es) * | 2012-02-13 | 2021-12-03 | Cosmo Technologies Ltd | Procedimiento para tratar enfermedades intestinales que presentan al menos un componente inflamatorio |
US10071058B2 (en) * | 2012-03-07 | 2018-09-11 | Santarus, Inc. | Controlled-release solid dosage forms of mesalamine |
AU2013286876B2 (en) * | 2012-07-03 | 2017-04-20 | Jay Pravda | Methods for treating, diagnosing and/or monitoring progression of oxo associated states |
WO2014074995A1 (en) * | 2012-11-09 | 2014-05-15 | Scidose, Llc | Enema composition for treatment of ulcerative colitis having long term stability |
CN103622974B (zh) * | 2013-12-05 | 2016-04-20 | 武汉武药科技有限公司 | 一种含美沙拉嗪和n-乙酰半胱氨酸的复方栓剂及其制备方法 |
ES2688119T3 (es) * | 2015-07-08 | 2018-10-31 | Dr. Falk Pharma Gmbh | Formulación farmacéutica para el tratamiento de cambios inflamatorios del recto |
US20180353447A1 (en) * | 2015-11-27 | 2018-12-13 | Birrbeheer B.V. | Butyrate salts for use in inflammatory diseases |
JP2019530477A (ja) * | 2016-09-26 | 2019-10-24 | プレシジョン・メディスン・ホールディングス・プロプライエタリー・リミテッド | 精神分裂病および分裂情動性精神病の診断、予後、および処置 |
WO2018122086A1 (en) * | 2016-12-28 | 2018-07-05 | Dr. Falk Pharma Gmbh | Enema for rectal application |
CN108034631A (zh) * | 2017-12-04 | 2018-05-15 | 武汉轻工大学 | 一种双氧水诱导猪小肠上皮细胞凋亡模型的建立方法 |
JP2019113375A (ja) * | 2017-12-22 | 2019-07-11 | サッポロホールディングス株式会社 | 腸内環境評価方法、大腸炎罹患リスク評価方法、及び腸内環境改善物質のスクリーニング方法 |
WO2019142799A1 (ja) * | 2018-01-18 | 2019-07-25 | 学校法人慶應義塾 | 潰瘍性大腸炎治療カプセル剤 |
WO2024026200A1 (en) * | 2022-07-27 | 2024-02-01 | Redox Bioscience LLC | Methods and compounds for treating ulcerative colitis, systemic lupus erythematosus, sepsis, and post-sepsis syndrome |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4211777A (en) * | 1977-11-25 | 1980-07-08 | Fisons Limited | Compositions comprising a compound having sodium cromoglycate activity and aminosalicylic acid |
JPS57500432A (pt) * | 1980-03-20 | 1982-03-11 | ||
US4657900A (en) * | 1983-09-27 | 1987-04-14 | Rowell Laboratories | Pharmaceutical article of manufacture comprising a bisulfite stabilized aqueous solution of 5-aminosalicylic acid and method |
EP0382066A3 (de) * | 1989-02-09 | 1992-01-08 | ASTA Medica Aktiengesellschaft | Verwendung von Dihydroliponsäure als Analgetikum, Antiphlogistikum und/oder Zytoprotektivum |
GB8909559D0 (en) * | 1989-04-26 | 1989-06-14 | Smith Kline French Lab | Pharmaceutical compositions |
US5378470A (en) * | 1989-07-25 | 1995-01-03 | Henning Berlin Gmbh | Rectally administered pharmaceutical preparation |
EP0427247B1 (de) * | 1989-11-09 | 1998-03-11 | ASTA Medica Aktiengesellschaft | Arzneimittel enthaltend als Wirkstoff R-alpha-Liponsäure oder S-alpha-Liponsäure |
US5569670A (en) * | 1992-06-05 | 1996-10-29 | Asta Medica Aktiengesellschaft | Combination medications containing alpha-lipoic acid and related |
DE4218572A1 (de) | 1992-06-05 | 1993-12-09 | Asta Medica Ag | Synergistische Kombination von Arzneimitteln enthaltend als Wirkstoff alpha-Liponsäure, Dihydroliponsäure, deren Metaboliten sowie die oxidierten und reduzierten Enantiomere der alpha-Liponsäure wie die R-alpha-Liponsäure oder S-alpha-Liponsäure sowie Metaboliten der alpha-Liponsäure mit den Vitaminen A, B1-6, B12, C und E |
US6444221B1 (en) * | 1992-06-30 | 2002-09-03 | Howard K. Shapiro | Methods of treating chronic inflammatory diseases using carbonyl trapping agents |
US8178516B2 (en) * | 1992-06-30 | 2012-05-15 | Sylvan Labs, LLC | Compositions and method for treatment of chronic inflammatory diseases |
US20050090553A1 (en) * | 1992-06-30 | 2005-04-28 | Shapiro Howard K. | Compositions and method for treatment of chronic inflammatory diseases |
JP2917799B2 (ja) * | 1994-03-11 | 1999-07-12 | 田辺製薬株式会社 | 消化管内適所放出型製剤 |
US5563131A (en) * | 1994-08-04 | 1996-10-08 | Pherin Corporation | Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods |
DE19509806A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Lagerstabile Arzneiformen |
US5817630A (en) * | 1997-03-18 | 1998-10-06 | Austin Nutriceutical Corporation | Glutathione antioxidant eye drops |
US6197749B1 (en) * | 1997-10-29 | 2001-03-06 | Ajinomoto Co., Inc. | Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes |
US6262019B1 (en) * | 1998-04-30 | 2001-07-17 | Vit-Immune, L. C. | Method of treatment of glutathione deficient mammals |
CA2274943A1 (en) * | 1998-06-17 | 1999-12-17 | Stephen L. Wolman | Compositions for the treatment and prevention of inflammatory diseases of the gastrointestinal tract and methods and uses thereof |
AR042572A1 (es) | 1999-04-02 | 2005-06-29 | Sod Conseils Rech Applic | Derivados de acido lipoico, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y utilizacion de dichos derivados para la preparacion de los referidos medicamentos |
US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
EP1172110A3 (de) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Verwendung von Liponsäure zur Verbesserung der Bioverfügbarkeit von Mineralsalzen |
US20030119797A1 (en) * | 2001-05-09 | 2003-06-26 | Salah-Dine Chibout | Methods for selective immunomodulation |
US20030235571A1 (en) * | 2002-06-19 | 2003-12-25 | Gabriel Gojon-Romanillos | Systemic treatment of pathological conditions resulting from oxidative stress and/or redox imbalance |
US7195766B2 (en) * | 2002-09-10 | 2007-03-27 | National Jewish Medical And Research Center | Product and process for liquefaction of mucus or sputum |
US7157444B2 (en) * | 2002-12-21 | 2007-01-02 | Deanna Jean Nelson | Aminosalicylate derivatives for treatment of inflammatory bowel disease |
DE10305661A1 (de) | 2003-02-12 | 2004-08-26 | Degussa Ag | Darreichungsform zur Kolon-spezifischen Wirkstofffreisetzung |
WO2004078172A2 (en) * | 2003-03-06 | 2004-09-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Sod mimic multifunctional compounds for treating inflammatory bowel disease |
US20100112088A1 (en) * | 2003-08-29 | 2010-05-06 | Jay Pravda | Materials and methods for treatment of disorders associated with oxidative stress |
-
2008
- 2008-06-13 BR BRPI0812729-8A patent/BRPI0812729A2/pt not_active IP Right Cessation
- 2008-06-13 CA CA2691132A patent/CA2691132C/en not_active Expired - Fee Related
- 2008-06-13 MX MX2009013683A patent/MX2009013683A/es active IP Right Grant
- 2008-06-13 KR KR1020107000650A patent/KR20100038098A/ko not_active Application Discontinuation
- 2008-06-13 AU AU2008266996A patent/AU2008266996A1/en not_active Abandoned
- 2008-06-13 WO PCT/US2008/007401 patent/WO2008156671A2/en active Application Filing
- 2008-06-13 NZ NZ581710A patent/NZ581710A/en not_active IP Right Cessation
- 2008-06-13 US US12/664,237 patent/US8476233B2/en not_active Expired - Fee Related
- 2008-06-13 AT AT08768441T patent/ATE529105T1/de not_active IP Right Cessation
- 2008-06-13 CN CN2008800201249A patent/CN101707877B/zh not_active Expired - Fee Related
- 2008-06-13 JP JP2010512198A patent/JP2010529197A/ja not_active Abandoned
- 2008-06-13 EP EP08768441A patent/EP2162125B1/en not_active Not-in-force
- 2008-06-13 EP EP11179459A patent/EP2392321A1/en not_active Withdrawn
-
2009
- 2009-12-10 IL IL202685A patent/IL202685A0/en unknown
- 2009-12-10 ZA ZA2009/08828A patent/ZA200908828B/en unknown
-
2013
- 2013-06-28 US US13/930,838 patent/US20130344184A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2691132A1 (en) | 2008-12-24 |
EP2162125A2 (en) | 2010-03-17 |
EP2162125A4 (en) | 2010-08-25 |
WO2008156671A2 (en) | 2008-12-24 |
ZA200908828B (en) | 2010-12-29 |
KR20100038098A (ko) | 2010-04-12 |
CN101707877B (zh) | 2013-01-09 |
NZ581710A (en) | 2012-02-24 |
ATE529105T1 (de) | 2011-11-15 |
IL202685A0 (en) | 2010-06-30 |
EP2392321A1 (en) | 2011-12-07 |
CN101707877A (zh) | 2010-05-12 |
US8476233B2 (en) | 2013-07-02 |
EP2162125B1 (en) | 2011-10-19 |
MX2009013683A (es) | 2010-04-07 |
US20130344184A1 (en) | 2013-12-26 |
JP2010529197A (ja) | 2010-08-26 |
CA2691132C (en) | 2016-01-12 |
AU2008266996A1 (en) | 2008-12-24 |
WO2008156671A3 (en) | 2009-03-12 |
US20100184728A1 (en) | 2010-07-22 |
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