BRPI0811902A2 - Síntese aprimorada do (2s-cis)-2-(bromometil)-2-(-4-clorofenil)-1,3-dioxola-no- 4-metanol metanosulfonato (éster) - Google Patents
Síntese aprimorada do (2s-cis)-2-(bromometil)-2-(-4-clorofenil)-1,3-dioxola-no- 4-metanol metanosulfonato (éster)Info
- Publication number
- BRPI0811902A2 BRPI0811902A2 BRPI0811902-3A2A BRPI0811902A BRPI0811902A2 BR PI0811902 A2 BRPI0811902 A2 BR PI0811902A2 BR PI0811902 A BRPI0811902 A BR PI0811902A BR PI0811902 A2 BRPI0811902 A2 BR PI0811902A2
- Authority
- BR
- Brazil
- Prior art keywords
- chlorophenyl
- cis
- ester
- methanol
- methanosulphonate
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- HQSRVYUCBOCBLY-XOOFNSLWSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2s,4r)-2-(4-chlorophenyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CSC=4N(C=NN=4)C)(OC3)C=3C=CC(Cl)=CC=3)=CC=2)C=C1 HQSRVYUCBOCBLY-XOOFNSLWSA-N 0.000 abstract 1
- 101150102415 Apob gene Proteins 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229950000884 mitratapide Drugs 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07108944.5 | 2007-05-25 | ||
| EP07108944 | 2007-05-25 | ||
| PCT/EP2008/056355 WO2008145605A1 (en) | 2007-05-25 | 2008-05-23 | Improved synthesis of (2s-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3 dioxolane-4-methanol methanesulfonate(ester) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0811902A2 true BRPI0811902A2 (pt) | 2014-11-18 |
| BRPI0811902B1 BRPI0811902B1 (pt) | 2020-03-24 |
Family
ID=38588176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0811902-3A BRPI0811902B1 (pt) | 2007-05-25 | 2008-05-23 | Síntese aprimorada do (2s-cis)-2-(bromometil)-2-(-4-clorofenil)-1,3-dioxolano-4-metanol metanosulfonato (éster) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8765979B2 (pt) |
| EP (1) | EP2152698B1 (pt) |
| JP (1) | JP5350367B2 (pt) |
| KR (1) | KR101484028B1 (pt) |
| CN (1) | CN101679391A (pt) |
| AT (1) | ATE474836T1 (pt) |
| BR (1) | BRPI0811902B1 (pt) |
| CA (1) | CA2685797C (pt) |
| DE (1) | DE602008001896D1 (pt) |
| ES (1) | ES2348530T3 (pt) |
| IL (1) | IL202253A (pt) |
| MX (1) | MX2009012739A (pt) |
| WO (1) | WO2008145605A1 (pt) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69519995T2 (de) | 1994-10-27 | 2001-08-23 | Janssen Pharmaceutica Nv | Apolipoprotein-b syntheseinhibitoren |
| ES2112151B1 (es) * | 1995-03-17 | 1999-09-16 | Menarini Lab | Nuevos compuestos homoquirales para la preparacion de ketoconazol, terconazol y antifungicos relacionados, procedimiento para su fabricacion y utilizacion de los mismos. |
| ES2195653T3 (es) * | 1998-12-22 | 2003-12-01 | Janssen Pharmaceutica Nv | Compuesto de s-oxido que disminuyen los lipidos. |
-
2008
- 2008-05-23 US US12/601,555 patent/US8765979B2/en active Active
- 2008-05-23 EP EP08759956A patent/EP2152698B1/en active Active
- 2008-05-23 WO PCT/EP2008/056355 patent/WO2008145605A1/en active Application Filing
- 2008-05-23 CN CN200880017239A patent/CN101679391A/zh active Pending
- 2008-05-23 ES ES08759956T patent/ES2348530T3/es active Active
- 2008-05-23 MX MX2009012739A patent/MX2009012739A/es active IP Right Grant
- 2008-05-23 CA CA2685797A patent/CA2685797C/en active Active
- 2008-05-23 KR KR1020097024954A patent/KR101484028B1/ko active IP Right Grant
- 2008-05-23 BR BRPI0811902-3A patent/BRPI0811902B1/pt not_active IP Right Cessation
- 2008-05-23 DE DE602008001896T patent/DE602008001896D1/de active Active
- 2008-05-23 AT AT08759956T patent/ATE474836T1/de not_active IP Right Cessation
- 2008-05-23 JP JP2010508862A patent/JP5350367B2/ja active Active
-
2009
- 2009-11-22 IL IL202253A patent/IL202253A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ES2348530T3 (es) | 2010-12-09 |
| KR20100017502A (ko) | 2010-02-16 |
| CN101679391A (zh) | 2010-03-24 |
| DE602008001896D1 (de) | 2010-09-02 |
| CA2685797C (en) | 2015-04-14 |
| BRPI0811902B1 (pt) | 2020-03-24 |
| MX2009012739A (es) | 2009-12-10 |
| EP2152698B1 (en) | 2010-07-21 |
| IL202253A0 (en) | 2010-06-16 |
| US8765979B2 (en) | 2014-07-01 |
| ATE474836T1 (de) | 2010-08-15 |
| JP5350367B2 (ja) | 2013-11-27 |
| IL202253A (en) | 2013-07-31 |
| CA2685797A1 (en) | 2008-12-04 |
| US20110196160A1 (en) | 2011-08-11 |
| KR101484028B1 (ko) | 2015-01-19 |
| WO2008145605A1 (en) | 2008-12-04 |
| JP2010527972A (ja) | 2010-08-19 |
| EP2152698A1 (en) | 2010-02-17 |
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