BRPI0808655A2 - anticorpos monoclonais de he4 e métodos para a sua utilização. - Google Patents
anticorpos monoclonais de he4 e métodos para a sua utilização.Info
- Publication number
- BRPI0808655A2 BRPI0808655A2 BRPI0808655A BRPI0808655A BRPI0808655A2 BR PI0808655 A2 BRPI0808655 A2 BR PI0808655A2 BR PI0808655 A BRPI0808655 A BR PI0808655A BR PI0808655 A BRPI0808655 A BR PI0808655A BR PI0808655 A2 BRPI0808655 A2 BR PI0808655A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- monoclonal antibodies
- monoclonal
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pregnancy & Childbirth (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90612607P | 2007-03-09 | 2007-03-09 | |
PCT/US2008/056132 WO2008112514A1 (en) | 2007-03-09 | 2008-03-07 | He4 monoclonal antibodies and methods for their use |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0808655A2 true BRPI0808655A2 (pt) | 2018-10-23 |
Family
ID=39567774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0808655A BRPI0808655A2 (pt) | 2007-03-09 | 2008-03-07 | anticorpos monoclonais de he4 e métodos para a sua utilização. |
Country Status (10)
Country | Link |
---|---|
US (2) | US7846692B2 (pt) |
EP (1) | EP2121761A1 (pt) |
JP (1) | JP2010520768A (pt) |
KR (1) | KR20100015438A (pt) |
CN (1) | CN101802014A (pt) |
AU (1) | AU2008226587A1 (pt) |
BR (1) | BRPI0808655A2 (pt) |
CA (1) | CA2679696A1 (pt) |
MX (1) | MX2009009450A (pt) |
WO (1) | WO2008112514A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002258518A1 (en) * | 2001-03-14 | 2002-09-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer |
US7270960B2 (en) * | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
WO2006119155A2 (en) * | 2005-05-02 | 2006-11-09 | The Brigham And Women's Hospital, Inc. | Diagnostic serum antibody profiling |
ES2384125T3 (es) * | 2007-03-23 | 2012-06-29 | F. Hoffmann-La Roche Ag | Apex como marcador de cáncer de pulmón |
WO2009099561A2 (en) * | 2008-01-31 | 2009-08-13 | The Brigham And Womens' Hospital, Inc. | Urinary ca125 peptides as biomarkers of ovarian cancer |
US8476026B2 (en) * | 2008-04-01 | 2013-07-02 | The Brigham And Women's Hospital, Inc. | Biomarkers of ovarian cancer |
WO2010061393A1 (en) * | 2008-11-30 | 2010-06-03 | Compugen Ltd. | He4 variant nucleotide and amino acid sequences, and methods of use thereof |
US20100227335A1 (en) * | 2009-03-05 | 2010-09-09 | Becton, Dickinson And Company | Matrix metalloproteinase-7 (mmp-7) monoclonal antibodies and methods for their use in the detection of ovarian cancer |
JP2012524521A (ja) | 2009-03-06 | 2012-10-18 | トライパス イメージング インコーポレイテッド | グリコデリンモノクローナル抗体および卵巣癌の検出におけるその使用のための方法 |
AU2011293217A1 (en) * | 2010-08-26 | 2013-04-11 | University Of Washington Through Its Center For Commercialization | Methods for detecting anti-HE4 antibodies and methods of diagnosis and/or prognosis of conditions associated with HE4-expressing cells |
US8795975B2 (en) * | 2010-11-29 | 2014-08-05 | Alere San Diego, Inc. | Methods and compositions for diagnosis and risk prediction in heart failure |
RU2650778C2 (ru) | 2011-02-17 | 2018-04-17 | Фуджиребио Диагностикс, Инк | Композиции и способы применения для определения не4а |
WO2012156447A1 (en) * | 2011-05-18 | 2012-11-22 | Pronota N.V. | New biomarker for the classification of ovarian tumours |
EP2717901A4 (en) * | 2011-06-06 | 2015-01-21 | Women And Infants Hospital Of Rhode Island | HE4-BASED THERAPY FOR MALIGNINE DISEASES |
EP2729803A4 (en) * | 2011-07-09 | 2015-08-05 | Astute Medical Inc | METHODS AND COMPOSITIONS FOR DIAGNOSING AND PROGNOSING RENAL INJURY AND RENAL FAILURE |
WO2013023994A1 (en) * | 2011-08-12 | 2013-02-21 | Pronota N.V. | New biomarker for the classification of ovarian tumours |
CN103374067A (zh) * | 2012-04-26 | 2013-10-30 | 清泓生物技术(上海)有限公司 | 一种在哺乳细胞中制备he4重组蛋白的方法 |
CN102890083B (zh) * | 2012-09-28 | 2016-08-10 | 辽宁科骏生物有限公司 | 化学发光底物溶液和含其的试剂盒及应用其的检测方法 |
KR20160146821A (ko) * | 2014-04-29 | 2016-12-21 | 다우 아그로사이언시즈 엘엘씨 | Cry1Ca에 특이적인 모노클로날 항체 및 관련된 검출 방법 |
WO2016094409A1 (en) * | 2014-12-09 | 2016-06-16 | Villarreal Anna | Methods and devices for female health monitoring |
CN105866418B (zh) * | 2016-06-03 | 2016-11-09 | 广州华弘生物科技有限公司 | 一种乳腺癌三联检诊断试剂盒 |
CN112979813B (zh) * | 2019-12-16 | 2022-11-08 | 东莞市朋志生物科技有限公司 | 一种可特异性结合检测人附睾蛋白4的结合蛋白及其制备方法和应用 |
CN113045663B (zh) * | 2021-04-18 | 2022-04-01 | 深圳市国创纳米抗体技术有限公司 | 一种抗he4的纳米抗体1a8及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001016354A1 (en) | 1999-09-02 | 2001-03-08 | Gene Logic, Inc. | Modulation of he4 in inflammatory and renal diseases |
WO2002046765A2 (en) | 2000-11-08 | 2002-06-13 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of ovarian cancer |
US7270960B2 (en) | 2001-08-29 | 2007-09-18 | Pacific Northwest Research Institute | Diagnosis of ovarian carcinomas |
US8486648B2 (en) | 2005-02-16 | 2013-07-16 | Dana-Farber Cancer Institute, Inc. | Methods of detecting ovarian cancer |
EP3026119B1 (en) * | 2006-01-04 | 2019-09-18 | Fujirebio America, Inc. | Use of he4 and other biochemical markers for assessment of ovarian cancers |
US20070212721A1 (en) * | 2006-01-27 | 2007-09-13 | Tripath Imaging, Inc. | Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor |
-
2008
- 2008-03-07 US US12/044,302 patent/US7846692B2/en not_active Expired - Fee Related
- 2008-03-07 BR BRPI0808655A patent/BRPI0808655A2/pt not_active Application Discontinuation
- 2008-03-07 CA CA002679696A patent/CA2679696A1/en not_active Abandoned
- 2008-03-07 JP JP2009553695A patent/JP2010520768A/ja active Pending
- 2008-03-07 WO PCT/US2008/056132 patent/WO2008112514A1/en active Application Filing
- 2008-03-07 CN CN200880007699A patent/CN101802014A/zh active Pending
- 2008-03-07 KR KR1020097021042A patent/KR20100015438A/ko not_active Application Discontinuation
- 2008-03-07 EP EP08731605A patent/EP2121761A1/en not_active Withdrawn
- 2008-03-07 MX MX2009009450A patent/MX2009009450A/es not_active Application Discontinuation
- 2008-03-07 AU AU2008226587A patent/AU2008226587A1/en not_active Abandoned
-
2010
- 2010-10-29 US US12/915,200 patent/US20110038883A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2009009450A (es) | 2009-12-01 |
KR20100015438A (ko) | 2010-02-12 |
US20080254048A1 (en) | 2008-10-16 |
CA2679696A1 (en) | 2008-09-18 |
WO2008112514A1 (en) | 2008-09-18 |
JP2010520768A (ja) | 2010-06-17 |
US7846692B2 (en) | 2010-12-07 |
EP2121761A1 (en) | 2009-11-25 |
CN101802014A (zh) | 2010-08-11 |
US20110038883A1 (en) | 2011-02-17 |
AU2008226587A1 (en) | 2008-09-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |