BRPI0707584A2 - composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica - Google Patents
composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica Download PDFInfo
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- BRPI0707584A2 BRPI0707584A2 BRPI0707584-7A BRPI0707584A BRPI0707584A2 BR PI0707584 A2 BRPI0707584 A2 BR PI0707584A2 BR PI0707584 A BRPI0707584 A BR PI0707584A BR PI0707584 A2 BRPI0707584 A2 BR PI0707584A2
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- pharmaceutical composition
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- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 claims abstract description 136
- 229920000642 polymer Polymers 0.000 claims abstract description 128
- 150000001875 compounds Chemical class 0.000 claims abstract description 63
- 239000004094 surface-active agent Substances 0.000 claims abstract description 37
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 17
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 10
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 claims abstract description 3
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims abstract description 3
- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims description 52
- 150000002367 halogens Chemical class 0.000 claims description 51
- 125000000217 alkyl group Chemical group 0.000 claims description 45
- 125000001424 substituent group Chemical group 0.000 claims description 34
- -1 R 45 halogen Chemical class 0.000 claims description 32
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- 238000000034 method Methods 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
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- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims description 21
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
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- 125000003118 aryl group Chemical group 0.000 claims description 16
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- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 claims description 15
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- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 14
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims description 13
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims description 13
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 12
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- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 10
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- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims description 9
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 5
- ZNPLZHBZUSCANM-UHFFFAOYSA-N acetic acid;benzene-1,3-dicarboxylic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC(C(O)=O)=C1 ZNPLZHBZUSCANM-UHFFFAOYSA-N 0.000 claims description 5
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- FMTQGBMMIVVKSN-UHFFFAOYSA-N acetic acid;terephthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=C(C(O)=O)C=C1 FMTQGBMMIVVKSN-UHFFFAOYSA-N 0.000 claims description 4
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
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- 238000008214 LDL Cholesterol Methods 0.000 abstract description 8
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- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 17
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 7
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- 125000005498 phthalate group Chemical group 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 7
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- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 6
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 description 6
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77178206P | 2006-02-09 | 2006-02-09 | |
| US60/771,782 | 2006-02-09 | ||
| PCT/US2007/003799 WO2007092642A2 (en) | 2006-02-09 | 2007-02-09 | Polymer formulations of cetp inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0707584A2 true BRPI0707584A2 (pt) | 2011-05-10 |
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| BRPI0707584-7A BRPI0707584A2 (pt) | 2006-02-09 | 2007-02-09 | composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica |
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| EP (1) | EP1983966B1 (enExample) |
| JP (2) | JP5773560B2 (enExample) |
| KR (1) | KR101418267B1 (enExample) |
| CN (2) | CN101378731B (enExample) |
| AU (1) | AU2007212197B2 (enExample) |
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| CA (1) | CA2641451C (enExample) |
| IL (1) | IL192977A (enExample) |
| NO (1) | NO341326B1 (enExample) |
| NZ (1) | NZ569700A (enExample) |
| RU (1) | RU2457841C2 (enExample) |
| WO (1) | WO2007092642A2 (enExample) |
| ZA (1) | ZA200805854B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004085996A2 (en) | 2003-03-20 | 2004-10-07 | Albert Einstein College Of Medicine Of Yeshiva University | Biomarkers for longevity and disease and uses thereof |
| US9040558B2 (en) | 2004-12-31 | 2015-05-26 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| US20090143423A1 (en) * | 2007-10-19 | 2009-06-04 | Abbott Gmbh & Co. Kg | Solid dispersion product containing n-aryl urea-based compound |
| WO2009108720A2 (en) | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| AR071375A1 (es) * | 2008-04-22 | 2010-06-16 | Solvay Pharm Gmbh | Formulaciones para ingredientes farmaceuticos activos de permeabilidad deficiente, proceso de preparacion y producto |
| KR101944124B1 (ko) | 2010-11-24 | 2019-01-30 | 멜린타 서브시디어리 코프. | 약학 조성물 |
| US9867811B2 (en) * | 2011-07-08 | 2018-01-16 | Novartis Ag | Method of treating atherosclerosis in high triglyceride subjects |
| US9199967B2 (en) | 2011-08-18 | 2015-12-01 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors |
| IN2014CN02290A (enExample) | 2011-09-27 | 2015-06-19 | Reddys Lab Ltd Dr | |
| RU2759837C2 (ru) | 2012-05-31 | 2021-11-18 | Мерк Шарп И Доум Корп. | Составы твердых дозированных лекарственных форм антагониста орексинового рецептора |
| JP6235584B2 (ja) * | 2012-07-17 | 2017-11-22 | ダウ グローバル テクノロジーズ エルエルシー | 高置換ヒドロキシアルキルメチルセルロースを含む固体分散体 |
| JP6301339B2 (ja) * | 2012-09-27 | 2018-03-28 | ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ | 少なくとも１種の水溶性ビタミンｅ誘導体および少なくとも１種の親水性ポリマーを含む、保存において安定な無塵の均質な粒子製剤 |
| CA2891502A1 (en) | 2012-11-19 | 2014-05-22 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| WO2015077273A1 (en) * | 2013-11-22 | 2015-05-28 | Merck Sharp & Dohme Corp. | Composition of a non-nucleoside reverse transcriptase inhibitor |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| KR20230107902A (ko) * | 2014-02-05 | 2023-07-18 | 머크 샤프 앤드 돔 엘엘씨 | Cgrp-활성 화합물에 대한 정제 제제 |
| JPWO2016084949A1 (ja) * | 2014-11-28 | 2017-09-07 | 興和株式会社 | 医薬 |
| JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| CN114617968B (zh) * | 2019-04-09 | 2023-10-03 | 北京五和博澳药业股份有限公司 | 黄酮多酚类药物自乳化组合物、其制备方法、药物组合物及用途 |
| HRP20241585T1 (hr) * | 2019-04-12 | 2025-01-31 | Oblita Therapeutics Bvba | Fototaloženje metalnih oksida za elektrokromne uređaje |
| TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
| AU2021319090A1 (en) | 2020-07-29 | 2023-03-02 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| WO2022140537A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| JP2024533756A (ja) | 2021-09-27 | 2024-09-12 | アラガン ファーマスーティカルズ インターナショナル リミテッド | アトゲパントを含む片頭痛の併用療法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
| US6627767B2 (en) * | 2000-08-29 | 2003-09-30 | Abbott Laboratories | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors |
| WO2003000294A1 (en) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions containing a solid dispersion of a poorly-soluble drug in a matrix and a solubility-enhancing polymer |
| EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| RS51865B (sr) | 2002-01-29 | 2012-02-29 | Laboratoires Serono Sa. | Supstituisani derivati metilen amida kao modulatori protein tirozin fosfataze (ptp) |
| EP1474144B1 (en) * | 2002-02-01 | 2008-08-06 | Pfizer Products Inc. | Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor |
| EP1469830A2 (en) | 2002-02-01 | 2004-10-27 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles |
| SK2332004A3 (en) * | 2002-08-30 | 2004-12-01 | Japan Tobacco Inc | Dibenzylamine compound and medicinal use thereof |
| ATE534381T1 (de) | 2003-03-17 | 2011-12-15 | Japan Tobacco Inc | Pharmazeutische cetp-inhibitor-zusammensetzungen |
| US20070043079A1 (en) | 2003-04-18 | 2007-02-22 | Hiromu Habashita | Heterocyclic compound containing nitrogen atom and use thereof |
| DOP2005000123A (es) * | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| FR2875409B1 (fr) * | 2004-09-17 | 2010-05-07 | Sanofi Aventis | Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose |
| AU2006265975B2 (en) * | 2005-07-01 | 2011-12-15 | Merck Sharp & Dohme Corp. | Process for synthesizing a CETP inhibitor |
| ATE516016T1 (de) | 2005-12-05 | 2011-07-15 | Merck Sharp & Dohme | Selbstemulgierende formulierungen von cetp- hemmern |
-
2007
- 2007-02-09 BR BRPI0707584-7A patent/BRPI0707584A2/pt not_active Application Discontinuation
- 2007-02-09 AU AU2007212197A patent/AU2007212197B2/en not_active Ceased
- 2007-02-09 RU RU2008136198/15A patent/RU2457841C2/ru not_active IP Right Cessation
- 2007-02-09 CN CN200780004561.7A patent/CN101378731B/zh not_active Expired - Fee Related
- 2007-02-09 CA CA2641451A patent/CA2641451C/en not_active Expired - Fee Related
- 2007-02-09 US US12/223,272 patent/US8030359B2/en not_active Expired - Fee Related
- 2007-02-09 EP EP07763707.2A patent/EP1983966B1/en not_active Not-in-force
- 2007-02-09 NZ NZ569700A patent/NZ569700A/en not_active IP Right Cessation
- 2007-02-09 JP JP2008554428A patent/JP5773560B2/ja not_active Expired - Fee Related
- 2007-02-09 KR KR1020087019569A patent/KR101418267B1/ko not_active Expired - Fee Related
- 2007-02-09 CN CN201410027847.9A patent/CN103735515A/zh active Pending
- 2007-02-09 WO PCT/US2007/003799 patent/WO2007092642A2/en not_active Ceased
-
2008
- 2008-07-04 ZA ZA200805854A patent/ZA200805854B/xx unknown
- 2008-07-22 IL IL192977A patent/IL192977A/en not_active IP Right Cessation
- 2008-09-08 NO NO20083821A patent/NO341326B1/no not_active IP Right Cessation
-
2012
- 2012-11-22 JP JP2012255810A patent/JP5648038B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007212197B2 (en) | 2012-12-13 |
| CN101378731A (zh) | 2009-03-04 |
| CN101378731B (zh) | 2014-03-05 |
| AU2007212197A1 (en) | 2007-08-16 |
| RU2008136198A (ru) | 2010-03-20 |
| IL192977A0 (en) | 2009-02-11 |
| ZA200805854B (en) | 2009-10-28 |
| EP1983966B1 (en) | 2013-06-26 |
| EP1983966A2 (en) | 2008-10-29 |
| US20100227903A1 (en) | 2010-09-09 |
| US8030359B2 (en) | 2011-10-04 |
| KR20080108420A (ko) | 2008-12-15 |
| KR101418267B1 (ko) | 2014-07-11 |
| NO20083821L (no) | 2008-09-30 |
| CA2641451A1 (en) | 2007-08-16 |
| WO2007092642A2 (en) | 2007-08-16 |
| CN103735515A (zh) | 2014-04-23 |
| JP2009526075A (ja) | 2009-07-16 |
| NO341326B1 (no) | 2017-10-16 |
| NZ569700A (en) | 2011-09-30 |
| WO2007092642A3 (en) | 2007-10-04 |
| JP2013067635A (ja) | 2013-04-18 |
| CA2641451C (en) | 2012-10-02 |
| JP5773560B2 (ja) | 2015-09-02 |
| JP5648038B2 (ja) | 2015-01-07 |
| RU2457841C2 (ru) | 2012-08-10 |
| IL192977A (en) | 2011-01-31 |
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| B25D | Requested change of name of applicant approved |
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| B25A | Requested transfer of rights approved |
Owner name: SCHERING CORPORATION, (US) |
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| B25D | Requested change of name of applicant approved |
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| B25G | Requested change of headquarter approved |
Owner name: MERCK SHARP AND DOHME CORP. (US) |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
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