BRPI0614608A2 - análogos de camptotecina, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os ditos compostos - Google Patents

análogos de camptotecina, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os ditos compostos

Info

Publication number
BRPI0614608A2
BRPI0614608A2 BRPI0614608A BRPI0614608A BRPI0614608A2 BR PI0614608 A2 BRPI0614608 A2 BR PI0614608A2 BR PI0614608 A BRPI0614608 A BR PI0614608A BR PI0614608 A BRPI0614608 A BR PI0614608A BR PI0614608 A2 BRPI0614608 A2 BR PI0614608A2
Authority
BR
Brazil
Prior art keywords
compounds
preparation
pharmaceutical compositions
compositions containing
camptothecin analogues
Prior art date
Application number
BRPI0614608A
Other languages
English (en)
Inventor
Alain Pierre
Gilbert Lavielle
John Hickman
Patrick Hautefaye
Stéphane Leonce
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0614608A2 publication Critical patent/BRPI0614608A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0614608A 2005-08-05 2006-08-04 análogos de camptotecina, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os ditos compostos BRPI0614608A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0508364A FR2889527A1 (fr) 2005-08-05 2005-08-05 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2006/001901 WO2007017585A2 (fr) 2005-08-05 2006-08-04 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BRPI0614608A2 true BRPI0614608A2 (pt) 2016-11-16

Family

ID=36216903

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0614608A BRPI0614608A2 (pt) 2005-08-05 2006-08-04 análogos de camptotecina, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os ditos compostos

Country Status (19)

Country Link
US (1) US20100168149A1 (pt)
EP (1) EP1910377A2 (pt)
JP (1) JP2009503039A (pt)
KR (1) KR20080032007A (pt)
CN (1) CN101238133A (pt)
AR (1) AR056189A1 (pt)
AU (1) AU2006277863A1 (pt)
BR (1) BRPI0614608A2 (pt)
CA (1) CA2617957C (pt)
EA (1) EA014689B1 (pt)
FR (1) FR2889527A1 (pt)
GE (1) GEP20115243B (pt)
MA (1) MA29653B1 (pt)
MX (1) MX2008001560A (pt)
MY (1) MY150497A (pt)
NO (1) NO20081169L (pt)
UA (1) UA95253C2 (pt)
WO (1) WO2007017585A2 (pt)
ZA (1) ZA200801991B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2014127214A1 (en) 2013-02-15 2014-08-21 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
ES2831625T3 (es) 2013-02-20 2021-06-09 Kala Pharmaceuticals Inc Compuestos terapéuticos y sus usos
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
WO2015066482A1 (en) 2013-11-01 2015-05-07 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN106188079A (zh) * 2016-07-09 2016-12-07 兰州大学 喜树碱7‑位哌嗪硫脲类化合物、制备方法和用途
AU2017324716B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324251A1 (en) 2016-09-08 2019-03-21 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
CN110357897A (zh) * 2019-07-26 2019-10-22 上海健康医学院 一种具有抗肿瘤活性的喜树碱衍生物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6111107A (en) * 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols
US6699876B2 (en) * 1999-11-18 2004-03-02 Les Laboratoires Servier Camptothecin analogue compounds
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
CN100443486C (zh) * 2002-09-11 2008-12-17 中国医学科学院药物研究所 7-酯化和7,20-双酯化的喜树碱衍生物及其制法和其药物组合物与用途
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ZA200801991B (en) 2009-08-26
WO2007017585A3 (fr) 2007-04-12
EA200800393A1 (ru) 2008-08-29
GEP20115243B (en) 2011-06-27
FR2889527A1 (fr) 2007-02-09
MA29653B1 (fr) 2008-07-01
AU2006277863A1 (en) 2007-02-15
CN101238133A (zh) 2008-08-06
NO20081169L (no) 2008-03-05
JP2009503039A (ja) 2009-01-29
UA95253C2 (ru) 2011-07-25
WO2007017585A2 (fr) 2007-02-15
CA2617957A1 (fr) 2007-02-15
MX2008001560A (es) 2008-02-15
US20100168149A1 (en) 2010-07-01
KR20080032007A (ko) 2008-04-11
CA2617957C (fr) 2011-09-20
AR056189A1 (es) 2007-09-26
MY150497A (en) 2014-01-30
EA014689B1 (ru) 2010-12-30
EP1910377A2 (fr) 2008-04-16

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Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SOLICITA-SE A REGULARIZACAO DA PROCURACAO, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO NO ORIGINAL, TRASLADO OU FOTOCOPIA AUTENTICADA.

B11Z Dismissal: petition dismissal - article 216, par 2 of industrial property law

Free format text: REFERENTE A PETICAO NO 20080016855/RJ DE 01/02/2008.

B11M Decision cancelled [chapter 11.13 patent gazette]

Free format text: O DESPACHO 11.6.1 ESTA SENDO ANULADO TENDO POR BASE A DETERMINACAO DO DIRETOR DE PATENTES, A QUAL E CALCADA NO PARECER NO 0003-2014 AGU/PGF/PFE/INPI/COOPHI-LBC-1.0.

B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]