BRPI0609939A2 - método para tratar cáncer de ovário avançado com doxorubicina capturada em lipossomas - Google Patents
método para tratar cáncer de ovário avançado com doxorubicina capturada em lipossomas Download PDFInfo
- Publication number
- BRPI0609939A2 BRPI0609939A2 BRPI0609939-4A BRPI0609939A BRPI0609939A2 BR PI0609939 A2 BRPI0609939 A2 BR PI0609939A2 BR PI0609939 A BRPI0609939 A BR PI0609939A BR PI0609939 A2 BRPI0609939 A2 BR PI0609939A2
- Authority
- BR
- Brazil
- Prior art keywords
- administration comprises
- comprises administering
- liposome
- captured
- ovarian cancer
- Prior art date
Links
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims abstract description 37
- 206010033128 Ovarian cancer Diseases 0.000 title claims abstract description 30
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims abstract description 23
- 229960004679 doxorubicin Drugs 0.000 title claims abstract description 18
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 26
- 230000004044 response Effects 0.000 claims abstract description 21
- 239000002502 liposome Substances 0.000 claims abstract description 14
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 13
- 229930012538 Paclitaxel Natural products 0.000 claims abstract description 11
- 229960001592 paclitaxel Drugs 0.000 claims abstract description 11
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims abstract description 11
- 239000002246 antineoplastic agent Substances 0.000 claims abstract description 5
- 229940127089 cytotoxic agent Drugs 0.000 claims abstract description 5
- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 201000011510 cancer Diseases 0.000 claims description 15
- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 9
- 230000004083 survival effect Effects 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 7
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 3
- 229960004316 cisplatin Drugs 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 230000000973 chemotherapeutic effect Effects 0.000 claims 4
- 238000002512 chemotherapy Methods 0.000 abstract description 18
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 abstract description 6
- 238000011282 treatment Methods 0.000 description 16
- 201000010099 disease Diseases 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 11
- 231100000419 toxicity Toxicity 0.000 description 9
- 230000001988 toxicity Effects 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 210000001672 ovary Anatomy 0.000 description 5
- 229940115080 doxil Drugs 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 206010065553 Bone marrow failure Diseases 0.000 description 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 3
- 102100023123 Mucin-16 Human genes 0.000 description 3
- 208000007660 Residual Neoplasm Diseases 0.000 description 3
- 238000009108 consolidation therapy Methods 0.000 description 3
- 238000011396 initial chemotherapy Methods 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 230000009401 metastasis Effects 0.000 description 3
- 206010028116 Mucosal inflammation Diseases 0.000 description 2
- 201000010927 Mucositis Diseases 0.000 description 2
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 238000011500 cytoreductive surgery Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000004197 pelvis Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010061819 Disease recurrence Diseases 0.000 description 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 1
- 229940123237 Taxane Drugs 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 231100000230 acceptable toxicity Toxicity 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- 190000008236 carboplatin Chemical compound 0.000 description 1
- 231100000026 common toxicity Toxicity 0.000 description 1
- 229960000975 daunorubicin Drugs 0.000 description 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 229960001904 epirubicin Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229960000908 idarubicin Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 208000004235 neutropenia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 238000011518 platinum-based chemotherapy Methods 0.000 description 1
- 210000004910 pleural fluid Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 238000011255 standard chemotherapy Methods 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67418805P | 2005-04-21 | 2005-04-21 | |
| US60/674,188 | 2005-04-21 | ||
| PCT/US2006/015528 WO2006116341A1 (en) | 2005-04-21 | 2006-04-20 | Method for treating advanced ovarian cancer with doxorubicin entrapped in liposomes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0609939A2 true BRPI0609939A2 (pt) | 2010-05-11 |
Family
ID=36811891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0609939-4A BRPI0609939A2 (pt) | 2005-04-21 | 2006-04-20 | método para tratar cáncer de ovário avançado com doxorubicina capturada em lipossomas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20070026060A1 (enExample) |
| EP (1) | EP1874324A1 (enExample) |
| JP (1) | JP2008538584A (enExample) |
| KR (1) | KR20080008367A (enExample) |
| CN (1) | CN101163485A (enExample) |
| AU (1) | AU2006238877A1 (enExample) |
| BR (1) | BRPI0609939A2 (enExample) |
| CA (1) | CA2605669A1 (enExample) |
| IL (1) | IL186699A0 (enExample) |
| MX (1) | MX2007013056A (enExample) |
| WO (1) | WO2006116341A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2609216T3 (en) | 2010-08-24 | 2016-09-12 | Dana Farber Cancer Inst Inc | Methods to predict anti-cancer response |
| EP3693473B1 (en) | 2011-06-17 | 2025-02-19 | Myriad Genetics, Inc. | Methods and materials for assessing allelic imbalance |
| UY34295A (es) * | 2011-09-08 | 2013-04-30 | Servier Lab | Nuevo esquema de administración de la n-hidroxi -4- {2-[3- (n,ndimetilaminometil)benzofuran -2- ilcarbonilamino]etoxi}benzamida |
| BR112014015152A2 (pt) | 2011-12-21 | 2017-07-04 | Myriad Genetics Inc | métodos e materiais para a avaliação da perda de heterozigosidade |
| DK3415915T3 (da) | 2012-02-23 | 2024-11-04 | Childrens Medical Center | Fremgangsmåde til at forudsige respons til PARP-inhibitorer |
| AU2013273466B2 (en) | 2012-06-07 | 2018-11-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for detecting inactivation of the homologous recombination pathway (BRCA1/2) in human tumors |
| WO2014160080A1 (en) | 2013-03-14 | 2014-10-02 | Children's Medical Center Corporation | Cancer diagnosis, treatment selection and treatment |
| WO2015086473A1 (en) | 2013-12-09 | 2015-06-18 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| ES2946251T3 (es) | 2014-08-15 | 2023-07-14 | Myriad Genetics Inc | Métodos y materiales para evaluar la deficiencia de recombinación homóloga |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6923966B2 (en) * | 1999-04-08 | 2005-08-02 | Schering Corporation | Melanoma therapy |
| WO2001032145A1 (en) * | 1999-10-29 | 2001-05-10 | Board Of Regents, The University Of Texas System | Method of cancer treatment |
-
2006
- 2006-04-20 BR BRPI0609939-4A patent/BRPI0609939A2/pt not_active IP Right Cessation
- 2006-04-20 KR KR1020077026950A patent/KR20080008367A/ko not_active Withdrawn
- 2006-04-20 CN CNA2006800130738A patent/CN101163485A/zh active Pending
- 2006-04-20 WO PCT/US2006/015528 patent/WO2006116341A1/en not_active Ceased
- 2006-04-20 MX MX2007013056A patent/MX2007013056A/es not_active Application Discontinuation
- 2006-04-20 AU AU2006238877A patent/AU2006238877A1/en not_active Abandoned
- 2006-04-20 JP JP2008507989A patent/JP2008538584A/ja not_active Withdrawn
- 2006-04-20 CA CA002605669A patent/CA2605669A1/en not_active Abandoned
- 2006-04-20 EP EP06751290A patent/EP1874324A1/en not_active Ceased
- 2006-04-20 US US11/408,201 patent/US20070026060A1/en not_active Abandoned
-
2007
- 2007-10-16 IL IL186699A patent/IL186699A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007013056A (es) | 2008-04-07 |
| CN101163485A (zh) | 2008-04-16 |
| AU2006238877A1 (en) | 2006-11-02 |
| JP2008538584A (ja) | 2008-10-30 |
| WO2006116341A1 (en) | 2006-11-02 |
| CA2605669A1 (en) | 2006-11-02 |
| US20070026060A1 (en) | 2007-02-01 |
| KR20080008367A (ko) | 2008-01-23 |
| EP1874324A1 (en) | 2008-01-09 |
| IL186699A0 (en) | 2008-02-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: JOHNSON AND JOHNSON (US) Free format text: TRANSFERIDO DE: ALZA CORPORATION |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |