BRPI0519141A2 - processo para e intermediÁrios na preparaÇço de canfosfamida e dos sais das mesmas, composiÇÕes farmacÊuticas contendo alguns intermediÁrios e o uso do mesmo como agentes anticÂncer - Google Patents
processo para e intermediÁrios na preparaÇço de canfosfamida e dos sais das mesmas, composiÇÕes farmacÊuticas contendo alguns intermediÁrios e o uso do mesmo como agentes anticÂncerInfo
- Publication number
- BRPI0519141A2 BRPI0519141A2 BRPI0519141-6A BRPI0519141A BRPI0519141A2 BR PI0519141 A2 BRPI0519141 A2 BR PI0519141A2 BR PI0519141 A BRPI0519141 A BR PI0519141A BR PI0519141 A2 BRPI0519141 A2 BR PI0519141A2
- Authority
- BR
- Brazil
- Prior art keywords
- intermediates
- salts
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/36—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/018,391 US8198247B2 (en) | 2004-12-21 | 2004-12-21 | Process for and intermediates in the preparation of canfosfamide and its salts |
| PCT/US2005/042693 WO2006068769A1 (en) | 2004-12-21 | 2005-11-23 | Process for and intermediates in the preparation of canfosfamide and its salts, pharmaceutical compositions containing some intermediates, and their use as anticancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519141A2 true BRPI0519141A2 (pt) | 2008-12-30 |
Family
ID=36216909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519141-6A BRPI0519141A2 (pt) | 2004-12-21 | 2005-11-23 | processo para e intermediÁrios na preparaÇço de canfosfamida e dos sais das mesmas, composiÇÕes farmacÊuticas contendo alguns intermediÁrios e o uso do mesmo como agentes anticÂncer |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8198247B2 (enExample) |
| EP (1) | EP1827605B1 (enExample) |
| JP (1) | JP5060306B2 (enExample) |
| KR (1) | KR20070089795A (enExample) |
| CN (1) | CN101080251B (enExample) |
| AR (1) | AR052167A1 (enExample) |
| AU (1) | AU2005319579B2 (enExample) |
| BR (1) | BRPI0519141A2 (enExample) |
| CA (1) | CA2587088A1 (enExample) |
| EA (1) | EA016052B1 (enExample) |
| IL (1) | IL182835A0 (enExample) |
| MX (1) | MX2007007215A (enExample) |
| TW (1) | TW200633717A (enExample) |
| WO (1) | WO2006068769A1 (enExample) |
| ZA (1) | ZA200704318B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100056825A1 (en) * | 2008-08-28 | 2010-03-04 | Telik, Inc. | Formulations of canfosfamide and their preparation |
| US8324426B2 (en) | 2008-08-28 | 2012-12-04 | Telik, Inc. | Formulations of canfosfamide and their preparation |
| CA2733732A1 (en) * | 2011-02-25 | 2012-08-25 | Telik, Inc. | Formulations of canfosfamide and their preparation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US6627732B1 (en) * | 1998-04-16 | 2003-09-30 | Teijin Limited | Glutathione derivatives and their dosage forms |
| US6417397B1 (en) * | 1999-10-04 | 2002-07-09 | The Regents Of The University Of California, San Diego | N-substituted alkylamino acids for use as amino-protecting groups |
| UA74574C2 (en) | 2000-05-02 | 2006-01-16 | Telik Inc | Bis (n,n'-bis(2-halogenethyl)amino)phosphodiamates, a method for producing thereof (variants), a pharmaceutical composition containing them, and a method for the treatment of tumors |
| US6506739B1 (en) * | 2001-05-01 | 2003-01-14 | Telik, Inc. | Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents |
| CN101090977B (zh) * | 2005-01-06 | 2013-04-10 | 泰立克公司 | 三肽和四肽硫醚 |
-
2004
- 2004-12-21 US US11/018,391 patent/US8198247B2/en not_active Expired - Fee Related
-
2005
- 2005-11-23 BR BRPI0519141-6A patent/BRPI0519141A2/pt not_active IP Right Cessation
- 2005-11-23 EA EA200701180A patent/EA016052B1/ru not_active IP Right Cessation
- 2005-11-23 WO PCT/US2005/042693 patent/WO2006068769A1/en not_active Ceased
- 2005-11-23 MX MX2007007215A patent/MX2007007215A/es active IP Right Grant
- 2005-11-23 AU AU2005319579A patent/AU2005319579B2/en not_active Ceased
- 2005-11-23 EP EP05852166.7A patent/EP1827605B1/en not_active Expired - Lifetime
- 2005-11-23 CA CA002587088A patent/CA2587088A1/en not_active Abandoned
- 2005-11-23 JP JP2007548240A patent/JP5060306B2/ja not_active Expired - Fee Related
- 2005-11-23 TW TW094141102A patent/TW200633717A/zh unknown
- 2005-11-23 CN CN2005800428600A patent/CN101080251B/zh not_active Expired - Fee Related
- 2005-11-23 KR KR1020077012351A patent/KR20070089795A/ko not_active Abandoned
- 2005-12-15 AR ARP050105289A patent/AR052167A1/es not_active Application Discontinuation
-
2007
- 2007-04-26 IL IL182835A patent/IL182835A0/en unknown
- 2007-05-25 ZA ZA200704318A patent/ZA200704318B/xx unknown
-
2012
- 2012-03-23 US US13/429,065 patent/US8334266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006068769A1 (en) | 2006-06-29 |
| AU2005319579B2 (en) | 2011-07-21 |
| CN101080251A (zh) | 2007-11-28 |
| JP2008524327A (ja) | 2008-07-10 |
| US8334266B2 (en) | 2012-12-18 |
| KR20070089795A (ko) | 2007-09-03 |
| IL182835A0 (en) | 2007-08-19 |
| TW200633717A (en) | 2006-10-01 |
| JP5060306B2 (ja) | 2012-10-31 |
| AR052167A1 (es) | 2007-03-07 |
| EP1827605A1 (en) | 2007-09-05 |
| MX2007007215A (es) | 2007-08-14 |
| EP1827605B1 (en) | 2014-03-26 |
| US20120238772A1 (en) | 2012-09-20 |
| CA2587088A1 (en) | 2006-06-29 |
| AU2005319579A1 (en) | 2006-06-29 |
| US20060135409A1 (en) | 2006-06-22 |
| ZA200704318B (en) | 2008-09-25 |
| US8198247B2 (en) | 2012-06-12 |
| EA016052B1 (ru) | 2012-01-30 |
| CN101080251B (zh) | 2012-08-29 |
| EA200701180A1 (ru) | 2008-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0712631A8 (pt) | compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações | |
| UY30481A1 (es) | Isoxazolinas sustituidas, composiciones farmaccuticas que contienen a las mismas, metodos de preparacion y usos. | |
| BR112014007193A2 (pt) | derivados de pirazoloquinolinona, preparação dos mesmos e uso terapêutico dos mesmos | |
| PA8772101A1 (es) | Imidazol-triazolopirimidinas sustituidas | |
| DOP2012000310A (es) | Morfolinopirimidinas y su uso en terapia | |
| BRPI0721905B8 (pt) | composto inibidor de proteassoma, sua composição farmacêutica e seu uso | |
| DOP2010000387A (es) | Compuestos pirazolicos 436 | |
| BR112012011793A2 (pt) | "acrilamidas heterocíclicas e seu uso como farmacêuticos" | |
| PA8660301A1 (es) | Pirazolo piridinas sustituidas, composiciones que las contienen, procedimiento de fabricacion y utilizacion | |
| CR11623A (es) | Compuestos | |
| BR112014016165A2 (pt) | compostos de benzaldeído substituído e métodos para seu uso no aumento da oxigenação do tecido | |
| BRPI0813237B8 (pt) | composto, método para preparar o composto, medicamento, e, uso do composto | |
| BRPI0916069B8 (pt) | composto, usos de um composto e composição farmacêutica | |
| CL2009001484A1 (es) | Sal glicinato de metformina; composición farmacéutica que comprende la sal; y su uso para tratar la hiperglicemia. | |
| DOP2013000130A (es) | Compuestos de pirimidinona para uso en el tratamiento de las enfermedades o condiciones mediada por lp - pla2 | |
| BRPI0509655A (pt) | uso de derivados de 9h-purina-2,6-diamina no tratamento de doenças proliferativas e novos derivados de 9h-purina-2,6-diamina | |
| BRPI0906444B8 (pt) | compostos de 4-piridinona, composição farmacêutica que os compreende, bem como uso dos mesmos | |
| BRPI0508540A (pt) | composto, composição farmacêutica, e, uso de um composto | |
| BR112014014452A2 (pt) | derivados de pirazolpiridina, processo de preparação dos mesmos e uso terapêutico dos mesmos | |
| BRPI0817597A2 (pt) | Compostos de diarila de oxadiazol, processo para sua preparação, composições farmacêuticas e kit compreendendo os mesmos, bem como seus usos | |
| BR112013032766A2 (pt) | "compostos de ligação com catepsina, composto que visa catepsina, processo para a preparação dos referidos compostos e usos dos mesmos na preparação de medicamentos | |
| BR112012012261A2 (pt) | compostos como moduladores de receptor com utilidade terapêutica | |
| BRPI0513819A (pt) | inibidores de hsp90 | |
| GT200600144A (es) | 1h-quinazolin-2,4-dionas | |
| BR112015005347A2 (pt) | composto, composição farmacêutica, e, método para tratamento ou profilaxia de infecção por hiv ou para tratamento, profilaxia, ou atraso no início de aids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2281 DE 23/09/2014. |