BRPI0515449A2 - n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers - Google Patents
n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymersInfo
- Publication number
- BRPI0515449A2 BRPI0515449A2 BRPI0515449-9A BRPI0515449A BRPI0515449A2 BR PI0515449 A2 BRPI0515449 A2 BR PI0515449A2 BR PI0515449 A BRPI0515449 A BR PI0515449A BR PI0515449 A2 BRPI0515449 A2 BR PI0515449A2
- Authority
- BR
- Brazil
- Prior art keywords
- trifluoro
- fluorophenyl
- cyanocyclopropyl
- propionamide
- ethylamino
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
POLIMORFOS DE INIBIDOR DE CISTEÍNA PROTEASE N-(1-CIANOCICLOPROPIL)-3-CICLOPROPILMETANOSSULFO- NIL-2 (R)-[2,2,2-TRIFLUORO-1(S)-(4-FLUOROFENIL) ETILAMINO] PRO- PIONAMIDA. A presente invenção refere-se a polimorfos de N-(1-cianociclo- propil)-3-ciclopropilmetanossulfanil-2 (R)-[2 ,2,2-Trifluoro-1 (S)-(4-fluorofenil) etilamino] propionamida, métodos de uso dos mesmos para tratamento de uma doença mediada por catepsina S, composições farmacêuticas contendo tais polimorfos e processos para prepará-las.N- (1-CYANOCYCLOPROPIL) -3-CYCLPROPYLMETANOSULFOUR-NYL 2-R (R) - [2,2,2-TRIFLUORO-1 (S) - (4-FLUOROPHENYL) ETHYLAMINE] PROPYNAMIDE POLYMORPHES The present invention relates to N- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfanyl-2 (R) - [2,2,2-Trifluoro-1 (S) - (4-fluorophenyl) ethylamino] propionamide polymorphs methods of using them for treating a cathepsin S-mediated disease, pharmaceutical compositions containing such polymorphs and processes for preparing them.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2004/030442 WO2005028429A2 (en) | 2003-09-18 | 2004-09-17 | Haloalkyl containing compounds as cysteine protease inhibitors |
US10/943,768 US7547701B2 (en) | 2003-09-18 | 2004-09-17 | Haloalkyl containing compounds as cysteine protease inhibitors |
US66424405P | 2005-03-21 | 2005-03-21 | |
PCT/US2005/033074 WO2006034006A1 (en) | 2004-09-17 | 2005-09-16 | Polymorphs of the cysteine protease inhibitor n- (1-cyanocyclopropyl)-3-cyclopropylmethansulfonyl-2 (r) - (2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino) propionamide |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515449A2 true BRPI0515449A2 (en) | 2008-12-16 |
Family
ID=38325575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515449-9A BRPI0515449A2 (en) | 2004-09-17 | 2005-09-16 | n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers |
Country Status (5)
Country | Link |
---|---|
BR (1) | BRPI0515449A2 (en) |
IL (1) | IL181791A0 (en) |
MX (1) | MX2007003112A (en) |
NO (1) | NO20071936L (en) |
ZA (1) | ZA200703104B (en) |
-
2005
- 2005-09-16 MX MX2007003112A patent/MX2007003112A/en unknown
- 2005-09-16 BR BRPI0515449-9A patent/BRPI0515449A2/en not_active Application Discontinuation
-
2007
- 2007-03-08 IL IL181791A patent/IL181791A0/en unknown
- 2007-04-16 NO NO20071936A patent/NO20071936L/en unknown
- 2007-04-16 ZA ZA200703104A patent/ZA200703104B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007003112A (en) | 2007-05-21 |
ZA200703104B (en) | 2008-09-25 |
NO20071936L (en) | 2007-06-12 |
IL181791A0 (en) | 2007-07-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA29135B1 (en) | POTENTIALIZERS OF GLUTAMATE RECEPTORS | |
EA200870127A1 (en) | POLYCYCLIC DERIVATIVES OF AMINO ACIDS AND METHODS OF THEIR APPLICATION | |
CL2003002683A1 (en) | ENANTIOMERS S OF COMPOUNDS DERIVED FROM ACID (2S) -3-4 (- {2-AMINO-2-OXOETOXI} PHENYL) -2-ETOXIPROPANOIC; PREPARATION PROCESS; INTERMEDIARY COMPOUNDS; PHARMACEUTICAL COMPOSITION; AND ITS USE FOR THE TREATMENT OR PREVENTION OF LIPID DISORDERS, | |
NO20083956L (en) | Prodrugs of GABA analogs, compositions and uses thereof | |
CY1111212T1 (en) | Sulphate Compounds as Inhibitors of Serine Protease NS3 of US Virus C | |
BR0305426A (en) | Hsv ns5b polymerase inhibitor compounds as well as pharmaceutical composition comprising the same | |
BRPI0508051A (en) | heteroarylaminopyrazole derivatives usable for the treatment of diabetes | |
BRPI0409227B8 (en) | "compound, pharmaceutical composition, use of a compound and process for the preparation of a compound of formula (i)" | |
EA200801711A1 (en) | PROCEDURES FOR EXCESSING AMINO ACIDS | |
BRPI0410081A (en) | compound, pharmaceutical composition, method of treating a jak3-mediated disease or condition, and process for the preparation of a compound | |
DK1465626T3 (en) | Pharmaceutical compositions (kits) comprising dihydropyridinone compounds and an immunoregulatory (or anti-inflammatory) agent and uses thereof | |
CY1110214T1 (en) | METHODS AND INTERMEDIATES | |
DE60229530D1 (en) | SUBSTITUTED PIPERAZINE AS MODULATORS OF MELANOCORTINRECEPTOR | |
BR0316771A (en) | Compounds for the treatment or prevention of flavivirus infections, use of a compound and pharmaceutical composition | |
NO20044808L (en) | Heterocyclic sulfonamides which are hepatitis C virus inhibitors | |
SE0301009D0 (en) | Novel compounds | |
NO20063205L (en) | Inhibitors of hepatitis C virus NS3 / NS4A serine protease | |
BRPI0507052A (en) | kinase inhibitors | |
BRPI0414868A (en) | compositions and methods comprising prostaglandin-related compounds and trifoliate factor family peptides for the treatment of glaucoma with reduced hyperemia | |
BR0316723A (en) | Anilinopyrazole derivatives useful for the treatment of diabetes | |
DE602005010421D1 (en) | New Cysteine Protease Inhibitors and Their Therapeutic Applications | |
CY1109975T1 (en) | PARA-ALKYL-SUBSTITUTED N-(4-HYDROXY-3-METHOXY-BENZYL) AMIDIA AMINAMIC ACID AND THEIR USE FOR PARASKA | |
BR0312522A (en) | Method for the preparation of virus inactivated thrombin, thrombin, pharmaceutical formulation, and pharmaceutical kit | |
AR039664A1 (en) | PHARMACEUTICAL COMPOSITION INCLUDED BY A LIPASE AND GLUCOMANAN INHIBITOR | |
EA200600737A1 (en) | COMPOUNDS AND METHODS FOR THE TREATMENT OF DYSLIPIDEMIA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |