BRPI0515449A2 - n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers - Google Patents
n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymersInfo
- Publication number
- BRPI0515449A2 BRPI0515449A2 BRPI0515449-9A BRPI0515449A BRPI0515449A2 BR PI0515449 A2 BRPI0515449 A2 BR PI0515449A2 BR PI0515449 A BRPI0515449 A BR PI0515449A BR PI0515449 A2 BRPI0515449 A2 BR PI0515449A2
- Authority
- BR
- Brazil
- Prior art keywords
- trifluoro
- fluorophenyl
- cyanocyclopropyl
- propionamide
- ethylamino
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
POLIMORFOS DE INIBIDOR DE CISTEÍNA PROTEASE N-(1-CIANOCICLOPROPIL)-3-CICLOPROPILMETANOSSULFO- NIL-2 (R)-[2,2,2-TRIFLUORO-1(S)-(4-FLUOROFENIL) ETILAMINO] PRO- PIONAMIDA. A presente invenção refere-se a polimorfos de N-(1-cianociclo- propil)-3-ciclopropilmetanossulfanil-2 (R)-[2 ,2,2-Trifluoro-1 (S)-(4-fluorofenil) etilamino] propionamida, métodos de uso dos mesmos para tratamento de uma doença mediada por catepsina S, composições farmacêuticas contendo tais polimorfos e processos para prepará-las.N- (1-CYANOCYCLOPROPIL) -3-CYCLPROPYLMETANOSULFOUR-NYL 2-R (R) - [2,2,2-TRIFLUORO-1 (S) - (4-FLUOROPHENYL) ETHYLAMINE] PROPYNAMIDE POLYMORPHES The present invention relates to N- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfanyl-2 (R) - [2,2,2-Trifluoro-1 (S) - (4-fluorophenyl) ethylamino] propionamide polymorphs methods of using them for treating a cathepsin S-mediated disease, pharmaceutical compositions containing such polymorphs and processes for preparing them.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2004/030442 WO2005028429A2 (en) | 2003-09-18 | 2004-09-17 | Haloalkyl containing compounds as cysteine protease inhibitors |
US10/943,768 US7547701B2 (en) | 2003-09-18 | 2004-09-17 | Haloalkyl containing compounds as cysteine protease inhibitors |
US66424405P | 2005-03-21 | 2005-03-21 | |
PCT/US2005/033074 WO2006034006A1 (en) | 2004-09-17 | 2005-09-16 | Polymorphs of the cysteine protease inhibitor n- (1-cyanocyclopropyl)-3-cyclopropylmethansulfonyl-2 (r) - (2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino) propionamide |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515449A2 true BRPI0515449A2 (en) | 2008-12-16 |
Family
ID=38325575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515449-9A BRPI0515449A2 (en) | 2004-09-17 | 2005-09-16 | n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers |
Country Status (5)
Country | Link |
---|---|
BR (1) | BRPI0515449A2 (en) |
IL (1) | IL181791A0 (en) |
MX (1) | MX2007003112A (en) |
NO (1) | NO20071936L (en) |
ZA (1) | ZA200703104B (en) |
-
2005
- 2005-09-16 BR BRPI0515449-9A patent/BRPI0515449A2/en not_active Application Discontinuation
- 2005-09-16 MX MX2007003112A patent/MX2007003112A/en unknown
-
2007
- 2007-03-08 IL IL181791A patent/IL181791A0/en unknown
- 2007-04-16 ZA ZA200703104A patent/ZA200703104B/en unknown
- 2007-04-16 NO NO20071936A patent/NO20071936L/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL181791A0 (en) | 2007-07-04 |
NO20071936L (en) | 2007-06-12 |
ZA200703104B (en) | 2008-09-25 |
MX2007003112A (en) | 2007-05-21 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |