BRPI0515449A2 - n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers - Google Patents

n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers

Info

Publication number
BRPI0515449A2
BRPI0515449A2 BRPI0515449-9A BRPI0515449A BRPI0515449A2 BR PI0515449 A2 BRPI0515449 A2 BR PI0515449A2 BR PI0515449 A BRPI0515449 A BR PI0515449A BR PI0515449 A2 BRPI0515449 A2 BR PI0515449A2
Authority
BR
Brazil
Prior art keywords
trifluoro
fluorophenyl
cyanocyclopropyl
propionamide
ethylamino
Prior art date
Application number
BRPI0515449-9A
Other languages
Portuguese (pt)
Inventor
Sheila M Zipfel
Soon H Woo
Donglai Yang
Simon Bates
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/030442 external-priority patent/WO2005028429A2/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Priority claimed from PCT/US2005/033074 external-priority patent/WO2006034006A1/en
Publication of BRPI0515449A2 publication Critical patent/BRPI0515449A2/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

POLIMORFOS DE INIBIDOR DE CISTEÍNA PROTEASE N-(1-CIANOCICLOPROPIL)-3-CICLOPROPILMETANOSSULFO- NIL-2 (R)-[2,2,2-TRIFLUORO-1(S)-(4-FLUOROFENIL) ETILAMINO] PRO- PIONAMIDA. A presente invenção refere-se a polimorfos de N-(1-cianociclo- propil)-3-ciclopropilmetanossulfanil-2 (R)-[2 ,2,2-Trifluoro-1 (S)-(4-fluorofenil) etilamino] propionamida, métodos de uso dos mesmos para tratamento de uma doença mediada por catepsina S, composições farmacêuticas contendo tais polimorfos e processos para prepará-las.N- (1-CYANOCYCLOPROPIL) -3-CYCLPROPYLMETANOSULFOUR-NYL 2-R (R) - [2,2,2-TRIFLUORO-1 (S) - (4-FLUOROPHENYL) ETHYLAMINE] PROPYNAMIDE POLYMORPHES The present invention relates to N- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfanyl-2 (R) - [2,2,2-Trifluoro-1 (S) - (4-fluorophenyl) ethylamino] propionamide polymorphs methods of using them for treating a cathepsin S-mediated disease, pharmaceutical compositions containing such polymorphs and processes for preparing them.

BRPI0515449-9A 2004-09-17 2005-09-16 n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers BRPI0515449A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2004/030442 WO2005028429A2 (en) 2003-09-18 2004-09-17 Haloalkyl containing compounds as cysteine protease inhibitors
US10/943,768 US7547701B2 (en) 2003-09-18 2004-09-17 Haloalkyl containing compounds as cysteine protease inhibitors
US66424405P 2005-03-21 2005-03-21
PCT/US2005/033074 WO2006034006A1 (en) 2004-09-17 2005-09-16 Polymorphs of the cysteine protease inhibitor n- (1-cyanocyclopropyl)-3-cyclopropylmethansulfonyl-2 (r) - (2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino) propionamide

Publications (1)

Publication Number Publication Date
BRPI0515449A2 true BRPI0515449A2 (en) 2008-12-16

Family

ID=38325575

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515449-9A BRPI0515449A2 (en) 2004-09-17 2005-09-16 n- (1-cyanocyclopropyl) -3-cyclopropylmethanesulfonyl -2 (r) - [2,2,2-trifluoro-1 (s) - (4-fluorophenyl) ethylamino] propionamide cysteine protease inhibitor polymers

Country Status (5)

Country Link
BR (1) BRPI0515449A2 (en)
IL (1) IL181791A0 (en)
MX (1) MX2007003112A (en)
NO (1) NO20071936L (en)
ZA (1) ZA200703104B (en)

Also Published As

Publication number Publication date
MX2007003112A (en) 2007-05-21
ZA200703104B (en) 2008-09-25
NO20071936L (en) 2007-06-12
IL181791A0 (en) 2007-07-04

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]