BRPI0515403B8 - formulação farmacêutica capaz de inibir a atividade biológica da il-15, e, formulação de vacina - Google Patents

formulação farmacêutica capaz de inibir a atividade biológica da il-15, e, formulação de vacina

Info

Publication number
BRPI0515403B8
BRPI0515403B8 BRPI0515403A BRPI0515403A BRPI0515403B8 BR PI0515403 B8 BRPI0515403 B8 BR PI0515403B8 BR PI0515403 A BRPI0515403 A BR PI0515403A BR PI0515403 A BRPI0515403 A BR PI0515403A BR PI0515403 B8 BRPI0515403 B8 BR PI0515403B8
Authority
BR
Brazil
Prior art keywords
peptide
inhibiting
biological activity
formulation
pharmaceutical formulation
Prior art date
Application number
BRPI0515403A
Other languages
English (en)
Inventor
Santos Savio Alicia
Cabrales Rico Ania
Aurora Arrieta Agüero Celia
Gerónimo Pérez Haydee
Reyes Acosta Osvaldo
Ernesto Perea Rodríguez Silvio
Original Assignee
Ct Ingenieria Genetica Biotecnologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotecnologia filed Critical Ct Ingenieria Genetica Biotecnologia
Publication of BRPI0515403A publication Critical patent/BRPI0515403A/pt
Publication of BRPI0515403B1 publication Critical patent/BRPI0515403B1/pt
Publication of BRPI0515403B8 publication Critical patent/BRPI0515403B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

peptídeo, corrente de ácido nucleico, formulação farmacêutica, formulação de vacina, anticorpo monoclonal e usos do peptídeo e do anticorpo monoclonal a presente invenção se relaciona com o ramo da farmacologia molecular e em particular com um peptídeo pertencente à seqüência da interleucina- 15 (il- 15), que é capaz de inibir a atividade biológica desta molécula; análogos ou miméticos do dito peptídeo. na presente invenção mostra-se que o peptídeo ao unir-se à subunidade alfa do receptor (il- 15r) inibe a proliferação de células t induzida pela il- 15 e a apoptose mediada por tnf. a invenção se relaciona além disso com o uso do peptídeo no tratamento de patologias onde a expressão anormal da il-15 ou il-15r está relacionada com o curso da doença.
BRPI0515403A 2004-09-17 2005-09-16 formulação farmacêutica capaz de inibir a atividade biológica da il-15, e, formulação de vacina BRPI0515403B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CU2004-0198 2004-09-17
CU20040198A CU23472A1 (es) 2004-09-17 2004-09-17 Péptido antagonista de la interleucina-15
PCT/CU2005/000007 WO2006029578A1 (es) 2004-09-17 2005-09-16 Péptido antagonista de la interleucina-15

Publications (3)

Publication Number Publication Date
BRPI0515403A BRPI0515403A (pt) 2008-07-22
BRPI0515403B1 BRPI0515403B1 (pt) 2019-03-26
BRPI0515403B8 true BRPI0515403B8 (pt) 2021-05-25

Family

ID=40262834

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515403A BRPI0515403B8 (pt) 2004-09-17 2005-09-16 formulação farmacêutica capaz de inibir a atividade biológica da il-15, e, formulação de vacina

Country Status (18)

Country Link
US (1) US7736638B2 (pt)
EP (1) EP1801119B1 (pt)
JP (1) JP4750795B2 (pt)
KR (1) KR101254113B1 (pt)
CN (1) CN101120015B (pt)
AR (1) AR051924A1 (pt)
AT (1) ATE434623T1 (pt)
AU (1) AU2005284529C1 (pt)
BR (1) BRPI0515403B8 (pt)
CA (1) CA2579798C (pt)
CU (1) CU23472A1 (pt)
DE (1) DE602005015131D1 (pt)
ES (1) ES2328717T3 (pt)
MX (1) MX2007002996A (pt)
PT (1) PT1801119E (pt)
RU (1) RU2396276C2 (pt)
WO (1) WO2006029578A1 (pt)
ZA (1) ZA200702128B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23716A1 (es) 2008-09-30 2011-10-05 Ct Ingenieria Genetica Biotech Péptido antagonista de la actividad de la interleucina-15
CN101831435B (zh) * 2010-05-10 2013-09-11 昆山贝瑞康生物科技有限公司 小鼠il-15亚型蛋白的制备及其应用
DK2665486T3 (da) 2011-01-18 2020-03-09 Bioniz Llc Sammensætninger til modulering af gamma-c-cytokin-aktivitet
PL404138A1 (pl) 2013-05-31 2014-12-08 Warszawski Uniwersytet Medyczny Pochodne kwasu benzoesowego jako inhibitory receptora IL-15Rα
PL404174A1 (pl) 2013-05-31 2014-12-08 Warszawski Uniwersytet Medyczny Zastosowanie pochodnych aminowych jako inhibitorów aktywności interleukiny 15
PL405506A1 (pl) 2013-09-30 2015-04-13 Warszawski Uniwersytet Medyczny Zastosowanie pochodnej kwasu 7-aminocefalosporanowego jako inhibitora aktywności biologicznej IL-15 i IL-2
PL405505A1 (pl) 2013-09-30 2015-04-13 Warszawski Uniwersytet Medyczny Zastosowanie pochodnej kwasu diaminodikarboksylowego jako inhibitora aktywności biologicznej IL-15 I IL-2
US9959384B2 (en) 2013-12-10 2018-05-01 Bioniz, Llc Methods of developing selective peptide antagonists
MX2016008631A (es) * 2014-01-08 2016-12-20 Shanghai hengrui pharmaceutical co ltd Proteina heterodimérica il-5 y usos de la misma.
EP3237910B1 (en) * 2014-12-23 2019-04-17 Siemens Healthcare Diagnostics Inc. Proteolytic digestion and determination of cardiac troponin
SG11201708380WA (en) * 2015-04-13 2017-11-29 Regeneron Pharma Humanized sirpa-il15 knockin mice and methods of use thereof
EP3359556B1 (en) 2015-10-09 2021-05-26 Bioniz, LLC Modulating gamma - c -cytokine activity
KR102649972B1 (ko) 2016-10-14 2024-03-22 젠코어 인코포레이티드 IL15/IL15Rα 이종이량체 Fc-융합 단백질
AU2018257917B2 (en) 2017-04-24 2023-05-04 University Of Massachusetts Diagnosis and treatment of vitiligo
KR101954214B1 (ko) 2017-05-23 2019-03-06 (주)케어젠 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도
CU24545B1 (es) * 2017-12-29 2021-09-07 Ct Ingenieria Genetica Biotecnologia Péptido antagonista de la actividad de la interleucina-15
EP3781599A1 (en) 2018-04-18 2021-02-24 Xencor, Inc. Pd-1 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and pd-1 antigen binding domains and uses thereof
CA3097741A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains
CR20210239A (es) 2018-10-12 2021-12-15 Xencor Inc Proteínas de fusión de il-15/il-15ralfa-fc dirigidas a pd-1 y usos de las mismas en terapias combinadas
EP3897853A1 (en) 2018-12-20 2021-10-27 Xencor, Inc. Targeted heterodimeric fc fusion proteins containing il-15/il-15ra and nkg2d antigen binding domains
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
WO2024028448A1 (en) 2022-08-04 2024-02-08 Calypso Biotech Sa Il-15 inhibitors useful for the treatment of atopic dermatitis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2261433A1 (en) * 1993-12-09 1995-06-10 Belinda Sanchez Ramirez Composition comprising autologous epidermal growth factor
CA2186747C (en) 1994-04-06 2009-01-27 Kenneth H. Grabstein Interleukin-15
US5696234A (en) * 1994-08-01 1997-12-09 Schering Corporation Muteins of mammalian cytokine interleukin-13
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
DE69733610T2 (de) 1996-04-26 2006-05-11 Beth Israel Deaconess Medical Center, Inc., Boston Interleukin-15 antagonisten
EP0849583A1 (en) * 1996-12-12 1998-06-24 European Community Split Hopkinson bar testing apparatus
US6344192B1 (en) * 1997-02-21 2002-02-05 Vlaams Interuniversitair Instituut Voor Biotechnologie Use of interleukin-15
GB9814892D0 (en) 1998-07-10 1998-09-09 Kennedy Rheumatology Inst Treatment of celiac disease
WO2001002003A1 (en) * 1999-07-06 2001-01-11 Bulfone Paus Silvia Method of treating psoriasis with il-15 antagonist
US7247304B2 (en) * 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
CU23093A1 (es) * 2002-10-09 2005-10-19 Ct Ingenieria Genetica Biotech Composición vacunal que comprende interleucina-15 (il-15)
WO2005085282A1 (en) * 2004-02-27 2005-09-15 Inserm (Institut National De La Sante Et De La Recherche Medicale) Il-15 binding site for il15-ralpha and specific il-15 mutants having agonists/antagonists activity

Also Published As

Publication number Publication date
AU2005284529C1 (en) 2011-07-07
RU2396276C2 (ru) 2010-08-10
ZA200702128B (en) 2008-08-27
CN101120015A (zh) 2008-02-06
AR051924A1 (es) 2007-02-21
MX2007002996A (es) 2007-05-16
DE602005015131D1 (de) 2009-08-06
ATE434623T1 (de) 2009-07-15
PT1801119E (pt) 2009-09-21
CN101120015B (zh) 2011-05-25
BRPI0515403B1 (pt) 2019-03-26
CA2579798C (en) 2012-08-21
RU2007114288A (ru) 2008-10-27
ES2328717T3 (es) 2009-11-17
US7736638B2 (en) 2010-06-15
EP1801119A1 (en) 2007-06-27
BRPI0515403A (pt) 2008-07-22
EP1801119B1 (en) 2009-06-24
WO2006029578A1 (es) 2006-03-23
CA2579798A1 (en) 2006-03-23
AU2005284529A1 (en) 2006-03-23
CU23472A1 (es) 2009-12-17
AU2005284529B2 (en) 2010-11-25
JP2008512994A (ja) 2008-05-01
KR20070072876A (ko) 2007-07-06
JP4750795B2 (ja) 2011-08-17
US20090136511A1 (en) 2009-05-28
KR101254113B1 (ko) 2013-04-15

Similar Documents

Publication Publication Date Title
BRPI0515403B8 (pt) formulação farmacêutica capaz de inibir a atividade biológica da il-15, e, formulação de vacina
RU2454463C2 (ru) Соединение, предназначенное для стимуляции пути передачи сигнала через il-15rбета/гамма, с целью индуцировать и/или стимулировать активацию и/или пролиферацию il-15rбета/гамма-положительных клеток, таких как nk-и/или t-клетки, нуклеиновая кислота, кодирующая соединение, вектор экспрессии, клетка-хозяин, адъювант для иммунотерапевтической композиции, фармацевтическая композиция и лекарственное средство для лечения состояния или заболевания, при котором желательно повышение активности il-15, способ in vitro индукции и/или стимуляции пролиферации и/или активации il-15rбета/гамма-положительных клеток и способ получения in vitro активированных nk-и/или t-клеток
NO20080084L (no) Molekyler som er i stand til a hemme bindingen mellom NGF og TrkA-reseptoren som analgetika med forlenget effekt
BR112019012693A2 (pt) combinações de composto de fgf21/agonista do glp-1r com razão de atividade otimizada
BRPI0509172A (pt) pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento
BRPI0518013A (pt) inibidores de proteìna tirosina fosfatase, composição farmacêutica, complexo e métodos de uso dos mesmos
BRPI0519241A2 (pt) agonistas, composiÇÕes, mÉtodos e usos de glp-1
NO20091218L (no) CPG-oligonukleotidanaloger inneholdende hydrofobe T-analoger med forbedret immunstimulatorisk aktivitet
EA200900626A1 (ru) Комбинированное лечение ингибиторами sglt-2 (натрийзависимый сопереносчик глюкозы 2) и содержащими их фармацевтическими композициями
BRPI0717156B8 (pt) inibidores do co-transportador 2 da glicose de sódio e composição farmacêutica que os compreende
MA30474B1 (fr) Formulations de molecule peptide(s) -anticorps therapeutique lyophilisee.
NO20080745L (no) Nye peptider for anvendelse i behandling av fedme
NO20084256L (no) DPP IV inhibitorformuleringer
BRPI0817028A2 (pt) composto inibidor de diacilglicerol acil tranferase, composição farmacêutica que o contém, uso do composto, métodos para o tratamento ou profilaxia de diabetes, obesidade, distúrbios de alimentação e dislidemias e diabetes do tipo ii
BRPI0408247A (pt) usos de antagonistas e agonistas de il-23 e reagentes relacionados
MA32397B1 (fr) Agonistes mixtes basés sur gip destinés au traitement de troubles métaboliques et de l'obésité
BRPI0817482B8 (pt) uso de um anticorpo do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd)
BRPI0413563A (pt) compostos e composições como inibidores de atividade do receptor de quìnase de tirosina
BRPI0617830B8 (pt) uso de um anticorpo de ligação il-1beta e composições farmacêuticas compreendendo o mesmo
Ahmed-Belkacem et al. Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues
BRPI0710232B8 (pt) composto antagonista do receptor de il-8, composição farmacêutica que compreende o dito composto e uso do mesmo para o tratamento de uma doença mediada por quimiocina
BR0314212C1 (pt) projeto de análogos a quimiocina de proteìna-10 (ip-10 ou cxcl10) induzìveis por interferon para o tratamento de doenças humanas
BR112022022456A2 (pt) Proteínas de ligação de repetição de anquirina e seus usos
BRPI0519148A2 (pt) inibidores de homodimerizaÇço de myd88
CY1123240T1 (el) Αντισωμα αντι fgf23 και μια φαρμακευτικη συνθεση που το περιλαμβανει

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/03/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/09/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2640 DE 10-08-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.