BRPI0513046A - composição para prevenção e tratamento de doença inflamatória alérgica - Google Patents
composição para prevenção e tratamento de doença inflamatória alérgicaInfo
- Publication number
- BRPI0513046A BRPI0513046A BRPI0513046-8A BRPI0513046A BRPI0513046A BR PI0513046 A BRPI0513046 A BR PI0513046A BR PI0513046 A BRPI0513046 A BR PI0513046A BR PI0513046 A BRPI0513046 A BR PI0513046A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- allergic inflammatory
- prevention
- treatment
- benzamidine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
COMPOSIçãO PARA PREVENçãO E TRATAMENTO DE DOENçA INFLAMATóRIA ALéRGICA. A presente invenção refere-se a composição para tratamento e prevenção de doenças inflamatórias alérgicas compreendendo N-hidróxi-4-{5-¢4-{5-isopropil-2-metil-1,3-tiazo-4-yl)fenóxi!pentóxi}-ben zamidina, 4-{5-¢4-(5-isopropil-2-metil-1,3-tiazol-4-yl)fenóxi!pentóxi}-benzamidina ou sais farmaceuticamente aceitáveis. A composição exibe efeitos medicinais excelentes em doenças inflamatórias alérgicas, com uma grande redução nos sintomas inflamatórios crónicos típicos, tais como um aumento do nível de eosinófilos no fluido de lavagem broncoalveolar, no nível total de leucócitos e nível de eosinófilos no sangue, hipertrofia ou hiperplasia do epitélio bronquial devido a um aumento no número de células de muco, uma redução na área de superfíce alveolar resultante de uma hipertrofia das paredes alveolares, e a infiltração de células inflamatórias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20040052071 | 2004-07-05 | ||
PCT/KR2005/002139 WO2006004370A1 (en) | 2004-07-05 | 2005-07-05 | Composition for the prevention and treatment of allergic inflammatory disease |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0513046A true BRPI0513046A (pt) | 2008-04-22 |
Family
ID=35783132
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0513046-8A BRPI0513046A (pt) | 2004-07-05 | 2005-07-05 | composição para prevenção e tratamento de doença inflamatória alérgica |
Country Status (12)
Country | Link |
---|---|
US (1) | US20080200526A1 (pt) |
EP (1) | EP1773333A4 (pt) |
JP (1) | JP4657297B2 (pt) |
KR (1) | KR100682199B1 (pt) |
CN (1) | CN1997367B (pt) |
AU (1) | AU2005260328B2 (pt) |
BR (1) | BRPI0513046A (pt) |
CA (1) | CA2572898C (pt) |
HK (1) | HK1101674A1 (pt) |
IL (1) | IL180526A (pt) |
WO (1) | WO2006004370A1 (pt) |
ZA (1) | ZA200700113B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20060017929A (ko) | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
CN101652355B (zh) * | 2007-04-19 | 2012-11-07 | 同和药品株式会社 | N-羟基-4-{5-[4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苄脒2乙磺酸盐、其制备方法和包含其的药物组合物 |
CN109387593B (zh) * | 2017-08-11 | 2020-10-09 | 上海市徐汇区中心医院 | 急性髓细胞白血病化疗敏感性测评试剂盒及其应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455274A (en) * | 1992-12-09 | 1995-10-03 | Ciba-Geigy Corporation | Hydroxyamidine derivatives |
DE4309285A1 (de) * | 1993-03-23 | 1994-09-29 | Boehringer Ingelheim Kg | Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung |
WO1995032201A1 (en) * | 1994-05-25 | 1995-11-30 | G.D. Searle & Co. | Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists |
DE4424714A1 (de) * | 1994-07-13 | 1996-01-18 | Boehringer Ingelheim Kg | Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff |
TW332201B (en) * | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
DE19636689A1 (de) * | 1996-09-10 | 1998-03-12 | Boehringer Ingelheim Kg | Neue Benzamidinderivate |
JP3191943B2 (ja) * | 1997-02-04 | 2001-07-23 | ドン ワ ファーマシューティカル インダストリアル カンパニー リミテッド | 3−アミノ−1,2−ベンゾイソオキサゾール誘導体類とその製造方法及び用途 |
US6291531B1 (en) * | 1999-10-07 | 2001-09-18 | Boehringer Ingelheim Pharma Kg | LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition |
KR100454767B1 (ko) * | 2001-07-19 | 2004-11-03 | 동화약품공업주식회사 | 4-[(4-티아졸릴)페녹시]알콕시-벤즈아미딘 유도체의골다공증 예방 및 치료제로서의 용도 |
US6921752B2 (en) * | 2002-03-26 | 2005-07-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of LTB4 antagonists in veterinary medicine |
KR20060017929A (ko) * | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
BRPI0514386B8 (pt) * | 2004-11-23 | 2021-05-25 | Dong Wha Pharmaceutical Ind Co Ltd | bis (metanossulfonato) de n-hidróxi-4-{5-[4-(5-isopropil-2-metil-1,3-triazol-4-il)fenóxi]pentóxi}benzamidina, método para preparar os mesmos, suas composições farmacêuticas e formulações orais |
CN101652355B (zh) * | 2007-04-19 | 2012-11-07 | 同和药品株式会社 | N-羟基-4-{5-[4-(5-异丙基-2-甲基-1,3-噻唑-4-基)苯氧基]戊氧基}苄脒2乙磺酸盐、其制备方法和包含其的药物组合物 |
-
2005
- 2005-07-05 KR KR1020050060439A patent/KR100682199B1/ko not_active IP Right Cessation
- 2005-07-05 CN CN2005800226596A patent/CN1997367B/zh not_active Expired - Fee Related
- 2005-07-05 WO PCT/KR2005/002139 patent/WO2006004370A1/en active Application Filing
- 2005-07-05 AU AU2005260328A patent/AU2005260328B2/en not_active Ceased
- 2005-07-05 CA CA2572898A patent/CA2572898C/en not_active Expired - Fee Related
- 2005-07-05 EP EP05756782A patent/EP1773333A4/en not_active Withdrawn
- 2005-07-05 JP JP2007519133A patent/JP4657297B2/ja not_active Expired - Fee Related
- 2005-07-05 US US11/631,762 patent/US20080200526A1/en not_active Abandoned
- 2005-07-05 BR BRPI0513046-8A patent/BRPI0513046A/pt not_active IP Right Cessation
-
2007
- 2007-01-03 IL IL180526A patent/IL180526A/en not_active IP Right Cessation
- 2007-01-05 ZA ZA200700113A patent/ZA200700113B/en unknown
- 2007-08-31 HK HK07109471.2A patent/HK1101674A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2572898A1 (en) | 2006-01-12 |
WO2006004370A1 (en) | 2006-01-12 |
JP2008505069A (ja) | 2008-02-21 |
AU2005260328B2 (en) | 2009-10-01 |
KR20060049860A (ko) | 2006-05-19 |
CN1997367B (zh) | 2010-11-24 |
US20080200526A1 (en) | 2008-08-21 |
KR100682199B1 (ko) | 2007-02-12 |
HK1101674A1 (en) | 2007-10-26 |
EP1773333A1 (en) | 2007-04-18 |
ZA200700113B (en) | 2007-09-26 |
CN1997367A (zh) | 2007-07-11 |
CA2572898C (en) | 2010-04-20 |
JP4657297B2 (ja) | 2011-03-23 |
EP1773333A4 (en) | 2010-04-21 |
IL180526A (en) | 2010-11-30 |
AU2005260328A1 (en) | 2006-01-12 |
IL180526A0 (en) | 2008-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved |
Owner name: DOWG WHA PHARMACEUTICAL CO., LTD. (KR) Free format text: ALTERADO DE: DONG WHA PHARMACEUTICAL IND. CO. LTD. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |