BRPI0509562A - uso de uma trioxopirimidina para o tratamento e a prevenção de doenças inflamatórias brÈnquicas - Google Patents

uso de uma trioxopirimidina para o tratamento e a prevenção de doenças inflamatórias brÈnquicas

Info

Publication number
BRPI0509562A
BRPI0509562A BRPI0509562-0A BRPI0509562A BRPI0509562A BR PI0509562 A BRPI0509562 A BR PI0509562A BR PI0509562 A BRPI0509562 A BR PI0509562A BR PI0509562 A BRPI0509562 A BR PI0509562A
Authority
BR
Brazil
Prior art keywords
mmp
sub
prevention
treatment
inflammatory diseases
Prior art date
Application number
BRPI0509562-0A
Other languages
English (en)
Inventor
Didier Cataldo
Luc Delattre
Brigitte Evrard
Jean-Michel Foidart
Hans-Willi Krell
Original Assignee
Hoffmann La Roche
Univ Li Ge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Univ Li Ge filed Critical Hoffmann La Roche
Publication of BRPI0509562A publication Critical patent/BRPI0509562A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

USO DE UMA TRIOXOPIRIMIDINA PARA O TRATAMENTO E A PREVENçãO DE DOENçAS INFLAMATóRIAS BRÈNQUICAS. A invenção refere-se ao uso de um composto de trioxopirimidina que tem uma atividade inibidora contra MMP-1, MMP-2, MMP-3, MMP-9 e MMP-14 definida como a) um valor de 1C~ 50~ menor do que 5 <109>M para MMP-2, MMP-9 e MMP-14 cada; b) uma razão maior do que 100 para os valores de IC~ 50~ de MMP-1:MMP-2, MMP-1: MMP-9, MMP-1:MMP-14 e c) uma razão maior do que 10 para os valores de IC~ 50~ de MMP-3:MMP-2, MMP-3: MMP-9, MMP-3:MMP-14, para a fabricação de medicamento ou para o tratamento ou a prevenção de doenças inflamatórias brónquicas.
BRPI0509562-0A 2004-04-01 2005-03-31 uso de uma trioxopirimidina para o tratamento e a prevenção de doenças inflamatórias brÈnquicas BRPI0509562A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04007920 2004-04-01
PCT/EP2005/003345 WO2005097133A1 (en) 2004-04-01 2005-03-31 Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases

Publications (1)

Publication Number Publication Date
BRPI0509562A true BRPI0509562A (pt) 2007-09-25

Family

ID=34924546

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509562-0A BRPI0509562A (pt) 2004-04-01 2005-03-31 uso de uma trioxopirimidina para o tratamento e a prevenção de doenças inflamatórias brÈnquicas

Country Status (13)

Country Link
US (1) US20070225253A1 (pt)
EP (1) EP1737464B1 (pt)
JP (1) JP4584981B2 (pt)
CN (1) CN100558362C (pt)
AT (1) ATE401889T1 (pt)
AU (1) AU2005230379B2 (pt)
BR (1) BRPI0509562A (pt)
CA (1) CA2561828C (pt)
DE (1) DE602005008418D1 (pt)
ES (1) ES2311220T3 (pt)
MX (1) MXPA06011030A (pt)
RU (1) RU2402329C2 (pt)
WO (1) WO2005097133A1 (pt)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19548624A1 (de) * 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
BR9810450A (pt) * 1997-06-21 2000-09-05 Roche Diagnostics Gmbh Derivados de ácido barbitúrico com atividade antimetastática e antitumor
DE19726427A1 (de) * 1997-06-23 1998-12-24 Boehringer Mannheim Gmbh Pyrimidin-2,4,6-trion-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
FI990888A0 (fi) * 1999-04-20 1999-04-20 Medix Biochemica Ab Oy Menetelmä ja testikittejä respiratorisen alueen tulehduksen läsnäolon ja vaikeusasteen arvioimiseksi
CO5210860A1 (es) * 1999-10-01 2002-10-30 Hoffmann La Roche Nuevos derivados de pirimidina-2,4,6-triona
CN1714084A (zh) * 2000-10-26 2005-12-28 辉瑞产品公司 嘧啶－2,4,6－三酮类金属蛋白酶抑制剂
CZ20031083A3 (cs) * 2000-10-26 2004-03-17 Pfizer Products Inc. 5-Spiropyrimidin-2, 4, 6-trionové inhibitory metaloproteinasy

Also Published As

Publication number Publication date
EP1737464B1 (en) 2008-07-23
AU2005230379B2 (en) 2010-07-22
CA2561828C (en) 2012-05-22
JP4584981B2 (ja) 2010-11-24
EP1737464A1 (en) 2007-01-03
MXPA06011030A (es) 2007-03-21
AU2005230379A1 (en) 2005-10-20
RU2006138430A (ru) 2008-06-10
RU2402329C2 (ru) 2010-10-27
US20070225253A1 (en) 2007-09-27
ATE401889T1 (de) 2008-08-15
CN1950087A (zh) 2007-04-18
CN100558362C (zh) 2009-11-11
DE602005008418D1 (de) 2008-09-04
JP2007530625A (ja) 2007-11-01
ES2311220T3 (es) 2009-02-01
WO2005097133A1 (en) 2005-10-20
CA2561828A1 (en) 2005-10-20

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: UNIVERSITE DE LIEGE (BE)

Free format text: TRANSFERIDO DE: F. HOFFMANN-LA ROCHE AG

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.