BRPI0507192A - método de ensaio para detectar a proteìna de prìon infecciosa em uma amostra de um indivìduo mamìfero, kit para o uso em um método de ensaio, e, uso de um anticorpo de ligação - Google Patents
método de ensaio para detectar a proteìna de prìon infecciosa em uma amostra de um indivìduo mamìfero, kit para o uso em um método de ensaio, e, uso de um anticorpo de ligaçãoInfo
- Publication number
- BRPI0507192A BRPI0507192A BRPI0507192-5A BRPI0507192A BRPI0507192A BR PI0507192 A BRPI0507192 A BR PI0507192A BR PI0507192 A BRPI0507192 A BR PI0507192A BR PI0507192 A BRPI0507192 A BR PI0507192A
- Authority
- BR
- Brazil
- Prior art keywords
- gly
- sample
- prion protein
- assay method
- lys
- Prior art date
Links
- 102000029797 Prion Human genes 0.000 title abstract 7
- 108091000054 Prion Proteins 0.000 title abstract 7
- 208000015181 infectious disease Diseases 0.000 title abstract 3
- 230000002458 infectious effect Effects 0.000 title abstract 3
- 238000003556 assay Methods 0.000 title 2
- 238000001514 detection method Methods 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000010998 test method Methods 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
MéTODO DE ENSAIO PARA DETECTAR A PROTEìNA DE PRìON INFECCIOSA EM AMOSTRA DE UM INDIVìDUO MAMìFERO, KIT PARA O USO EM UM MéTODO DE ENSAIO, E, USO DE UM ANTICORPO DE LIGAçãO A presente invenção porvê um método de ensaio para detectar a proteína de príon infecciosa em uma amostra a partir de um indivíduo mamífero, o referido método compreendendo: obter uma amostra contendo a proteína de príon a partir do referido indivíduo; contactar a referida amostra com um agente, que serve para digerir a proteína de príon não-infecciosa e ára digerir parcialmente a proteína de príon infectada de modo a produzir um ersíduo de polipeptídeo da proteína de príon: contactar a amostra digerida com um anticorpo capaz de se ligar a um polipeptídeo tendo a seqüência de aminoácido Vc(Gly-Gly-Gly-Trp)-Gly-Gly-Gly-Gly-R~1~-R~2~-His-R~3~-Gln- Trp-Asn-Lys-Pro-R~4~- Lys-Pro-Lys-Thr-R~5~-R~6~-Lys (His-R~7~ Ala-Gly) (Vc) edetectar conjugados do referido anticorpo e do referido resíduo de polipeptídeo da proteína de príon; em que a detecção dos referidos conjugados compreende a amplificação química, biológica ou bioquímica de espécies detectáveis e a detecção da espécie amplificada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0402123.4A GB0402123D0 (en) | 2004-01-30 | 2004-01-30 | Method |
| PCT/GB2005/000328 WO2005073731A2 (en) | 2004-01-30 | 2005-01-27 | Cjd prion testing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0507192A true BRPI0507192A (pt) | 2007-06-26 |
Family
ID=31971788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0507192-5A BRPI0507192A (pt) | 2004-01-30 | 2005-01-27 | método de ensaio para detectar a proteìna de prìon infecciosa em uma amostra de um indivìduo mamìfero, kit para o uso em um método de ensaio, e, uso de um anticorpo de ligação |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080318209A1 (pt) |
| EP (1) | EP1714159A2 (pt) |
| JP (1) | JP2007519918A (pt) |
| KR (1) | KR20070006757A (pt) |
| CN (1) | CN1922491A (pt) |
| AR (1) | AR047524A1 (pt) |
| AU (1) | AU2005208087A1 (pt) |
| BR (1) | BRPI0507192A (pt) |
| CA (1) | CA2554286A1 (pt) |
| GB (1) | GB0402123D0 (pt) |
| SG (1) | SG150520A1 (pt) |
| WO (1) | WO2005073731A2 (pt) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0616613T3 (da) * | 1991-12-03 | 1999-09-27 | Proteus Molecular Design | Fragmenter af prionprotein |
| US6537548B1 (en) * | 2000-07-27 | 2003-03-25 | The Regents Of The University Of California | Antibodies specific for ungulate PrP |
| US20020164335A1 (en) * | 2001-03-28 | 2002-11-07 | Harris David A. | Compositions and methods for the study and diagnosis of prion diseases |
| JP3568198B2 (ja) * | 2001-10-15 | 2004-09-22 | 独立行政法人農業・生物系特定産業技術研究機構 | 異常プリオンタンパク質の検出方法 |
| DE10152677A1 (de) * | 2001-10-19 | 2003-05-08 | Aventis Behring Gmbh | Antikörper zum spezifischen Nachweis von pathogenen Prionen humanen Ursprungs und damit durchgeführten Nachweisverfahren |
-
2004
- 2004-01-30 GB GBGB0402123.4A patent/GB0402123D0/en not_active Ceased
-
2005
- 2005-01-27 EP EP05702074A patent/EP1714159A2/en not_active Withdrawn
- 2005-01-27 WO PCT/GB2005/000328 patent/WO2005073731A2/en active Application Filing
- 2005-01-27 KR KR1020067017580A patent/KR20070006757A/ko not_active Application Discontinuation
- 2005-01-27 US US10/588,078 patent/US20080318209A1/en not_active Abandoned
- 2005-01-27 BR BRPI0507192-5A patent/BRPI0507192A/pt not_active IP Right Cessation
- 2005-01-27 SG SG200901063-8A patent/SG150520A1/en unknown
- 2005-01-27 AU AU2005208087A patent/AU2005208087A1/en not_active Abandoned
- 2005-01-27 CA CA002554286A patent/CA2554286A1/en not_active Abandoned
- 2005-01-27 CN CNA2005800055145A patent/CN1922491A/zh active Pending
- 2005-01-27 JP JP2006550308A patent/JP2007519918A/ja active Pending
- 2005-01-31 AR ARP050100352A patent/AR047524A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070006757A (ko) | 2007-01-11 |
| AU2005208087A1 (en) | 2005-08-11 |
| US20080318209A1 (en) | 2008-12-25 |
| GB0402123D0 (en) | 2004-03-03 |
| EP1714159A2 (en) | 2006-10-25 |
| AR047524A1 (es) | 2006-01-25 |
| WO2005073731A3 (en) | 2006-03-23 |
| WO2005073731A2 (en) | 2005-08-11 |
| CN1922491A (zh) | 2007-02-28 |
| JP2007519918A (ja) | 2007-07-19 |
| CA2554286A1 (en) | 2005-08-11 |
| SG150520A1 (en) | 2009-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011. |