BRPI0413575A - anticorpos anti-idiotìpicos anti-lewis y e seus usos - Google Patents

anticorpos anti-idiotìpicos anti-lewis y e seus usos

Info

Publication number
BRPI0413575A
BRPI0413575A BRPI0413575-0A BRPI0413575A BRPI0413575A BR PI0413575 A BRPI0413575 A BR PI0413575A BR PI0413575 A BRPI0413575 A BR PI0413575A BR PI0413575 A BRPI0413575 A BR PI0413575A
Authority
BR
Brazil
Prior art keywords
lewis
lmh
specific
present
antibody
Prior art date
Application number
BRPI0413575-0A
Other languages
English (en)
Inventor
Zhanqi Liu
Andrew Mark Scott
Fiona Elizabeth Smyth
Original Assignee
Wyeth Corp
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Ludwig Inst Cancer Res filed Critical Wyeth Corp
Publication of BRPI0413575A publication Critical patent/BRPI0413575A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

"ANTICORPOS ANTI-IDIOTìPICOS ANTI-LEWIS Y E SEUS USOS". A presente invenção provê anticorpo antiidiotipos específicos para anticorpos monocionais anti-Lewis Y. A presente invenção é também direcionada contra um processo de seleção ELISA de mAbs produzidos por clones hibridomas para específica ligação às regiões variáveis de hu3S193 e a habilidade do mAB anti-idiotípico inibir ligação de hu3S193 a antígeno Lewis Y. Adicionalmente, a presente invenção provê um hibridoma capaz de produzir um anticorpo antiidiotipo específico para anticorpo monocional anti-Lewis Y. Ainda um aspecto da invenção é prover um hibridoma, que é específico para anticorpo monocional anti-Lewis Y selecionado do grupo consistindo em LMH-1, LMH-2, LMH-3, ou LMH-4. A presente invenção é também direcionada contra um processo para detectar respostas HAM, HACA e HAHA usando o anticorpo da invenção.
BRPI0413575-0A 2003-08-14 2004-08-10 anticorpos anti-idiotìpicos anti-lewis y e seus usos BRPI0413575A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49555703P 2003-08-14 2003-08-14
PCT/US2004/025789 WO2005019271A1 (en) 2003-08-14 2004-08-10 Anti-lewis y anti-idiotypic antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0413575A true BRPI0413575A (pt) 2006-10-17

Family

ID=34215928

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413575-0A BRPI0413575A (pt) 2003-08-14 2004-08-10 anticorpos anti-idiotìpicos anti-lewis y e seus usos

Country Status (8)

Country Link
US (1) US20080268459A1 (pt)
EP (1) EP1660538A1 (pt)
JP (1) JP2007528868A (pt)
CN (1) CN1867587A (pt)
AU (1) AU2004266216A1 (pt)
BR (1) BRPI0413575A (pt)
CA (1) CA2535804A1 (pt)
WO (1) WO2005019271A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200621282A (en) * 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
TWI434855B (zh) 2006-11-21 2014-04-21 Hoffmann La Roche 結合物及其在免疫分析中作為參考標準之用途
CN101407580B (zh) * 2008-11-28 2011-06-08 吉林大学 一种合成三聚氰胺完全抗原的方法及检测三聚氰胺的elisa试剂盒
NZ621655A (en) 2009-10-26 2015-08-28 Nestec Sa Assays for the detection of anti-tnf drugs and autoantibodies
EP2630495B1 (en) 2010-10-18 2017-02-08 Nestec S.A. Methods for determining anti-drug antibody isotypes
AU2012278802B2 (en) 2011-07-06 2015-11-26 Société des Produits Nestlé S.A. Assays for detecting neutralizing autoantibodies to biologic therapy with TNF alpha
JP2015518471A (ja) * 2012-03-28 2015-07-02 ジェネンテック， インコーポレイテッド 抗ｈｃｍｖイディオタイプ抗体およびそれらの使用
JP6188390B2 (ja) * 2013-04-10 2017-08-30 積水メディカル株式会社 Ｍｍｐ−３の測定方法
CA2926306C (en) * 2013-11-05 2022-12-06 F. Hoffmann-La Roche Ag A method for determining the total amount and/or concentration of an analyte in a sample
BR112017011545A2 (pt) 2014-12-05 2018-03-13 Nestec Sa ensaio de desvio de mobilidade homogênea indireto para a detecção de produtos biológicos nas amostras do paciente

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242824A (en) * 1988-12-22 1993-09-07 Oncogen Monoclonal antibody to human carcinomas
US6020145A (en) * 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
US20020146410A1 (en) * 1992-05-22 2002-10-10 Helmut Eckert Monoclonal antibodies and their use
CA2134751C (en) * 1992-05-22 2003-12-16 Helmut Eckert Monoclonal antibodies and their use
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
WO1999019506A2 (en) * 1997-10-09 1999-04-22 Ixsys, Incorporated Method for identifying binding ligands to receptors

Also Published As

Publication number Publication date
EP1660538A1 (en) 2006-05-31
JP2007528868A (ja) 2007-10-18
CA2535804A1 (en) 2005-03-03
US20080268459A1 (en) 2008-10-30
CN1867587A (zh) 2006-11-22
WO2005019271A1 (en) 2005-03-03
AU2004266216A1 (en) 2005-03-03

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.