BRPI0410789A - moléculas de ácido nucleico, composto ou oligonucleotìdeo, composição farmacêutica, métodos para induzir a morte da célula pré-cancerosa ou cancerosa em células ou tecidos, para tratar um ser humano ou animal suspeito de ter pré-cáncer ou cáncer, para melhorar a eficácia de um tratamento de cáncer com medicamento quimioterapêutico e de hibridização para distinguir entre células normais, pré-cancerosas ou cancerosas, kit, e, método de hibridização in situ para determinar a localização da célula do rna quimérico mitocondrial anti-sentido ou sentido no citoplasma, núcleo e nucléolo das células presentes na amostra - Google Patents
moléculas de ácido nucleico, composto ou oligonucleotìdeo, composição farmacêutica, métodos para induzir a morte da célula pré-cancerosa ou cancerosa em células ou tecidos, para tratar um ser humano ou animal suspeito de ter pré-cáncer ou cáncer, para melhorar a eficácia de um tratamento de cáncer com medicamento quimioterapêutico e de hibridização para distinguir entre células normais, pré-cancerosas ou cancerosas, kit, e, método de hibridização in situ para determinar a localização da célula do rna quimérico mitocondrial anti-sentido ou sentido no citoplasma, núcleo e nucléolo das células presentes na amostraInfo
- Publication number
- BRPI0410789A BRPI0410789A BRPI0410789-6A BRPI0410789A BRPI0410789A BR PI0410789 A BRPI0410789 A BR PI0410789A BR PI0410789 A BRPI0410789 A BR PI0410789A BR PI0410789 A BRPI0410789 A BR PI0410789A
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- precancerous
- cancer
- cancerous
- normal
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 5
- 108091092236 Chimeric RNA Proteins 0.000 title abstract 4
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 4
- 230000000692 anti-sense effect Effects 0.000 title abstract 2
- 238000009396 hybridization Methods 0.000 title abstract 2
- 230000002438 mitochondrial effect Effects 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 title 4
- 238000000034 method Methods 0.000 title 2
- 230000030833 cell death Effects 0.000 title 1
- 230000000973 chemotherapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 210000000805 cytoplasm Anatomy 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000007901 in situ hybridization Methods 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 210000001519 tissue Anatomy 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 3
- 230000004611 cancer cell death Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 108091064355 mitochondrial RNA Proteins 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
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- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- Biotechnology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Public Health (AREA)
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- Cell Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract
"MOLéCULAS DE áCIDO NUCLEICO, COMPOSTO OU OLIGONUCLEOTìDEO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA INDUZIR A MORTE DA CéLULA PRé-CANCEROSA OU CANCEROSA EM CéLULAS OU TECIDOS, PARA TRATAR UM SER HUMANO OU ANIMAL SUSPEITO DE TER PRé-CáNCER OU CáNCER, PARA MELHORAR A EFICáCIA DE UM TRATAMENTO DE CáNCER COM MEDICAMENTO QUIMIOTERAPêUTICO E DE HIBRIDIZAçãO PARA DISTINGUIR ENTRE CéLULAS NORMAIS, PRé-CANCEROSAS OU CANCEROSAS, KIT, E, MéTODO DE HIBRIDIZAçãO IN SITU PARA DETERMINAR A LOCALIZAçãO DA CéLULA DO RNA QUIMéRICO MITOCONDRIAL ANTI-SENTIDO OU SENTIDO NO CITOPLASMA, NúCLEO E NUCLéOLO DAS CéLULAS PRESENTES NA AMOSTRA". Uma nova família de RNAs mitocondriais humanos, aludidos como RNAs quiméricos, que são diferencialmente expressados em células normais, pré-cancerosas e cancerosas, é descrita. Oligonucleotídeos cujos alvos são os RNAs quiméricos são fornecidos. Os oligonucleotídeos descritos ou seus análogos podem ser usado para diagnósticos do câncer e terapia do câncer assim como para pesquisa. Em uma forma de realização desta invenção, estes oligonucleotídeos hibridizam com os RNAs quiméricos mitocondriais sentido ou anti-sentido e o resultado da hibridização é útil para diferenciar entre células proliferativas normais, células pré-cancerosas e células cancerosas. Em uma outra forma de realização da invenção, as composições compreendem oligonucleotídeos que hibridizam com os RNAs quiméricos humanos resultando na morte da célula cancerosa e da célula cancerosa, enquanto não há nenhum efeito nas células normais, constituindo portanto, um novo método para a terapia do câncer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47210603P | 2003-05-21 | 2003-05-21 | |
| US60/472,106 | 2003-05-21 | ||
| PCT/US2004/015929 WO2005001030A2 (en) | 2003-05-21 | 2004-05-21 | Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0410789A true BRPI0410789A (pt) | 2006-08-01 |
| BRPI0410789B1 BRPI0410789B1 (pt) | 2020-11-10 |
| BRPI0410789B8 BRPI0410789B8 (pt) | 2021-05-25 |
Family
ID=33551438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410789A BRPI0410789B8 (pt) | 2003-05-21 | 2004-05-21 | composição farmacêutica, uso de um ou mais oligonucleotídeos, e, método de detecção |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US8318686B2 (pt) |
| EP (3) | EP2270159B1 (pt) |
| JP (3) | JP5201834B2 (pt) |
| AT (1) | ATE506437T1 (pt) |
| BR (1) | BRPI0410789B8 (pt) |
| CA (1) | CA2526639C (pt) |
| DE (1) | DE602004032329D1 (pt) |
| DK (3) | DK2270159T3 (pt) |
| ES (3) | ES2365511T3 (pt) |
| HU (1) | HUE032575T2 (pt) |
| MX (1) | MXPA05012620A (pt) |
| PL (3) | PL2270159T3 (pt) |
| WO (1) | WO2005001030A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2270159B1 (en) | 2003-05-21 | 2015-01-07 | Andes Biotechnologies S.A. | Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein |
| CA2585587C (en) * | 2004-10-29 | 2016-02-16 | Maarten Tjerk Penning | Methods using mitochondrial nucleic acid for determining a health status of an individual |
| CN102589945B (zh) * | 2012-02-16 | 2013-10-23 | 中国人民解放军第三军医大学第二附属医院 | 骨髓涂片存放盒 |
| EP2970970B1 (en) | 2013-03-14 | 2018-12-12 | Andes Biotechnologies Global, Inc. | Antisense oligonucleotides for treatment of cancer stem cells |
| CN105283466A (zh) * | 2013-03-14 | 2016-01-27 | 安第斯生物技术股份有限公司 | 用于检测和治疗多发性骨髓瘤的方法 |
| WO2015066485A2 (en) * | 2013-10-31 | 2015-05-07 | The Children's Hospital Of Philadelphia | Mitochondrial disease genetic diagnostics |
| EP3116513A4 (en) * | 2014-03-14 | 2017-10-25 | Andes Biotechnologies S.A. | Pharmaceutical compositions comprising rna and use for treating cancer |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US6537973B1 (en) | 1992-03-16 | 2003-03-25 | Isis Pharmaceuticals, Inc. | Oligonucleotide inhibition of protein kinase C |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5646262A (en) * | 1994-07-28 | 1997-07-08 | Georgetown University | Antisense oligonucleotides against hepatitis B viral replication |
| US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
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