BRPI0408274B8 - compostos de ligação de amiloide e composição farmacêutica - Google Patents
compostos de ligação de amiloide e composição farmacêuticaInfo
- Publication number
- BRPI0408274B8 BRPI0408274B8 BRPI0408274A BRPI0408274A BRPI0408274B8 BR PI0408274 B8 BRPI0408274 B8 BR PI0408274B8 BR PI0408274 A BRPI0408274 A BR PI0408274A BR PI0408274 A BRPI0408274 A BR PI0408274A BR PI0408274 B8 BRPI0408274 B8 BR PI0408274B8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- disease
- pharmaceutical composition
- deposit
- amyloid
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/388,173 US7270800B2 (en) | 2000-08-24 | 2003-03-14 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US10/388,173 | 2003-03-14 | ||
| US10/645,847 | 2003-08-22 | ||
| US10/645,847 US20050043523A1 (en) | 2003-08-22 | 2003-08-22 | Benzothiazole derivative compounds, compositions and uses |
| PCT/US2004/007797 WO2004083195A1 (en) | 2003-03-14 | 2004-03-15 | Benzothiazole derivative compounds, compositions and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0408274A BRPI0408274A (pt) | 2006-03-21 |
| BRPI0408274B1 BRPI0408274B1 (pt) | 2019-02-26 |
| BRPI0408274B8 true BRPI0408274B8 (pt) | 2021-05-25 |
Family
ID=35057877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0408274A BRPI0408274B8 (pt) | 2003-03-14 | 2004-03-15 | compostos de ligação de amiloide e composição farmacêutica |
Country Status (16)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5022554B2 (ja) * | 2000-08-24 | 2012-09-12 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
| US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
| US20050261365A1 (en) * | 2004-05-20 | 2005-11-24 | The Scripps Research Institute | Transthyretin stabilization |
| GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
| ES2414614T3 (es) * | 2007-01-30 | 2013-07-22 | Ge Healthcare Limited | Herramientas para ayudar en el diagnóstico de enfermedades neurodegenerativas |
| CN101293878B (zh) * | 2007-04-25 | 2010-12-15 | 中国科学院上海应用物理研究所 | 苯并噻唑苯胺类化合物及其制备方法和应用 |
| EP2323697A2 (en) * | 2008-07-24 | 2011-05-25 | Siemens Medical Solutions USA, Inc. | Imaging agents useful for identifying ad pathology |
| US8895313B2 (en) * | 2008-09-23 | 2014-11-25 | Wista Laboratories Ltd. | Ligands for aggregated tau molecules |
| CA2920068A1 (en) * | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
| JP6260967B2 (ja) * | 2013-11-06 | 2018-01-17 | 国立大学法人京都大学 | 放射性ヨウ素標識化合物、及び、これを含む放射性医薬 |
| CN103613589B (zh) * | 2013-11-29 | 2016-03-30 | 江苏华益科技有限公司 | 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法 |
| JP2017528520A (ja) * | 2014-08-29 | 2017-09-28 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | ハンチントンタンパク質のイメージング用プローブ |
| CN109400615B (zh) * | 2017-08-18 | 2021-07-16 | 上海交通大学医学院附属新华医院 | 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用 |
| GR1009516B (el) * | 2018-03-22 | 2019-05-02 | Εκεφε Δημοκριτος | Τρικαρβονυλο-συμπλοκα μεταλλων μεταπτωσεως με βενζο-ετεροκυκλικο παραγωγο του κυκλοπενταδιενυλικου ανιοντος με υψηλη διαπερατοτητα του αιματοεγκεφαλικου φραγμου για εφαρμογες στη διαγνωση και θεραπεια νοσων του κνς |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID22275A (id) * | 1996-11-22 | 1999-09-23 | Elan Pharm Inc | Komposisi farmasi yang terdiri dari derivat asam amino n-(aril atau heteroaril) dan metode untuk menghambat pelepasan b-amiloid peptida dan atau sintesisnya dengan menggunakan senyawa tersebut |
| GB9919673D0 (en) * | 1999-08-20 | 1999-10-20 | Cancer Res Campaign Tech | 2-Arlybenzazole compounds |
| JP5022554B2 (ja) * | 2000-08-24 | 2012-09-12 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
| EP1345914A1 (en) * | 2000-12-22 | 2003-09-24 | AstraZeneca AB | Therapeutic compounds |
| US6696039B2 (en) * | 2001-04-23 | 2004-02-24 | Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
| GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
-
2004
- 2004-03-15 DK DK04720788.1T patent/DK1611115T3/da active
- 2004-03-15 EP EP04720788A patent/EP1611115B1/en not_active Expired - Lifetime
- 2004-03-15 PT PT47207881T patent/PT1611115E/pt unknown
- 2004-03-15 JP JP2006507179A patent/JP4875487B2/ja not_active Expired - Lifetime
- 2004-03-15 CN CN201110437182.5A patent/CN102532055B/zh not_active Expired - Lifetime
- 2004-03-15 BR BRPI0408274A patent/BRPI0408274B8/pt active IP Right Grant
- 2004-03-15 RU RU2005131872/04A patent/RU2440995C2/ru not_active Application Discontinuation
- 2004-03-15 AU AU2004221897A patent/AU2004221897B2/en not_active Expired
- 2004-03-15 SI SI200431952T patent/SI1611115T1/sl unknown
- 2004-03-15 ES ES04720788T patent/ES2393921T3/es not_active Expired - Lifetime
- 2004-03-15 PL PL04720788T patent/PL1611115T3/pl unknown
- 2004-03-15 CN CNA2004800125035A patent/CN1784392A/zh active Pending
-
2005
- 2005-10-11 NO NO20054674A patent/NO330861B1/no active Protection Beyond IP Right Term
-
2006
- 2006-07-04 HK HK06107502.0A patent/HK1086270A1/xx not_active IP Right Cessation
-
2011
- 2011-02-16 AU AU2011200667A patent/AU2011200667B2/en not_active Expired
- 2011-07-06 NO NO20110980A patent/NO20110980L/no not_active Application Discontinuation
-
2012
- 2012-11-16 CY CY20121101106T patent/CY1113334T1/el unknown
-
2015
- 2015-01-27 BE BE2015C005C patent/BE2015C005I2/fr unknown
- 2015-02-18 NO NO2015005C patent/NO2015005I1/no not_active IP Right Cessation
- 2015-02-18 HU HUS1500006C patent/HUS1500006I1/hu unknown
- 2015-03-04 CY CY2015007C patent/CY2015007I1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/02/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25G | Requested change of headquarter approved |
Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |