BRPI0206336B8 - process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin - Google Patents

process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin

Info

Publication number
BRPI0206336B8
BRPI0206336B8 BRPI0206336A BRPI0206336B8 BR PI0206336 B8 BRPI0206336 B8 BR PI0206336B8 BR PI0206336 A BRPI0206336 A BR PI0206336A BR PI0206336 B8 BRPI0206336 B8 BR PI0206336B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
antimicrobials
anesthetics
release
present
Prior art date
Application number
Other languages
Portuguese (pt)
Inventor
Luiz Pataro André
Esperanza Cortés Segura María
Victor Furtado Araújo Michel
Dario Sinisterra Millán Rubén
Original Assignee
Univ Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minas Gerais filed Critical Univ Minas Gerais
Priority to BR0206336-0 priority Critical patent/BRPI0206336B8/en
Publication of BR0206336A publication Critical patent/BR0206336A/en
Publication of BR0206336C1 publication Critical patent/BR0206336C1/en
Publication of BRPI0206336B1 publication Critical patent/BRPI0206336B1/en
Publication of BRPI0206336B8 publication Critical patent/BRPI0206336B8/en

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

"processo de preparação de composições farmacêuticas de antimicrobianos, anestésicos, antifúngicos e antiinflamatórios para liberação lenta e produtos derivados". a presente invenção destaca o processo de preparação de composições farmacêuticas de antimicrobianos, anestésicos, antifúngicos e antiinflamatórios em compostos de inclusão, modulando a taxa de liberação dos fármacos. essas composições podem estar em forma de géis mucoadesivos e biodegradáveis, como carbopol ou soluções, cremes, suspensões, comprimidos, pastas, pomadas, sabonetes, xampus e suas misturas. a presente invenção tem as vantagens de apresentar maior estabilidade, substantividade, biodisponibilidade, biocompatibilidade e atividade sobre bactérias, fungos, vírus e aftas, além de diminuir a destruição do colágeno em processos infecciosos. insere-se também a importante vantagem de ter alta efetividade para microorganismos, bactérias e fungos resistentes a antimicrobianos convencionais sem aumentar a concentração do fármaco. no estado da arte existem várias composições farmacêuticas de antimicrobianos de liberação controlada, contudo apresentam ainda efeito de explosão no perfil de liberação. adicionalmente, as composições aqui relatadas apresentam uma melhor atuação sobre os tecidos orais. uma caraterística importante das composições farmacêuticas obtidas na presente invenção é que além da associação de antibióticos, anestésicos e antiinflamatórios, elimina-se o uso do álcool no seu processo de obtenção. as composições farmacêuticas de antimicrobianos em compostos de inclusão podem ser usados na prevenção de infecções dentárias, tais como cárie e doença periodontal, e na terapia de lesões e/ou infecções dentárias, da cavidade oral, dermatológicas, nasais, auditivas e vaginais em seres humanos e/ou animais."Process of preparation of pharmaceutical compositions of antimicrobials, anesthetics, antifungals and anti-inflammatories for slow release and derived products". the present invention highlights the process of preparing pharmaceutical compositions of antimicrobials, anesthetics, antifungals and anti-inflammatories in inclusion compounds, modulating the rate of drug release. these compositions can be in the form of mucoadhesive and biodegradable gels, such as carbopol or solutions, creams, suspensions, tablets, pastes, ointments, soaps, shampoos and mixtures thereof. the present invention has the advantages of presenting greater stability, substantivity, bioavailability, biocompatibility and activity on bacteria, fungi, viruses and thrush, in addition to reducing collagen destruction in infectious processes. it also includes the important advantage of having high effectiveness for microorganisms, bacteria and fungi resistant to conventional antimicrobials without increasing the concentration of the drug. in the state of the art, there are several pharmaceutical compositions of controlled-release antimicrobials, however they still present an explosion effect on the release profile. additionally, the compositions reported here have a better performance on oral tissues. an important characteristic of the pharmaceutical compositions obtained in the present invention is that, in addition to the association of antibiotics, anesthetics and anti-inflammatory drugs, the use of alcohol in its production process is eliminated. pharmaceutical compositions of antimicrobials in inclusion compounds can be used in the prevention of dental infections, such as caries and periodontal disease, and in the therapy of dental, oral cavity, dermatological, nasal, auditory and vaginal lesions and/or infections in humans. and/or animals.

BR0206336-0 2002-12-06 2002-12-06 process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin BRPI0206336B8 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR0206336-0 BRPI0206336B8 (en) 2002-12-06 2002-12-06 process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BR0206336-0 BRPI0206336B8 (en) 2002-12-06 2002-12-06 process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin

Publications (4)

Publication Number Publication Date
BR0206336A BR0206336A (en) 2004-10-05
BR0206336C1 BR0206336C1 (en) 2008-06-24
BRPI0206336B1 BRPI0206336B1 (en) 2017-06-13
BRPI0206336B8 true BRPI0206336B8 (en) 2021-05-25

Family

ID=62915434

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0206336-0 BRPI0206336B8 (en) 2002-12-06 2002-12-06 process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin

Country Status (1)

Country Link
BR (1) BRPI0206336B8 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115634234B (en) * 2022-10-24 2024-03-22 山西医科大学 Poloxamer 407 antibacterial anti-inflammatory temperature-sensitive hydrogel containing chlorhexidine/gardenin/hyaluronic acid and preparation and application thereof

Also Published As

Publication number Publication date
BR0206336C1 (en) 2008-06-24
BRPI0206336B1 (en) 2017-06-13
BR0206336A (en) 2004-10-05

Similar Documents

Publication Publication Date Title
BRPI0011640B8 (en) oligosaccharide aldonic acids and their topical use
US4748022A (en) Topical composition
BRPI9504791B8 (en) polypeptide compound and pharmaceutical composition.
BR9911071A (en) Preparations for the application of anti-inflammatory agents, especially antiseptics and / or agents that promote healing of wounds in the upper respiratory tract and / or the ear
ITFI20080035A1 (en) DENTAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF STOMATITIS AND ULCERAZONIES OF ORAL MUCOSA
EP1444984B1 (en) Topical pharmaceutical compositions containing natural active constituents suitable for the prevention and treatment of mucosal inflammation processes
AT15430U1 (en) Dental agent based on hyaluronan and octenidine dihydrochloride
US20060105057A1 (en) Compositions using tetrasilver tetroxide and methods for management of skin conditions using same
RU2184538C2 (en) Use of dichlorobenzyl alcohol for preparing medicinal agent for treatment of topical inflammation and medicinal agent comprising dichlorobenzyl alcohol
BRPI0206336B8 (en) process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin
JP2001089383A (en) Composition for oral cavity and ophthalmology
WO2020079717A1 (en) Ozonized phytotherapic composition for tissue and bone regeneration
US5100653A (en) Topical compositions for treating mouth tissues
Rathod et al. Aloe vera: A natural remedy
Phillips et al. Focal epithelial hyperplasia: Report of a case
Bezhuk et al. Effectiveness of using domestic quaternary ammonium antiseptic in general medicine and dentistry (modern view and clinical case)
US20040022868A1 (en) Compositions using tetrasilver tetroxide and methods for management of skin conditions using same
KR102372384B1 (en) Oral hygiene composition for preventing or alleviating periodontal disease and halitosis
SOMASUNDARAM Aloe vera as an herbal remedy in dentistry.
Jain et al. Herbs in periodontology–Local drug delivery
Abed et al. Comparison between the effects of Aloe vera and chlorhexidine on clinical periodontal parameters
WO2016126217A1 (en) Stable pharmaceutical combination containing benzydamine
Ahmad Soolari et al. Plasma Cell Gingivitis Associated with the Pfizer-BioNTech COVID-19 Vaccine: A Case Report
Shergill et al. Comparative evaluation of three commercially available local drug delivery medicaments in the treatment of chronic periodontitis
Qureshi et al. Local Drug Delivery to the Oral Cavity

Legal Events

Date Code Title Description
B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 06/12/2022