BRPI0206336B8 - process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin - Google Patents
process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrinInfo
- Publication number
- BRPI0206336B8 BRPI0206336B8 BRPI0206336A BRPI0206336B8 BR PI0206336 B8 BRPI0206336 B8 BR PI0206336B8 BR PI0206336 A BRPI0206336 A BR PI0206336A BR PI0206336 B8 BRPI0206336 B8 BR PI0206336B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical compositions
- antimicrobials
- anesthetics
- release
- present
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
"processo de preparação de composições farmacêuticas de antimicrobianos, anestésicos, antifúngicos e antiinflamatórios para liberação lenta e produtos derivados". a presente invenção destaca o processo de preparação de composições farmacêuticas de antimicrobianos, anestésicos, antifúngicos e antiinflamatórios em compostos de inclusão, modulando a taxa de liberação dos fármacos. essas composições podem estar em forma de géis mucoadesivos e biodegradáveis, como carbopol ou soluções, cremes, suspensões, comprimidos, pastas, pomadas, sabonetes, xampus e suas misturas. a presente invenção tem as vantagens de apresentar maior estabilidade, substantividade, biodisponibilidade, biocompatibilidade e atividade sobre bactérias, fungos, vírus e aftas, além de diminuir a destruição do colágeno em processos infecciosos. insere-se também a importante vantagem de ter alta efetividade para microorganismos, bactérias e fungos resistentes a antimicrobianos convencionais sem aumentar a concentração do fármaco. no estado da arte existem várias composições farmacêuticas de antimicrobianos de liberação controlada, contudo apresentam ainda efeito de explosão no perfil de liberação. adicionalmente, as composições aqui relatadas apresentam uma melhor atuação sobre os tecidos orais. uma caraterística importante das composições farmacêuticas obtidas na presente invenção é que além da associação de antibióticos, anestésicos e antiinflamatórios, elimina-se o uso do álcool no seu processo de obtenção. as composições farmacêuticas de antimicrobianos em compostos de inclusão podem ser usados na prevenção de infecções dentárias, tais como cárie e doença periodontal, e na terapia de lesões e/ou infecções dentárias, da cavidade oral, dermatológicas, nasais, auditivas e vaginais em seres humanos e/ou animais."Process of preparation of pharmaceutical compositions of antimicrobials, anesthetics, antifungals and anti-inflammatories for slow release and derived products". the present invention highlights the process of preparing pharmaceutical compositions of antimicrobials, anesthetics, antifungals and anti-inflammatories in inclusion compounds, modulating the rate of drug release. these compositions can be in the form of mucoadhesive and biodegradable gels, such as carbopol or solutions, creams, suspensions, tablets, pastes, ointments, soaps, shampoos and mixtures thereof. the present invention has the advantages of presenting greater stability, substantivity, bioavailability, biocompatibility and activity on bacteria, fungi, viruses and thrush, in addition to reducing collagen destruction in infectious processes. it also includes the important advantage of having high effectiveness for microorganisms, bacteria and fungi resistant to conventional antimicrobials without increasing the concentration of the drug. in the state of the art, there are several pharmaceutical compositions of controlled-release antimicrobials, however they still present an explosion effect on the release profile. additionally, the compositions reported here have a better performance on oral tissues. an important characteristic of the pharmaceutical compositions obtained in the present invention is that, in addition to the association of antibiotics, anesthetics and anti-inflammatory drugs, the use of alcohol in its production process is eliminated. pharmaceutical compositions of antimicrobials in inclusion compounds can be used in the prevention of dental infections, such as caries and periodontal disease, and in the therapy of dental, oral cavity, dermatological, nasal, auditory and vaginal lesions and/or infections in humans. and/or animals.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0206336-0 BRPI0206336B8 (en) | 2002-12-06 | 2002-12-06 | process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0206336-0 BRPI0206336B8 (en) | 2002-12-06 | 2002-12-06 | process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin |
Publications (4)
Publication Number | Publication Date |
---|---|
BR0206336A BR0206336A (en) | 2004-10-05 |
BR0206336C1 BR0206336C1 (en) | 2008-06-24 |
BRPI0206336B1 BRPI0206336B1 (en) | 2017-06-13 |
BRPI0206336B8 true BRPI0206336B8 (en) | 2021-05-25 |
Family
ID=62915434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206336-0 BRPI0206336B8 (en) | 2002-12-06 | 2002-12-06 | process of preparation of controlled-release pharmaceutical compositions comprising antimicrobial and cyclodextrin |
Country Status (1)
Country | Link |
---|---|
BR (1) | BRPI0206336B8 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115634234B (en) * | 2022-10-24 | 2024-03-22 | 山西医科大学 | Poloxamer 407 antibacterial anti-inflammatory temperature-sensitive hydrogel containing chlorhexidine/gardenin/hyaluronic acid and preparation and application thereof |
-
2002
- 2002-12-06 BR BR0206336-0 patent/BRPI0206336B8/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR0206336C1 (en) | 2008-06-24 |
BRPI0206336B1 (en) | 2017-06-13 |
BR0206336A (en) | 2004-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 06/12/2022 |