BRPI0100254B1 - Sensitizing composition that transmits initial sensation when in contact. - Google Patents
Sensitizing composition that transmits initial sensation when in contact. Download PDFInfo
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- BRPI0100254B1 BRPI0100254B1 BRPI0100254-6A BR0100254A BRPI0100254B1 BR PI0100254 B1 BRPI0100254 B1 BR PI0100254B1 BR 0100254 A BR0100254 A BR 0100254A BR PI0100254 B1 BRPI0100254 B1 BR PI0100254B1
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
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- A23G4/00—Chewing gum
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- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/20—Synthetic spices, flavouring agents or condiments
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- C07C43/00—Ethers; Compounds having groups, groups or groups
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- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
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- C07C2601/00—Systems containing only non-condensed rings
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Abstract
Description
"COMPOSIÇÃO SEMSIBILIZANTE QUE TRANSMITE SENSAÇÃO INICIAL QUANDO EM CONTATO" ANTECEDENTES DA INVENÇÃO A presente invenção se refere a uma composição que transmite uma sensação inicial similar a um formigamento ao primeiro contato. Mais especificamente, a presente invenção é uma composição que inclui um sensibilizante de refresca-mento, um sensibilizante de aquecimento, e um sensibilizante do tipo formigamento, os quais quando usados em combinação transmite imediatamente uma sensação inicial. A sensação inicial pode ser melhor descrita como um formigamento ou uma impressão de picadas que também estimulam a sensação dos outros sensibilizantes usados na composição. Adicionalmente, a composição da presente invenção também ajuda a moderar os efeitos estimulativos desagradáveis dos agentes de resfriamento. Esta moderação dos efeitos desagradáveis dos agentes de resfriamento é aqui referido como um efeito emoliente. Vários tipos de produtos incorporam ingredientes que conferem algum tipo de sensação às membranas mucosas, cavidade oral, garganta ou pele. Esses ingredientes podem ser usados como aromatizantes ou fragrâncias em uma ampla faixa de produtos tais como produtos de cuidados pessoais (perfumes desodorantes, cosméticos xampus, cremes para pele, cremes dentais e similares) , produtos farmacêuticos (tais como xaropes para tosse, gotas para tosse e similares) e alimentos tais como goma de mascar, soda e similares).BACKGROUND OF THE INVENTION The present invention relates to a composition that imparts an initial sensation similar to a tingling at first contact. More specifically, the present invention is a composition comprising a refreshment sensitizer, a heat sensitizer, and a tingle-type sensitizer, which when used in combination immediately transmits an initial sensation. The initial sensation may best be described as a tingling or stinging impression that also stimulates the sensation of the other sensitizers used in the composition. Additionally, the composition of the present invention also helps to moderate the unpleasant stimulatory effects of cooling agents. This moderation of the unpleasant effects of the cooling agents is referred to herein as an emollient effect. Several types of products incorporate ingredients that give some kind of sensation to the mucous membranes, oral cavity, throat or skin. These ingredients can be used as flavorings or fragrances in a wide range of products such as personal care products (deodorant perfumes, cosmetic shampoos, skin creams, toothpastes and the like), pharmaceuticals (such as cough syrups, cough drops). and the like) and foods such as chewing gum, soda and the like).
Por exemplo, o 1-mentol e o 3-(1-mentoxi)propan-1,2-diol são usados como ingredientes ativos em produtos para conferir uma sensação refrescante na boca ou pele (Patente U.S. No. 4.459.425). Entretanto, o 1-mentol possui a desvantagem de ser muito volátil bem como irritante à pele e âs membranas mucosas. Existe um limite para o quanto de 1-mentol pode ser usado em um produto para produzir uma sensação refrescante, devido ao fato de que quando usado em quantidades maiores o 1-mentol se torna muito desagradável e irritante. Muitas pesquisas têm sido feitas para descobrir alternativas para o mentol como um agente de refrescamento. Em New Compounds with the Menthol Cooling Effect, J. Soc. Cos-met. Chem, 29: 185-200 (1978), por H.R. Watson e outros, a base fisiológica para o efeito de refrescamento do mentol é discutida. Adicionalmente, alguns importantes requisitos moleculares foram descritos que são acreditados serem necessários a fim de que um composto possua o efeito desejado. Vários compostos N-alquil-carboxamida foram descobertos possuírem a sensação refrescante do mentol ao mesmo tempo em que possuem a vantagem de serem menos voláteis. A farmacologia e a toxicologia do uso do mentol em vários produtos e quanto aos vários modos de administração tem sido também reportada. Ver Mentol and Related Cooling Compounds, J. Pharm. Phrma-col, 46:618-630 (1994) por R.Eccles. Uma outra alternativa para o mentol é a 1(2-hidroxifenil)-4-(3-nitrofenil)-1,2,3,5-tetrahidropirimidin-2-ona. Este composto como discutido em A Chemical Which Produces Sensations of Cold, Envi-ronment, Drugs and Thermoregulation, 5th International Symp. Pharmacol. Thermoregulation, Saint-Paul-de-Vence, 1982, pp. 183-186 (Karger, Basel, 1983) por E.T.Wei.For example, 1-menthol and 3- (1-menthoxy) propan-1,2-diol are used as active ingredients in products to impart a refreshing mouth or skin sensation (U.S. Patent No. 4,459,425). However, 1-menthol has the disadvantage that it is very volatile as well as irritating to skin and mucous membranes. There is a limit to how much 1-menthol can be used in a product to produce a refreshing sensation, because when used in larger amounts 1-menthol becomes very unpleasant and irritating. Much research has been done to find alternatives to menthol as a refreshing agent. In New Compounds with the Menthol Cooling Effect, J. Soc. Cos-met. Chem, 29: 185-200 (1978), by H.R. Watson et al., The physiological basis for the refreshing effect of menthol is discussed. Additionally, some important molecular requirements have been described that are believed to be necessary in order for a compound to have the desired effect. Several N-alkyl carboxamide compounds have been found to have the refreshing sensation of menthol while having the advantage of being less volatile. The pharmacology and toxicology of menthol use in various products and the various modes of administration has also been reported. See Menthol and Related Cooling Compounds, J. Pharm. Phrma-col, 46: 618-630 (1994) by R. Eccles. Another alternative to menthol is 1- (2-hydroxyphenyl) -4- (3-nitrophenyl) -1,2,3,5-tetrahydropyrimidin-2-one. This compound as discussed in A Chemical Which Produces Sensations of Cold, Environment, Drugs and Thermoregulation, 5th International Symp. Pharmacol. Thermoregulation, Saint-Paul-de-Vence, 1982, p. 183-186 (Karger, Basel, 1983) by E.T.Wei.
Outros agentes de refrescamento fisiológicos conhecidos incluindo o óleo de menta, p-mentano-3-carboxamidas N-substituídas, acrílico carboxamidas terciárias e secundárias, 3-(l-mentoxi)propan-l,2-diol têm sido também reportados (Ver PCT Pedido publicado No. WO 97/06695).Other known physiological refreshing agents including mint oil, N-substituted p-menthane-3-carboxamides, tertiary and secondary acrylic carboxamides, 3- (1-menthoxy) propan-1,2-diol have also been reported (See PCT Published Application No. WO 97/06695).
Sensibilizantes de aquecimento e/ou de calor são também conhecidos. O vanilil álcool n-butil éter (éter vani-lil butílico) é conhecido como um ingrediente ativo em produtos para conferir um sabor amargo penetrante, ou uma sensação de aquecimento/calor (Pedido Japonês em aberto No. 54-67040). Uma formulação de gotas para tosse foi reportada a qual inclui um agente de refrescamento fisiológico e um agente de aquecimento (Pedido PCT publicado No. WO 97/06695). Agentes de refrescamento fisiológicos de aqui revelados incluem o óleo de menta, p-mentano-3-carboxamidas N-substituídas, acrílico carboxamidas terciárias e secundárias, 3-(1-mentoxi)-propan-1,2-diol. Agentes fisiológicos de aquecimento aqui revelados incluem o vanilil álcool n-butil éter, vanilil álcool n-propil éter, vanilil álcool isopropil éter, vanilil álcool isobutil éter, vanilil álcool n-amino éter, vanilil álcool isoamil éter, vanilil álcool n-hexil éter, vanilil álcool metil éter, vanilil álcool etil éter, gingerol, shogaol, paradol, zingerona, capsaicina, dihidro-capsaicina, nordihidrocapsaicina, homocapsaicina, hemodihi-drocapsaicina, etanol, álcool isopropílico, álcool isoamíli-co, álcool benzílico clorofórmio, eugenol, óleo de canela, aldeído cinâmico e seus fosfato-derivados.Heat and / or heat sensitizers are also known. Vanylyl alcohol n-butyl ether (vani-lil butyl ether) is known as an active ingredient in products to impart a bitter penetrating taste or a warm / warm sensation (Open Japanese Order No. 54-67040). A cough drop formulation has been reported which includes a physiological cooling agent and a heating agent (PCT Application published No. WO 97/06695). Physiological refreshing agents disclosed herein include mint oil, N-substituted p-menthan-3-carboxamides, tertiary and secondary acrylic carboxamides, 3- (1-menthoxy) propan-1,2-diol. Physiological heating agents disclosed herein include vanylyl n-butyl ether alcohol, vanylyl n-propyl ether alcohol, vanylyl alcohol isopropyl ether, vanylyl alcohol isobutyl ether, vanylyl alcohol n-amino ether, vanylyl alcohol isoamyl ether, vanylyl alcohol n-hexyl ether , vanylyl alcohol methyl ether, vanylyl ethyl ether alcohol, gingerol, shogaol, paradol, zingerone, capsaicin, dihydro-capsaicin, nordihydrocapsaicin, homocapsaicin, hemodihi-drocapsaicin, ethanol, isopropyl alcohol, isoamyl-alcohol, benzyl alcohol and chloroform, benzyl chloroform alcohol cinnamon, cinnamic aldehyde and its phosphate derivatives.
Um composto que possui um paladar quente, de quei-mação e de formigamento que seja de longa duração foi reportado como o 4-(1-mentoximetil)-2-fenil-l,3-dioxolano ou seus derivados representado pela fórmula geral a seguir (I): (I) onde R1 representa um átomo de hidrogênio, um grupo hidroxi-la ou um grupo alcoxila inferior, e R2 e R3, que podem ser iguais ou diferentes, cada um representa um átomo de hidrogênio, um grupo hidroxila, ou um grupo alcoxila inferior, ou quando tomados juntamente, R2, e R3 representam um grupo di-oxi metileno. Ver a Patente U.S. No. 5.545.424 que é aqui incorporada por referência. Esta sensibilização de aquecimento foi também reportada prolongar as sensações de alguns sensibilizantes de refrescamento, por exemplo em combinação com o 1-mentol, 3 -(1-mentoxi)propan-1,2-diol ("TK-10" por Takasago International Corp., Tokyo, Japan) ou o isopulegol. A combinação dos sensibilizantes de refrescamento e de aquecimento indicados prolongaram os efeitos ao usuário. Assim, as sensações de queimação, picantes ou amargas associadas com esse sensibilizante de aquecimento foram capazes de con- duzir ao usuário uma melhor apreciação do sensibilizante de refrescamento.A compound that has a long-lasting, hot, tingling, burning taste has been reported as 4- (1-menthoxymethyl) -2-phenyl-1,3-dioxolane or its derivatives represented by the following general formula (I): (I) where R1 represents a hydrogen atom, a hydroxy-a group or a lower alkoxy group, and R2 and R3, which may be the same or different, each represents a hydrogen atom, a hydroxyl group, or a lower alkoxy group, or when taken together, R 2 and R 3 represent a dioxymethylene group. See U.S. Patent No. 5,545,424 which is incorporated herein by reference. This warming sensitization has also been reported to prolong the sensations of some cooling sensitizers, for example in combination with 1-menthol, 3- (1-menthoxy) propan-1,2-diol ("TK-10" by Takasago International Corp. ., Tokyo, Japan) or isopulegol. The combination of the indicated cooling and heating sensitizers prolonged the effects to the user. Thus, the burning, spicy or bitter sensations associated with this heating sensitizer were able to lead the user to a better appreciation of the cooling sensitizer.
Adicionalmente, o vanilil álcool n-butil éter (éter vanilil butílico) é conhecido como um ingrediente ativo em produtos para transmitir um paladar amargo penetrante, ou uma sensação de aquecimento/calor (Pedido Japonês em aberto No. 54-67040 e o Pedido de Patente Japonesa examinado No. 61-9293).Additionally, vanylyl alcohol n-butyl ether (vanylyl butyl ether) is known as an active ingredient in products to impart a penetrating bitter taste, or a warm / warm sensation (Open Japanese Application No. 54-67040 and Japanese Patent Examined No. 61-9293).
Alguns materiais são conhecidos por provocarem uma sensação de formigamento, dormência e/ou picante e são usados em alimentos como temperos populares e/ou condimentos de ervas. Estes incluem a resina oleosa de Jambu ou para-agrião (Spilanthes sp.) o ingrediente ativo sendo o espilantol; extrato de pimenta japonesa (Zanthoxylum peperitum) que possui ingrediente(s) ativo(s) conhecido como Saanshool-I, Saansho-ol-II e Sanshoamida; extrato de pimenta preta (Piper nigrum) que possui os ingredientes ativos Chavicina e Piperina. É também conhecido combinar compostos conhecidos a possuírem sabor e/ou compostos sensibilizantes para produzir um novo ingrediente que possui propriedades alteradas. Por exemplo, o pedido PCT WO 98/47482 revela formulações de gotas para tosse que incluem um agente fisiológico de refrescamento (tal como o mentol, o óleo de menta, p-mentano-3-carboxamidas N-substituídas, acrílico carboxamidas terciárias e secundárias, 3-(1-mentoxi)-propan-1,2-diol) e um agente fisiológico de aquecimento (tal como o vanilil álcool n-butil éter, vanilil álcool n-propil éter, vanilil álcool isopropil éter, vanilil álcool isobutil éter, vanilil álcool n-amino éter, vanilil álcool isoamil éter, vanilil álcool n-hexil éter, vanilil álcool metil éter, vanilil álcool etil éter, gingerol, shogaol, paradol, zingerona, capsaicina, dihidrocapsaicina, nordihidrocapsaicina, horaocapsaicina, he-modihidrocapsaicina, etanol, álcool isopropílico, álcool isoamílico, álcool benzílico clorofórmio, eugenol, óleo de canela, aldeído cinâmico e seus fosfato-derivados. O uso de éter vanilil butílico com um agente de refrescamento é revelado no pedido co-pendente intitulado "COOL FEELING COMPOSITION" arquivado em cerca de 4 de agosto de 1999, por um ou mais dos inventores da presente invenção. A composição aqui revelada transmite uma sensação de refres-camento em vários produtos de consumo.Some materials are known to cause a tingling, numb and / or spicy sensation and are used in foods such as popular spices and / or herbal spices. These include oily jambu or para-cress resin (Spilanthes sp.) The active ingredient being spilanthol; Japanese pepper extract (Zanthoxylum peperitum) which has active ingredient (s) known as Saanshool-I, Saansho-ol-II and Sanshoamide; Black pepper extract (Piper nigrum) that has the active ingredients Chavicina and Piperina. It is also known to combine known flavoring and / or sensitizing compounds to produce a novel ingredient having altered properties. For example, PCT application WO 98/47482 discloses cough drop formulations that include a physiological refreshing agent (such as menthol, mint oil, N-substituted p-menthane-3-carboxamides, tertiary and secondary acrylic carboxamides , 3- (1-menthoxy) -propan-1,2-diol) and a physiological heating agent (such as vanylyl alcohol n-butyl ether, vanylyl alcohol n-propyl ether, vanylyl alcohol isopropyl ether, vanylyl alcohol isobutyl ether vanylyl alcohol n-amino ether, vanylyl alcohol isoamyl ether, vanylyl alcohol n-hexyl ether, vanylyl alcohol methyl ether, vanylyl alcohol ether, gingerol, shogaol, paradol, zingerone, capsaicin, dihydrocapsaicin, nordihydrocapsaicin, horaocapsaicin, heocapsaicin ethanol, isopropyl alcohol, isoamyl alcohol, benzyl alcohol chloroform, eugenol, cinnamon oil, cinnamic aldehyde and its phosphate derivatives The use of vanyl butyl ether with a cooling agent is disclosed in the application co Title entitled "COOL FEELING COMPOSITION" filed on August 4, 1999 by one or more of the inventors of the present invention. The composition disclosed herein conveys a refreshing sensation in various consumer products.
Os conhecidos compostos sensibilizantes de refres-camento, e de aquecimento e suas combinações tendem a possuírem um decurso de tempo entre o primeiro contato e quando a sensação é primeiramente detectada. É geralmente segundos antes da sensação ser realmente percebida pelo usuário. Adicionalmente, os compostos sensibilizantes de refrescamento e de aquecimento, e suas combinações que são conhecidas até o momento, não duram muito. É geralmente apenas uns poucos segundos ou minutos antes da sensação se desvanecer. É desejável ter um composto sensibilizante de refrescamento, de aquecimento ou uma combinação de compostos sensibilizantes que seja percebida pelo usuário imediatamente ao primeiro contato com o usuário. É também desejável que a sensação percebida permaneça por um período de tempo maior do que simplesmente os primeiros poucos segundos ou algo parecido.Known cooling, warming and sensitizing compounds and combinations thereof tend to have a time course between the first contact and when the sensation is first detected. It is usually seconds before the sensation is actually perceived by the user. Additionally, the cooling and heating sensitizing compounds, and combinations thereof which are known to date, do not last long. It is usually only a few seconds or minutes before the sensation fades. It is desirable to have a cooling, warming sensitizing compound or combination of sensitizing compounds that is perceived by the user immediately upon first contact with the user. It is also desirable that the perceived sensation remain for a longer period of time than simply the first few seconds or so.
OBJETIVOS E SUMÁRIO DA INVENÇÃO É um objetivo da presente invenção proporcionar um sensibilizante de contato e paladar que supere as limitações da técnica já existente. É um objetivo da presente invenção proporcionar um composto sensibilizante que proporcione um forte manifestação inicial ao usuário. É um objetivo adicional da presente invenção proporcionar um composto sensibilizante que proporcione uma impressão de formigamento e/ou picante quando em contato. É um objetivo adicional da presente invenção proporcionar um composto sensibilizante que proporcione uma sensação de longa duração além daquela do primeiro contato. Ξ um objetivo adicional da presente invenção proporcionar um composto sensibilizante que proporcione um efeito emoliente sobre um ou mais do co-ingredientes estimu-lativos.OBJECTS AND SUMMARY OF THE INVENTION It is an object of the present invention to provide a contact and taste sensitizer that overcomes the limitations of the existing technique. It is an object of the present invention to provide a sensitizing compound that provides a strong initial manifestation to the user. It is a further object of the present invention to provide a sensitizing compound which provides a tingling and / or spicy impression upon contact. It is a further object of the present invention to provide a sensitizing compound that provides a long lasting sensation beyond that of first contact. It is a further object of the present invention to provide a sensitizing compound which provides an emollient effect on one or more of the stimulatory co-ingredients.
Após extensiva pesquisa, os inventores da presente invenção descobriram que combinando sensibilizantes de re-frescamento com sensibilizantes de aquecimento e um sensibilizante de formigamento (tal como a resina oleosa de Jambu ou espilantol), resulta em melhoria do sabor e/ou sensação dos sensibilizantes de refrescamento e/ou de aquecimento. Adicionalmente, esta combinação mostrou iniciar a sensação do paladar dos sensibilizantes em um período curto de tempo que ocorre quando ou o sensibilizante de refrescamento, sensibilizante de aquecimento, ou uma combinação dos dois é usada sem o sensibilizante de formigamento.After extensive research, the inventors of the present invention have found that combining re-cooling sensitizers with heating sensitizers and a tingling sensitizer (such as Jambu or spilanthol oil resin) results in improved taste and / or sensation of cooling and / or heating. Additionally, this combination has been shown to initiate sensitization taste sensation in a short period of time that occurs when either the cooling sensitizer, heating sensitizer, or a combination of the two is used without the tingling sensitizer.
Em resumo, a presente invenção é uma composição sensibilizante que inclui pelo menos um sensibilizante de refrescamento, pelo menos um sensibilizante de aquecimento e pelo menos um sensibilizante de formigamento.In summary, the present invention is a sensitizing composition comprising at least one cooling sensitizer, at least one heating sensitizer and at least one tingling sensitizer.
Em uma modalidade da presente invenção, um método de usar uma composição sensibilizante como pelo menos uma parte de uma fragrância e um aromatizante é proporcionada, a qual inclui formar uma composição sensibilizante possuindo pelo menos um sensibilizante de refrescamento, pelo menos um sensibilizante de aquecimento e pelo menos um sensibilizante de formigamento contendo quantidades efetivas dos sensibili-zantes e misturando as composições sensibilizantes com um veículo adequado.In one embodiment of the present invention, a method of using a sensitizing composition as at least a part of a fragrance and a flavorant is provided which includes forming a sensitizing composition having at least one refreshing sensitizer, at least one heating sensitizer and at least one tingling sensitizer containing effective amounts of the sensitizers and mixing the sensitizing compositions with a suitable carrier.
Os objetivos acima, e outros objetivos, características e vantagens da presente invenção se tornarão evidentes a partir da descrição a seguir. Entretanto, esses exemplos não são para serem considerados a limitar o escopo da invenção.The above objectives, and other objects, features and advantages of the present invention will become apparent from the following description. However, these examples are not to be considered to limit the scope of the invention.
DESCRIÇÃO DETALHADA DA MODALIDADE PREFERIDADETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
Como descrito acima, 1-mentol, 3-(l-mentoxi)propan-1,2-diol e outros compostos são conhecidos agentes de refrescamento. Adicionalmente o éter vanilil bu-tílico é conhecido como um sensibilizante de aquecimento. A resina oleosa de Jambu é um extrato usado para conferir um paladar de formigamento em alimentos.As described above, 1-menthol, 3- (1-menthoxy) propan-1,2-diol and other compounds are known cooling agents. Additionally vanyl butyl ether is known as a heating sensitizer. Jambu Oily Resin is an extract used to impart a tingling taste in food.
No novo sensibilizante da presente invenção, o éter vanilil butílico é combinado com um sensibilizante refrescante e um sensibilizante de aquecimento para transmitir uma imediata sensação ao contato que também proporciona um efeito emoliente sobre o sensibilizante de refrescamento. 0 sensibilizante de refrescamento pode ser um sensibilizante de refrescamento singular ou uma combinação de diferentes sensibilizantes de refrescamento. O sensibilizante de aquecimento pode ser um tal sensibilizante de aquecimento singular ou uma combinação deles. Não existem limitações específicas para as quantidades relativas dos compostos da composição, Entretanto, é preferido que o éter vanilil butílico seja usado em uma quantidade relativa com respeito ao agente de refrescamento de modo que não ocorra efeito de aquecimento perceptível. De modo proferido, o éter vanilil butílico é usado em uma base em peso, desde 1/1000 até 2 vezes tanto quanto o agente de refrescamento. Mais preferivelmente, o éter vanilil butílico está presente na composição desde 1/200 até 1 vez a quantidade do agente de refrescamento em uma base em peso. A nova composição sensibilizante da presente invenção pode adicionalmente conter diluentes (etanol, água purificada, etc.) que sejam seguros para uso em produtos usados para o consumo e/ou uso tópico. A nova composição sensibilizante da presente invenção pode ser usada em vários produtos para os quais as qualidades do sensibilizante são desejáveis. Exemplos de produtos adequados incluem: cosméticos (tais como batons, loções após barba, base cosmética e similares), produtos de cuidados pessoal (tal como cremes para pele, loções adstringentes, loções de limpeza, desodorantes, , xampus, condicionadores, sabões, géis capilares, tônicos capilares, estimulantes de crescimento de cabelos, espumas para barbear, cremes de barbear, pérolas para banho de espuma e similares) e composições para uso farmacêutico (tais como aerossóis repelentes de insetos, tônicos capilares, preparações analgésicas, comprimidos e similares). Estes são apresentados como exemplos, entretanto os produtos nos quais a composição da presente invenção pode ser usada não estão limitados a estes. A quantidade da composição sensibilizante da presente invenção em um produto varia amplamente dependendo da quantidade de produto utilizada em um momento e do modo no qual ele é usado ou aplicado. Em geral, o teor da composição sensibilizante pode ser desde 0,001 até 20% em peso, preferivelmente de 0,01 até 10% em peso da composição total do produto. Entretanto, a composição sensibilizante pode ser adicionada a um produto em qualquer quantidade, na medida em que o efeito da composição esteja presente. A composição sensibilizante pode ser feita primeiro, e em seguida acrescentada ao produto. De modo alternativo, o agente de refres-camento, agente de aquecimento e o agente de formigamento podem ser adicionados em separado ao produto. A presente invenção será descrita em maiores detalhes por referência às Modalidades e Exemplos Comparativos a seguir, entretanto, deve ser notado que a invenção não está limitada a esses exemplos.In the novel sensitizer of the present invention, vanyl butyl ether is combined with a refreshing sensitizer and a heating sensitizer to impart an immediate contact sensation that also provides an emollient effect on the refreshing sensitizer. The refreshing sensitizer may be a unique refreshing sensitizer or a combination of different refreshing sensitizers. The heating sensitizer may be such a unique heating sensitizer or a combination thereof. There are no specific limitations on the relative amounts of the compounds of the composition. However, it is preferred that vanyl butyl ether be used in a relative amount with respect to the cooling agent so that no noticeable warming effect occurs. Accordingly, vanyl butyl ether is used on a weight basis, from 1/1000 to 2 times as much as the cooling agent. More preferably, vanyl butyl ether is present in the composition from 1/200 to 1 times the amount of the cooling agent on a weight basis. The novel sensitizing composition of the present invention may additionally contain diluents (ethanol, purified water, etc.) that are safe for use in products used for consumption and / or topical use. The novel sensitizing composition of the present invention may be used in various products for which sensitizer qualities are desirable. Examples of suitable products include: cosmetics (such as lipsticks, aftershave, cosmetic foundation and the like), personal care products (such as skin creams, astringent lotions, cleansing lotions, deodorants, shampoos, conditioners, soaps, gels hair toners, hair growth stimulants, shaving foams, shaving creams, bubble bath beads and the like) and pharmaceutical compositions (such as insect repellent aerosols, hair tonics, analgesic preparations, tablets and the like) . These are presented as examples, however the products in which the composition of the present invention may be used are not limited to these. The amount of the sensitizing composition of the present invention in a product varies widely depending upon the amount of product used at a time and the manner in which it is used or applied. In general, the content of the sensitizing composition may be from 0.001 to 20% by weight, preferably from 0.01 to 10% by weight of the total product composition. However, the sensitizing composition may be added to a product in any amount as long as the effect of the composition is present. The sensitizing composition may be made first, and then added to the product. Alternatively, the cooling agent, heating agent and tingling agent may be added separately to the product. The present invention will be described in more detail by reference to the following Comparative Examples and Modalities, however, it should be noted that the invention is not limited to such examples.
Modalidade 1 A modalidade 1 foi preparada pela mistura de N-etil-2 -isopropil-5-metilciclohexano carboxamida como um agente de refrescamento, éter vanilil butílico como um agente de aquecimento e resina oleosa de Jambu como um agente de formigamento com outros ingredientes de acordo com a formulação a seguir para produzir um colutório. Esses ingredientes são preparados de acordo com os métodos que são conhecidos na arte.Modality 1 Modality 1 was prepared by mixing N-ethyl-2-isopropyl-5-methylcyclohexane carboxamide as a cooling agent, vanyl butyl ether as a heating agent and Jambu oily resin as a tingling agent with other ingredients. according to the following formulation to produce a mouthwash. These ingredients are prepared according to methods that are known in the art.
Uma avaliação sensorial foi realizada no colutório da Modalidade 1. Oito membros de uma lista de julgadores treinados como Flavoristas avaliaram os produtos. Eles descobriram que a mistura produziu um perfil de paladar e sabor único. Os componentes da lista de julgadores reportaram uma sensação de formigamento ao primeiro contato com o colutório. Não foi reportado atraso em perceber a sensação.A sensory evaluation was performed in the Mode 1 mouthwash. Eight members of a list of judges trained as Flavorists evaluated the products. They found that the mixture produced a unique taste and taste profile. The judging list members reported a tingling sensation upon first contact with the mouthwash. No delay in noticing the sensation was reported.
Exemplo Comparativo 1 O Exemplo Comparativo 1 foi feito do mesmo modo como a Modalidade 1, exceto que foi omitido a resina oleosa de Jambu.Comparative Example 1 Comparative Example 1 was made in the same manner as Modality 1, except that the Jambu oily resin was omitted.
Uma lista de julgadores foi convidada a avaliar quaisquer diferenças percebidas na natureza do colutório da Modalidade 1 e do Exemplo Comparativo 1. Os julgadores foram indagados a comparar a sensação de paladar dos dois produtos e a comentarem sobre quaisquer diferenças. A maioria dos julgadores notou que havia uma distinta diferença na percepção da sensação de aquecimento e o seu início. A amostra codificada contendo a resina oleosa de Jambu foi descrita como possuindo um efeito de formigamento e de aquecimento mais completo se comparado ao sistema livre de Jambu que foi menos complexo e menos estimulante com um início quase retardado da percepção refrescante, houve um notado efeito sinérgico entre os ingredientes. Os perfis foram descritos como um formigamento significativo e uma melhora da sensação de refrescamento e de aquecimento do produto. 0 estudo mostrou que todos os três componentes, de re-frescamento, de aquecimento e de formigamento são necessários para produzir o efeito singular observado.A list of judges was invited to evaluate any perceived differences in the nature of the Mode 1 mouthwash and Comparative Example 1. The judges were asked to compare the taste sensation of the two products and to comment on any differences. Most judges noted that there was a distinct difference in the perception of the warming sensation and its onset. The coded sample containing the Jambu oil resin was described as having a more complete tingling and warming effect compared to the less complex and less stimulating Jambu free system with an almost delayed onset of refreshing perception, there was a noted synergistic effect. between the ingredients. Profiles have been described as a significant tingling and an improved cooling and warming sensation of the product. The study showed that all three components of cooling, warming and tingling are necessary to produce the observed singular effect.
Modalidade 2 A Modalidade 2 foi preparada por meio da mistura de 3-(l-mentoxi)propan-l,2-diol ("TK-10") da Takasago, Taka-sago International Corp., Tokyo, Japan) como um agente de refrescamento, a resina oleosa de pimenta-da-guiné como um agente de aquecimento e a resina oleosa de Jambu como um agente de formigamento com outros ingredientes de acordo com a formulação a seguir para produzir um creme dental de acordo com os métodos que são conhecidos na arte.Modality 2 Modality 2 was prepared by mixing 3- (1-menthoxy) propan-1,2-diol ("TK-10") from Takasago, Taka-sago International Corp., Tokyo, Japan) as an agent. refreshing, guinea pepper oil resin as a heating agent and Jambu oil resin as a tingling agent with other ingredients according to the following formulation to produce a toothpaste according to the methods that are known in the art.
Exemplo Comparativo 2 O Exemplo Comparativo 2 foi preparado do mesmo modo como a Modalidade 2, exceto que a resina oleosa de Jam-bu foi omitida.Comparative Example 2 Comparative Example 2 was prepared in the same manner as Modality 2, except that the Jam-bu oily resin was omitted.
Uma lista de julgadores avaliou as diferenças percebidas na natureza entre a preparação do creme dental da Modalidade 2 e do Exemplo Comparativo 2. Os julgadores foram indagados a comparar a sensação de paladar dos dois produtos e comentar sobre quaisquer diferenças. As avaliações foram realizadas em cego. A maioria dos avaliadores notou que a amostra contendo o material sensibilizante de formigamento teve um início da sensação de formigamento mais rápido e um paladar posterior agradável e melhorada, mais longa duração de re-frescamento, formigamento. Os avaliadores em sua maioria sentiram o Exemplo Comparativo 2 mais agradável porém carente do encorpamento e do impacto da Modalidade 2.A list of judges evaluated the perceived differences in nature between the preparation of Mode 2 toothpaste and Comparative Example 2. The judges were asked to compare the taste sensation of the two products and comment on any differences. The evaluations were performed in blind. Most evaluators noted that the sample containing the tingling sensitizing material had a faster onset of tingling sensation and a pleasant, improved aftertaste, longer duration of re-cooling, tingling. Most evaluators felt Comparative Example 2 was more pleasant but lacking in the bulk and impact of Modality 2.
Modalidade 3 A Modalidade 3 foi preparada por meio da mistura de 4-(1-mentoxi-metil)-2-(3'-metoxi-4'-hidroxifenil)-1,3- dioxolano, resina oleosa de gengibre, éter vanilil butílico e resina oleosa de Jambu com outros ingredientes de acordo com a formulação de bala a seguir a qual foi preparada de acordo com os métodos bem conhecidos na arte.Modality 3 Modality 3 was prepared by mixing 4- (1-menthoxymethyl) -2- (3'-methoxy-4'-hydroxyphenyl) -1,3-dioxolane, ginger oil resin, vanyl butyl ether and Jambu oily resin with other ingredients according to the following candy formulation which was prepared according to methods well known in the art.
Exemplo Comparativo 3 O Exemplo Comparativo 3 foi preparado do mesmo modo como a Modalidade 3, exceto que a resina oleosa de Jambu foi omitida.Comparative Example 3 Comparative Example 3 was prepared in the same manner as Modality 3, except that the Jambu oily resin was omitted.
Uma lista de julgadores foi convidada a avaliar a Modalidade 3 e o Exemplo Comparativo 3 em um modo cego aleatório e a comentar sobre quaisquer diferenças notadas. Oito membros de uma lista de julgadores treinados como Flavoris-tas avaliaram o produto. Os membros da lista de avaliadores reportaram uma sensação de formigamento ao primeiro contato com a bala. Não foi relatado atraso em perceber a sensação. A análise dos comentários dos avaliadores mostrou uma notada melhora da sensação de aquecimento que foi percebida na Mo- dalidade 3 como comparada ao Exemplo Comparativo 3. 0 início do paladar foi mais pronunciado na Modalidade 3 do que no Exemplo Comparativo 3. Os julgadores observaram que o Exemplo Comparativo 3 pareceu ser menos brilhante e mais lento em exibir quaisquer sensações singulares.A list of judges was invited to evaluate Modality 3 and Comparative Example 3 in a random blind mode and to comment on any noted differences. Eight members of a list of judges trained as Flavorists evaluated the product. Members of the evaluator list reported a tingling sensation upon first contact with the bullet. There was no reported delay in noticing the sensation. Analysis of the reviewers' comments showed a marked improvement in the warm sensation that was perceived in Mode 3 as compared to Comparative Example 3. The onset of taste was more pronounced in Mode 3 than in Comparative Example 3. Judges noted that Comparative Example 3 appeared to be less bright and slower to exhibit any unique sensations.
Modalidade 4 (E4) A Modalidade 4 foi preparada através da mistura de mentol, 3-(1-mentoxi)propan-1,2-diol, éter vanilil butílico e resina oleosa de Jambu com outros ingredientes de acordo com a formulação a seguir. Uma colônia cosmética ou outro produto similar pode ser preparada a partir dessa formulação através da mistura com ingredientes de acordo com formulações bem conhecidas na arte.Modality 4 (E4) Modality 4 was prepared by mixing menthol, 3- (1-menthoxy) propan-1,2-diol, vanyl butyl ether and Jambu oily resin with other ingredients according to the following formulation. A cosmetic cologne or other similar product may be prepared from such formulation by mixing with ingredients according to formulations well known in the art.
Exemplo Comparativo 4 (CE4) O Exemplo Comparativo 4 foi feito do mesmo modo como a Modalidade 4, exceto que a resina oleosa de Jambu foi omitida.Comparative Example 4 (CE4) Comparative Example 4 was made in the same manner as Modality 4, except that the Jambu oily resin was omitted.
Exemplo Comparativo 5 (CE5) O Exemplo Comparativo 5 foi feito do mesmo modo como a Modalidade 4, exceto que o éter vanilil butílico foi omitido.Comparative Example 5 (CE5) Comparative Example 5 was made in the same manner as Modality 4, except that vanyl butyl ether was omitted.
Uma lista formal de julgadores avaliou a Modalidade 4 e os Exemplos Comparativos 4 e 5 de acordo com o protocolo a seguir. 0,1 ml da composição foi colocada sobre uma almofada de tecido e aplicada ao antebraço de cada um dos julgadores. As composições sensibilizantes foram avaliadas quanto às suas performances relativas nas seguintes categorias: sensibilização de refrescamento, estimulação, emolien-te e conforto/preferência. Os resultados estão reportados na Tabela 1. TABELA 1 Julgadores Sensibili- Conforto/ (A-C) e zação de Estimulação Emoliente Preferência Tempo de refresca- Os resultados mostraram que a adição de resina oleosa de Jambu aumentou o efeito emoliente sobre o mentol e o éter vanilil butílico sem perda do efeito de refrescamen-to. Quase todos os julgadores preferiram a Modalidade 4 aos Exemplos Comparativos 4 e 5.A formal list of judges evaluated Mode 4 and Comparative Examples 4 and 5 according to the following protocol. 0.1 ml of the composition was placed on a tissue pad and applied to the forearm of each of the judges. Sensitizing compositions were evaluated for their relative performances in the following categories: refreshing sensitization, stimulation, softening and comfort / preference. The results are reported in Table 1. TABLE 1 Sensitivity-Comfort / (AC) Judges and Emollient Stimulation Judgments Preference Refreshment time- Results showed that the addition of Jambu oily resin increased the emollient effect on menthol and vanillyl ether. butyl without loss of cooling effect. Almost all judges preferred Mode 4 to Comparative Examples 4 and 5.
Tendo descrito as modalidades preferidas da invenção com referência aos desenhos anexos, é para ser entendido que a invenção não está limitada àquelas modalidades específicas, e que várias alterações e modificações podem ser efetuadas na mesma por aqueles com habilidade na técnica sem se afastar do escopo ou espírito da invenção como definido através das reivindicações em anexo.Having described preferred embodiments of the invention with reference to the accompanying drawings, it is to be understood that the invention is not limited to those specific embodiments, and that various changes and modifications may be made thereto by those skilled in the art without departing from the scope or spirit of the invention as defined by the appended claims.
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-
2000
- 2000-02-04 US US09/498,592 patent/US6780443B1/en not_active Expired - Lifetime
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- 2001-02-02 DE DE60143597T patent/DE60143597D1/en not_active Expired - Lifetime
- 2001-02-02 JP JP2001027361A patent/JP2001279227A/en active Pending
- 2001-02-02 ID IDP20010107D patent/ID29168A/en unknown
- 2001-02-02 AT AT01400266T patent/ATE490759T1/en not_active IP Right Cessation
- 2001-02-02 EP EP01400266A patent/EP1121927B1/en not_active Expired - Lifetime
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2003
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- 2003-07-22 US US10/625,074 patent/US6890567B2/en not_active Expired - Fee Related
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ATE490759T1 (en) | 2010-12-15 |
US6780443B1 (en) | 2004-08-24 |
ID29168A (en) | 2001-08-09 |
US20040052735A1 (en) | 2004-03-18 |
BR0100254A (en) | 2001-10-02 |
JP2001279227A (en) | 2001-10-10 |
US20030215532A1 (en) | 2003-11-20 |
EP1121927B1 (en) | 2010-12-08 |
DE60143597D1 (en) | 2011-01-20 |
EP1121927A3 (en) | 2003-05-14 |
EP1121927A2 (en) | 2001-08-08 |
US6899901B2 (en) | 2005-05-31 |
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