BR9915005A - Screening test for early detection of colorectal cancer - Google Patents

Screening test for early detection of colorectal cancer

Info

Publication number
BR9915005A
BR9915005A BR9915005-0A BR9915005A BR9915005A BR 9915005 A BR9915005 A BR 9915005A BR 9915005 A BR9915005 A BR 9915005A BR 9915005 A BR9915005 A BR 9915005A
Authority
BR
Brazil
Prior art keywords
sample
detecting
early detection
screening test
galactose
Prior art date
Application number
BR9915005-0A
Other languages
Portuguese (pt)
Inventor
Jiri J Krepinsky
Jacek Chociej
Original Assignee
Jiri J Krepinsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002253093A external-priority patent/CA2253093A1/en
Application filed by Jiri J Krepinsky filed Critical Jiri J Krepinsky
Publication of BR9915005A publication Critical patent/BR9915005A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

"TESTE DE TRIAGEM PARA DETECçãO PRECOCE DECâNCER COLORRETAL". é descrito um método para detectarneoplasia ou câncer do cólon ou reto que compreende obter umaamostra do muco colorretal do reto de um paciente e detectar apresença de um marcador selecionado do grupo que consiste emaldeídos alifáticos de cadeia longa contendo de 12 a 20 átomosde carbono, particularmente CH~ 3~(CH~ 2~)~ 14~CHO e CH~3~(CH~ 2~)~ 16~CHO; e precursores ligados a plasmalogênio dosmesmos. Preferivelmente, o método compreende tratar a amostracom reagente de Schiff e detectar neoplasia ou câncer do cólonou reto com base na coloração produzida a cerca de 550-590 nmna amostra pelo tratamento. o método não requer a etapa deadicionar uma enzima para detectar o marcador dissacarídeocontendo ßD-Gal(1-3)-D-GalNAc(<224>l-Thr/Ser) e um marcadorsacarídeo contendo D-galactose e/ou2-acetamido-2-desoxi-D-galactose."SCREENING TEST FOR EARLY DETECTION COLORRETAL DECANCER". a method for detecting colon or rectal neoplasm or cancer is described, which comprises obtaining a sample of a patient's colorectal mucus from the rectum and detecting the presence of a marker selected from the group consisting of long chain aliphatic emaldehydes containing 12 to 20 carbon atoms, particularly CH ~ 3 ~ (CH ~ 2 ~) ~ 14 ~ CHO and CH ~ 3 ~ (CH ~ 2 ~) ~ 16 ~ CHO; and precursors linked to plasmalogen dosmesmos. Preferably, the method comprises treating the sample with Schiff's reagent and detecting neoplasia or colon or rectal cancer based on the stain produced at about 550-590 nm in the sample by treatment. the method does not require the step of adding an enzyme to detect the disaccharide marker containing ßD-Gal (1-3) -D-GalNAc (<224> 1-Thr / Ser) and a saccharide marker containing D-galactose and / or 2-acetamido-2 -deoxy-D-galactose.

BR9915005-0A 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer BR9915005A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA002253093A CA2253093A1 (en) 1998-11-06 1998-11-06 Screening test for early detection of colorectal cancer
US09/270,103 US6187591B1 (en) 1998-11-06 1999-03-16 Screening test for early detection of colorectal cancer
PCT/CA1999/001034 WO2000028329A1 (en) 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer

Publications (1)

Publication Number Publication Date
BR9915005A true BR9915005A (en) 2001-11-20

Family

ID=25680625

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915005-0A BR9915005A (en) 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer

Country Status (6)

Country Link
EP (1) EP1125131A1 (en)
JP (1) JP2002529739A (en)
AU (1) AU766057B2 (en)
BR (1) BR9915005A (en)
IL (1) IL139545A0 (en)
WO (1) WO2000028329A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2299210A1 (en) * 2000-02-17 2001-08-17 Gregory R. Wade A method of assessing the biological status of cancer development

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416025A (en) * 1993-11-29 1995-05-16 Krepinsky; Jiri J. Screening test for early detection of colorectal cancer

Also Published As

Publication number Publication date
WO2000028329A1 (en) 2000-05-18
JP2002529739A (en) 2002-09-10
IL139545A0 (en) 2002-02-10
AU1022700A (en) 2000-05-29
AU766057B2 (en) 2003-10-09
EP1125131A1 (en) 2001-08-22

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Legal Events

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B25A Requested transfer of rights approved

Owner name: PROCYON BIOPHARMA INC. (CA)

Free format text: TRANSFERIDO DE: UNIVERSITY OF TORONTO INNOVATIONS FOUNDATION

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13, 10 (VIII) E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.