CA2352184A1 - Screening test for early detection of colorectal cancer - Google Patents
Screening test for early detection of colorectal cancer Download PDFInfo
- Publication number
- CA2352184A1 CA2352184A1 CA002352184A CA2352184A CA2352184A1 CA 2352184 A1 CA2352184 A1 CA 2352184A1 CA 002352184 A CA002352184 A CA 002352184A CA 2352184 A CA2352184 A CA 2352184A CA 2352184 A1 CA2352184 A1 CA 2352184A1
- Authority
- CA
- Canada
- Prior art keywords
- detecting
- sample
- rectum
- marker
- colorectal cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010009944 Colon cancer Diseases 0.000 title 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 238000012216 screening Methods 0.000 title 1
- 239000003550 marker Substances 0.000 abstract 3
- 210000000664 rectum Anatomy 0.000 abstract 3
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000015634 Rectal Neoplasms Diseases 0.000 abstract 2
- 208000029742 colonic neoplasm Diseases 0.000 abstract 2
- 230000009826 neoplastic cell growth Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 abstract 1
- -1 aliphatic aldehydes Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 210000003097 mucus Anatomy 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A method for detecting neoplasia or cancer of the colon or rectum comprising obtaining a sample of colorectal mucus from the rectum of a patient, and detecting the presence of a marker selected from the group consisting of long chain aliphatic aldehydes containing 12 - 20 carbon atoms, particularly CH3(CH2)14CHO and CH3(CH2)16CHO; and plasmalogen-bound precursors thereof. Preferably the method comprises treating the sample with Schiff s Reagent and detecting neoplasia or cancer of the colon or rectum based upon the coloration produced at about 550 - 590 nm in the sample by the treatment. The method does not require the step of adding an enzyme for detecting the disaccharide marker .beta.-D-Gal(1-3)-D-GalNAc(.alpha. l-Thr/Ser) and a saccharide marker containing D-galactose and/or 2-acetamido-2-deoxy-D-galactose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002352184A CA2352184C (en) | 1998-11-06 | 1999-11-03 | Screening test for early detection of colorectal cancer |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002253093A CA2253093A1 (en) | 1998-11-06 | 1998-11-06 | Screening test for early detection of colorectal cancer |
| CA2,253,093 | 1998-11-06 | ||
| US09/270,103 | 1999-03-16 | ||
| US09/270,103 US6187591B1 (en) | 1998-11-06 | 1999-03-16 | Screening test for early detection of colorectal cancer |
| PCT/CA1999/001034 WO2000028329A1 (en) | 1998-11-06 | 1999-11-03 | Screening test for early detection of colorectal cancer |
| CA002352184A CA2352184C (en) | 1998-11-06 | 1999-11-03 | Screening test for early detection of colorectal cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2352184A1 true CA2352184A1 (en) | 2000-05-18 |
| CA2352184C CA2352184C (en) | 2007-05-29 |
Family
ID=27170865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002352184A Expired - Fee Related CA2352184C (en) | 1998-11-06 | 1999-11-03 | Screening test for early detection of colorectal cancer |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2352184C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244246A (en) * | 2021-05-11 | 2021-08-13 | 江南大学 | Application of microbial plasmalogen in treatment of colon cancer |
-
1999
- 1999-11-03 CA CA002352184A patent/CA2352184C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113244246A (en) * | 2021-05-11 | 2021-08-13 | 江南大学 | Application of microbial plasmalogen in treatment of colon cancer |
| CN113244246B (en) * | 2021-05-11 | 2022-05-06 | 江南大学 | Application of microbial plasmalogen in treatment of colon cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2352184C (en) | 2007-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |