CA2352184A1 - Screening test for early detection of colorectal cancer - Google Patents

Screening test for early detection of colorectal cancer Download PDF

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Publication number
CA2352184A1
CA2352184A1 CA002352184A CA2352184A CA2352184A1 CA 2352184 A1 CA2352184 A1 CA 2352184A1 CA 002352184 A CA002352184 A CA 002352184A CA 2352184 A CA2352184 A CA 2352184A CA 2352184 A1 CA2352184 A1 CA 2352184A1
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CA
Canada
Prior art keywords
detecting
sample
rectum
marker
colorectal cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002352184A
Other languages
French (fr)
Other versions
CA2352184C (en
Inventor
Jiri J. Krepinsky
Jacek Chociej (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procyon Biopharma Inc
Original Assignee
Jiri J. Krepinsky
Jacek Chociej (Deceased)
Chociej, Malgorzata
University Of Toronto Innovations Foundation
Procyon Biopharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002253093A external-priority patent/CA2253093A1/en
Application filed by Jiri J. Krepinsky, Jacek Chociej (Deceased), Chociej, Malgorzata, University Of Toronto Innovations Foundation, Procyon Biopharma Inc. filed Critical Jiri J. Krepinsky
Priority to CA002352184A priority Critical patent/CA2352184C/en
Priority claimed from PCT/CA1999/001034 external-priority patent/WO2000028329A1/en
Publication of CA2352184A1 publication Critical patent/CA2352184A1/en
Application granted granted Critical
Publication of CA2352184C publication Critical patent/CA2352184C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A method for detecting neoplasia or cancer of the colon or rectum comprising obtaining a sample of colorectal mucus from the rectum of a patient, and detecting the presence of a marker selected from the group consisting of long chain aliphatic aldehydes containing 12 - 20 carbon atoms, particularly CH3(CH2)14CHO and CH3(CH2)16CHO; and plasmalogen-bound precursors thereof. Preferably the method comprises treating the sample with Schiff s Reagent and detecting neoplasia or cancer of the colon or rectum based upon the coloration produced at about 550 - 590 nm in the sample by the treatment. The method does not require the step of adding an enzyme for detecting the disaccharide marker .beta.-D-Gal(1-3)-D-GalNAc(.alpha. l-Thr/Ser) and a saccharide marker containing D-galactose and/or 2-acetamido-2-deoxy-D-galactose.
CA002352184A 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer Expired - Fee Related CA2352184C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002352184A CA2352184C (en) 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CA2,253,093 1998-11-06
CA002253093A CA2253093A1 (en) 1998-11-06 1998-11-06 Screening test for early detection of colorectal cancer
US09/270,103 US6187591B1 (en) 1998-11-06 1999-03-16 Screening test for early detection of colorectal cancer
US09/270,103 1999-03-16
CA002352184A CA2352184C (en) 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer
PCT/CA1999/001034 WO2000028329A1 (en) 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer

Publications (2)

Publication Number Publication Date
CA2352184A1 true CA2352184A1 (en) 2000-05-18
CA2352184C CA2352184C (en) 2007-05-29

Family

ID=27170865

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002352184A Expired - Fee Related CA2352184C (en) 1998-11-06 1999-11-03 Screening test for early detection of colorectal cancer

Country Status (1)

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CA (1) CA2352184C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113244246A (en) * 2021-05-11 2021-08-13 江南大学 Application of microbial plasmalogen in treatment of colon cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113244246A (en) * 2021-05-11 2021-08-13 江南大学 Application of microbial plasmalogen in treatment of colon cancer
CN113244246B (en) * 2021-05-11 2022-05-06 江南大学 Application of microbial plasmalogen in treatment of colon cancer

Also Published As

Publication number Publication date
CA2352184C (en) 2007-05-29

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