BR9913694A - Polìmeros - Google Patents

Polìmeros

Info

Publication number
BR9913694A
BR9913694A BR9913694-5A BR9913694A BR9913694A BR 9913694 A BR9913694 A BR 9913694A BR 9913694 A BR9913694 A BR 9913694A BR 9913694 A BR9913694 A BR 9913694A
Authority
BR
Brazil
Prior art keywords
polymers
porous
units
devices
manufacture
Prior art date
Application number
BR9913694-5A
Other languages
English (en)
Inventor
Hassan Chaouk
Timothy Charles Hughes
John Stuart Wilkie
Gordon Francis Meijs
Original Assignee
Novartis Ag
Commw Scient Ind Res Org
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Commw Scient Ind Res Org filed Critical Novartis Ag
Publication of BR9913694A publication Critical patent/BR9913694A/pt

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/50—Polyethers having heteroatoms other than oxygen
    • C08G18/5003—Polyethers having heteroatoms other than oxygen having halogens
    • C08G18/5015—Polyethers having heteroatoms other than oxygen having halogens having fluorine atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/81—Unsaturated isocyanates or isothiocyanates
    • C08G18/8108—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group
    • C08G18/8116—Unsaturated isocyanates or isothiocyanates having only one isocyanate or isothiocyanate group esters of acrylic or alkylacrylic acid having only one isocyanate or isothiocyanate group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C08G65/005—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens
    • C08G65/007—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds containing halogens containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Polyethers (AREA)
  • Graft Or Block Polymers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Materials For Medical Uses (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

Patente de Invenção: <B>"POLìMEROS"<D>. A presente invenção refere-se a polímeros compreendendo uma ou mais unidades de perfluoralquilpoliéter e uma ou mais unidades diferentes carregadas, a um processo para produção de tais polímeros em forma não porosa ou particularmente em forma porosa e a moldagens compostas destes. Os novos polímeros têm uma umectabilidade melhorada e capacidade de desenvolvimento celular e são por conseguinte úteis, por exemplo, para a fabricação de dispositivos biomédicos, em particular dispositivos oftálmicos.
BR9913694-5A 1998-09-15 1999-09-13 Polìmeros BR9913694A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117421 1998-09-15
PCT/EP1999/006767 WO2000015686A1 (en) 1998-09-15 1999-09-13 Polymers

Publications (1)

Publication Number Publication Date
BR9913694A true BR9913694A (pt) 2001-06-05

Family

ID=8232633

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913694-5A BR9913694A (pt) 1998-09-15 1999-09-13 Polìmeros

Country Status (14)

Country Link
US (1) US6225367B1 (pt)
EP (1) EP1161476B1 (pt)
JP (1) JP2002524628A (pt)
CN (1) CN1318076A (pt)
AT (1) ATE356157T1 (pt)
AU (1) AU754125C (pt)
BR (1) BR9913694A (pt)
CA (1) CA2343159C (pt)
DE (1) DE69935457T2 (pt)
ES (1) ES2284268T3 (pt)
NO (1) NO20011292L (pt)
TW (1) TWI230712B (pt)
WO (1) WO2000015686A1 (pt)
ZA (1) ZA200102072B (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451287B1 (en) * 2000-05-26 2002-09-17 Smithkline Beecham Corporation Fluorinated copolymer surfactants and use thereof in aerosol compositions
US6544286B1 (en) * 2000-07-18 2003-04-08 Tissue Engineering Refraction, Inc. Pre-fabricated corneal tissue lens method of corneal overlay to correct vision
US7497866B2 (en) 2000-07-18 2009-03-03 Tissue Engineering Refraction Inc. Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses
US6660828B2 (en) 2001-05-14 2003-12-09 Omnova Solutions Inc. Fluorinated short carbon atom side chain and polar group containing polymer, and flow, or leveling, or wetting agents thereof
CN1209392C (zh) * 2001-05-14 2005-07-06 阿姆诺洼化学有限公司 由含侧氟碳基的环状单体得到的聚合物表面活性剂
US20030060878A1 (en) 2001-08-31 2003-03-27 Shadduck John H. Intraocular lens system and method for power adjustment
US7261737B2 (en) * 2002-12-12 2007-08-28 Powervision, Inc. Accommodating intraocular lens system and method
US8048155B2 (en) 2002-02-02 2011-11-01 Powervision, Inc. Intraocular implant devices
AU2002309806A1 (en) * 2002-04-10 2003-10-27 Honeywell International, Inc. New porogens for porous silica dielectric for integral circuit applications
US7381441B2 (en) * 2002-04-10 2008-06-03 Honeywell International Inc. Low metal porous silica dielectric for integral circuit applications
EP1364663A1 (en) * 2002-05-21 2003-11-26 Commonwealth Scientific And Industrial Research Organisation Ocular devices with functionalized surface with adhesive properties
AU2003254677A1 (en) * 2002-08-09 2004-02-25 Ottawa Health Research Institute Innervated artificial tissues and uses thereof
US7217288B2 (en) 2002-12-12 2007-05-15 Powervision, Inc. Accommodating intraocular lens having peripherally actuated deflectable surface and method
US8328869B2 (en) 2002-12-12 2012-12-11 Powervision, Inc. Accommodating intraocular lenses and methods of use
US8361145B2 (en) 2002-12-12 2013-01-29 Powervision, Inc. Accommodating intraocular lens system having circumferential haptic support and method
US7247168B2 (en) * 2002-12-12 2007-07-24 Powervision, Inc. Accommodating intraocular lens system and method
US7637947B2 (en) * 2002-12-12 2009-12-29 Powervision, Inc. Accommodating intraocular lens system having spherical aberration compensation and method
EP1585563A4 (en) * 2002-12-12 2012-03-21 Powervision Inc ACCOMODING INTRAOCULAR LENS SYSTEM AND METHOD
US10835373B2 (en) 2002-12-12 2020-11-17 Alcon Inc. Accommodating intraocular lenses and methods of use
EP1569581A4 (en) * 2002-12-12 2006-09-20 Powervision LENS SYSTEM FOR ENERGY ADJUSTMENT WITH MICROPUMP
US7425601B2 (en) * 2002-12-20 2008-09-16 Exxonmobil Chemical Patents Inc. Polymers with new sequence distributions
WO2004058827A1 (en) * 2002-12-20 2004-07-15 Exxonmobil Chemical Patents Inc. Polymerization processes
CA2510860C (en) * 2002-12-20 2012-10-09 Exxonmobil Chemical Patents Inc. Polymerization process utilizing hydrofluorocarbons as diluents
DE60333123D1 (de) * 2002-12-20 2010-08-05 Exxonmobil Chem Patents Inc Polymerisationsverfahren
CA2517576A1 (en) * 2003-03-06 2004-09-23 John H. Shadduck Adaptive optic lens and method of making
US7307118B2 (en) * 2004-11-24 2007-12-11 Molecular Imprints, Inc. Composition to reduce adhesion between a conformable region and a mold
US20050273146A1 (en) * 2003-12-24 2005-12-08 Synecor, Llc Liquid perfluoropolymers and medical applications incorporating same
US20050271794A1 (en) * 2003-12-24 2005-12-08 Synecor, Llc Liquid perfluoropolymers and medical and cosmetic applications incorporating same
US20050142315A1 (en) * 2003-12-24 2005-06-30 Desimone Joseph M. Liquid perfluoropolymers and medical applications incorporating same
US8076386B2 (en) * 2004-02-23 2011-12-13 Molecular Imprints, Inc. Materials for imprint lithography
US7981984B2 (en) * 2004-06-21 2011-07-19 Exxonmobil Chemical Patents Inc. Polymerization process
WO2006009942A1 (en) * 2004-06-21 2006-01-26 Exxonmobil Chemical Patents Inc. Polymerization process
WO2006009951A1 (en) * 2004-06-21 2006-01-26 Exxonmobil Chemical Patents Inc. Polymer recovery method
WO2006009945A1 (en) 2004-06-21 2006-01-26 Exxonmobil Chemical Patents Inc. Impact copolymers
US9872763B2 (en) 2004-10-22 2018-01-23 Powervision, Inc. Accommodating intraocular lenses
US7799882B2 (en) * 2005-06-20 2010-09-21 Exxonmobil Chemical Patents Inc. Polymerization process
US8808808B2 (en) 2005-07-22 2014-08-19 Molecular Imprints, Inc. Method for imprint lithography utilizing an adhesion primer layer
US8557351B2 (en) 2005-07-22 2013-10-15 Molecular Imprints, Inc. Method for adhering materials together
US7759407B2 (en) * 2005-07-22 2010-07-20 Molecular Imprints, Inc. Composition for adhering materials together
US20070088433A1 (en) * 2005-10-17 2007-04-19 Powervision Accommodating intraocular lens system utilizing direct force transfer from zonules and method of use
EP1801140A1 (en) * 2005-12-22 2007-06-27 Mnemoscience GmbH Macro-diacrylate
CA2650819A1 (en) * 2006-05-11 2007-11-22 Air Products And Chemicals, Inc. Personal care compositions containing functionalized polymers
US20080110557A1 (en) * 2006-11-15 2008-05-15 Molecular Imprints, Inc. Methods and Compositions for Providing Preferential Adhesion and Release of Adjacent Surfaces
JP4912140B2 (ja) * 2006-12-26 2012-04-11 株式会社イノアックコーポレーション 紫外線硬化発泡体
AU2008218313B2 (en) 2007-02-21 2014-01-09 Alcon Inc. Polymeric materials suitable for ophthalmic devices and methods of manufacture
CA2693808C (en) * 2007-07-19 2015-10-20 Alcon, Inc. High ion and metabolite flux lenses and materials
US8314927B2 (en) 2007-07-23 2012-11-20 Powervision, Inc. Systems and methods for testing intraocular lenses
AU2008279167B2 (en) 2007-07-23 2014-10-09 Alcon Inc. Post-implant lens power modification
US20090026924A1 (en) * 2007-07-23 2009-01-29 Leung Roger Y Methods of making low-refractive index and/or low-k organosilicate coatings
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
EP2671541B1 (en) 2007-07-23 2019-04-17 PowerVision, Inc. Accommodating intraocular lenses
CN101754728B (zh) 2007-07-23 2013-09-18 力景公司 晶状体递送系统
US20090098359A1 (en) 2007-10-11 2009-04-16 Waller Jr Clinton P Hydrophilic porous substrates
EP2232304B1 (en) * 2007-12-10 2012-04-04 Novartis AG Method for making silicone hydrogel contact lenses
JP2009168875A (ja) * 2008-01-11 2009-07-30 Mo-Wei Hung シリコンコンタクトレンズの成型方法とその構造
CN102112524B (zh) * 2008-08-08 2013-02-27 Dic株式会社 含氟化合物以及使用其的活性能量射线固化型树脂组合物
US10299913B2 (en) 2009-01-09 2019-05-28 Powervision, Inc. Accommodating intraocular lenses and methods of use
EP2435506B1 (en) * 2009-05-25 2014-04-02 Solvay Specialty Polymers Italy S.p.A. Protective film for a solar cell module
US8394870B2 (en) * 2009-07-16 2013-03-12 E.I. Du Pont De Nemours And Company Crosslinked fluoropolymer networks
WO2011026068A2 (en) 2009-08-31 2011-03-03 Powervision, Inc. Lens capsule size estimation
US9233063B2 (en) * 2009-12-17 2016-01-12 Air Products And Chemicals, Inc. Polymeric compositions for personal care products
US9138308B2 (en) 2010-02-03 2015-09-22 Apollo Endosurgery, Inc. Mucosal tissue adhesion via textured surface
EP3263574B1 (en) 2010-02-23 2019-04-03 PowerVision, Inc. Accomodating intraocular lens
ES2623475T3 (es) 2010-05-11 2017-07-11 Allergan, Inc. Composiciones de porógenos, métodos para hacerlas y usos
WO2012006616A2 (en) 2010-07-09 2012-01-12 Powervision, Inc. Intraocular lens delivery devices and methods of use
WO2012129407A2 (en) 2011-03-24 2012-09-27 Powervision, Inc. Intraocular lens loading systems and methods of use
US9090772B2 (en) 2011-08-04 2015-07-28 Solvay Specialty Polymers Italy S.P.A. Compositions of ionisable fluoropolymers
US10433949B2 (en) 2011-11-08 2019-10-08 Powervision, Inc. Accommodating intraocular lenses
WO2014022657A1 (en) 2012-08-02 2014-02-06 Allergan, Inc. Mucosal tissue adhesion via textured surface
EP2900289A1 (en) 2012-09-28 2015-08-05 Allergan, Inc. Porogen compositions, methods of making and uses
US10195020B2 (en) 2013-03-15 2019-02-05 Powervision, Inc. Intraocular lens storage and loading devices and methods of use
EP3221382B1 (en) * 2014-11-19 2020-05-06 Solvay Specialty Polymers Italy S.p.A. Zwitterionic derivatives of (per)fluoropolyethers
EP3884905A1 (en) 2015-11-06 2021-09-29 Alcon Inc. Ccommodating intraocular lenses
WO2020036205A1 (en) * 2018-08-16 2020-02-20 Terumo Kabushiki Kaisha Cell culture substrate
EP3830237A1 (en) * 2018-08-16 2021-06-09 TERUMO Kabushiki Kaisha Cell culture substrate
AU2020357870A1 (en) 2019-10-04 2022-04-28 Alcon Inc. Adjustable intraocular lenses and methods of post-operatively adjusting intraocular lenses

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA962021A (en) * 1970-05-21 1975-02-04 Robert W. Gore Porous products and process therefor
US4440918A (en) * 1982-01-18 1984-04-03 Minnesota Mining And Manufacturing Company Contact lens containing a fluorinated telechelic polyether
US4818801A (en) * 1982-01-18 1989-04-04 Minnesota Mining And Manufacturing Company Ophthalmic device comprising a polymer of a telechelic perfluoropolyether
US4799931A (en) * 1986-05-14 1989-01-24 Lindstrom Richard L Intracorneal lens
JP2550036B2 (ja) * 1986-11-21 1996-10-30 株式会社メニコン コンタクトレンズ用液剤組成物
US5244799A (en) * 1987-05-20 1993-09-14 Anderson David M Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate
US5238613A (en) * 1987-05-20 1993-08-24 Anderson David M Microporous materials
JPH04239504A (ja) * 1991-01-22 1992-08-27 Yokohama Rubber Co Ltd:The 光硬化型ゲル基材
AU666485B2 (en) * 1991-07-05 1996-02-15 Biocompatibles Uk Limited Polymeric surface coatings
DK0810239T3 (da) * 1991-07-05 2001-01-02 Biocompatibles Ltd Polymere overfladecoatings
IT1251487B (it) * 1991-09-17 1995-05-15 Syremont Spa Dispersioni acquose di poliuretani fluorurati
JP3165992B2 (ja) * 1995-03-14 2001-05-14 東レ株式会社 抗菌性樹脂とその製造方法及び抗菌性繊維構造物
CN1121430C (zh) * 1995-04-04 2003-09-17 诺瓦提斯公司 细胞生长基质聚合物
AUPN215995A0 (en) * 1995-04-04 1995-04-27 Ciba-Geigy Ag Novel materials
AUPN354595A0 (en) 1995-06-14 1995-07-06 Ciba-Geigy Ag Novel materials
EP0885248A1 (en) 1996-03-04 1998-12-23 Exxon Chemical Patents Inc. Stable metallocene catalyst systems
NZ332019A (en) * 1996-03-27 2000-02-28 Novartis Ag High water content porous polymer comprising a perfluoropolyether unit
CN1214708A (zh) 1996-03-27 1999-04-21 诺瓦提斯公司 使用成孔材料制造多孔聚合物的方法

Also Published As

Publication number Publication date
ATE356157T1 (de) 2007-03-15
ES2284268T3 (es) 2007-11-01
AU754125C (en) 2006-08-31
DE69935457T2 (de) 2007-11-15
WO2000015686A1 (en) 2000-03-23
DE69935457D1 (de) 2007-04-19
US6225367B1 (en) 2001-05-01
EP1161476A1 (en) 2001-12-12
NO20011292D0 (no) 2001-03-14
CA2343159A1 (en) 2000-03-23
NO20011292L (no) 2001-05-14
AU754125B2 (en) 2002-11-07
TWI230712B (en) 2005-04-11
EP1161476B1 (en) 2007-03-07
AU6190699A (en) 2000-04-03
CA2343159C (en) 2010-06-22
JP2002524628A (ja) 2002-08-06
ZA200102072B (en) 2001-10-30
CN1318076A (zh) 2001-10-17

Similar Documents

Publication Publication Date Title
NO20011292D0 (no) Polymerer
NO964632L (no) Gjennvinnbare plastfilmer
DE50002772D1 (de) Polyethylen formmasse mit verbesserter escr-steifigkeitsrelation und schwellrate, verfahren zu ihrer herstellung und ihre verwendung
AU2002251725A1 (en) Compositions and methods for biomedical applications
HUP9901201A3 (en) Linear block polymer comprising urea and urethane groups, method for the production of linear block polymers and use of the block polymers as implants
DE60114565D1 (de) Hydrogele
DE59600721D1 (de) Verfahren zur Herstellung von hochmolekularen Polymerisaten
HUP0001256A2 (hu) Biológiailag lebomló tereftalát-poliészter-polifoszfonát-polimerek, készítmények, eljárás előállításukra és alkalmazásuk
DE69126126D1 (de) Quartäre vernetzte allylammoniumpolymere, ihre herstellung und verwendung
DE69605780D1 (de) Perfluoroalkylether enthaltendes polysiloxan and dessen herstellung und verwendung
DE59811911D1 (de) Verfahren zur Herstellung von stabilen, feinteiligen Polymerdispersionen
MXPA05006414A (es) Poliazoles de alto peso molecular.
CA2279300A1 (en) Polyesteramides from cyclic monomers and surgical articles made therefrom
ATE551046T1 (de) Polymere duftkapseln und ihre herstellung
DK1003443T3 (da) Fremgangmåde til fremstilling af en genstand af poröst materiale
ATE188199T1 (de) Sphärische keramikformkörper, verfahren zu ihrer herstellung sowie deren verwendung
ATE287736T1 (de) Humanisierte biomaterialien enthaltend monozyten oder makrophagen, ein verfahren zu ihrer herstellung und ihre anwendungen
ATE357469T1 (de) Sterilisierende polymere und deren herstellung und verwendung
ATE223460T1 (de) Bioabbaubare zusammensetzungen auf der basis von sorghummehl, daraus hergestellte formkörper und verfahren zur herstellung dieser formkörper
DE69114537D1 (de) Hochzäher, nichtgewebter Faserstoff, Verfahren zu seiner Herstellung und diesen Faserstoff enthaltenden Akkumulatorseparator.
EP1471111A4 (en) STYRENE RESIN COMPOSITION AND METHOD OF MANUFACTURING THEREOF
DE60117973D1 (de) Verfahren zur herstellung und verwendung von geträgerten phosphazenium katalysatoren
DE59801711D1 (de) Geschlossenporige siliconschäume, verfahren zu ihrer herstellung und ihre verwendung
BR0109086A (pt) Polìmeros reativos
DE59901675D1 (de) Zusammensetzung zur herstellung von formkörpern und verfahren zur herstellung von formkörpern aus einer solchen zusammensetzung

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]