BR9913140A - 2-oxo-2h-quinoline derivatives - Google Patents

2-oxo-2h-quinoline derivatives

Info

Publication number
BR9913140A
BR9913140A BR9913140-4A BR9913140A BR9913140A BR 9913140 A BR9913140 A BR 9913140A BR 9913140 A BR9913140 A BR 9913140A BR 9913140 A BR9913140 A BR 9913140A
Authority
BR
Brazil
Prior art keywords
oxo
quinoline derivatives
prophylaxis
inhibitors
formula
Prior art date
Application number
BR9913140-4A
Other languages
Portuguese (pt)
Inventor
Horst Juraszyk
Hanns Wurziger
Joachim Gante
Dieter Dorsch
Hans-Peter Buchstaller
Sabine Bernotat-Danielowski
Guido Melzer
Soheila Anzali
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9913140A publication Critical patent/BR9913140A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS 2-OXO-2H-QUINOLINA"<D>. Novos compostos de fórmula I em que X, Y, R, R¹, R², R³ e n têm o significado dado de acordo com a reivindicação 1, são inibidores do fator de coagulação Xa e podem ser empregados para a profilaxia e/ou de doenças tromboembólicas.Invention Patent: <B> "2-OXO-2H-QUINOLINE DERIVATIVES" <D>. New compounds of formula I in which X, Y, R, R¹, R², R³ en have the meaning given according to claim 1, are inhibitors of coagulation factor Xa and can be used for prophylaxis and / or thromboembolic diseases .

BR9913140-4A 1998-08-29 1999-07-26 2-oxo-2h-quinoline derivatives BR9913140A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19839499A DE19839499A1 (en) 1998-08-29 1998-08-29 2-oxo-2H-quinoline derivatives
PCT/EP1999/005315 WO2000012479A1 (en) 1998-08-29 1999-07-26 2-oxo-2h-quinoline derivatives

Publications (1)

Publication Number Publication Date
BR9913140A true BR9913140A (en) 2001-05-08

Family

ID=7879227

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913140-4A BR9913140A (en) 1998-08-29 1999-07-26 2-oxo-2h-quinoline derivatives

Country Status (17)

Country Link
EP (1) EP1107954A1 (en)
JP (1) JP2002523494A (en)
KR (1) KR20010072862A (en)
CN (1) CN1315942A (en)
AR (1) AR021782A1 (en)
AU (1) AU5164199A (en)
BR (1) BR9913140A (en)
CA (1) CA2342230A1 (en)
DE (1) DE19839499A1 (en)
HK (1) HK1042478A1 (en)
HU (1) HUP0103212A3 (en)
ID (1) ID27863A (en)
NO (1) NO20010996L (en)
PL (1) PL346045A1 (en)
SK (1) SK2652001A3 (en)
WO (1) WO2000012479A1 (en)
ZA (1) ZA200102565B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
AU2015295405B2 (en) 2014-08-01 2020-04-09 Nuevolution A/S Compounds active towards bromodomains

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI59246C (en) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd FOERFARANDE FOER FRAMSTAELLNING AV BENSCYKLOAMIDDERIVAT ANVAENDBARA VID TROMBOS- OCH EMBOLITERAPIN
IE43079B1 (en) * 1975-03-20 1980-12-17 Ici Ltd Quinolone derivatives
JPS596858B2 (en) * 1975-04-30 1984-02-15 オオツカセイヤク カブシキガイシヤ Method for producing 3,4-dihydrocarbostyryl derivative
AT347956B (en) * 1976-03-18 1979-01-25 Ici Ltd Process for the preparation of new quinol-2-on-4-yl-alkanoic acids and their base addition salts
DE2651581A1 (en) * 1976-11-12 1978-05-18 Merck Patent Gmbh CHINOLONE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
WO1992004328A1 (en) * 1990-09-07 1992-03-19 Schering Corporation Antiviral compounds and antihypertensive compounds
US5412104A (en) * 1990-09-07 1995-05-02 Schering Corporation Ester and alkoxy substituted benzopyrans
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
DE4208304A1 (en) * 1992-03-16 1993-09-23 Merck Patent Gmbh 2-OXOCHINOLINDERIVATE
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
DE19528418A1 (en) * 1995-08-02 1997-02-06 Merck Patent Gmbh Endothelin receptor antagonists
DE19530996A1 (en) * 1995-08-23 1997-02-27 Boehringer Mannheim Gmbh Cyclic guanidines, process for their preparation and pharmaceuticals
US5968959A (en) * 1997-12-12 1999-10-19 Orion Corporation Method for the prevention and treatment of stunned myocardium

Also Published As

Publication number Publication date
HUP0103212A2 (en) 2002-05-29
EP1107954A1 (en) 2001-06-20
ZA200102565B (en) 2002-06-28
ID27863A (en) 2001-04-26
CN1315942A (en) 2001-10-03
NO20010996D0 (en) 2001-02-27
WO2000012479A1 (en) 2000-03-09
KR20010072862A (en) 2001-07-31
AR021782A1 (en) 2002-08-07
PL346045A1 (en) 2002-01-14
AU5164199A (en) 2000-03-21
JP2002523494A (en) 2002-07-30
DE19839499A1 (en) 2000-03-02
HUP0103212A3 (en) 2002-06-28
CA2342230A1 (en) 2000-03-09
NO20010996L (en) 2001-02-27
SK2652001A3 (en) 2001-09-11
HK1042478A1 (en) 2002-08-16

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]